Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide

Molecular and Cellular Endocrinology

Volumn 477, Issue , 2018, Pages 15-28

  Kumar, Durgesh ^a,b   Shankar, Kripa ^a   Patel, Saraswati ^a   Gupta, Abhishek ^a   Varshney, Salil ^a,b   Gupta, Sanchita ^a,b   Rajan, Sujith ^a,b   Srivastava, Ankita ^a,b   Vishwakarma, Achchhe Lal ^a   Gaikwad, Anil N ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

Hyperinsulinemia; Immunometabolism; Insulin resistance; Nitric oxide; Obesity

Indexed keywords

ARGINASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; NITRIC OXIDE; STREPTOZOCIN;

3T3-L1 CELL LINE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BONE MARROW DERIVED MACROPHAGE; CALORIC INTAKE; CHRONIC HYPERINSULINEMIA; CONTROLLED STUDY; DB/DB MOUSE; DIET INDUCED OBESITY; EOSINOPHIL; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HISTOLOGY; HYPERINSULINEMIA; IMMUNOCOMPETENT CELL; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CHRONIC DISEASE; COMPLICATION; DEFICIENCY; DISEASE MODEL; GENETICS; HYPERINSULINISM; LIPID DIET; METABOLISM; OBESITY; PATHOLOGY;

3T3-L1 CELLS; ADIPOSE TISSUE; ANIMALS; CHRONIC DISEASE; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; HYPERINSULINISM; INFLAMMATION; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OBESITY;

EID: 85047196905     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2018.05.010     Document Type: Article

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