메뉴 건너뛰기




Volumn 61, Issue 9, 2009, Pages 1137-1145

Diabetic neuropathy: Therapies on the horizon

Author keywords

Diabetic neuropathy; Non immunosuppressive immunophilin ligand; Poly(ADP ribose) polymerase inhibitors

Indexed keywords

2 ISOPROPYLIDENEHYDRAZONO 4 OXO 5 THIAZOLIDINYLACETANILIDE; AMINOGUANIDINE; C PEPTIDE; CALCITONIN GENE RELATED PEPTIDE; CORTICOSTEROID; CYCLOSPORIN; EPALRESTAT; ERYTHROPOIETIN; FIDARESTAT; FK 1706; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; GPI 15427; IMMUNOGLOBULIN; IMMUNOPHILIN; INOSITOL; ISLET NEOGENESIS ASSOCIATED PROTEIN PEPTIDE; LEVACECARNINE; LYCOPENE; MELOXICAM; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; RANIRESTAT; RUBOXISTAURIN; SORBINIL; SUBSTANCE P; SUBSTANCE P ANTAGONIST; SYNTHETIC PEPTIDE; THIOCTIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; ANTIOXIDANT; ENZYME INHIBITOR; SIGNAL PEPTIDE;

EID: 85047682290     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.09.0002     Document Type: Review
Times cited : (30)

References (75)
  • 1
    • 0031840543 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy
    • Boulton AJM et al. Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. Diabet Med 1998; 15: 508-514.
    • (1998) Diabet Med , vol.15 , pp. 508-514
    • Boulton, A.J.M.1
  • 2
    • 0002654874 scopus 로고
    • Epidemiology of the complications of diabetes
    • Leslie RDG, Robbins DC, eds, Cambridge: Cambridge University Press
    • Vinik AI et al. Epidemiology of the complications of diabetes. In: Leslie RDG, Robbins DC, eds. Diabetes: Clinical Science in Practice. Cambridge: Cambridge University Press, 1995: 221-287.
    • (1995) Diabetes: Clinical Science in Practice , pp. 221-287
    • Vinik, A.I.1
  • 3
    • 3042521056 scopus 로고    scopus 로고
    • Understanding diabetic neuropathies
    • Vinik AI, Mehrabyan A. Understanding diabetic neuropathies. Emerg Med 2004; 5: 39-44.
    • (2004) Emerg Med , vol.5 , pp. 39-44
    • Vinik, A.I.1    Mehrabyan, A.2
  • 4
    • 0027459676 scopus 로고
    • A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population
    • Young MJ et al. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993; 36: 1-5.
    • (1993) Diabetologia , vol.36 , pp. 1-5
    • Young, M.J.1
  • 5
    • 33847618393 scopus 로고    scopus 로고
    • Current and emerging therapies for painful diabetic neuropathies
    • Khwaja GA, Chaudhry N. Current and emerging therapies for painful diabetic neuropathies. J Ind Acad Clin Med 2007; 8: 53-64.
    • (2007) J Ind Acad Clin Med , vol.8 , pp. 53-64
    • Khwaja, G.A.1    Chaudhry, N.2
  • 6
    • 0043095569 scopus 로고    scopus 로고
    • The health care costs of diabetic peripheral neuropathy in the US
    • Gordois A et al. The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care 2003; 26: 1790-1795.
    • (2003) Diabetes Care , vol.26 , pp. 1790-1795
    • Gordois, A.1
  • 7
    • 0030963672 scopus 로고    scopus 로고
    • Classification, differential diagnosis, and staging of diabetic peripheral neuropathy
    • Thomas PK. Classification, differential diagnosis, and staging of diabetic peripheral neuropathy. Diabetes 1997; 46: S54-S57.
    • (1997) Diabetes , vol.46
    • Thomas, P.K.1
  • 8
    • 20144389536 scopus 로고    scopus 로고
    • Diabetic neuropathies: A statement by the American Diabetes Association
    • Boulton AJ et al. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 2005; 28: 956-962.
    • (2005) Diabetes Care , vol.28 , pp. 956-962
    • Boulton, A.J.1
  • 9
    • 0033546655 scopus 로고    scopus 로고
    • Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group
    • Greene DA et al. Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group. Neurology 1999; 53: 580-591.
    • (1999) Neurology , vol.53 , pp. 580-591
    • Greene, D.A.1
  • 10
    • 11144324314 scopus 로고    scopus 로고
    • Advanced glycation endproducts - role in pathology of diabetic complications
    • Ahmed N. Advanced glycation endproducts - role in pathology of diabetic complications. Diabetes Res Clin Pract 2005; 67: 3-21.
