Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes

Metabolic Engineering

Volumn 48, Issue , 2018, Pages 82-93

  McCloskey, Douglas ^a,b   Xu, Sibei ^a   Sandberg, Troy E ^a   Brunk, Elizabeth ^a   Hefner, Ying ^a   Szubin, Richard ^a   Feist, Adam M ^a,b   Palsson, Bernhard O ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Technical University of Denmark   (Denmark)

Author keywords

Adaptive laboratory evolution; E. coli; Multi omics data integration; Mutation analysis; Systems biology; tpiA gene knockout

Indexed keywords

BIOCHEMISTRY; DATA INTEGRATION; DETOXIFICATION; ENZYME ACTIVITY; GENES; METABOLISM; NUCLEIC ACIDS; PATHOLOGY; TOXICITY;

ADAPTIVE LABORATORY EVOLUTION; E. COLI; GENE KNOCKOUT; MUTATION ANALYSIS; SYSTEMS BIOLOGY;

ESCHERICHIA COLI;

CARBON; DNA; METHYLGLYOXAL; NUCLEOTIDE; PHOSPHATE; PHOSPHOTRANSFERASE; RNA;

ADAPTATION; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIAL STRAIN; BIOSYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE DELETION; GENE REGULATORY NETWORK; GLYCOLYSIS; LABORATORY TEST; MACROMOLECULE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TPIA GENE;

EID: 85047937970     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2018.05.012     Document Type: Article

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