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Volumn 11, Issue 3, 2018, Pages 581-589

Mucocutaneous IL-17 immunity in mice and humans: Host defense vs. excessive inflammation

Author keywords

[No Author keywords available]

Indexed keywords

BRODALUMAB; CNTO 6785; CYTOKINE; DEXAMETHASONE; GUSELKUMAB; HALOFUGINONE; INTERLEUKIN 17; INTERLEUKIN 17F; IXEKIZUMAB; MONOCLONAL ANTIBODY; RISANKIZUMAB; SECUKINUMAB; TILDRAKIZUMAB; UNCLASSIFIED DRUG; IL17A PROTEIN, HUMAN; IL17A PROTEIN, MOUSE; IL17F PROTEIN, HUMAN;

EID: 85047986823     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2017.97     Document Type: Review
Times cited : (113)

References (137)
  • 1
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated Tcell, bearing AU-rich messengerRNAinstability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier, E., Luciani,M. F., Mattei, M. G.,Denizot, F. &Golstein, P. CTLA-8, cloned from an activated Tcell, bearing AU-rich messengerRNAinstability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150, 5445-5456 (1993).
    • (1993) J. Immunol. , vol.150 , pp. 5445-5456
    • Rouvier, E.1    Luciani, M.F.2    Mattei, M.G.3    Denizot, F.4    Golstein, P.5
  • 2
    • 0029555301 scopus 로고
    • Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
    • Yao, Z. et al. Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3, 811-821 (1995).
    • (1995) Immunity , vol.3 , pp. 811-821
    • Yao, Z.1
  • 3
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls, J. K. &Linden, A. Interleukin-17 family members and inflammation. Immunity 21, 467-476 (2004).
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 4
    • 17944368518 scopus 로고    scopus 로고
    • IL-17s adopt a cystine knot fold: Structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
    • Hymowitz, S. G. et al. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 20, 5332-5341 (2001).
    • (2001) EMBO J. , vol.20 , pp. 5332-5341
    • Hymowitz, S.G.1
  • 5
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L. E. et al. Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 6
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish, C. L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 233-240
    • Langrish, C.L.1
  • 7
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133-1141 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1133-1141
    • Park, H.1
  • 8
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang, S. C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2271-2279
    • Liang, S.C.1
  • 9
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper Tcells
    • Wilson, N. J. et al. Development, cytokine profile and function of human interleukin 17-producing helper Tcells. Nat. Immunol. 8, 950-957 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 950-957
    • Wilson, N.J.1
  • 11
    • 84856559843 scopus 로고    scopus 로고
    • Human CD90 identifies Th17/Tc17 Tcell subsets that are depleted in HIV-infected patients
    • Guillot-Delost, M. et al. Human CD90 identifies Th17/Tc17 Tcell subsets that are depleted in HIV-infected patients. J. Immunol. 188, 981-991 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 981-991
    • Guillot-Delost, M.1
  • 12
    • 4344603836 scopus 로고    scopus 로고
    • Involvement of IL-17 in Fas ligand-induced inflammation
    • Umemura, M. et al. Involvement of IL-17 in Fas ligand-induced inflammation. Int. Immunol. 16, 1099-1108 (2004).
    • (2004) Int. Immunol. , vol.16 , pp. 1099-1108
    • Umemura, M.1
  • 13
    • 15244344110 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
    • Stark, M. A., Huo, Y., Burcin, T. L., Morris, M. A., Olson, T. S. &Ley, K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22, 285-294 (2005).
    • (2005) Immunity , vol.22 , pp. 285-294
    • Stark, M.A.1    Huo, Y.2    Burcin, T.L.3    Morris, M.A.4    Olson, T.S.5    Ley, K.6
  • 14
    • 34249059942 scopus 로고    scopus 로고
    • Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia
    • Michel, M. L. et al. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J. Exp. Med. 204, 995-1001 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 995-1001
    • Michel, M.L.1
  • 15
    • 58149384437 scopus 로고    scopus 로고
    • Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation
    • Michel, M. L. et al. Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc. Natl Acad. Sci. USA 105, 19845-19850 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19845-19850
    • Michel, M.L.1
  • 17
    • 80054830970 scopus 로고    scopus 로고
    • Identification of human NK17/NK1 cells
    • Pandya, A. D. et al. Identification of human NK17/NK1 cells. PLoS ONE 6, e26780 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e26780
    • Pandya, A.D.1
  • 18
    • 57849131584 scopus 로고    scopus 로고
    • Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC CD127 natural killer-like cells
    • Cupedo, T. et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC CD127 natural killer-like cells. Nat. Immunol. 10, 66-74 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 66-74
    • Cupedo, T.1
  • 19
    • 60549102720 scopus 로고    scopus 로고
    • Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    • Takatori, H. et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206, 35-41 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 35-41
    • Takatori, H.1
  • 20
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 21
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-A proposal for uniform nomenclature
    • Spits, H. et al. Innate lymphoid cells-A proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013).
