Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations

Journal of Allergy and Clinical Immunology

Volumn 143, Issue 1, 2019, Pages 114-125.e4

  Zhu, Jie ^a   Message, Simon D ^a,b   Mallia, Patrick ^a,b   Kebadze, Tatiana ^a   Contoli, Marco ^a,b,c   Ward, Christine K ^d   Barnathan, Elliot S ^d   Mascelli, Mary Ann ^d   Kon, Onn M ^b   Papi, Alberto ^c   Stanciu, Luminita A ^a   Edwards, Michael R ^a   Jeffery, Peter K ^a   Johnston, Sebastian L ^a,b  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^c UNIVERSITY OF FERRARA   (Italy)

^d CENTOCOR INC   (United States)

Author keywords

Asthma exacerbation; pattern recognition receptors; rhinovirus infection; type I interferon

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; IMMUNOGLOBULIN E; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR 3; DDX58 PROTEIN, HUMAN; IFIH1 PROTEIN, HUMAN; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; TLR3 PROTEIN, HUMAN;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; BRONCHUS BIOPSY; BRONCHUS EPITHELIUM; BRONCHUS MUCOSA; CLINICAL ARTICLE; CLINICAL OUTCOME; COMMON COLD SYMPTOM; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; EXPERIMENTAL ASTHMA; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATORY CELL; LUNG FUNCTION; MALE; NASAL LAVAGE FLUID; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY TRACT ALLERGY; RHINOVIRUS INFECTION; VIRUS LOAD; YOUNG ADULT; ASTHMA; BIOPSY; BIOSYNTHESIS; BRONCHUS; CLINICAL TRIAL; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; PATHOLOGY; PICORNAVIRUS INFECTION; RHINOVIRUS; SEVERITY OF ILLNESS INDEX;

ADULT; ASTHMA; BIOPSY; BRONCHI; DEAD BOX PROTEIN 58; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-INDUCED HELICASE, IFIH1; MALE; PICORNAVIRIDAE INFECTIONS; RHINOVIRUS; SEVERITY OF ILLNESS INDEX; TOLL-LIKE RECEPTOR 3;

EID: 85046859746     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2018.04.003     Document Type: Article

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