    • (2005) Diabetes Res Clin Pract , vol.67 , pp. 3-21
    • Ahmed, N.1
  • 11
    • 42449157139 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE) and experimental diabetic neuropathy
    • Toth C et al. Receptor for advanced glycation end products (RAGE) and experimental diabetic neuropathy. Diabetes 2008; 57: 1002-1017.
    • (2008) Diabetes , vol.57 , pp. 1002-1017
    • Toth, C.1
  • 12
    • 23744467294 scopus 로고    scopus 로고
    • Role of advanced glycation end products and their receptors in development of diabetic neuropathy
    • Wada R, Yagihashi S. Role of advanced glycation end products and their receptors in development of diabetic neuropathy. Ann NY Acad Sci 2005; 1043: 598-604.
    • (2005) Ann NY Acad Sci , vol.1043 , pp. 598-604
    • Wada, R.1    Yagihashi, S.2
  • 13
    • 33845499323 scopus 로고    scopus 로고
    • Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial
    • Ziegler D et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006; 29: 2365-2370.
    • (2006) Diabetes Care , vol.29 , pp. 2365-2370
    • Ziegler, D.1
  • 14
    • 0033781544 scopus 로고    scopus 로고
    • Protein kinase C activation and its pharmacological inhibition in vascular disease
    • Meier M, King GL. Protein kinase C activation and its pharmacological inhibition in vascular disease. Vas Med 2000; 5: 173-185.
    • (2000) Vas Med , vol.5 , pp. 173-185
    • Meier, M.1    King, G.L.2
  • 15
    • 0038015951 scopus 로고    scopus 로고
    • The diabetic neuropathies: Types, diagnosis and management
    • Llewelyn JG. The diabetic neuropathies: types, diagnosis and management. J Neurol Neurosurg Psychiatry 2003; 74: 15-19.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 15-19
    • Llewelyn, J.G.1
  • 16
    • 30744436835 scopus 로고    scopus 로고
    • HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy
    • Chattopadhyay M. HSV-mediated gene transfer of vascular endothelial growth factor to dorsal root ganglia prevents diabetic neuropathy. Gene Ther 2005; 12: 1377-1384.
    • (2005) Gene Ther , vol.12 , pp. 1377-1384
    • Chattopadhyay, M.1
  • 17
    • 20844441940 scopus 로고    scopus 로고
    • Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy
    • Kusano KF et al. Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy. Arterioscler Thromb Vasc Biol 2004; 4: 2102-2107.
    • (2004) Arterioscler Thromb Vasc Biol , vol.4 , pp. 2102-2107
    • Kusano, K.F.1
  • 18
    • 14644396138 scopus 로고    scopus 로고
    • Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats
    • Kato N et al. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. Diabetes 2005; 54: 846-854.
    • (2005) Diabetes , vol.54 , pp. 846-854
    • Kato, N.1
  • 19
    • 0026532827 scopus 로고
    • Depletion of substance P and calcitonin generelated peptide in sciatic nerve of rats with experimental diabetes: Effects of insulin and aldose reductase inhibition
    • Diemel et al. Depletion of substance P and calcitonin generelated peptide in sciatic nerve of rats with experimental diabetes: effects of insulin and aldose reductase inhibition. Neurosci Lett 1992; 137: 253-256.
    • (1992) Neurosci Lett , vol.137 , pp. 253-256
    • Diemel1
  • 20
  • 21
    • 0028883432 scopus 로고
    • Neurotrophic factors in the therapy of peripheral neuropathy
    • Apfel SC, Kessler JA. Neurotrophic factors in the therapy of peripheral neuropathy. Baillieres Clin Neurol 1995; 4: 593-606.
    • (1995) Baillieres Clin Neurol , vol.4 , pp. 593-606
    • Apfel, S.C.1    Kessler, J.A.2
  • 22
    • 38849171678 scopus 로고    scopus 로고
    • Growth factors as therapeutics for diabetic neuropathy
    • Calcutt NA et al. Growth factors as therapeutics for diabetic neuropathy. Curr Drug Targets 2008; 9: 47-59.
    • (2008) Curr Drug Targets , vol.9 , pp. 47-59
    • Calcutt, N.A.1
  • 23
    • 0035019625 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy for diabetic amyotrophy
    • Ogawa T et al. Intravenous immunoglobulin therapy for diabetic amyotrophy. Intern Med 2001; 40: 349-352.