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 145-149
    • Spits, H.1
  • 22
    • 0037442137 scopus 로고    scopus 로고
    • IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger
    • Ferretti, S., Bonneau, O., Dubois, G. R., Jones, C. E. &Trifilieff, A. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 170, 2106-2112 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2106-2112
    • Ferretti, S.1    Bonneau, O.2    Dubois, G.R.3    Jones, C.E.4    Trifilieff, A.5
  • 23
    • 79959584686 scopus 로고    scopus 로고
    • Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    • Lin, A. M. et al. Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J. Immunol. 187, 490-500 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 490-500
    • Lin, A.M.1
  • 24
    • 84892827750 scopus 로고    scopus 로고
    • Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2
    • Taylor, P. R. et al. Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgammat and dectin-2. Nat. Immunol. 15, 143-151 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 143-151
    • Taylor, P.R.1
  • 25
    • 84985017808 scopus 로고    scopus 로고
    • Neutrophils do not express IL-17a in the context of acute oropharyngeal candidiasis
    • Huppler, A.R., Verma, A. H.,Conti, H. R. &Gaffen, S. L. neutrophils do not express IL-17a in the context of acute oropharyngeal candidiasis. Pathogens 4, 559-572 (2015).
    • (2015) Pathogens , vol.4 , pp. 559-572
    • Huppler, A.R.1    Verma, A.H.2    Conti, H.R.3    Gaffen, S.L.4
  • 26
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells
    • Ivanov, II et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells. Cell 126, 1121-1133 (2006).
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1
  • 27
    • 34247593586 scopus 로고    scopus 로고
    • STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    • Yang, X. O. et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282, 9358-9363 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 9358-9363
    • Yang, X.O.1
  • 28
    • 37849048599 scopus 로고    scopus 로고
    • T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    • Yang, X. O. et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28, 29-39 (2008).
    • (2008) Immunity , vol.28 , pp. 29-39
    • Yang, X.O.1
  • 29
    • 34248574863 scopus 로고    scopus 로고
    • A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
    • Chang, S. H. &Dong, C. A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses. Cell Res. 17, 435-440 (2007).
    • (2007) Cell Res. , vol.17 , pp. 435-440
    • Chang, S.H.1    Dong, C.2
  • 30
    • 38849097777 scopus 로고    scopus 로고
    • An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
    • Liang, S. C. et al. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J. Immunol. 179, 7791-7799 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 7791-7799
    • Liang, S.C.1
  • 31
    • 34250305962 scopus 로고    scopus 로고
    • Identification of an interleukin 17F/17A heterodimer in activated human CD4 T cells
    • Wright, J. F. et al. Identification of an interleukin 17F/17A heterodimer in activated human CD4 T cells. J. Biol. Chem. 282, 13447-13455 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 13447-13455
    • Wright, J.F.1
  • 32
    • 85013077432 scopus 로고    scopus 로고
    • IL-17 signaling: The Yin and the Yang
    • Amatya, N., Garg, A. V. &Gaffen, S. L. IL-17 signaling: the Yin and the Yang. Trends. Immunol. 38, 310-322 (2017).
    • (2017) Trends. Immunol. , vol.38 , pp. 310-322
    • Amatya, N.1    Garg, A.V.2    Gaffen, S.L.3
  • 33
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen, S. L. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9, 556-567 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 556-567
    • Gaffen, S.L.1
  • 34
    • 38449094307 scopus 로고    scopus 로고
    • Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F
    • Kuestner, R. E. et al. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. J. Immunol. 179, 5462-5473 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 5462-5473
    • Kuestner, R.E.1
  • 35
    • 84865793094 scopus 로고    scopus 로고
    • Immunity to infection in IL-17-deficient mice and humans
    • Cypowyj, S. et al. Immunity to infection in IL-17-deficient mice and humans. Eur. J. Immunol. 42, 2246-2254 (2012).
