-
1
-
-
84876909069
-
The ageing haematopoietic stem cell compartment
-
Geiger H, de Haan G, Florian MC. The ageing haematopoietic stem cell compartment. Nat Rev Immunol. 2013;13(5):376-389.
-
(2013)
Nat Rev Immunol.
, vol.13
, Issue.5
, pp. 376-389
-
-
Geiger, H.1
De, H.G.2
Florian, M.C.3
-
2
-
-
85006810996
-
The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging
-
Latchney SE, Calvi LM. The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging. Semin Hematol. 2017;54(1):25-32.
-
(2017)
Semin Hematol
, vol.54
, Issue.1
, pp. 25-32
-
-
Latchney, S.E.1
Calvi, L.M.2
-
3
-
-
21544467270
-
Cell intrinsic alterations underlie hematopoietic stem cell aging
-
P
-
Rossi DJ, Bryder D, Zahn JM, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA. 2005;102(26): 9194-9199.
-
(2005)
Roc Natl Acad Sci USA
, vol.102
, Issue.26
, pp. 9194-9199
-
-
Rossi, D.J.1
Bryder, D.2
Zahn, J.M.3
-
4
-
-
84055200841
-
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
-
Pang WW, Price EA, Sahoo D, et al. Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA. 2011;108(50):20012-20017.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.50
, pp. 20012-20017
-
-
Pang, W.W.1
Price, E.A.2
Sahoo, D.3
-
5
-
-
0029813378
-
The aging of hematopoietic stem cells.
-
Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. The aging of hematopoietic stem cells. Nat Med. 1996;2(9):1011-1016.
-
(1996)
Nat Med
, vol.2
, Issue.9
, pp. 1011-1016
-
-
Morrison, S.J.1
Wandycz, A.M.2
Akashi, K.3
Globerson, A.4
Weissman, I.L.5
-
6
-
-
84906254220
-
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
-
Flach J, Bakker ST, Mohrin M, et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. 2014; 512(7513):198-202.
-
(2014)
Nature
, vol.512
, Issue.7513
, pp. 198-202
-
-
Flach, J.1
Bakker, S.T.2
Mohrin, M.3
-
7
-
-
84904043095
-
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
-
Beerman I, Seita J, Inlay MA, Weissman IL, Rossi DJ. Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle. Cell Stem Cell. 2014;15(1):37-50.
-
(2014)
Cell Stem Cell
, vol.15
, Issue.1
, pp. 37-50
-
-
Beerman, I.1
Seita, J.2
Inlay, M.A.3
Weissman, I.L.4
Rossi, D.J.5
-
9
-
-
0037268338
-
The fanconi anaemia/brca pathway
-
D'Andrea AD, Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer. 2003;3(1):23-34.
-
(2003)
Nat Rev Cancer
, vol.3
, Issue.1
, pp. 23-34
-
-
D'Andrea, A.D.1
Grompe, M.2
-
10
-
-
84908587479
-
Bone marrow failure and the telomeropathies.
-
Townsley DM, Dumitriu B, Young NS. Bone marrow failure and the telomeropathies. Blood. 2014;124(18):2775-2783.
-
(2014)
Blood
, vol.124
, Issue.18
, pp. 2775-2783
-
-
Townsley, D.M.1
Dumitriu, B.2
Young, N.S.3
-
11
-
-
84897543657
-
Current concepts in the pathophysiology and treatment of aplastic anemia
-
Young NS. Current concepts in the pathophysiology and treatment of aplastic anemia. Hematology Am Soc Hematol Educ Program. 2013;2013:76-81.
-
(2013)
Hematology Am Soc Hematol Educ Program
, vol.2013
, pp. 76-81
-
-
Young, N.S.1
-
12
-
-
77951431225
-
Ribosomopathies: Human disorders of ribosome dysfunction
-
Narla A, Ebert BL. Ribosomopathies: Human disorders of ribosome dysfunction. Blood. 2010;115(16):3196-3205.
-
(2010)
Blood
, vol.115
, Issue.16
, pp. 3196-3205
-
-
Narla, A.1
Ebert, B.L.2
-
13
-
-
85008182977
-
Hematopoiesis in aging: Current concepts and challenges
-
Park CY. Hematopoiesis in aging: Current concepts and challenges. Semin Hematol. 2017;54(1):1-3.
-
(2017)
Semin Hematol
, vol.54
, Issue.1
, pp. 1-3
-
-
Park, C.Y.1
-
14
-
-
84969884860
-
In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early and steady-state reconstitution phases
-
Biasco L, Pellin D, Scala S, et al. In vivo tracking of human hematopoiesis reveals patterns of clonal dynamics during early and steady-state reconstitution phases. Cell Stem Cell. 2016;19(1):107-119.