    • (2001) Intern Med , vol.40 , pp. 349-352
    • Ogawa, T.1
  • 24
    • 18444366460 scopus 로고    scopus 로고
    • Intravenous immunoglobulin as first treatment in diabetics with concomitant distal symmetric axonal polyneuropathy and CIDP
    • Cocito D et al. Intravenous immunoglobulin as first treatment in diabetics with concomitant distal symmetric axonal polyneuropathy and CIDP. J Neurol 2002; 249: 719-722.
    • (2002) J Neurol , vol.249 , pp. 719-722
    • Cocito, D.1
  • 25
    • 0036091494 scopus 로고    scopus 로고
    • Diabetic demyelinating polyneuropathy responsive to intravenous immunoglobulin therapy
    • Sharma KR et al. Diabetic demyelinating polyneuropathy responsive to intravenous immunoglobulin therapy. Arch Neurol 2002; 59: 751-757.
    • (2002) Arch Neurol , vol.59 , pp. 751-757
    • Sharma, K.R.1
  • 26
    • 1842782797 scopus 로고    scopus 로고
    • Diabetic neuropathy: Pathogenesis and treatment
    • Siemionow M, Demir Y. Diabetic neuropathy: pathogenesis and treatment. J Reconstr Microsurg 2004; 20: 241-252.
    • (2004) J Reconstr Microsurg , vol.20 , pp. 241-252
    • Siemionow, M.1    Demir, Y.2
  • 27
    • 21544463410 scopus 로고    scopus 로고
    • Aldose reductase in diabetic microvascular complications
    • Chung SS, Chung SK. Aldose reductase in diabetic microvascular complications. Curr Drug Targets 2005; 6: 475-486.
    • (2005) Curr Drug Targets , vol.6 , pp. 475-486
    • Chung, S.S.1    Chung, S.K.2
  • 28
    • 47749127326 scopus 로고    scopus 로고
    • Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats
    • Matsumoto T et al. Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats. J Pharmacol Sci 2008; 107: 231-237.
    • (2008) J Pharmacol Sci , vol.107 , pp. 231-237
    • Matsumoto, T.1
  • 29
    • 33644876711 scopus 로고    scopus 로고
    • Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy
    • Bril V, Buchanan RA. Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy. Diabetes Care 2006; 29: 68-72.
    • (2006) Diabetes Care , vol.29 , pp. 68-72
    • Bril, V.1    Buchanan, R.A.2
  • 30
    • 38849177363 scopus 로고    scopus 로고
    • Aldose reductase, still a compelling target for diabetic neuropathy
    • Oates PJ. Aldose reductase, still a compelling target for diabetic neuropathy. Curr Drug Targets 2008; 9: 14-36.
    • (2008) Curr Drug Targets , vol.9 , pp. 14-36
    • Oates, P.J.1
  • 31
    • 33746456027 scopus 로고    scopus 로고
    • Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: The 3-year, multicenter, comparative aldose reductase inhibitordiabetes complications trial
    • Hotta N et al. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative aldose reductase inhibitordiabetes complications trial. Diabetes Care 2006; 29: 1538-1544.
    • (2006) Diabetes Care , vol.29 , pp. 1538-1544
    • Hotta, N.1
  • 32
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
    • Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 2002; 54: 375-429.
    • (2002) Pharmacol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 33
    • 39949084154 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: A commentary on "PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy
    • Pacher P. Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: a commentary on "PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy". Free Radic Biol Med 2008; 44: 969-971.
    • (2008) Free Radic Biol Med , vol.44 , pp. 969-971
    • Pacher, P.1
  • 34
    • 54049089162 scopus 로고    scopus 로고
    • FK1706, a novel non immunosuppressive immunophilin ligand, modifies the course of painful diabetic neuropathy
    • Yamazaki S et al. FK1706, a novel non immunosuppressive immunophilin ligand, modifies the course of painful diabetic neuropathy. Neuropharmacology 2008; 55: 1226-1250.
    • (2008) Neuropharmacology , vol.55 , pp. 1226-1250
    • Yamazaki, S.1
  • 35
    • 0022572232 scopus 로고
    • Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients
    • Polonsky KS et al. Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 1986; 77: 98-105.
    • (1986) J Clin Invest , vol.77 , pp. 98-105
    • Polonsky, K.S.1
  • 36
    • 0029775874 scopus 로고    scopus 로고
    • Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
    • Zierath JR et al. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 1996; 39: 1180-1189.