    • (2012) Eur. J. Immunol. , vol.42 , pp. 2246-2254
    • Cypowyj, S.1
  • 36
    • 63049138176 scopus 로고    scopus 로고
    • Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
    • Conti, H. R. et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206, 299-311 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 299-311
    • Conti, H.R.1
  • 37
    • 77955489738 scopus 로고    scopus 로고
    • IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail
    • Ho, A.W. et al. IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J. Immunol. 185, 1063-1070 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1063-1070
    • Ho, A.W.1
  • 40
    • 84994719165 scopus 로고    scopus 로고
    • IL-17 receptor signaling in oral epithelial cells is critical for protection against oropharyngeal candidiasis
    • Conti, H. R. et al. IL-17 receptor signaling in oral epithelial cells is critical for protection against oropharyngeal candidiasis. Cell Host Microbe 20, 606-617 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 606-617
    • Conti, H.R.1
  • 41
    • 70349448417 scopus 로고    scopus 로고
    • Thymic self-reactivity selects natural interleukin 17-producing Tcells that can regulate peripheral inflammation
    • Marks, B. R. et al. Thymic self-reactivity selects natural interleukin 17-producing Tcells that can regulate peripheral inflammation. Nat. Immunol. 10, 1125-1132 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 1125-1132
    • Marks, B.R.1
  • 42
    • 84872171847 scopus 로고    scopus 로고
    • Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection
    • Gladiator, A., Wangler, N., Trautwein-Weidner, K. &LeibundGut-Landmann, S. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J. Immunol. 190, 521-525 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 521-525
    • Gladiator, A.1    Wangler, N.2    Trautwein-Weidner, K.3    LeibundGut-Landmann, S.4
  • 43
    • 84907202739 scopus 로고    scopus 로고
    • Oral-resident natural Th17 cells and gammadelta Tcells control opportunistic Candida albicans infections
    • Conti, H. R. et al. Oral-resident natural Th17 cells and gammadelta Tcells control opportunistic Candida albicans infections. J. Exp. Med. 211, 2075-2084 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 2075-2084
    • Conti, H.R.1
  • 44
    • 78149491862 scopus 로고    scopus 로고
    • IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans
    • Kagami, S., Rizzo, H. L., Kurtz, S. E., Miller, L. S. &Blauvelt, A. IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J. Immunol. 185, 5453-5462 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 5453-5462
    • Kagami, S.1    Rizzo, H.L.2    Kurtz, S.E.3    Miller, L.S.4    Blauvelt, A.5
  • 45
    • 84906535154 scopus 로고    scopus 로고
    • The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing
    • Gaffen, S. L., Jain, R., Garg, A. V. &Cua, D. J. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat. Rev. Immunol. 14, 585-600 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 585-600
    • Gaffen, S.L.1    Jain, R.2    Garg, A.V.3    Cua, D.J.4
  • 46
    • 77951861324 scopus 로고    scopus 로고
    • IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection inmice
    • Cho, J. S. et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection inmice. J. Clin. Invest. 120, 1762-1773 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1762-1773
    • Cho, J.S.1
  • 47
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses
    • Ishigame, H. et al. Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30, 108-119 (2009).
    • (2009) Immunity , vol.30 , pp. 108-119
    • Ishigame, H.1
  • 48
    • 77957718356 scopus 로고    scopus 로고
    • Resident bacterial flora in the skin of C57BL/6 mice housed under SPF conditions
    • Tavakkol, Z. et al. Resident bacterial flora in the skin of C57BL/6 mice housed under SPF conditions. J. Am. Assoc. Lab. Anim. Sci. 49, 588-591 (2010).
    • (2010) J. Am. Assoc. Lab. Anim. Sci. , vol.49 , pp. 588-591
    • Tavakkol, Z.1
  • 49
    • 84948581722 scopus 로고    scopus 로고
    • Primary immunodeficiency diseases: An update on the classification from the international union of immunological societies expert committee for primary immunodeficiency 2015
    • Picard, C. et al. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency 2015. J. Clin. Immunol. 35, 696-726 (2015).
    • (2015) J. Clin. Immunol. , vol.35 , pp. 696-726
    • Picard, C.1
  • 50
    • 85046362411 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity
    • Okada, S., Puel, A., Casanova, J. L. &Kobayashi, M. Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. Clin. Transl. Immunol. 5, e114 (2016).
    • (2016) Clin. Transl. Immunol. , vol.5 , pp. e114
    • Okada, S.1    Puel, A.2    Casanova, J.L.3    Kobayashi, M.4
  • 51
    • 77955710658 scopus 로고    scopus 로고
    • Inborn errors of mucocutaneous immunity to Candida albicans in humans: A role for IL-17 cytokines?
    • Puel, A., Picard, C., Cypowyj, S., Lilic, D., Abel, L. &Casanova, J. L. Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?. Curr. Opin. Immunol. 22, 467-474 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 467-474
    • Puel, A.1    Picard, C.2    Cypowyj, S.3    Lilic, D.4    Abel, L.5    Casanova, J.L.6
  • 53
    • 84888128171 scopus 로고    scopus 로고
    • Primary immunodeficiencies underlying fungal infections
    • Lanternier, F. et al. Primary immunodeficiencies underlying fungal infections. Curr. Opin. Pediatr. 25, 736-747 (2013).
    • (2013) Curr. Opin. Pediatr. , vol.25 , pp. 736-747
    • Lanternier, F.1
  • 54
    • 79953284685 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    • Puel, A. et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 332, 65-68 (2011).
    • (2011) Science , vol.332 , pp. 65-68
    • Puel, A.1
  • 55
    • 84947559428 scopus 로고    scopus 로고
    • IL-17 receptor A and adenosine deaminase 2 deficiency in siblings with recurrent infections and chronic inflammation
    • e1181-1182
    • Fellmann, F. et al. IL-17 receptor A and adenosine deaminase 2 deficiency in siblings with recurrent infections and chronic inflammation. J. Allergy Clin. Immunol. 137, 1189-1196 (2016). e1181-1182.