-
(2016)
Cell Stem Cell
, vol.19
, Issue.1
, pp. 107-119
-
-
Biasco, L.1
Pellin, D.2
Scala, S.3
-
15
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011; 20(1):11-24.
-
(2011)
Cancer Cell
, vol.20
, Issue.1
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
-
16
-
-
84925116257
-
Dnmt3a and dnmt3b have overlapping and distinct functions in hematopoietic stem cells
-
Challen GA, Sun D, Mayle A, et al. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014;15(3): 350-364.
-
(2014)
Cell Stem Cell
, vol.15
, Issue.3
, pp. 350-364
-
-
Challen, G.A.1
Sun, D.2
Mayle, A.3
-
17
-
-
84899768899
-
Epigenomic profiling of young and aged hscs reveals concerted changes during aging that reinforce self-renewal
-
Sun D, Luo M, Jeong M, et al. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014;14(5):673-688.
-
(2014)
Cell Stem Cell
, vol.14
, Issue.5
, pp. 673-688
-
-
Sun, D.1
Luo, M.2
Jeong, M.3
-
18
-
-
85009080571
-
Molecular mechanisms underlying lineage bias in aging hematopoiesis
-
Elias HK, Bryder D, Park CY. Molecular mechanisms underlying lineage bias in aging hematopoiesis. Semin Hematol. 2017;54(1):4-11.
-
(2017)
Semin Hematol
, vol.54
, Issue.1
, pp. 4-11
-
-
Elias, H.K.1
Bryder, D.2
Park, C.Y.3
-
19
-
-
85006093278
-
The many faces of hematopoietic stem cell heterogeneity
-
Crisan M, Dzierzak E. The many faces of hematopoietic stem cell heterogeneity. Development. 2016;143(24):4571-4581.
-
(2016)
Development
, vol.143
, Issue.24
, pp. 4571-4581
-
-
Crisan, M.1
Dzierzak, E.2
-
20
-
-
84940446838
-
Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell populations
-
Wilson NK, Kent DG, Buettner F, et al. Combined single-cell functional and gene expression analysis resolves heterogeneity within stem cell Populations. Cell Stem Cell. 2015;16(6):712-724.
-
(2015)
Cell Stem Cell
, vol.16
, Issue.6
, pp. 712-724
-
-
Wilson, N.K.1
Kent, D.G.2
Buettner, F.3
-
21
-
-
84969847331
-
A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells
-
Reinisch A, Thomas D, Corces MR, et al. A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells. Nat Med. 2016;22(7):812-821.
-
(2016)
Nat Med
, vol.22
, Issue.7
, pp. 812-821
-
-
Reinisch, A.1
Thomas, D.2
Corces, M.R.3
-
22
-
-
84952945434
-
Humanized hemato-lymphoid system mice
-
Theocharides AP, Rongvaux A, Fritsch K, Flavell RA, Manz MG. Humanized hemato-lymphoid system mice. Haematologica. 2016;101(1):5-19.
-
(2016)
Haematologica
, vol.101
, Issue.1
, pp. 5-19
-
-
Theocharides, A.P.1
Rongvaux, A.2
Fritsch, K.3
Flavell, R.A.4
Manz, M.G.5
-
23
-
-
84858649330
-
Rantes/ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing
-
Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012;119(11): 2500-2509.
-
(2012)
Blood
, vol.119
, Issue.11
, pp. 2500-2509
-
-
Ergen, A.V.1
Boles, N.C.2
Goodell, M.A.3
-
24
-
-
10644247684
-
Mesenchymal stem cells in myelodysplastic syndromes: Phenotypic and cytogenetic characterization
-
Flores-Figueroa E, Arana-Trejo RM, Guti errez-Espindola G, Perez-Cabrera A, Mayani H. Mesenchymal stem cells in myelodysplastic syndromes: Phenotypic and cytogenetic characterization. Leuk Res. 2005;29(2):215-224.
-
(2005)
Leuk Res.
, vol.29
, Issue.2
, pp. 215-224
-
-
Flores-Figueroa, E.1
Arana-Trejo, R.M.2
Guti, E.-E.G.3
Perez-Cabrera, A.4
Mayani, H.5
-
25
-
-
81555196340
-
Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts
-
Blau O, Baldus CD, Hofmann WK, et al. Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts. Blood. 2011;118(20):5583-5592.
-
(2011)
Blood
, vol.118
, Issue.20
, pp. 5583-5592
-
-
Blau, O.1
Baldus, C.D.2
Hofmann, W.K.3
-
26
-
-
0242268524
-
Osteoblastic cells regulate the haematopoietic stem cell niche
-
Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-846.
-
(2003)
Nature
, vol.425
, Issue.6960
, pp. 841-846
-
-
Calvi, L.M.1
Adams, G.B.2
Weibrecht, K.W.3
-
27
-
-
84902200836
-
Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit
-
Medyouf H, Mossner M, Jann JC, et al. Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell. 2014;14(6):824-837.