    • (1996) Diabetologia , vol.39 , pp. 1180-1189
    • Zierath, J.R.1
  • 37
    • 0030031555 scopus 로고    scopus 로고
    • +-ATPase activity in synergism with neuropeptide Y
    • +-ATPase activity in synergism with neuropeptide Y. Diabetologia 1996; 39: 199-205.
    • (1996) Diabetologia , vol.39 , pp. 199-205
    • Ohtomo, Y.1
  • 38
    • 9644264237 scopus 로고    scopus 로고
    • C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes
    • Kamiya H et al. C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes. Ann Neurol 2004; 56: 827-835.
    • (2004) Ann Neurol , vol.56 , pp. 827-835
    • Kamiya, H.1
  • 39
    • 7044241260 scopus 로고    scopus 로고
    • A pentadecapeptide fragment of islet neogenesis associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice
    • Rosenberg L et al. A pentadecapeptide fragment of islet neogenesis associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice. Ann Surg 2004; 240: 875-884.
    • (2004) Ann Surg , vol.240 , pp. 875-884
    • Rosenberg, L.1
  • 40
    • 9444222520 scopus 로고    scopus 로고
    • INGAP peptide improves nerve function and enhances regeneration in streptozotocin-induced diabetic C57BL/6 mice
    • Tam J et al. INGAP peptide improves nerve function and enhances regeneration in streptozotocin-induced diabetic C57BL/6 mice. FASEB J 2005; 8: 1767-1769.
    • (2005) FASEB J , vol.8 , pp. 1767-1769
    • Tam, J.1
  • 41
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998; 47: 859-866.
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 42
    • 0032836509 scopus 로고    scopus 로고
    • A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats
    • Nakamura J et al. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes 1999; 48: 2090-2095.
    • (1999) Diabetes , vol.48 , pp. 2090-2095
    • Nakamura, J.1
  • 43
    • 0036712066 scopus 로고    scopus 로고
    • Effects of protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes
    • Cotter MA et al. Effects of protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes. Clin Sci (Lond) 2002; 103: 311-321.
    • (2002) Clin Sci (Lond) , vol.103 , pp. 311-321
    • Cotter, M.A.1
  • 44
    • 0035215435 scopus 로고    scopus 로고
    • Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy
    • Obrosova I et al. Taurine counteracts oxidative stress and nerve growth factor deficit in early experimental diabetic neuropathy. Exp Neurol 2001; 172: 211-219.
    • (2001) Exp Neurol , vol.172 , pp. 211-219
    • Obrosova, I.1
  • 45
    • 25844459952 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial
    • Vinik AI et al. Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial. Clin Ther 2005; 27: 1164-1180.
    • (2005) Clin Ther , vol.27 , pp. 1164-1180
    • Vinik, A.I.1
  • 46
    • 0029986949 scopus 로고    scopus 로고
    • Primary preventive and secondary interventional effects of acetyl-L-carnitine on diabetic neuropathy in the BB/W-rat
    • Sima AAF et al. Primary preventive and secondary interventional effects of acetyl-L-carnitine on diabetic neuropathy in the BB/W-rat. J Clin Invest 1996; 97: 1900-1907.
    • (1996) J Clin Invest , vol.97 , pp. 1900-1907
    • Sima, A.A.F.1
  • 47
    • 11844273799 scopus 로고    scopus 로고
    • Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy
    • Sima AF et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy. Diabetes Care 2005; 28: 96-101.
    • (2005) Diabetes Care , vol.28 , pp. 96-101
    • Sima, A.F.1
  • 48
    • 44649133859 scopus 로고    scopus 로고
    • Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice
    • Ohsawa M et al. Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice. Eur J Pharmacol 2008; 588: 213-216.
    • (2008) Eur J Pharmacol , vol.588 , pp. 213-216
    • Ohsawa, M.1
  • 49
    • 42949176731 scopus 로고    scopus 로고
    • Lycopene attenuates thermal hypoalgesia in a diabetic mouse model of neuropathic pain
    • Khuhad A et al. Lycopene attenuates thermal hypoalgesia in a diabetic mouse model of neuropathic pain. Eur J Pain 2008; 12: 624-632.
    • (2008) Eur J Pain , vol.12 , pp. 624-632
    • Khuhad, A.1
  • 50
    • 0034773628 scopus 로고    scopus 로고
    • Molecular aspects of lipoic acid in the prevention of diabetes complications
    • Packer L et al. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 2001; 17: 888-895.
