Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte

Journal of Endocrinology

Volumn 230, Issue 3, 2016, Pages 275-290

  Rajan, Sujith ^a,b   Shankar, Kripa ^a   Beg, Muheeb ^a   Varshney, Salil ^a   Gupta, Abhishek ^a   Srivastava, Ankita ^a,b   Kumar, Durgesh ^a,b   Mishra, Raj K ^c   Hussain, Zakir ^a   Gayen, Jiaur R ^a   Gaikwad, Anil N ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^c Burn and Trauma Centre   (India)

Author keywords

Brown adipocytes; Differentiation; Human mesenchymal stem cells; Insulin; Insulin resistance

Indexed keywords

FAT DROPLET; INSULIN GLARGINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN; PROTEIN PRDM16; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOCYTE; BROWN ADIPOSE TISSUE; C57BL 6 MOUSE; CELL DIFFERENTIATION; CELL METABOLISM; CELL STRUCTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENERGY EXPENDITURE; FAT MASS; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INFLAMMATION; INSULIN PUMP; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WEIGHT GAIN; ANIMAL; BODY COMPOSITION; BODY WEIGHT; C57BL MOUSE; CHEMICALLY INDUCED; CYTOLOGY; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; MESENCHYMAL STROMA CELL; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY;

ADIPOCYTES, BROWN; ANIMALS; BODY COMPOSITION; BODY WEIGHT; CELL DIFFERENTIATION; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; TRANSCRIPTION FACTORS; WEIGHT GAIN;

EID: 84986253518     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-16-0099     Document Type: Article

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