Apyrase administration prolongs discordant xenograft survival

Transplantation

Volumn 62, Issue 12, 1996, Pages 1739-1743

  Koyamada, Nozomi ^a   Miyatake, Tsukasa ^a   Candinas, Daniel ^a,b   Hechenleitner, Paul ^a   Siegel, Jonathan ^a   Hancock, Wayne W ^a   Bach, Fritz H ^a   Robson, Simon C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

APYRASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; GRAFT REJECTION; GRAFT SURVIVAL; GUINEA PIG; HEART TRANSPLANTATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORGAN BLOOD FLOW; PRIORITY JOURNAL; THROMBOCYTE ADHESION; XENOGRAFT;

ADENOSINE DIPHOSPHATE; ANIMALS; AORTA; APYRASE; ENDOTHELIUM, VASCULAR; GRAFT SURVIVAL; GUINEA PIGS; HEART TRANSPLANTATION; INJECTIONS, INTRA-ARTERIAL; MALE; PLATELET AGGREGATION; RATS; RATS, INBRED LEW; TRANSPLANTATION, HETEROLOGOUS;

EID: 0030475414     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199612270-00008     Document Type: Conference Paper

References (21)

1. Bach FH, Robson SC, Ferran C, et al. Endothelial cell activation and thromboregulation during xenograft rejection. Immunol Rev 1994; 141: 5.
2. Robson SC, Candinas D, Hancock WW, Winkler H, Wrighton CW, Bach FH. The role of endothelial cells in transplantation. Int Arch Allergy Immunol 1995; 106: 305.
3. Bach FH, Winkler H, Ferran C, Hancock WW, Robson SC. Delayed xenograft rejection. Immunol Today 1996; 17: 379.
4. Robson SC, Young VK, Cook NS, et al. Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation 1996; 61: 862.
5. Candinas D, Lesnikoski B, Hancock WW, et al. Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts. Transplantation 1996; 62: 1.
6. Marcus AJ, Safier LB. Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis. FASEB J 1993; 7: 516.
7. Marcus AJ, Safier LB, Hajjar KA, et al. Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase: thromboregulation by endothelial cells. J Clin Invest 1991; 88: 1690.
8. Cote YP, Filep JG, Battistini B, Gauvreau J, Sirois P, Beaudoin AR. Characterization of ATP-diphosphohydrolase activities in the intima and media of the bovine aorta: evidence for a regulatory role in platelet activation in vitro. Biochim Biophys Acta 1992; 1139: 133.
9. Robson SC, Kaczmarek K, Sevigny J, et al. Inhibition of vascular endothelial ecto-ATPases in association with activation responses and oxidative stress. Transplant Proc 1996; 28: 536.
10. Handa M, Guidotti G. Purification and cloning of a soluble ATP-diphosphohydrolase (Apyrase) from potato tubers (Solanum tuberosum). Biochem Biophys Res Commun 1996; 218: 916.
11. Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
12. Blakely ML, van der Werf WJ, Berndt MC, Dalmasso AP, Bach FH, Hancock WW. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 1994; 58: 1059.
13. Shons AR, Najarian JS. Modification of xenograft rejection by aspirin, dextran, and cinanserin: The importance of platelets in hyperacute rejection. Transplant Proc 1974; 6: 435.
14. Plesner L. Ecto-ATPases: identities and functions. Int Rev Cytol 1995; 158: 141.
15. Kroll MH, Schafer AI. Biochemical mechanisms of platelet activation. Blood 1989; 74: 1181.
16. Ambrosio G, Oriente A, Napoli C, et al. Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet-activating factor. J Clin Invest 1994; 93: 2408.
17. Cote YP, Picher M, St JP, Beliveau R, Potier M, Beaudoin AR. Identification and localization of ATP-diphosphohydrolase (apyrase) in bovine aorta: relevance to vascular tone and platelet aggregation. Biochim Biophys Acta 1991; 1078: 187.
18. Picher M, Cote YP, Beliveau R, Potier M, Beaudoin AR. Demonstration of a novel type of ATP-diphosphohydrolase (EC 3.6.1.5) in the bovine lung. J Biol Chem 1993; 268: 4699.
19. Picher M, Beliveau R, Potier M, Savaria D, Rousseau E, Beaudoin AR. Demonstration of an ectoATP-diphosphohydrolase (E.C.3.6.1.5.) in non-vascular smooth muscles of the bovine trachea. Biochim Biophys Acta 1994; 1200: 167.
20. Coughlan AF, Berndt MC, Dunlop LC, Hancock WW. In vivo studies of P-selectin and platelet-activating factor during endotoxemia, accelerated allograft rejection and discordant xenograft rejection. Transplant Proc 1993; 25: 2930.
21. Makowka L, Chapman FA, Cramer DV, Qian SG, Sun H, Starzl TE. Platelet-activating factor and hyperacute rejection: the effect of a platelet-activating factor antagonist, SRI 63-441, on rejection of xenografts and allografts in sensitized hosts. Transplantation 1990; 50: 359.