Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation

Nature Genetics

Volumn 48, Issue 7, 2016, Pages 747-757

  Zheng, Jian ^a   Huang, Xudong ^a   Tan, Wen ^a   Yu, Dianke ^a   Du, Zhongli ^a   Chang, Jiang ^a   Wei, Lixuan ^a   Han, Yaling ^a   Wang, Chengfeng ^a   Che, Xu ^a   Zhou, Yifeng ^b   Miao, Xiaoping ^c   Jiang, Guoliang ^d   Yu, Xianjun ^d   Yang, Xianghong ^e   Cao, Guangwen ^f   Zuo, Chaohui ^g   Li, Zhaoshen ^f   Wang, Chunyou ^c   Cheung, Siu Tim ^h   Jia, Yongfeng ⁱ   Zheng, Xiongwei ^j   Shen, Hongbing ^k   Wu, Chen ^a   Lin, Dongxin ^a,l   more..

^a CANCER HOSPITAL   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d FUDAN UNIVERSITY   (China)

^e CHINA MEDICAL UNIVERSITY   (China)

^f SECOND MILITARY MEDICAL UNIVERSITY   (China)

^g HUNAN CANCER HOSPITAL   (China)

^h UNIVERSITY OF HONG KONG   (Hong Kong)

ⁱ Xianning Medical College   (China)

^j Fujian Provincial Cancer Hospital   (China)

^k NANJING MEDICAL UNIVERSITY   (China)

^l Department of Colorectal Surgery   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

LONG UNTRANSLATED RNA; MICRORNA; MICRORNA 1231; PROTEIN TYROSINE PHOSPHATASE SHP 2; PRPF19 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; DNA LIGASE; MIRN1231 MICRORNA, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR PROTEIN; PROTEIN TYROSINE KINASE; PRPF19 PROTEIN, HUMAN; PTPN11 PROTEIN, HUMAN; RNA SPLICING FACTOR; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN;

ARTICLE; CANCER RISK; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPING TECHNIQUE; GERMLINE MUTATION; HUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA BINDING; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE; UBIQUITINATION; BINDING SITE; CASE CONTROL STUDY; CELL PROLIFERATION; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PANCREAS; PANCREAS TUMOR; PATHOLOGY; SIGNAL TRANSDUCTION;

BINDING SITES; CASE-CONTROL STUDIES; CELL PROLIFERATION; DNA REPAIR ENZYMES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICRORNAS; NUCLEAR PROTEINS; PANCREAS; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTEOLYSIS; RNA SPLICING FACTORS; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; STAT1 TRANSCRIPTION FACTOR; UBIQUITINATION;

EID: 84969753263     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3568     Document Type: Article

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