Modulation of nucleotide triphosphate diphosphohydrolase-1 (NTPDase-1)/cd39 in xenograft rejection

Molecular Medicine

Volumn 5, Issue 11, 1999, Pages 743-752

  Imai, M ^a   Takigami, K ^a   Guckelberger, O ^a   Enjyoji, K ^a   Smith, R N ^a   Lin, Y ^a   Csizmadia, E ^a   Sevigny J ^a   Rosenberg, R D ^a   Bach, F H ^a   Robson, S C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; NUCLEOTIDASE; NUCLEOTIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 1; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; APYRASE; CD39 ANTIGEN; LEUKOCYTE ANTIGEN; MESSENGER RNA; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MODIFICATION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; MEDIATOR RELEASE; MEMBRANE FLUIDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; TUMOR XENOGRAFT; VASCULAR ENDOTHELIUM; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; LEWIS RAT; MALE; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; RAT; WESTERN BLOTTING; XENOGRAFT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTIGENS, CD; APYRASE; BLOTTING, WESTERN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, MUTANT STRAINS; P-SELECTIN; RATS; RATS, INBRED LEW; RNA, MESSENGER; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033276629     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402098     Document Type: Article

References (41)

1. Endothelial cell activation and thromboregulation during xenograft rejection
2. Role of endothelial cells in transplantation
3. Delayed xenograft rejection
4. Xenotransplantation: Problems and prospects
5. Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection
6. Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts
7. Factors in xenograft rejection
8. Identification and characterization of CD39/vascular ATP diphosphohydrolase
9. Identification and localization of ATP-diphosphohydrolase (apyrase) in bovine aorta: Relevance to vascular tone and platelet aggregation
10. Origin, metabolism and function of extracellular adenine nucleotides in the blood
11. Ecto-ATPases: Identities and functions
12. 5′-nucleotidase: Molecular structure and functional aspects
13. The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization
14. 2+)-apyrase
15. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells
16. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39
17. Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
18. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
19. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides
20. Involvement of multiple receptors in the actions of extracellular ATP: The example of vascular endothelial cells
21. The P2Z purinoceptor: An intriguing role in immunity, inflammation and cell death
22. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages
23. Thromboregulation: Multicellular modulation of platelet reactivity in hemostasis and thrombosis
24. Pharmacological characterization of endothelial cell nitric oxide synthase inhibitors in isolated rabbit aorta
25. Involvement of ATP in the non-adrenergic non-cholinergic inhibitory neurotransmission of lamb isolated coronary small arteries
26. Cardiovascular pharmacology of purines
27. Barriers to xenotransplantation
28. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection
29. Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions
30. Modulation of vascular ATP diphosphohydrolase by fatty acids
31. Loss of ATP diphosphohydrolase activity with endothelial cell activation
32. Loss of ATP diphosphohydrolase activity following endothelial cell activation
33. Accommodation of vascularized xenografts: Expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment
34. Transient complement inhibition plus T-cell immunosuppression induces long-term survival of mouse-to-rat cardiac xenografts
35. Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques
36. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
37. A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay
38. Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells
39. Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity
40. Apyrase administration prolongs discordant xenograft survival
41. CD39 gene transfer prolongs discordant xenograft survival