Poly(ADP-ribose) polymerase inhibition as a novel therapeutic approach against intraepidermal nerve fiber loss and neuropathic pain associated with advanced diabetic neuropathy: A commentary on "PARP Inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy"

Free Radical Biology and Medicine

Volumn 44, Issue 6, 2008, Pages 969-971

  Pacher, Pal ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GPI 15427; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CONFOCAL MICROSCOPY; DIABETIC NEUROPATHY; DISEASE ASSOCIATION; ENZYME INHIBITION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NERVE FIBER; NERVE FIBER DEGENERATION; NEUROPATHIC PAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SENSORY NERVE;

EID: 39949084154     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.12.020     Document Type: Note

References (19)

1. G. Said Diabetic neuropathy—a review Nat. Clin. Pract. 3 2007 331 340
2. I.G. Obrosova Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications Antioxid. Redox Signal. 7 2005 1543 1552
3. M. Brownlee The pathobiology of diabetic complications: a unifying mechanism Diabetes 54 2005 1615 1625
4. P. Pacher J.S. Beckman L. Liaudet Nitric oxide and peroxynitrite in health and disease Physiol. Rev. 87 2007 315 424
5. P. Pacher C. Szabo Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme Antioxid. Redox Signal. 7 2005 1568 1580
6. F. Garcia Soriano L. Virag P. Jagtap E. Szabo J.G. Mabley L. Liaudet A. Marton D.G. Hoyt K.G. Murthy A.L. Salzman G.J. Southan C. Szabo Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation Nat. Med. 7 2001 108 113
7. F.G. Soriano P. Pacher J. Mabley L. Liaudet C. Szabo Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase Circ. Res. 89 2001 684 691
8. C. Szabo J.G. Mabley S.M. Moeller R. Shimanovich P. Pacher L. Virag F.G. Soriano J.H. Van Duzer W. Williams A.L. Salzman J.T. Groves Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst Mol. Med. 8 2002 571 580
9. P. Pacher L. Liaudet F.G. Soriano J.G. Mabley E. Szabo C. Szabo The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes Diabetes 51 2002 514 521
10. X. Du T. Matsumura D. Edelstein L. Rossetti Z. Zsengeller C. Szabo M. Brownlee Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells J. Clin. Invest. 112 2003 1049 1057
11. C. Szabo A. Zanchi K. Komjati P. Pacher A.S. Krolewski W.C. Quist F.W. LoGerfo E.S. Horton A. Veves Poly(ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity Circulation 106 2002 2680 2686
12. N.E. Cameron S.E. Eaton M.A. Cotter S. Tesfaye Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy Diabetologia 44 2001 1973 1988
13. I.G. Obrosova W. Xu V.V. Lyzogubov O. Ilnytska N. Mashtalir I. Vareniuk I. Pavlov J. Zhang B. Slusher V.R. Drel PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy Free Radic. Biol. Med. 44 2008 972 981
14. R.A. Malik P. Kallinikos C.A. Abbott C.H. van Schie P. Morgan N. Efron A.J. Boulton Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients Diabetologia 46 2003 683 688
15. G.L. Pittenger M. Ray N.I. Burcus P. McNulty B. Basta A.I. Vinik Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients Diabetes Care 27 2004 1974 1979
16. C.J. Sumner S. Sheth J.W. Griffin D.R. Cornblath M. Polydefkis The spectrum of neuropathy in diabetes and impaired glucose tolerance Neurology 60 2003 108 111
17. V.R. Drel N. Mashtalir O. Ilnytska J. Shin F. Li V.V. Lyzogubov I.G. Obrosova The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity Diabetes 55 2006 3335 3343
18. I. Vareniuk I.A. Pavlov V.R. Drel V.V. Lyzogubov O. Ilnytska S.R. Bell J. Tibrewala J.T. Groves I.G. Obrosova Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice Exp. Neurol. 205 2007 425 436
19. C. Toth V. Brussee D.W. Zochodne Remote neurotrophic support of epidermal nerve fibres in experimental diabetes Diabetologia 49 2006 1081 1088