The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Du, Meng ^a   Yuan, Lin ^a   Tan, Xin ^a   Huang, Dandan ^a   Wang, Xiaojing ^a   Zheng, Zhe ^a   Mao, Xiaoxiang ^a   Li, Xiangrao ^a   Yang, Liu ^a   Huang, Kun ^a   Zhang, Fengxiao ^a   Wang, Yan ^a   Luo, Xi ^a   Huang, Dan ^a   Huang, Kai ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRIDAE; MUS;

LIPOPOLYSACCHARIDE; LONG UNTRANSLATED RNA; MIRT2 LONG NONCODING RNA, MOUSE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; HEK293 CELL LINE; HUMAN; INFLAMMATION; MACROPHAGE; MALE; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; HEK293 CELLS; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; RAW 264.7 CELLS; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSCRIPTOME;

EID: 85046958229     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02229-1     Document Type: Article

References (46)

1. Medzhitov, R. & Horng, T. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 9, 692–703 (2009).
2. Foster, S. L. & Medzhitov, R. Gene-specific control of the TLR-induced inflammatory response. Clin. Immunol. 130, 7–15 (2009).
3. Murray, P. J. & Smale, S. T. Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat. Immunol. 13, 916–924 (2012).
4. Kawai, T. & Akira, S. Toll-like receptor and RIG-I-like receptor signaling. Ann. NY Acad. Sci. 1143, 1–20 (2008).
5. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085–2088 (1998).
6. Kawai, T. & Akira, S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373–384 (2010).
7. Hirotani, T. et al. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochem. Biophys. Res. Commun. 328, 383–392 (2005).
8. Skaug, B., Jiang, X. & Chen, Z. J. The role of ubiquitin in NF-kappaB regulatory pathways. Annu. Rev. Biochem. 78, 769–796 (2009).
9. Lamothe, B. et al. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J. Biol. Chem. 282, 4102–4112 (2007).
10. Kishimoto, K., Matsumoto, K. & Ninomiya-Tsuji, J. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem. 275, 7359–7364 (2000).
11. Ponting, C. P., Oliver, P. L. & Reik, W. Evolution and functions of long noncoding RNAs. Cell 136, 629–641 (2009).
12. Goodrich, J. A. & Kugel, J. F. Non-coding-RNA regulators of RNA polymerase II transcription. Nat. Rev. Mol. Cell Biol. 7, 612–616 (2006).
13. Bartolomei, M. S., Zemel, S. & Tilghman, S. M. Parental imprinting of the mouse H19 gene. Nature 351, 153–155 (1991).
14. Zheng, J. et al. Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat. Genet. 48, 747–757 (2016).
15. Li, Z. et al. The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL. Proc. Natl Acad. Sci. USA 111, 1002–1007 (2014).
16. Carpenter, S. et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science 341, 789–792 (2013).
17. Hu, G. et al. Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation. Nat. Immunol. 14, 1190–1198 (2013).
18. McGuire, V. A. et al. Beta interferon production is regulated by p38 mitogen-activated protein kinase in macrophages via both MSK1/2- and tristetraprolin-dependent pathways. Mol. Cell. Biol. 37, e00454-16 (2017).
19. Navarro, L. & David, M. p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J. Biol. Chem. 274, 35535–35538 (1999).
20. Rhee, S. H., Jones, B. W., Toshchakov, V., Vogel, S. N. & Fenton, M. J. Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages. J. Biol. Chem. 278, 22506–22512 (2003).
21. Jeyaseelan, S. et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia. J. Immunol. 178, 3153–3160 (2007).
22. Kirkwood, K. L. & Rossa, C. Jr. The potential of p38 MAPK inhibitors to modulate periodontal infections. Curr. Drug Metab. 10, 55–67 (2009).
23. Witthuhn, B. A. et al. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370, 153–157 (1994).
24. Yin, Q. et al. E2 interaction and dimerization in the crystal structure of TRAF6. Nat. Struct. Mol. Biol. 16, 658–666 (2009).
25. Lamothe, B. et al. The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL. J. Biol. Chem. 283, 24871–24880 (2008).
26. Deng, L. et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351–361 (2000).
27. Strickson, S. et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc. Natl Acad. Sci. USA 114, E3481–E3489 (2017).
28. Salomao, R. et al. Bacterial sensing, cell signaling, and modulation of the immune response during sepsis. Shock 38, 227–242 (2012).
29. NE, I. I. et al. Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nat. Commun. 5, 3979 (2014).
30. Liu, B. et al. A cytoplasmic NF-kappaB interacting long noncoding RNA blocks IkappaB phosphorylation and suppresses breast cancer metastasis. Cancer Cell 27, 370–381 (2015).
31. Xiao, N. et al. Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFalpha-induced cancer cell migration. Biochem. J. 441, 979–986 (2012).
32. Zhou, F. et al. Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. J. Biol. Chem. 287, 11002–11010 (2012).
33. Boone, D. L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol. 5, 1052–1060 (2004).
34. Jin, W. et al. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J. Clin. Investig. 118, 1858–1866 (2008).
35. Liang, J. et al. MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J. Exp. Med. 207, 2959–2973 (2010).
36. He, X. et al. USP2a negatively regulates IL-1beta- and virus-induced NF-kappaB activation by deubiquitinating TRAF6. J. Mol. Cell Biol. 5, 39–47 (2013).
37. Wang, N., Liang, H. & Zen, K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front. Immunol. 5, 614 (2014).
38. Murray, P. J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14–20 (2014).
39. Muraille, E., Leo, O. & Moser, M. TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism? Front. Immunol. 5, 603 (2014).
40. Gordon, S. Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23–35 (2003).
41. Tsai, M. C. et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 329, 689–693 (2010).
42. Ray, A. & Dittel, B. N. Isolation of mouse peritoneal cavity cells. J. Vis. Exp. 35, pii: 1488 (2010).
43. Wu, C. A. et al. Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways. Cell. Immunol. 264, 32–41 (2010).
44. Huang, K. et al. PARP1-mediated PPARalpha poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. J. Hepatol. 66, 962–977 (2017).
45. Lo, K. A., Ng, P. Y., Kabiri, Z., Virshup, D. & Sun, L. Wnt inhibition enhances browning of mouse primary white adipocytes. Adipocyte 5, 224–231 (2016).
46. Seok, H. Y. et al. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ. Res. 114, 1585–1595 (2014).