    • (2016) J. Allergy Clin. Immunol. , vol.137 , pp. 1189-1196
    • Fellmann, F.1
  • 56
    • 85006873332 scopus 로고    scopus 로고
    • Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency
    • Levy,R. et al. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc. Natl Acad. Sci. USA 113, E8277-E8285 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E8277-E8285
    • Levy, R.1
  • 57
    • 84885865938 scopus 로고    scopus 로고
    • An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis
    • Boisson, B. et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity 39, 676-686 (2013).
    • (2013) Immunity , vol.39 , pp. 676-686
    • Boisson, B.1
  • 58
    • 84937713659 scopus 로고    scopus 로고
    • Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis
    • Ling, Y. et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J. Exp. Med. 212, 619-631 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 619-631
    • Ling, Y.1
  • 59
    • 84873691650 scopus 로고    scopus 로고
    • The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin
    • Weaver, C. T., Elson, C. O., Fouser, L. A. &Kolls, J. K. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. Annu. Rev. Pathol. 8, 477-512 (2013).
    • (2013) Annu. Rev. Pathol. , vol.8 , pp. 477-512
    • Weaver, C.T.1    Elson, C.O.2    Fouser, L.A.3    Kolls, J.K.4
  • 60
    • 84922704299 scopus 로고    scopus 로고
    • The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis
    • Lande, R. et al. The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis. Nat. Commun. 5, 5621 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5621
    • Lande, R.1
  • 61
    • 84961202842 scopus 로고    scopus 로고
    • Melanocyte antigen triggers autoimmunity in human psoriasis
    • Arakawa, A. et al. Melanocyte antigen triggers autoimmunity in human psoriasis. J. Exp. Med. 212, 2203-2212 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 2203-2212
    • Arakawa, A.1
  • 62
    • 85017204228 scopus 로고    scopus 로고
    • Psoriatic Tcells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a
    • Cheung, K. L. et al. Psoriatic Tcells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a. J. Exp. Med. 213, 2399-2412 (2016).
    • (2016) J. Exp. Med. , vol.213 , pp. 2399-2412
    • Cheung, K.L.1
  • 63
    • 33751546237 scopus 로고    scopus 로고
    • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    • Chan, J. R. et al. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J. Exp. Med. 203, 2577-2587 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2577-2587
    • Chan, J.R.1
  • 64
    • 80755180843 scopus 로고    scopus 로고
    • Pivotal role of dermal IL-17-producing gammadelta Tcells in skin inflammation
    • Cai, Y. et al. Pivotal role of dermal IL-17-producing gammadelta Tcells in skin inflammation. Immunity 35, 596-610 (2011).
    • (2011) Immunity , vol.35 , pp. 596-610
    • Cai, Y.1
  • 66
    • 66949162673 scopus 로고    scopus 로고
    • Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis
    • van der Fits, L. et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182, 5836-5845 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 5836-5845
    • Van Der Fits, L.1
  • 67
    • 84872611862 scopus 로고    scopus 로고
    • An alternative pathway of imiquimod-induced psoriasislike skin inflammation in the absence of interleukin-17 receptor a signaling
    • El Malki, K. et al. An alternative pathway of imiquimod-induced psoriasislike skin inflammation in the absence of interleukin-17 receptor a signaling. J. Invest. Dermatol. 133, 441-451 (2013).
    • (2013) J. Invest. Dermatol. , vol.133 , pp. 441-451
    • El Malki, K.1
  • 68
    • 84906311286 scopus 로고    scopus 로고
    • IL-17 drives psoriatic inflammation via distinct, target cellspecificmechanisms
    • Ha, H. L. et al. IL-17 drives psoriatic inflammation via distinct, target cellspecificmechanisms. Proc.Natl Acad. Sci.USA 111, E3422-E3431 (2014).
    • (2014) Proc.Natl Acad. Sci.USA , vol.111 , pp. E3422-E3431
    • Ha, H.L.1
  • 69
    • 79955045064 scopus 로고    scopus 로고
    • Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model
    • Nakajima, K. et al. Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. J. Immunol. 186, 4481-4489 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 4481-4489
    • Nakajima, K.1
  • 71
    • 33846608131 scopus 로고    scopus 로고
    • A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    • Cargill, M. et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet. 80, 273-290 (2007).
    • (2007) Am. J. Hum. Genet. , vol.80 , pp. 273-290
    • Cargill, M.1
  • 72
    • 78049350350 scopus 로고    scopus 로고
    • Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
    • Huffmeier, U. et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat. Genet. 42, 996-999 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 996-999
    • Huffmeier, U.1
  • 73
    • 84860390352 scopus 로고    scopus 로고
    • Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis
    • Marrakchi, S. et al. Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N. Engl. J. Med. 365, 620-628 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 620-628
    • Marrakchi, S.1
  • 74
    • 80052744921 scopus 로고    scopus 로고
    • Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis
    • Onoufriadis, A. et al. Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis. Am. J. Hum. Genet. 89, 432-437 (2011).
