Hyperinsulinemic syndrome: The metabolic syndrome is broader than you think

Surgery (United States)

Volumn 156, Issue 2, 2014, Pages 405-411

  Kelly, Christopher T ^a   Mansoor, Janet ^a   Dohm, G Lynis ^a   Chapman, William H H ^a   Pender, John R ^a   Pories, Walter J ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATHEROSCLEROSIS; BARIATRIC SURGERY; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; DISEASE ASSOCIATION; DYSLIPIDEMIA; HUMAN; HYPERINSULINEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; KIDNEY FAILURE; METABOLIC SYNDROME X; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SLEEP DISORDERED BREATHING; SYSTEMATIC REVIEW;

DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC BYPASS; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; OBESITY; RISK FACTORS;

EID: 84904246243     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2014.04.028     Document Type: Conference Paper

References (91)

1. G.M. Reaven Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607
2. W.J. Pories, K.G. MacDonald Jr., and E.J. Morgan et al. Surgical treatment of obesity and its effect on diabetes: 10-y follow-up Am J Clin Nutr 55 2 Suppl 1992 582S 585S
3. M.A. Reed, W.J. Pories, and W. Chapman et al. Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes J Clin Endocrinol Metab 96 2011 2525 2531
4. W.J. Pories, and G.L. Dohm Diabetes: have we got it all wrong? Hyperinsulinism as the culprit: surgery provides the evidence Diabetes Care 35 2012 2438 2442
5. A. Jimenez, V. Perea, R. Corcelles, V. Moize, A. Lacy, and J. Vidal Metabolic effects of bariatric surgery in insulin-sensitive morbidly obese subjects Obes Surg 23 2013 494 500
6. W.J. Lee, M.T. Huang, W. Wang, C.M. Lin, T.C. Chen, and I.R. Lai Effects of obesity surgery on the metabolic syndrome Arch Surg 139 2004 1088 1092
7. R. Blackstone, J.C. Bunt, M.C. Cortes, and H.J. Sugerman Type 2 diabetes after gastric bypass: remission in five models using HbA1c, fasting blood glucose, and medication status Surg Obes Relat Dis 8 2012 548 555
8. K.J. Neff, and C.W. le Roux Bariatric surgery: the indications in metabolic disease Dig Surg 31 2014 6 12
9. H. Buchwald, Y. Avidor, and E. Braunwald et al. Bariatric surgery: a systematic review and meta-analysis JAMA 292 2004 1724 1737
10. W.H. Chapman, E. Cunningham, and W.J. Pories Bariatric surgery and diabetes: access denied Diabetes Technol Ther 15 Suppl 1 2013 S83 S87
11. M.J. Ravesloot, A.A. Hilgevoord, B.A. van Wagensveld, and N. de Vries Assessment of the effect of bariatric surgery on obstructive sleep apnea at two postoperative intervals Obes Surg 24 2014 22 31
12. S. Hafeez, and M.H. Ahmed Bariatric surgery as potential treatment for nonalcoholic fatty liver disease: a future treatment by choice or by chance? J Obes 2013 2013 839275
13. M. Jamal, Y. Gunay, A. Capper, A. Eid, D. Heitshusen, and I. Samuel Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis Surg Obes Relat Dis 8 2012 440 444
14. Y. Gunay, M. Jamal, A. Capper, A. Eid, D. Heitshusen, and I. Samuel Roux-en-Y gastric bypass achieves substantial resolution of migraine headache in the severely obese: 9-year experience in 81 patients Surg Obes Relat Dis 9 2013 55 62
15. R.S. Gill, D.P. Al-Adra, X. Shi, A.M. Sharma, D.W. Birch, and S. Karmali The benefits of bariatric surgery in obese patients with hip and knee osteoarthritis: a systematic review Obes Rev 12 2011 1083 1089
16. V.N. Prachand, and J.C. Alverdy Gastroesophageal reflux disease and severe obesity: fundoplication or bariatric surgery? World J Gastroenterol 16 2010 3757 3761
17. T.D. Adams, and S.C. Hunt Cancer and obesity: effect of bariatric surgery World J Surg 33 2009 2028 2033
18. M. Turchiano, V. Sweat, A. Fierman, and A. Convit Obesity, metabolic syndrome, and insulin resistance in urban high school students of minority race/ethnicity Arch Pediatr Adolesc Med 166 2012 1030 1036
19. E. Bonora, I. Zavaroni, and O. Alpi et al. Relationship between blood pressure and plasma insulin in non-obese and obese non-diabetic subjects Diabetologia 30 1987 719 723
