-
1
-
-
84856738988
-
Hematopoiesis: A human perspective
-
Doulatov, S., Notta, F., Laurenti, E. and Dick, J.E. Hematopoiesis: a human perspective. Cell Stem Cell 10, 120-136 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 120-136
-
-
Doulatov, S.1
Notta, F.2
Laurenti, E.3
Dick, J.E.4
-
2
-
-
77958013367
-
AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3
-
Wunderlich, M. et al. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24, 1785-1788 (2010).
-
(2010)
Leukemia
, vol.24
, pp. 1785-1788
-
-
Wunderlich, M.1
-
3
-
-
1242329864
-
NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration
-
Nicolini, F.E., Cashman, J.D., Hogge, D.E., Humphries, R.K. and Eaves, C.J. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 18, 341-347 (2004).
-
(2004)
Leukemia
, vol.18
, pp. 341-347
-
-
Nicolini, F.E.1
Cashman, J.D.2
Hogge, D.E.3
Humphries, R.K.4
Eaves, C.J.5
-
4
-
-
84900850997
-
Development and function of human innate immune cells in a humanized mouse model
-
Rongvaux, A. et al. Development and function of human innate immune cells in a humanized mouse model. Nat. Biotechnol. 32, 364-372 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 364-372
-
-
Rongvaux, A.1
-
5
-
-
79952304617
-
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
-
Willinger, T. et al. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc. Natl. Acad. Sci. USA 108, 2390-2395 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 2390-2395
-
-
Willinger, T.1
-
6
-
-
84928524428
-
Xenograft models for normal and malignant stem cells
-
Goyama, S., Wunderlich, M. and Mulloy, J.C. Xenograft models for normal and malignant stem cells. Blood 125, 2630-2640 (2015).
-
(2015)
Blood
, vol.125
, pp. 2630-2640
-
-
Goyama, S.1
Wunderlich, M.2
Mulloy, J.C.3
-
7
-
-
78650950098
-
Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice
-
Sarry, J.E. et al. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice. J. Clin. Invest. 121, 384-395 (2011).
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 384-395
-
-
Sarry, J.E.1
-
8
-
-
70450265398
-
A robust xenotransplantation model for acute myeloid leukemia
-
Sanchez, P.V. et al. A robust xenotransplantation model for acute myeloid leukemia. Leukemia 23, 2109-2117 (2009).
-
(2009)
Leukemia
, vol.23
, pp. 2109-2117
-
-
Sanchez, P.V.1
-
9
-
-
84869087279
-
Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ-/- mice
-
Patel, S. et al. Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ-/- mice. Leukemia 26, 2432-2435 (2012).
-
(2012)
Leukemia
, vol.26
, pp. 2432-2435
-
-
Patel, S.1
-
10
-
-
84871238560
-
CD19-CD45low/- CD38high/CD138+ plasma cells enrich for human tumorigenic myeloma cells
-
Kim, D., Park, C.Y., Medeiros, B.C. and Weissman, I.L. CD19-CD45low/- CD38high/CD138+ plasma cells enrich for human tumorigenic myeloma cells. Leukemia 26, 2530-2537 (2012).
-
(2012)
Leukemia
, vol.26
, pp. 2530-2537
-
-
Kim, D.1
Park, C.Y.2
Medeiros, B.C.3
Weissman, I.L.4
-
11
-
-
84871182464
-
Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
-
Kim, D. et al. Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells. Leukemia 26, 2538-2545 (2012).
-
(2012)
Leukemia
, vol.26
, pp. 2538-2545
-
-
Kim, D.1
-
12
-
-
84874235360
-
Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes
-
Pang, W.W. et al. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc. Natl. Acad. Sci. USA 110, 3011-3016 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 3011-3016
-
-
Pang, W.W.1
-
13
-
-
84902200836
-
Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit
-
Medyouf, H. et al. Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit. Cell Stem Cell 14, 824-837 (2014).