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 432-437
    • Onoufriadis, A.1
  • 75
    • 84863980712 scopus 로고    scopus 로고
    • Familial pityriasis rubra pilaris is caused by mutations in CARD14
    • Fuchs-Telem, D. et al. Familial pityriasis rubra pilaris is caused by mutations in CARD14. Am. J. Hum. Genet. 91, 163-170 (2012).
    • (2012) Am. J. Hum. Genet. , vol.91 , pp. 163-170
    • Fuchs-Telem, D.1
  • 76
    • 84860725325 scopus 로고    scopus 로고
    • Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis
    • Jordan, C. T. et al. Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am. J. Hum. Genet. 90, 796-808 (2012).
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 796-808
    • Jordan, C.T.1
  • 77
    • 84860770362 scopus 로고    scopus 로고
    • PSORS2 is due to mutations in CARD14
    • Jordan, C. T. et al. PSORS2 is due to mutations in CARD14. Am. J. Hum. Genet. 90, 784-795 (2012).
    • (2012) Am. J. Hum. Genet. , vol.90 , pp. 784-795
    • Jordan, C.T.1
  • 78
    • 85018517607 scopus 로고    scopus 로고
    • Risankizumab versus Ustekinumab for moderate-tosevere plaque psoriasis
    • Papp, K. A. et al. Risankizumab versus Ustekinumab for moderate-tosevere plaque psoriasis. N. Engl. J. Med. 376, 1551-1560 (2017).
    • (2017) N. Engl. J. Med. , vol.376 , pp. 1551-1560
    • Papp, K.A.1
  • 79
    • 84936763292 scopus 로고    scopus 로고
    • A phase 2 trial of guselkumab versus adalimumab for plaque psoriasis
    • Gordon, K. B. et al. A phase 2 trial of guselkumab versus adalimumab for plaque psoriasis. N. Engl. J. Med. 373, 136-144 (2015).
    • (2015) N. Engl. J. Med. , vol.373 , pp. 136-144
    • Gordon, K.B.1
  • 80
    • 84929359284 scopus 로고    scopus 로고
    • Clinical improvement in psoriasis with specific targeting of interleukin-23
    • Kopp, T. et al. Clinical improvement in psoriasis with specific targeting of interleukin-23. Nature 521, 222-226 (2015).
    • (2015) Nature , vol.521 , pp. 222-226
    • Kopp, T.1
  • 81
    • 84923105894 scopus 로고    scopus 로고
    • Secukinumab: First global approval
    • Sanford,M. &McKeage, K. Secukinumab: first global approval. Drugs 75, 329-338 (2015).
    • (2015) Drugs , vol.75 , pp. 329-338
    • Sanford, M.1    McKeage, K.2
  • 82
    • 84964407326 scopus 로고    scopus 로고
    • &Ixekizumab, First global approval
    • Markham, A. &Ixekizumab, First global approval. Drugs 76, 901-905 (2016).
    • (2016) Drugs , vol.76 , pp. 901-905
    • Markham, A.1
  • 83
    • 84985898452 scopus 로고    scopus 로고
    • &Brodalumab, First global approval
    • Greig, S. L. &Brodalumab, First global approval. Drugs 76, 1403-1412 (2016).
    • (2016) Drugs , vol.76 , pp. 1403-1412
    • Greig, S.L.1
  • 84
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan, P. R. et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441, 231-234 (2006).
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1
  • 85
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 282-289
    • Zheng, Y.1
  • 86
    • 84960336674 scopus 로고    scopus 로고
    • Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation
    • Kumar, P. et al. Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation. Immunity 44, 659-671 (2016).
    • (2016) Immunity , vol.44 , pp. 659-671
    • Kumar, P.1
  • 87
    • 41849142985 scopus 로고    scopus 로고
    • Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
    • Raffatellu, M. et al. Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat. Med. 14, 421-428 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 421-428
    • Raffatellu, M.1
  • 88
    • 78649566744 scopus 로고    scopus 로고
    • IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S
    • Songhet, P. et al. IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium. PLoS ONE 5, e13804 (2010).
    • (2010) Typhimurium. PLoS ONE , vol.5 , pp. e13804
    • Songhet, P.1
  • 89
    • 78649424618 scopus 로고    scopus 로고
    • Interleukin-17A is required to suppress invasion of Salmonella enterica serovar Typhimurium to enteric mucosa
    • Mayuzumi, H., Inagaki-Ohara, K., Uyttenhove, C., Okamoto, Y. &Matsuzaki, G. Interleukin-17A is required to suppress invasion of Salmonella enterica serovar Typhimurium to enteric mucosa. Immunology 131, 377-385 (2010).