-
(2014)
Cell Stem Cell
, vol.14
, Issue.6
, pp. 824-837
-
-
Medyouf, H.1
Mossner, M.2
Jann, J.C.3
-
28
-
-
85006999434
-
Lymphocyte generation and population homeostasis throughout life
-
Yanes RE, Gustafson CE, Weyand CM, Goronzy JJ. Lymphocyte generation and population homeostasis throughout life. Semin Hematol. 2017;54(1): 33-38.
-
(2017)
Semin Hematol
, vol.54
, Issue.1
, pp. 33-38
-
-
Yanes, R.E.1
Gustafson, C.E.2
Weyand, C.M.3
Goronzy, J.J.4
-
29
-
-
84949724849
-
Hsc aging and senescent immune remodeling
-
Denkinger MD, Leins H, Schirmbeck R, Florian MC, Geiger H. HSC aging and senescent immune remodeling. Trends Immunol. 2015;36(12):815-824.
-
(2015)
Trends Immunol
, vol.36
, Issue.12
, pp. 815-824
-
-
Denkinger, M.D.1
Leins, H.2
Schirmbeck, R.3
Florian, M.C.4
Geiger, H.5
-
30
-
-
80053133049
-
Inflammatory modulation of hscs: Viewing the hsc as a foundation for the immune response
-
King KY, Goodell MA. Inflammatory modulation of HSCs: Viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011;11(10): 685-692.
-
(2011)
Nat Rev Immunol
, vol.11
, Issue.10
, pp. 685-692
-
-
King, K.Y.1
Goodell, M.A.2
-
31
-
-
84920053873
-
Age-related clonal hematopoiesis associated with adverse outcomes
-
Jaiswal S, Fontanillas P, Flannick J, et al. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014;371(26):2488-2498.
-
(2014)
N Engl J Med
, vol.371
, Issue.26
, pp. 2488-2498
-
-
Jaiswal, S.1
Fontanillas, P.2
Flannick, J.3
-
32
-
-
85023756316
-
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
-
Jaiswal S, Natarajan P, Silver AJ, et al. Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease. N Engl J Med. 2017;377(2):111-121.
-
(2017)
N Engl J Med
, vol.377
, Issue.2
, pp. 111-121
-
-
Jaiswal, S.1
Natarajan, P.2
Silver, A.J.3
-
33
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
Genovese G, Kahler AK, Handsaker RE, et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371(26):2477-2487.
-
(2014)
N Engl J Med.
, vol.371
, Issue.26
, pp. 2477-2487
-
-
Genovese, G.1
Kahler, A.K.2
Handsaker, R.E.3
-
34
-
-
85010198872
-
Clonal hematopoiesis associated with tet2 deficiency accelerates atherosclerosis development in mice
-
Fuster JJ, MacLauchlan S, Zuriaga MA, et al. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017;355(6327):842-847.
-
(2017)
Science
, vol.355
, Issue.6327
, pp. 842-847
-
-
Fuster, J.J.1
MacLauchlan, S.2
Zuriaga, M.A.3
-
35
-
-
84893438578
-
You are what you host: Microbiome modulation of the aging process
-
Heintz C, Mair W. You are what you host: Microbiome modulation of the aging process. Cell. 2014;156(3):408-411.
-
(2014)
Cell
, vol.156
, Issue.3
, pp. 408-411
-
-
Heintz, C.1
Mair, W.2
-
37
-
-
84952639987
-
Aging-induced stem cell mutations as drivers for disease and cancer
-
Adams PD, Jasper H, Rudolph KL. Aging-induced stem cell mutations as drivers for disease and cancer. Cell Stem Cell. 2015;16(6):601-612.
-
(2015)
Cell Stem Cell.
, vol.16
, Issue.6
, pp. 601-612
-
-
Adams, P.D.1
Jasper, H.2
Rudolph, K.L.3
-
38
-
-
84937904208
-
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
-
Steensma DP, Bejar R, Jaiswal S, et al. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood. 2015; 126(1):9-16.
-
(2015)
Blood
, vol.126
, Issue.1
, pp. 9-16
-
-
Steensma, D.P.1
Bejar, R.2
Jaiswal, S.3
-
39
-
-
84865827060
-
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.
-
Jan M, Snyder TM, Corces-Zimmerman MR, et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med. 2012;4(149):149ra118.
-
(2012)
Sci Transl Med
, vol.4
, Issue.149
, pp. 149ra118
-
-
Jan, M.1
Snyder, T.M.2
Corces-Zimmerman, M.R.3
-
40
-
-
85011371579
-
Cd99 is a therapeutic target on disease stem cells in myeloid malignancies
-
Chung SS, Eng WS, Hu W, et al. CD99 is a therapeutic target on disease stem cells in myeloid malignancies. Sci Transl Med. 2017;9(374):eaaj2025.
