Cas4 Nucleases Define the PAM, Length, and Orientation of DNA Fragments Integrated at CRISPR Loci

Molecular Cell

Volumn 70, Issue 5, 2018, Pages 814-824.e6

  Shiimori, Masami ^a   Garrett, Sandra C ^b   Graveley, Brenton R ^b   Terns, Michael P ^a,c  

^a University of Georgia   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

adaptation; Cas; Cas4; CRISPR; immunity; PAM; protospacer; Pyrococcus furiosus; spacer

Indexed keywords

CAS4 1 NUCLEASE; CAS4 2 NUCLEASE; DNA FRAGMENT; NUCLEASE; SPACER DNA; UNCLASSIFIED DRUG; BACTERIAL DNA; BACTERIAL PROTEIN; CRISPR ASSOCIATED PROTEIN;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; ENZYME ACTIVITY; HYPERTHERMOPHILIC ARCHAEON; NONHUMAN; PROTEIN DNA INTERACTION; PROTEIN MOTIF; PYROCOCCUS FURIOSUS; ADAPTIVE IMMUNITY; CHEMISTRY; CONFORMATION; CRISPR CAS SYSTEM; ENZYMOLOGY; GENE EDITING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE MOTIF;

ADAPTIVE IMMUNITY; BACTERIAL PROTEINS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DNA, BACTERIAL; DNA, INTERGENIC; GENE EDITING; GENE EXPRESSION REGULATION, BACTERIAL; NUCLEIC ACID CONFORMATION; NUCLEOTIDE MOTIFS; PYROCOCCUS FURIOSUS;

EID: 85047261088     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2018.05.002     Document Type: Article

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