    • (2010) Immunology , vol.131 , pp. 377-385
    • Mayuzumi, H.1    Inagaki-Ohara, K.2    Uyttenhove, C.3    Okamoto, Y.4    Matsuzaki, G.5
  • 91
    • 54449102022 scopus 로고    scopus 로고
    • Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice
    • Ito, R. et al. Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochem. Biophys. Res. Commun. 377, 12-16 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.377 , pp. 12-16
    • Ito, R.1
  • 92
    • 43549110961 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by IL-17F
    • Yang, X. O. et al. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205, 1063-1075 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1063-1075
    • Yang, X.O.1
  • 93
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • Ogawa, A., Andoh, A., Araki, Y., Bamba, T. &Fujiyama, Y. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin. Immunol. 110, 55-62 (2004).
    • (2004) Clin. Immunol. , vol.110 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3    Bamba, T.4    Fujiyama, Y.5
  • 94
    • 84944675546 scopus 로고    scopus 로고
    • Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability
    • Lee, J. S. et al. Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability. Immunity 43, 727-738 (2015).
    • (2015) Immunity , vol.43 , pp. 727-738
    • Lee, J.S.1
  • 95
    • 84941743444 scopus 로고    scopus 로고
    • Growth factor FGF2 cooperates with interleukin-17 to repair intestinal epithelial damage
    • Song, X. et al. Growth factor FGF2 cooperates with interleukin-17 to repair intestinal epithelial damage. Immunity 43, 488-501 (2015).
    • (2015) Immunity , vol.43 , pp. 488-501
    • Song, X.1
  • 96
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cellmediated intestinal inflammation
    • O'Connor, W. Jr. et al. A protective function for interleukin 17A in T cellmediated intestinal inflammation. Nat. Immunol. 10, 603-609 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 603-609
    • O'Connor, W.1
  • 97
    • 84944682316 scopus 로고    scopus 로고
    • Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation
    • Maxwell, J. R. et al. Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation. Immunity 43, 739-750 (2015).
    • (2015) Immunity , vol.43 , pp. 739-750
    • Maxwell, J.R.1
  • 98
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber, W. et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61, 1693-1700 (2012).
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1
  • 99
    • 84980349524 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase 2 study of brodalumab in patients with moderate-to-severe Crohn's disease
    • Targan, S. R. et al. A randomized, double-blind, placebo-controlled phase 2 study of brodalumab in patients with moderate-to-severe Crohn's disease. Am. J. Gastroenterol. 111, 1599-1607 (2016).
    • (2016) Am. J. Gastroenterol. , vol.111 , pp. 1599-1607
    • Targan, S.R.1
  • 100
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino, S. et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52, 65-70 (2003).
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1
  • 101
    • 72549107316 scopus 로고    scopus 로고
    • Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    • Rovedatti, L. et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 58, 1629-1636 (2009).
    • (2009) Gut , vol.58 , pp. 1629-1636
    • Rovedatti, L.1
  • 102
    • 77952222918 scopus 로고    scopus 로고
    • The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease
    • Sugihara, T. et al. The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease. Clin. Exp. Immunol. 160, 386-393 (2010).
    • (2010) Clin. Exp. Immunol. , vol.160 , pp. 386-393
    • Sugihara, T.1
  • 103
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia, A. et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127-1133 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1127-1133
    • Geremia, A.1
  • 104
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye, P. et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194, 519-527 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 519-527
    • Ye, P.1
  • 105
    • 84994787743 scopus 로고    scopus 로고
    • IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K pneumoniae
    • Chen, K. et al. IL-17 receptor signaling in the lung epithelium is required for mucosal chemokine gradients and pulmonary host defense against K. pneumoniae. Cell Host Microbe 20, 596-605 (2016).
    • (2016) Cell Host Microbe , vol.20 , pp. 596-605
    • Chen, K.1
  • 106
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gramnegative bacterial pneumonia
    • Aujla, S. J. et al. IL-22 mediates mucosal host defense against Gramnegative bacterial pneumonia. Nat. Med. 14, 275-281 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 275-281
    • Aujla, S.J.1
  • 107
    • 85014585052 scopus 로고    scopus 로고
    • Two types of interleukin 17A-producing gammadelta T cells in protection against pulmonary infection with Klebsiella pneumoniae
    • Murakami, T., Hatano, S., Yamada, H., Iwakura, Y. &Yoshikai, Y. Two types of interleukin 17A-producing gammadelta T cells in protection against pulmonary infection with Klebsiella pneumoniae. J. Infect. Dis. 214, 1752-1761 (2016).