-
(2014)
Cell Stem Cell
, vol.14
, pp. 824-837
-
-
Medyouf, H.1
-
14
-
-
84905756677
-
Hematopoietic stem cell niche maintenance during homeostasis and regeneration
-
Mendelson, A. and Frenette, P.S. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat. Med. 20, 833-846 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 833-846
-
-
Mendelson, A.1
Frenette, P.S.2
-
15
-
-
35948984135
-
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
-
Ishikawa, F. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat. Biotechnol. 25, 1315-1321 (2007).
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1315-1321
-
-
Ishikawa, F.1
-
16
-
-
84924272696
-
Normal and leukemic stem cell niches: Insights and therapeutic opportunities
-
Schepers, K., Campbell, T.B. and Passegue, E. Normal and leukemic stem cell niches: insights and therapeutic opportunities. Cell Stem Cell 16, 254-267 (2015).
-
(2015)
Cell Stem Cell
, vol.16
, pp. 254-267
-
-
Schepers, K.1
Campbell, T.B.2
Passegue, E.3
-
17
-
-
84920973388
-
Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation
-
Reinisch, A. et al. Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation. Blood 125, 249-260 (2015).
-
(2015)
Blood
, vol.125
, pp. 249-260
-
-
Reinisch, A.1
-
18
-
-
77749294821
-
Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells
-
Saito, Y. et al. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci. Transl. Med. 2, 17ra9 (2010).
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 17ra9
-
-
Saito, Y.1
-
19
-
-
77950974931
-
An in vivo model to study and manipulate the hematopoietic stem cell niche
-
Song, J. et al. An in vivo model to study and manipulate the hematopoietic stem cell niche. Blood 115, 2592-2600 (2010).
-
(2010)
Blood
, vol.115
, pp. 2592-2600
-
-
Song, J.1
-
20
-
-
20444371961
-
Anabolic actions of PTH (1-34): Use of a novel tissue engineering model to investigate temporal effects on bone
-
Pettway, G.J. et al. Anabolic actions of PTH (1-34): use of a novel tissue engineering model to investigate temporal effects on bone. Bone 36, 959-970 (2005).
-
(2005)
Bone
, vol.36
, pp. 959-970
-
-
Pettway, G.J.1
-
21
-
-
0242363225
-
Identification of the haematopoietic stem cell niche and control of the niche size
-
Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841 (2003).
-
(2003)
Nature
, vol.425
, pp. 836-841
-
-
Zhang, J.1
-
22
-
-
84896081834
-
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia
-
Klco, J.M. et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell 25, 379-392 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 379-392
-
-
Klco, J.M.1
-
23
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648 (1994).
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
-
24
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet, D. and Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730-737 (1997).
-
(1997)
Nat. Med.
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
25
-
-
1542398821
-
Acute promyelocytic leukemia: Where does it stem from?
-
Grimwade, D. and Enver, T. Acute promyelocytic leukemia: where does it stem from? Leukemia 18, 375-384 (2004).
-
(2004)
Leukemia
, vol.18
, pp. 375-384
-
-
Grimwade, D.1
Enver, T.2
-
26
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics, R. et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352, 1779-1790 (2005).
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
-
27
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
Cancer Genome Project
-
Baxter, E.J. et al. Cancer Genome Project. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365, 1054-1061 (2005).
-
(2005)
Lancet
, vol.365
, pp. 1054-1061
-
-
Baxter, E.J.1
-
28
-
-
84890372480
-
Somatic mutations of calreticulin in myeloproliferative neoplasms
-
Klampfl, T. et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N. Engl. J. Med. 369, 2379-2390 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 2379-2390
-
-
Klampfl, T.1
-
29
-
-
84890328032
-
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
-
Nangalia, J. et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N. Engl. J. Med. 369, 2391-2405 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 2391-2405
-
-
Nangalia, J.1
-
30
-
-
54049110222
-
The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity
-
James, C. et al. The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity. Blood 112, 2429-2438 (2008).
-
(2008)
Blood
, vol.112
, pp. 2429-2438
-
-
James, C.1
-
31
-
-
35448956762
-
Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice
-
Ishii, T. et al. Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice. Exp. Hematol. 35, 1633-1640 (2007).
-
(2007)
Exp. Hematol.
