Reduction in Gal-α1,3-Gal epitope expression in transgenic mice expressing human H-transferase

Xenotransplantation

Volumn 3, Issue 1 PART 2, 1996, Pages 69-75

  Chen, Chao Guang ^a   Fisicaro, Nella ^a   Shinkel, Trixie A ^a   Aitken, Victoria ^a   Katerelos, Marina ^a   Van Denderen, Bryce J W ^a   Tange, Margaret J ^a   Crawford, Robert J ^b   Robins, Allan J ^b   Pearse, Martin J ^a   D'Apice, Anthony J F ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b Bresatec Ltd   (Australia)

Author keywords

Galactose 1,3 galactose; H substance; H transferase; Xenotransplantation; 1,2 fucosyltransferase; 1,3 galactosyltransferase

Indexed keywords

EID: 0002009732     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.1996.tb00121.x     Document Type: Article

References (22)

1. AUCHINCLOSS H. Xenogeneic transplantation. Transplantation 1988:46:1
2. PLATT JL, FISCHEL RJ, MATAS AJ, REIF SA, BOLMAN RM, BACH FH. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 1991:52:214.
3. CALNE RY. Organ transplantation between widely disparate species. Transplant Proc 1970:2:550.
4. HAMMER C, CHAUSSY C, BRENDEL W. Preformed natural antibodies in animals and man. Outlook on xenotransplantation. Eur Surg Res 1973:5:162.
5. GALILI U, SHOHET SB, KORBIN E, STULTS CLM, MACHER BA. Man, apes and old world monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells. J Biol Chem 1988:263:17755.
6. SANDRIN MS, VAUGHAN HA, DABKOWSKI PL, MCKENZIE IFC. Anti-pig IgM antibodies in human serum react predominantly with Gal(α1-3)Gal epitopes. Proc Natl Acad Sci USA 1993:90:11391.
7. COOPER DKC, GOOD AH, KOREN E, et al. Identification of α-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man. Transplant Immunol 1993:1:198.
8. ORIOL R, YE Y, KOREN E, COOPER DKC. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular Rejection in pig-to-man organ xenotransplantation. Transplantation 1993:56:1433.
9. GALILI U, CLARK MR, SHOHET SB, BUEHLER J, MACHER BA. Evolutionary relationship between natural anti-Gal antibody and the Gal α 1-3 Gal epitope in primates. Proc Natl Acad Sci USA 1987:84:1369.
10. GALILI U, SWANSON K. Gene sequences suggest inactivation of alpha-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys. Proc Natl Acad Sci USA 1991:88:7401.
11. LARSEN RD, RIVERA-MARRENO CA, ERNST LK, CUMMINGS RD, LOWE JB. Frameshift and nonsense mutations in a human sequence homologous to a murine UDP-Gal:β-D-Gal(1,4)-D-GlcNAc α1,3-Galactosyltransferase cDNA. J Biol Chem 1990:265:7055.
12. TEARLE RG, TANGE MJ, ZANNETTINO ZL et al. The α-1,3-Galactosyltransferase knockout mouse: Implications for xenotransplantation. Transplantation 1995:61:13-19.
13. SANDRIN MS, MOUHTOURIS E, OSMAN N, et al. Elimination of the major porcine xenoantigen, Galα1,3Gal, by expression of α(1,2)Fcosyltransferase. Glycoconjugate J 1995:12:468.
14. LARSEN RD, ERNST LK, NAIR RP, CUMMINGS RD, LOWE JB. Molecular cloning, sequence, and expression of a human GDP-L-fucose: beta-D-galactoside 2-alpha-1-fucosyltransferase cDNA that can form the H blood group antige. Proc Natl Acad Sci USA 1990:87:6674.
15. CHOI T, HUANG M, GORMAN C, JAENISH R. A generic intron increases gene expression in transgenic mice. Mol Cell Biol 1991:11:3070.
16. WEISS E, GOLDEN L, ZAKUT R, et al. The DNA sequence of the H-2Kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibility antigens. EMBO J 1983:2:453.
17. GALFRE G, MILSTEIN C. Preparation of monoclonal antibodies: Strategies and procedures. Methods Enzymol 1981:73:3.
18. HOGAN B, CONSTANTINI F, LACY E. Manipulating the Mouse Embryo: A Laboratory Manual. New York: Cold Spring Harbour Laboratory. 1986, p.151.
19. PANACCIO M, GEORGESZ M, LEW AM. FoLT PCR: A simple protocol for amplifying DNA directly from whole blood. Biotechniques 1993:14:238.
20. COWAN PJ, SHINKEL TA, WITORT EW, BARLOW H, et al. The human ICAM-2 promoter targets gene expression to endothelial cells in transgenic mice. Transplantation (in press).
21. CLAUSEN H, BENNETT EP, DABELSTEEN E. Carbohydrates of the cell surface. Molecular aspects of the glycosyltransferases and their genes. APMIS 1992:100(Suppl. 27):9.
22. RABOUILLE C, HUI N, HUNTE F, KIECKBUSCH R, et al. Mapping the distribution of the Golgi enzymes involved in the construction of complex oligosaccharides. J Cell Sci 1995:108:1617.