    • (2016) J. Infect. Dis. , vol.214 , pp. 1752-1761
    • Murakami, T.1    Hatano, S.2    Yamada, H.3    Iwakura, Y.4    Yoshikai, Y.5
  • 108
    • 84962124830 scopus 로고    scopus 로고
    • Innate lymphocyte/Ly6C(hi) monocyte crosstalk promotes klebsiella pneumoniae clearance
    • Xiong, H.,Keith, J.W.,Samilo,D.W., Carter,R. A., Leiner, I.M.&Pamer, E. G. Innate lymphocyte/Ly6C(hi) monocyte crosstalk promotes klebsiella pneumoniae clearance. Cell 165, 679-689 (2016).
    • (2016) Cell , vol.165 , pp. 679-689
    • Xiong, H.1    Keith, J.W.2    Samilo, D.W.3    Carter, R.A.4    Leiner, I.M.5    Pamer, E.G.6
  • 109
    • 79251548900 scopus 로고    scopus 로고
    • Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice
    • Kudva, A. et al. Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J. Immunol. 186, 1666-1674 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 1666-1674
    • Kudva, A.1
  • 110
    • 70449501815 scopus 로고    scopus 로고
    • Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    • Lin, Y. et al. Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 31, 799-810 (2009).
    • (2009) Immunity , vol.31 , pp. 799-810
    • Lin, Y.1
  • 111
    • 77951227349 scopus 로고    scopus 로고
    • IL-17/Th17 promotes type 1T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function
    • Bai, H. et al. IL-17/Th17 promotes type 1T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J. Immunol. 183, 5886-5895 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5886-5895
    • Bai, H.1
  • 112
    • 70049112374 scopus 로고    scopus 로고
    • AMyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum
    • Zhang, X. et al. AMyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J. Immunol. 183, 1291-1300 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 1291-1300
    • Zhang, X.1
  • 113
    • 33751506710 scopus 로고    scopus 로고
    • Interleukin-17 is a negative regulator of established allergic asthma
    • Schnyder-Candrian, S. et al. Interleukin-17 is a negative regulator of established allergic asthma. J. Exp. Med. 203, 2715-2725 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2715-2725
    • Schnyder-Candrian, S.1
  • 114
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375-387 (2002).
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1
  • 115
    • 56149097181 scopus 로고    scopus 로고
    • TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
    • McKinley, L. et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 181, 4089-4097 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 4089-4097
    • McKinley, L.1
  • 116
    • 84939795095 scopus 로고    scopus 로고
    • TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
    • Choy, D. F. et al. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci. Transl. Med. 7, 301ra129 (2015).
    • (2015) Sci. Transl. Med. , vol.7 , pp. 301ra129
    • Choy, D.F.1
  • 117
    • 78149326083 scopus 로고    scopus 로고
    • A novel subset of CD4() T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
    • Wang, Y. H. et al. A novel subset of CD4() T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J. Exp. Med. 207, 2479-2491 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2479-2491
    • Wang, Y.H.1
  • 119
    • 84913530341 scopus 로고    scopus 로고
    • Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
    • e1177
    • Irvin, C. et al. Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J. Allergy Clin. Immunol. 134, 1175-1186 e1177 (2014).
    • (2014) J. Allergy Clin. Immunol. , vol.134 , pp. 1175-1186
    • Irvin, C.1
  • 120
    • 84890026323 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
    • Busse,W.W. et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am. J. Respir. Crit. Care Med. 188, 1294-1302 (2013).
    • (2013) Am. J. Respir. Crit. Care Med. , vol.188 , pp. 1294-1302
    • Busse, W.W.1
  • 121
    • 79957613753 scopus 로고    scopus 로고
    • IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke
    • Chen, K. et al. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS ONE 6, e20333 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e20333
    • Chen, K.1
  • 122
    • 84856068597 scopus 로고    scopus 로고
    • Cigarette smoke induction of osteopontin (SPP1)mediates T(H)17 inflammation in human and experimental emphysema
    • Shan,M. et al. Cigarette smoke induction of osteopontin (SPP1)mediates T(H)17 inflammation in human and experimental emphysema. Sci. Transl. Med. 4, 117ra119 (2012).
    • (2012) Sci. Transl. Med. , vol.4 , pp. 117ra119
    • Shan, M.1
  • 123
    • 79953672286 scopus 로고    scopus 로고
    • Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice
    • Shen, N., Wang, J., Zhao, M., Pei, F. &He, B. Anti-interleukin-17 antibodies attenuate airway inflammation in tobacco-smoke-exposed mice. Inhal. Toxicol. 23, 212-218 (2011).
    • (2011) Inhal. Toxicol. , vol.23 , pp. 212-218
    • Shen, N.1    Wang, J.2    Zhao, M.3    Pei, F.4    He, B.5
  • 124
    • 84872360544 scopus 로고    scopus 로고
    • IL-17A is essential to the development of elastaseinduced pulmonary inflammation and emphysema in mice
    • Kurimoto, E. et al. IL-17A is essential to the development of elastaseinduced pulmonary inflammation and emphysema in mice. Respir. Res. 14, 5 (2013).