, vol.35
, pp. 1633-1640
-
-
Ishii, T.1
-
32
-
-
84868612626
-
Spleens of myelofibrosis patients contain malignant hematopoietic stem cells
-
Wang, X. et al. Spleens of myelofibrosis patients contain malignant hematopoietic stem cells. J. Clin. Invest. 122, 3888-3899 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 3888-3899
-
-
Wang, X.1
-
33
-
-
0001639195
-
Some speculations on the myeloproliferative syndromes
-
Dameshek, W. Some speculations on the myeloproliferative syndromes. Blood 6, 372-375 (1951).
-
(1951)
Blood
, vol.6
, pp. 372-375
-
-
Dameshek, W.1
-
34
-
-
36749098400
-
Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
-
Majeti, R., Park, C.Y. and Weissman, I.L. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1, 635-645 (2007).
-
(2007)
Cell Stem Cell
, vol.1
, pp. 635-645
-
-
Majeti, R.1
Park, C.Y.2
Weissman, I.L.3
-
35
-
-
80052468964
-
Stem cell gene expression programs influence clinical outcome in human leukemia
-
Eppert, K. et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat. Med. 17, 1086-1093 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 1086-1093
-
-
Eppert, K.1
-
36
-
-
78651416188
-
Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia
-
Goardon, N. et al. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell 19, 138-152 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 138-152
-
-
Goardon, N.1
-
37
-
-
0027331702
-
PML/RARα fusion gene is expressed in both granuloid/macrophage and erythroid colonies in acute promyelocytic leukaemia
-
Takatsuki, H. et al. PML/RARα fusion gene is expressed in both granuloid/macrophage and erythroid colonies in acute promyelocytic leukaemia. Br. J. Haematol. 85, 477-482 (1993).
-
(1993)
Br. J. Haematol.
, vol.85
, pp. 477-482
-
-
Takatsuki, H.1
-
38
-
-
0028942312
-
Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia
-
Turhan, A.G. et al. Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia. Blood 85, 2154-2161 (1995).
-
(1995)
Blood
, vol.85
, pp. 2154-2161
-
-
Turhan, A.G.1
-
39
-
-
7844251185
-
Cell lineage specific involvement in acute promyelocytic leukaemia (APL) using a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques for the detection of the translocation t(15;17)(q22;q12
-
Haferlach, T. et al. Cell lineage specific involvement in acute promyelocytic leukaemia (APL) using a combination of May-Grunwald-Giemsa staining and fluorescence in situ hybridization techniques for the detection of the translocation t(15;17)(q22;q12). Br. J. Haematol. 103, 93-99 (1998).
-
(1998)
Br. J. Haematol.
, vol.103
, pp. 93-99
-
-
Haferlach, T.1
-
40
-
-
0028235669
-
Cell lineage involvement of recurrent chromosomal abnormalities in hematologic neoplasms
-
Knuutila, S. et al. Cell lineage involvement of recurrent chromosomal abnormalities in hematologic neoplasms. Genes Chromosom. Cancer 10, 95-102 (1994).
-
(1994)
Genes Chromosom. Cancer
, vol.10
, pp. 95-102
-
-
Knuutila, S.1
-
41
-
-
76249123883
-
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia
-
Guibal, F.C. et al. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood 114, 5415-5425 (2009).
-
(2009)
Blood
, vol.114
, pp. 5415-5425
-
-
Guibal, F.C.1
-
42
-
-
0030615230
-
A PMLRARα transgene initiates murine acute promyelocytic leukemia
-
Brown, D. et al. A PMLRARα transgene initiates murine acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 94, 2551-2556 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2551-2556
-
-
Brown, D.1
-
43
-
-
0034663431
-
PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype
-
Grignani, F. et al. PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype. Blood 96, 1531-1537 (2000).
-
(2000)
Blood
, vol.96
, pp. 1531-1537
-
-
Grignani, F.1
-
44
-
-
84928541987
-
Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice
-
Matsushita, H. et al. Establishment of a humanized APL model via the transplantation of PML-RARA-transduced human common myeloid progenitors into immunodeficient mice. PLoS One 9, e111082 (2014).
