The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease

Cell Reports

Volumn 23, Issue 10, 2018, Pages 2976-2988

  Schöndorf, David C ^a,b   Ivanyuk, Dina ^a,b   Baden, Pascale ^a,b   Sanchez Martinez, Alvaro ^c   De Cicco, Silvia ^a,b   Yu, Cong ^a,b   Giunta, Ivana ^c   Schwarz, Lukas K ^a,b   Di Napoli, Gabriele ^a,b   Panagiotakopoulou, Vasiliki ^a,b   Nestel, Sigrun ^d   Keatinge, Marcus ^e   Pruszak, Jan ^d,f   Bandmann, Oliver ^e   Heimrich, Bernd ^d   Gasser, Thomas ^a,b   Whitworth, Alexander J ^c   Deleidi, Michela ^a,b  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF FREIBURG   (Germany)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

GBA; induced pluripotent stem cells; lysosomal storage diseases; mitochondria; NAD+; neurodegeneration; Parkinson's disease

Indexed keywords

GLUCOSYLCERAMIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE RIBOSIDE; NICOTINAMIDE; NICOTINAMIDE-BETA-RIBOSIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; DROSOPHILA; ENDOPLASMIC RETICULUM STRESS; GENETIC RISK; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MITOCHONDRIAL RESPIRATION; MOTOR DYSFUNCTION; NERVE CELL LESION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE METABOLISM; PARKINSON DISEASE; PRIORITY JOURNAL; ANIMAL; AUTOPHAGY; DROSOPHILA MELANOGASTER; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; ULTRASTRUCTURE; UNFOLDED PROTEIN RESPONSE;

ANIMALS; AUTOPHAGY; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DROSOPHILA MELANOGASTER; ENDOPLASMIC RETICULUM STRESS; GLUCOSYLCERAMIDASE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MOTOR ACTIVITY; NAD; NEURONS; NIACINAMIDE; PARKINSON DISEASE; UNFOLDED PROTEIN RESPONSE;

EID: 85047488499     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2018.05.009     Document Type: Article

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