20. M.C. Pouliot, J.P. Despres, and A. Nadeau et al. Visceral obesity in men. Associations with glucose tolerance, plasma insulin, and lipoprotein levels Diabetes 41 1992 826 834
21. E. Ferrannini, A. Natali, P. Bell, P. Cavallo-Perin, N. Lalic, and G. Mingrone Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR) J Clin Invest 100 1997 1166 1173
22. C. Weyer, T. Funahashi, and S. Tanaka et al. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia J Clin Endocrinol Metab 86 2001 1930 1935
23. J.H. Warram, B.C. Martin, A.S. Krolewski, J.S. Soeldner, and C.R. Kahn Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents Ann Intern Med 113 1990 909 915
24. I. Zavaroni, L. Bonini, and P. Gasparini et al. Hyperinsulinemia in a normal population as a predictor of non-insulin-dependent diabetes mellitus, hypertension, and coronary heart disease: The barilla factory revisited Metabolism 48 1999 989 994
25. S.M. Haffner, M.P. Stern, H.P. Hazuda, B.D. Mitchell, and J.K. Patterson Cardiovascular risk factors in confirmed prediabetic individuals. does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA 263 1990 2893 2898
26. M. Modan, H. Halkin, and S. Almog et al. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance J Clin Invest 75 1985 809 817
27. L. Lissner, C. Bengtsson, L. Lapidus, K. Kristjansson, and H. Wedel Fasting insulin in relation to subsequent blood pressure changes and hypertension in women Hypertension 20 1992 797 801
28. C.P. Lucas, J.A. Estigarribia, L.L. Darga, and G.M. Reaven Insulin and blood pressure in obesity Hypertension 7 1985 702 706
29. I. Zavaroni, E. Bonora, and M. Pagliara et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance N Engl J Med 320 1989 702 706
30. D. Johnson, D. Prud'homme, J.P. Despres, A. Nadeau, A. Tremblay, and C. Bouchard Relation of abdominal obesity to hyperinsulinemia and high blood pressure in men Int J Obes Relat Metab Disord 16 1992 881 890
31. S.E. Park, E.J. Rhee, and C.Y. Park et al. Impact of hyperinsulinemia on the development of hypertension in normotensive, nondiabetic adults: a 4-year follow-up study Metabolism 62 2013 532 538
32. F. Kronenberg, S.S. Rich, and P. Sholinsky et al. Insulin and hypertension in the NHLBI family heart study: a sibpair approach to a controversial issue Am J Hypertens 13 2000 240 250
33. S. Zimmermann, R.A. Phillips, and A. Dunaif et al. Polycystic ovary syndrome: lack of hypertension despite profound insulin resistance J Clin Endocrinol Metab 75 1992 508 513
34. G.M. Reaven, Y.D. Chen, J. Jeppesen, P. Maheux, and R.M. Krauss Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles J Clin Invest 92 1993 141 146
35. B. Becker, F. Kronenberg, and J.T. Kielstein et al. Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study J Am Soc Nephrol 16 2005 1091 1098
36. J. Chen, P. Muntner, and L.L. Hamm et al. Insulin resistance and risk of chronic kidney disease in nondiabetic US adults J Am Soc Nephrol 14 2003 469 477
37. D. Fliser, G. Pacini, and R. Engelleiter et al. Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease Kidney Int 53 1998 1343 1347
38. M. Chonchol, and R. Scragg 25-hydroxyvitamin D, insulin resistance, and kidney function in the third national health and nutrition examination survey Kidney Int 71 2007 134 139
39. T.J. Hsiao, J.C. Chen, and J.D. Wang Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients Int J Obes Relat Metab Disord 28 2004 167 172
40. E. Bugianesi, A. Gastaldelli, and E. Vanni et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms Diabetologia 48 2005 634 642
41. S.H. Park, B.I. Kim, and J.W. Yun et al. Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men J Gastroenterol Hepatol 19 2004 694 698
42. S. Chitturi, S. Abeygunasekera, and G.C. Farrell et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome Hepatology 35 2002 373 379
43. G. Marchesini, M. Brizi, and A.M. Morselli-Labate et al. Association of nonalcoholic fatty liver disease with insulin resistance Am J Med 107 1999 450 455