-
(2014)
PLoS One
, vol.9
, pp. e111082
-
-
Matsushita, H.1
-
45
-
-
78650670563
-
Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells
-
Wang, X. et al. Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells. Blood 116, 5972-5982 (2010).
-
(2010)
Blood
, vol.116
, pp. 5972-5982
-
-
Wang, X.1
-
46
-
-
79952294749
-
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
-
Rongvaux, A. et al. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc. Natl. Acad. Sci. USA 108, 2378-2383 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 2378-2383
-
-
Rongvaux, A.1
-
47
-
-
79959782679
-
Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement
-
Willinger, T., Rongvaux, A., Strowig, T., Manz, M.G. and Flavell, R.A. Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. Trends Immunol. 32, 321-327 (2011).
-
(2011)
Trends Immunol.
, vol.32
, pp. 321-327
-
-
Willinger, T.1
Rongvaux, A.2
Strowig, T.3
Manz, M.G.4
Flavell, R.A.5
-
48
-
-
84864128108
-
Reconstructing the human hematopoietic niche in immunodeficient mice: Opportunities for studying primary multiple myeloma
-
Groen, R.W. et al. Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma. Blood 120, e9-e16 (2012).
-
(2012)
Blood
, vol.120
, pp. e9-e16
-
-
Groen, R.W.1
-
49
-
-
84881241272
-
Guide for the care and use of laboratory animals - Natl-Res-Council
-
Alvarez, L.L. and Pardo, H.G. Guide for the care and use of laboratory animals - Natl-Res-Council. Psicothema 9, 232-234 (1997).
-
(1997)
Psicothema
, vol.9
, pp. 232-234
-
-
Alvarez, L.L.1
Pardo, H.G.2
-
50
-
-
84889875169
-
-
(ed. Gad, S.C. (John Wiley and Sons, Inc.
-
Rohde, E., Schallmoser, K., Bartmann, C., Reinisch, A and Dirk, S. in Pharmaceutical Manufacturing Handbook: Regulations and Quality (ed. Gad, S.C.) 97-115 (John Wiley and Sons, Inc., 2008).
-
(2008)
Pharmaceutical Manufacturing Handbook: Regulations and Quality
, pp. 97-115
-
-
Rohde, E.1
Schallmoser, K.2
Bartmann, C.3
Reinisch, A.4
Dirk, S.5
-
51
-
-
51449124598
-
Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum
-
Schallmoser, K. et al. Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum. Tissue Eng. Part C Methods 14, 185-196 (2008).
-
(2008)
Tissue Eng. Part C Methods
, vol.14
, pp. 185-196
-
-
Schallmoser, K.1
-
52
-
-
33747713246
-
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
-
Dominici, M. et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8, 315-317 (2006).
-
(2006)
Cytotherapy
, vol.8
, pp. 315-317
-
-
Dominici, M.1
-
53
-
-
79960106880
-
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
-
Notta, F. et al. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 333, 218-221 (2011).
-
(2011)
Science
, vol.333
, pp. 218-221
-
-
Notta, F.1
-
54
-
-
84925535544
-
Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands
-
Moraga, I. et al. Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands. Cell 160, 1196-1208 (2015).
-
(2015)
Cell
, vol.160
, pp. 1196-1208
-
-
Moraga, I.1
-
55
-
-
84894304555
-
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
-
Corces-Zimmerman, M.R., Hong, W.J., Weissman, I.L., Medeiros, B.C. and Majeti, R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc. Natl. Acad. Sci. USA 111, 2548-2553 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 2548-2553
-
-
Corces-Zimmerman, M.R.1
Hong, W.J.2
Weissman, I.L.3
Medeiros, B.C.4
Majeti, R.5
-
56
-
-
0021223477
-
The total marrow mass of the mouse: A simplified method of measurement
-
Boggs, D.R. The total marrow mass of the mouse: a simplified method of measurement. Am. J. Hematol. 16, 277-286 (1984).
-
(1984)
Am. J. Hematol.
, vol.16
, pp. 277-286
-
-
Boggs, D.R.1
|