    • (2001) Nutrition , vol.17 , pp. 888-895
    • Packer, L.1
  • 51
    • 8544230643 scopus 로고    scopus 로고
    • The diabetic neuropathies
    • Gooch C, Podwall D. The diabetic neuropathies. Neurologist 2004; 10: 311-322.
    • (2004) Neurologist , vol.10 , pp. 311-322
    • Gooch, C.1    Podwall, D.2
  • 52
    • 33745902804 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats
    • Sharma S et al. Resveratrol, a polyphenolic phytoalexin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats. Indian J Exp Biol 2006; 44: 566-569.
    • (2006) Indian J Exp Biol , vol.44 , pp. 566-569
    • Sharma, S.1
  • 53
    • 33847334999 scopus 로고    scopus 로고
    • Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy
    • Kumar A et al. Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy. Life Sci 2007; 80: 1236-1244.
    • (2007) Life Sci , vol.80 , pp. 1236-1244
    • Kumar, A.1
  • 54
    • 33846260752 scopus 로고    scopus 로고
    • Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain
    • Sharma S et al. Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Fund Clin Pharmacol 2007; 21: 89-94.
    • (2007) Fund Clin Pharmacol , vol.21 , pp. 89-94
    • Sharma, S.1
  • 55
    • 0028845524 scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN study)
    • Ziegler D et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN study). Diabetologia 1995; 38: 1425-1433.
    • (1995) Diabetologia , vol.38 , pp. 1425-1433
    • Ziegler, D.1
  • 56
    • 0031028636 scopus 로고    scopus 로고
    • Effects of treatment with the antioxidant alphalipoic acid on cardiac autonomic neuropathy in NIDDM patients: A 4-month randomized controlled multicenter trial (DEKAN study). Deutsche kardiale autonome neuropathie
    • Ziegler D et al. Effects of treatment with the antioxidant alphalipoic acid on cardiac autonomic neuropathy in NIDDM patients: a 4-month randomized controlled multicenter trial (DEKAN study). Deutsche kardiale autonome neuropathie. Diabetes Care 1997; 20: 369-373.
    • (1997) Diabetes Care , vol.20 , pp. 369-373
    • Ziegler, D.1
  • 57
    • 0032788081 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III study group. α-Lipoic acid in diabetic neuropathy
    • Ziegler D et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III study group. α-Lipoic acid in diabetic neuropathy. Diabetes Care 1999; 22: 1296-1301.
    • (1999) Diabetes Care , vol.22 , pp. 1296-1301
    • Ziegler, D.1
  • 58
    • 0032836681 scopus 로고    scopus 로고
    • Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes
    • Cameron NE, Cotter MA. Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes. Diabetes Res Clin Pract 1999; 45: 137-146.
    • (1999) Diabetes Res Clin Pract , vol.45 , pp. 137-146
    • Cameron, N.E.1    Cotter, M.A.2
  • 59
    • 0031810195 scopus 로고    scopus 로고
    • A lipoic acid-gamma linoleic acid conjugate is effective against multiple indices of experimental diabetic neuropathy
    • Hounsom L et al. A lipoic acid-gamma linoleic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Diabetologia 1998; 41: 839-843.
    • (1998) Diabetologia , vol.41 , pp. 839-843
    • Hounsom, L.1
  • 60
    • 0035183290 scopus 로고    scopus 로고
    • The effects of gamma-linoleic acid-alphalipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    • Biessels GJ et al. The effects of gamma-linoleic acid-alphalipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats. J Neurol Sci 2001; 182: 99-106.
    • (2001) J Neurol Sci , vol.182 , pp. 99-106
    • Biessels, G.J.1
  • 61
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor deficient mice
    • Zang M et al. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor deficient mice. Diabetes 2006; 55: 2180-2191.
    • (2006) Diabetes , vol.55 , pp. 2180-2191
    • Zang, M.1
  • 62
    • 34250854589 scopus 로고    scopus 로고
    • Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells
    • Chen WP et al. Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells. Eur J Pharmacol 2007; 568: 269-277.
    • (2007) Eur J Pharmacol , vol.568 , pp. 269-277
    • Chen, W.P.1
  • 63
    • 21544470960 scopus 로고    scopus 로고
    • Effectiveness of vitamin B12 on diabetic neuropathy: Systematic review of clinical controlled trials
    • Sun Y et al. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol 2005; 14: 48-54.
