The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Capper, Michael J ^a   Wright, Gareth S A ^a   Barbieri, Letizia ^b,c   Luchinat, Enrico ^b,d   Mercatelli, Eleonora ^b   McAlary, Luke ^e   Yerbury, Justin J ^e   O'Neill, Paul M ^a   Antonyuk, Svetlana V ^a   Banci, Lucia ^b   Hasnain, S Samar ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF FLORENCE   (Italy)

^c Magnetic Resonance Center (CERM) and Interuniversity Consortium for Magnetic Resonance of Metallo Proteins (CIRMMP)   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

^e UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTEINE; EBSELEN; EBSULPHUR; ORGANOSELENIUM DERIVATIVE; UNCLASSIFIED DRUG; ANTIOXIDANT; CCS PROTEIN, HUMAN; CHAPERONE; DISULFIDE; NORPHENAZONE; PROTEIN BINDING; PYRROLE DERIVATIVE; SOD1 PROTEIN, HUMAN;

AGGREGATION; ANTIOXIDANT; CELL; DRUG; ENZYME; ENZYME ACTIVITY; MATURATION; PATHOGENICITY; REDUCTION; TOXICITY;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; DISULFIDE BOND; HEK293T CELL LINE; HUMAN; HUMAN CELL; MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; WESTERN BLOTTING; AMYOTROPHIC LATERAL SCLEROSIS; ASTHMA; CHEMISTRY; DRUG EFFECT; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; PATHOLOGY; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; X RAY CRYSTALLOGRAPHY;

AMYOTROPHIC LATERAL SCLEROSIS; ANTIOXIDANTS; ASTHMA; AZOLES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DISULFIDES; EDARAVONE; HEK293 CELLS; HUMANS; MOLECULAR CHAPERONES; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANOSELENIUM COMPOUNDS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; SUPEROXIDE DISMUTASE-1;

EID: 85046149452     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-04114-x     Document Type: Article

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