44. I. Tarkun, B.C. Arslan, Z. Canturk, E. Turemen, T. Sahin, and C. Duman Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation J Clin Endocrinol Metab 89 2004 5592 5596
45. D.A. Ehrmann, D.R. Liljenquist, and K. Kasza et al. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome J Clin Endocrinol Metab 91 2006 48 53
46. J.E. Nestler, and D.J. Jakubowicz Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens J Clin Endocrinol Metab 82 1997 4075 4079
47. V.D. Lewy, K. Danadian, S.F. Witchel, and S. Arslanian Early metabolic abnormalities in adolescent girls with polycystic ovarian syndrome J Pediatr 138 2001 38 44
48. H.F. Escobar-Morreale, S. Samino, and M. Insenser et al. Metabolic heterogeneity in polycystic ovary syndrome is determined by obesity: plasma metabolomic approach using GC-MS Clin Chem 58 2012 999 1009
49. I. Banu, M. Wahab, B. Debnath, D. Begum, and M. Arslan Characteristics of insulin and androgen status in polycystic ovary syndrome Bangladesh J Med Biochem 3 2010
50. J. Kozakowski, and W. Zgliczynski Body composition, glucose metabolism markers and serum androgens - association in women with polycystic ovary syndrome Endokrynol Pol 64 2013 94 100
51. A.N. Vgontzas, R.S. Legro, E.O. Bixler, A. Grayev, A. Kales, and G.P. Chrousos Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance J Clin Endocrinol Metab 86 2001 517 520
52. A.N. Vgontzas, D.A. Papanicolaou, and E.O. Bixler et al. Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance, and hypercytokinemia J Clin Endocrinol Metab 85 2000 1151 1158
53. A.N. Vgontzas, E.O. Bixler, and G.P. Chrousos Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance J Intern Med 254 2003 32 44
54. A.J. Pyykkonen, B. Isomaa, and A.K. Pesonen et al. Subjective sleep complaints are associated with insulin resistance in individuals without diabetes: the PPP-botnia study Diabetes Care 35 2012 2271 2278
55. J. Theorell-Haglow, C. Berne, C. Janson, and E. Lindberg Obstructive sleep apnoea is associated with decreased insulin sensitivity in females Eur Respir J 31 2008 1054 1060
56. S.R. Coughlin, L. Mawdsley, J.A. Mugarza, P.M. Calverley, and J.P. Wilding Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome Eur Heart J 25 2004 735 741
57. A. Barcelo, F. Barbe, and M. de la Pena et al. Insulin resistance and daytime sleepiness in patients with sleep apnoea Thorax 63 2008 946 950
58. J. Ma, H. Li, and E. Giovannucci et al. Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis Lancet Oncol 9 2008 1039 1047
59. U.A. Hvidtfeldt, M.J. Gunter, and T. Lange et al. Quantifying mediating effects of endogenous estrogen and insulin in the relation between obesity, alcohol consumption, and breast cancer Cancer Epidemiol Biomarkers Prev 21 2012 1203 1212
60. I. Walraven, E. van 't Riet, and C.D. Stehouwer et al. Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study Diabetologia 56 2013 1148 1154
61. B.M. Wolpin, Y. Bao, and Z.R. Qian et al. Hyperglycemia, insulin resistance, impaired pancreatic beta-cell function, and risk of pancreatic cancer J Natl Cancer Inst 105 2013 1027 1035
62. R. Dankner, M.H. Shanik, L. Keinan-Boker, C. Cohen, and A. Chetrit Effect of elevated basal insulin on cancer incidence and mortality in cancer incident patients: the Israel GOH 29-year follow-up study Diabetes Care 35 2012 1538 1543
63. E. Bonora, J. Willeit, and S. Kiechl et al. Relationship between insulin and carotid atherosclerosis in the general population. The bruneck study Stroke 28 1997 1147 1152
64. M.A. Marini, S. Frontoni, and E. Succurro et al. Insulin clearance is associated with carotid artery intima-media thickness Atherosclerosis 229 2013 453 458
65. T. Naya, N. Hosomi, and H. Ohyama et al. Smoking, fasting serum insulin, and obesity are the predictors of carotid atherosclerosis in relatively young subjects Angiology 58 2007 677 684
66. J.P. Despres, B. Lamarche, and P. Mauriege et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease N Engl J Med 334 1996 952 957