-
(2017)
Sci Transl Med.
, vol.9
, Issue.374
, pp. eaaj2025
-
-
Chung, S.S.1
Eng, W.S.2
Hu, W.3
-
41
-
-
79953223346
-
Prospective separation of normal and leukemic stem cells based on differential expression of tim3, a human acute myeloid leukemia stem cell marker
-
Jan M, Chao MP, Cha AC, et al. Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker. Proc Natl Acad Sci USA. 2011;108(12):5009-5014.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.12
, pp. 5009-5014
-
-
Jan, M.1
Chao, M.P.2
Cha, A.C.3
-
42
-
-
84921288028
-
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions
-
Tomasetti C, Vogelstein B. Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science. 2015; 347(6217):78-81.
-
(2015)
Science
, vol.347
, Issue.6217
, pp. 78-81
-
-
Tomasetti, C.1
Vogelstein, B.2
-
43
-
-
85007496735
-
Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: A proof-of-concept, case-control study
-
Gillis NK, Ball M, Zhang Q, et al. Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: A proof-of-concept, case-control study. Lancet Oncol. 2017;18(1):112-121.
-
(2017)
Lancet Oncol
, vol.18
, Issue.1
, pp. 112-121
-
-
Gillis, N.K.1
Ball, M.2
Zhang, Q.3
-
44
-
-
84925518008
-
Role of tp53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
-
Wong TN, Ramsingh G, Young AL, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 2015; 518(7540):552-555.
-
(2015)
Nature
, vol.518
, Issue.7540
, pp. 552-555
-
-
Wong, T.N.1
Ramsingh, G.2
Young, A.L.3
-
45
-
-
85028324157
-
Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes
-
Coombs CC, Zehir A, Devlin SM, et al. Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes. Cell Stem Cell. 2017;21(3):374-382.e4.
-
(2017)
Cell Stem Cell.
, vol.21
, Issue.3
, pp. 374-382e4
-
-
Coombs, C.C.1
Zehir, A.2
Devlin, S.M.3
-
46
-
-
77956251480
-
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
-
Mohrin M, Bourke E, Alexander D, et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell. 2010; 7(2):174-185.
-
(2010)
Cell Stem Cell
, vol.7
, Issue.2
, pp. 174-185
-
-
Mohrin, M.1
Bourke, E.2
Alexander, D.3
-
47
-
-
85006121567
-
Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment
-
Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H. Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment. Front Immunol. 2016;7:502.
-
(2016)
Front Immunol
, vol.7
, pp. 502
-
-
Kovtonyuk, L.V.1
Fritsch, K.2
Feng, X.3
Manz, M.G.4
Takizawa, H.5
-
48
-
-
84874235360
-
Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes
-
Pang WW, Pluvinage JV, Price EA, et al. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc Natl Acad Sci USA. 2013;110(8):3011-3016.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.8
, pp. 3011-3016
-
-
Pang, W.W.1
Pluvinage, J.V.2
Price, E.A.3
-
49
-
-
84866180518
-
Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations
-
Will B, Zhou L, Vogler TO, et al. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood. 2012;120(10):2076-2086.
-
(2012)
Blood
, vol.120
, Issue.10
, pp. 2076-2086
-
-
Will, B.1
Zhou, L.2
Vogler, T.O.3
-
50
-
-
84902480315
-
Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo
-
Woll PS, Kjallquist U, Chowdhury O, et al. Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer Cell. 2014;25(6):794-808.
-
(2014)
Cancer Cell.
, vol.25
, Issue.6
, pp. 794-808
-
-
Woll, P.S.1
Kjallquist, U.2
Chowdhury, O.3
-
51
-
-
79955960781
-
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments
-
Gibbs KD Jr, Gilbert PM, Sachs K, et al. Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood. 2011;117(16):4226-4233.
-
(2011)
Blood
, vol.117
, Issue.16
, pp. 4226-4233
-
-
Gibbs, K.D.1
Gilbert, P.M.2
Sachs, K.3
-
52
-
-
84906908742
-
Acquired initiating mutations in early hematopoietic cells of cll patients
-
Damm F, Mylonas E, Cosson A, et al. Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov. 2014;4(9):1088-1101.
-
(2014)
Cancer Discov.
, vol.4
, Issue.9
, pp. 1088-1101
-
-
Damm, F.1
Mylonas, E.2
Cosson, A.3
-
53
-
-
85007017094
-
Rejuvenation of aged hematopoietic stem cells
-
Guidi N, Geiger H. Rejuvenation of aged hematopoietic stem cells. Semin Hematol. 2017;54(1):51-55.
-
(2017)
Semin Hematol
, vol.54
, Issue.1
, pp. 51-55
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Guidi N, G.H.1
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