    • (2013) Respir. Res. , vol.14 , pp. 5
    • Kurimoto, E.1
  • 125
    • 85009469627 scopus 로고    scopus 로고
    • Role of IL-17A in murine models of COPD airway disease
    • Yanagisawa, H. et al. Role of IL-17A in murine models of COPD airway disease. Am. J. Physiol. Lung Cell Mol. Physiol. 312, L122-L130 (2017).
    • (2017) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.312 , pp. L122-L130
    • Yanagisawa, H.1
  • 127
    • 79953732157 scopus 로고    scopus 로고
    • CD8 positive Tcells express IL-17 in patients with chronic obstructive pulmonary disease
    • Chang, Y. et al. CD8 positive Tcells express IL-17 in patients with chronic obstructive pulmonary disease. Respir. Res. 12, 43 (2011).
    • (2011) Respir. Res. , vol.12 , pp. 43
    • Chang, Y.1
  • 128
    • 80054974908 scopus 로고    scopus 로고
    • The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients
    • Chu, S., Zhong, X., Zhang, J., Lao, Q., He, Z. &Bai, J. The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients. Int. Immunopharmacol. 11, 1780-1788 (2011).
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 1780-1788
    • Chu, S.1    Zhong, X.2    Zhang, J.3    Lao, Q.4    He, Z.5    Bai, J.6
  • 129
    • 85026428507 scopus 로고    scopus 로고
    • A randomized, placebo-controlled phase 2 trial of cnto 6785 in chronic obstructive pulmonary disease
    • Eich, A. et al. A randomized, placebo-controlled phase 2 trial of cnto 6785 in chronic obstructive pulmonary disease. COPD 14, 476-483 (2017).
    • (2017) COPD , vol.14 , pp. 476-483
    • Eich, A.1
  • 130
    • 77951483708 scopus 로고    scopus 로고
    • Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
    • Feinen, B., Jerse, A. E., Gaffen, S. L. &Russell, M.W. Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection. Mucosal. Immunol. 3, 312-321 (2010).
    • (2010) Mucosal. Immunol. , vol.3 , pp. 312-321
    • Feinen, B.1    Jerse, A.E.2    Gaffen, S.L.3    Russell, M.W.4
  • 131
    • 84884481545 scopus 로고    scopus 로고
    • The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization
    • Andrew, D. W. et al. The duration of Chlamydia muridarum genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization. PLoS ONE 8, e76664 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e76664
    • Andrew, D.W.1
  • 132
    • 79952300227 scopus 로고    scopus 로고
    • Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection
    • Scurlock, A. M. et al. Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection. Infect. Immun. 79, 1349-1362 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 1349-1362
    • Scurlock, A.M.1
  • 133
    • 79960832335 scopus 로고    scopus 로고
    • Th17 cells and IL-17 in protective immunity to vaginal candidiasis
    • Pietrella, D. et al. Th17 cells and IL-17 in protective immunity to vaginal candidiasis. PLoS ONE 6, e22770 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e22770
    • Pietrella, D.1
  • 134
    • 66749107425 scopus 로고    scopus 로고
    • Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
    • Sundrud, M. S. et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 324, 1334-1338 (2009).
    • (2009) Science , vol.324 , pp. 1334-1338
    • Sundrud, M.S.1
  • 135
    • 84866650842 scopus 로고    scopus 로고
    • The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway
    • Yano, J., Kolls, J. K.,Happel, K. I., Wormley, F., Wozniak, K. L. &Fidel, P. L. Jr. The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway. PLoS ONE 7, e46311 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e46311
    • Yano, J.1    Kolls, J.K.2    Happel, K.I.3    Wormley, F.4    Wozniak, K.L.5    Fidel, P.L.6
  • 136
    • 85020111766 scopus 로고    scopus 로고
    • Candida infections in patients with psoriasis and psoriatic arthritis treated with interleukin-17 inhibitors and their practical management
    • Saunte, D. M.,Mrowietz, U., Puig, L. &Zachariae, C. Candida infections in patients with psoriasis and psoriatic arthritis treated with interleukin-17 inhibitors and their practical management. Br. J. Dermatol. 177, 47-62 (2017).
    • (2017) Br. J. Dermatol. , vol.177 , pp. 47-62
    • Saunte, D.M.1    Mrowietz, U.2    Puig, L.3    Zachariae, C.4
  • 137
    • 85034257477 scopus 로고    scopus 로고
    • Infections from 7 clinical trials of ixekizumab, an antiinterleukin-17a monoclonal antibody, in patients with moderate-tosevere psoriasis
    • Papp, K. A. et al. Infections from 7 clinical trials of ixekizumab, an antiinterleukin-17a monoclonal antibody, in patients with moderate-tosevere psoriasis. Br. J. Dermatol.; doi: 10.1111/bjd.15723 (2017).
    • (2017) Br. J. Dermatol
    • Papp, K.A.1


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