    • (2005) Acta Neurol , vol.14 , pp. 48-54
    • Sun, Y.1
  • 64
    • 54949103935 scopus 로고    scopus 로고
    • Alpha-lipoic acid supplementation and diabetes
    • Singh et al. Alpha-lipoic acid supplementation and diabetes. Nutrition Rev 2008; 66: 646-657.
    • (2008) Nutrition Rev , vol.66 , pp. 646-657
    • Singh1
  • 65
    • 0035064310 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture
    • Nagai A et al. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 2001; 60: 386-392.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 386-392
    • Nagai, A.1
  • 66
    • 2942588678 scopus 로고    scopus 로고
    • Erythropoietin for neurologic protection and diabetic neuropathy
    • Lipton SA. Erythropoietin for neurologic protection and diabetic neuropathy. N Engl J Med 2004; 350: 2516-2517.
    • (2004) N Engl J Med , vol.350 , pp. 2516-2517
    • Lipton, S.A.1
  • 67
    • 33745428781 scopus 로고    scopus 로고
    • The NK(1)-receptor antagonist TKA731 in painful diabetic neuropathy: A randomised, controlled trial
    • Sindrup SH et al. The NK(1)-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial. Eur J Pain 2006; 10: 567-571.
    • (2006) Eur J Pain , vol.10 , pp. 567-571
    • Sindrup, S.H.1
  • 68
    • 0036323283 scopus 로고    scopus 로고
    • Dissection of metabolic, vascular and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration
    • Pop-Busui R et al. Dissection of metabolic, vascular and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. Diabetes 2002; 51: 2619-2628.
    • (2002) Diabetes , vol.51 , pp. 2619-2628
    • Pop-Busui, R.1
  • 70
    • 0029938105 scopus 로고    scopus 로고
    • Slowing of peripheral nerve conduction was ameliorated by amino guanidine in streptozotocin induced diabetic rats
    • Miyauchi et al. Slowing of peripheral nerve conduction was ameliorated by amino guanidine in streptozotocin induced diabetic rats. Eur J Endocrinol 1996; 134: 467-473.
    • (1996) Eur J Endocrinol , vol.134 , pp. 467-473
    • Miyauchi1
  • 71
    • 0030049672 scopus 로고    scopus 로고
    • Effect of aminoguanidine on the frequency of neuroaxonal dystrophy in superior mesenteric sympathetic autonomic ganglia of rats with STZ-induced diabetes
    • Schmidt RE et al. Effect of aminoguanidine on the frequency of neuroaxonal dystrophy in superior mesenteric sympathetic autonomic ganglia of rats with STZ-induced diabetes. Diabetes 1996; 45: 284-290.
    • (1996) Diabetes , vol.45 , pp. 284-290
    • Schmidt, R.E.1
  • 72
    • 0034950643 scopus 로고    scopus 로고
    • Effects ofOPB-9195, anti-glycation agent, on experimental diabetic neuropathy
    • Wada R et al. Effects ofOPB-9195, anti-glycation agent, on experimental diabetic neuropathy. Eur J Clin Invest 2001; 31: 513-520.
    • (2001) Eur J Clin Invest , vol.31 , pp. 513-520
    • Wada, R.1
  • 73
    • 21044443182 scopus 로고    scopus 로고
    • Diabetic vascular complications: Pathophysiology, biochemical basis and potential therapeutic strategy
    • Yamagishi SI, Imaizumi T. Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharmaceut Des 2005; 11: 2279-2299.
    • (2005) Curr Pharmaceut Des , vol.11 , pp. 2279-2299
    • Yamagishi, S.I.1    Imaizumi, T.2
  • 74
    • 10744223527 scopus 로고    scopus 로고
    • Randomized clinical trial of an inhibitor of formation of AGE products in diabetic neuropathy
    • Bolton et al. Randomized clinical trial of an inhibitor of formation of AGE products in diabetic neuropathy. Am J Nephrol 2004; 24: 32-40.
    • (2004) Am J Nephrol , vol.24 , pp. 32-40
    • Bolton1
  • 75
    • 0037082872 scopus 로고    scopus 로고
    • GCPII (NAALADase) inhibition prevents longterm diabetic neuropathy in type 1 diabetic BB/W or rats
    • Zhang W et al. GCPII (NAALADase) inhibition prevents longterm diabetic neuropathy in type 1 diabetic BB/W or rats. J Neurol Sci 2002; 194: 21-28.
    • (2002) J Neurol Sci , vol.194 , pp. 21-28
    • Zhang, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.