Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin

Biochemistry

Volumn 35, Issue 15, 1996, Pages 4923-4928

  Kim, Dennis H ^a   Lees, Watson J ^a   Kempsell, Karen E ^b   Lane, William S ^c   Duncan, Kenneth ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; FOSFOMYCIN; TRANSFERASE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; COMPETITIVE INHIBITION; ENTEROBACTER CLOACAE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ESCHERICHIA COLI; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ALKYL AND ARYL TRANSFERASES; ANTI-BACTERIAL AGENTS; ASPARTIC ACID; CATALYSIS; CELL WALL; CYSTEINE; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; FOSFOMYCIN; KINETICS; MUTAGENESIS, SITE-DIRECTED; THERMODYNAMICS; TRANSFERASES;

EID: 0029967416     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952937w     Document Type: Article

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