Active vacuolar H+ atpase and functional cycle of rab5 are required for the vacuolation defect triggered by ptdins(3,5)p2 loss under PIKfyve or Vps34 deficiency

American Journal of Physiology - Cell Physiology

Volumn 311, Issue 3, 2016, Pages C366-C377

  Compton, Lauren M ^a   Ikonomov, Ognian C ^a   Sbrissa, Diego ^a   Garg, Puneet ^b   Shisheva, Assia ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Bafilomycin A1; Chloroquine; Cytoplasmic vacuolation; NH4Cl; PIKfyve inactivation; Rab5a GTPase; Vacuolar H+ ATPase; Vps34 inactivation; Wortmannin; YM201636

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BAFILOMYCIN A1; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RAB PROTEIN; UNCLASSIFIED DRUG; YM 201636; 6-AMINO-N-(3-(4-(4-MORPHOLINYL)PYRIDO(3',2'-4,5)FURO(3,2-D)PYRIMIDIN-2-YL)PHENYL)-3-PYRIDINECARBOXAMIDE; AMINOPYRIDINE DERIVATIVE; FUSED HETEROCYCLIC RINGS; MACROLIDE; PHOSPHATIDYLINOSITOL 3,5-DIPHOSPHATE; POLYPHOSPHOINOSITIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; ENDOSOME; ENZYME DEFICIENCY; ENZYME INHIBITION; GENE DISRUPTION; INTRACELLULAR SIGNALING; MAMMAL CELL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHOSPHATIDYLINOSITOL 3 KINASE DEFICIENCY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; CELL LINE; CELL MEMBRANE; CHLOROCEBUS AETHIOPS; COS CELL LINE; DRUG EFFECTS; ENDOCYTOSIS; METABOLISM;

AMINOPYRIDINES; ANIMALS; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CLASS III PHOSPHATIDYLINOSITOL 3-KINASES; COS CELLS; ENDOCYTOSIS; ENDOSOMES; HETEROCYCLIC COMPOUNDS, 3-RING; MACROLIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; RAB5 GTP-BINDING PROTEINS; VACUOLAR PROTON-TRANSLOCATING ATPASES; VACUOLES;

EID: 85047289425     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00104.2016     Document Type: Article

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