67. K. Pyorala Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: results from two population studies in finland Diabetes Care 2 1979 131 141
68. P. Ducimetiere, E. Eschwege, L. Papoz, J.L. Richard, J.R. Claude, and G. Rosselin Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population Diabetologia 19 1980 205 210
69. N. Patel, T.H. Taveira, G. Choudhary, H. Whitlatch, and W.C. Wu Fasting serum C-peptide levels predict cardiovascular and overall death in nondiabetic adults J Am Heart Assoc 1 2012 e003152
70. A. Fontbonne, M.A. Charles, and N. Thibult et al. Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris prospective study, 15-year follow-up Diabetologia 34 1991 356 361
71. M. Pyorala, H. Miettinen, M. Laakso, and K. Pyorala Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki policemen study Circulation 98 1998 398 404
72. B. Lamarche, A. Tchernof, and P. Mauriege et al. Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease JAMA 279 1998 1955 1961
73. E. Ferrannini, S.M. Haffner, B.D. Mitchell, and M.P. Stern Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome Diabetologia 34 1991 416 422
74. Y.C. Hwang, J.H. Jee, and E.Y. Oh et al. Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans Int J Cardiol 134 2009 313 321
75. C.M. Burchfiel, J.D. Curb, and R. Arakaki et al. Cardiovascular risk factors and hyperinsulinemia in elderly men: The Honolulu heart program Ann Epidemiol 6 1996 490 497
76. K.G. Alberti, P. Zimmet, J. Shaw IDF Epidemiology Task Force Consensus Group The metabolic syndrome - a new worldwide definition Lancet 366 2005 1059 1062
77. K.G. Alberti, and P.Z. Zimmet Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 15 1998 539 553
78. B. Balkau, and M.A. Charles Comment on the provisional report from the WHO consultation. european group for the study of insulin resistance (EGIR) Diabet Med 16 1999 442 443
79. S.M. Grundy, Brewer HB Jr., and J.I. Cleeman et al. Definition of metabolic syndrome: Report of the national heart, lung, and blood institute/american heart association conference on scientific issues related to definition Circulation 109 2004 433 438
80. C. Lorenzo, K. Williams, K.J. Hunt, and S.M. Haffner The National Cholesterol Education Program - Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes Diabetes Care 30 2007 8 13
81. E. Kassi, P. Pervanidou, G. Kaltsas, and G. Chrousos Metabolic syndrome: Definitions and controversies BMC Med 9 2011 48
82. R. Nistala, and A. Whaley-Connell Resistance to insulin and kidney disease in the cardiorenal metabolic syndrome; role for angiotensin II Mol Cell Endocrinol 378 2013 53 58
83. M.J. Ribeiro, J.F. Sacramento, C. Gonzalez, M.P. Guarino, E.C. Monteiro, and S.V. Conde Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets Diabetes 62 2013 2905 2916
84. S.M. Harlan, D.F. Guo, D.A. Morgan, C. Fernandes-Santos, and K. Rahmouni Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects Cell Metab 17 2013 599 606
85. F. Tosi, C. Negri, and F. Perrone et al. Hyperinsulinemia amplifies GnRH agonist stimulated ovarian steroid secretion in women with polycystic ovary syndrome J Clin Endocrinol Metab 97 2012 1712 1719
86. A. Dunaif Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis Endocr Rev 18 1997 774 800
87. J. Ge, W. Zhai, and B. Cheng et al. Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein alpha J Cell Biochem 114 2013 2188 2198
88. Y.M. Park, S. R Kashyap, J. A Major, and R.L. Silverstein Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis Lab Invest 92 2012 1171 1180
89. R. Dankner, A. Chetrit, M.H. Shanik, I. Raz, and J. Roth Basal state hyperinsulinemia in healthy normoglycemic adults heralds dysglycemia after more than two decades of follow up Diabetes Metab Res Rev 28 2012 618 624
90. J.L. Johnson, D.S. Duick, M.A. Chui, and S.A. Aldasouqi Identifying prediabetes using fasting insulin levels Endocr Pract 16 2010 47 52
91. M.H. Shanik, Y. Xu, J. Skrha, R. Dankner, Y. Zick, and J. Roth Insulin resistance and hyperinsulinemia: Is hyperinsulinemia the cart or the horse? Diabetes Care 31 Suppl 2 2008 S262 S268