-
2
-
-
85047809104
-
Which therapeutic developments are more likely to modify progression in Parkinson's disease?
-
Lang AE, Espay AJ. Which therapeutic developments are more likely to modify progression in Parkinson's disease? Mov Disord 2018
-
(2018)
Mov Disord
-
-
Lang, A.E.1
Espay, A.J.2
-
3
-
-
85042097433
-
Genetics of Parkinson disease
-
Domingo A, Klein C. Genetics of Parkinson disease. Handb Clin Neurol 2018;147:211-227.
-
(2018)
Handb Clin Neurol
, vol.147
, pp. 211-227
-
-
Domingo, A.1
Klein, C.2
-
5
-
-
84952645933
-
The synaptic function of alpha-synuclein
-
Burre J. The synaptic function of alpha-synuclein. J Parkinsons Dis 2015;5(4):699-713.
-
(2015)
J Parkinsons Dis
, vol.5
, Issue.4
, pp. 699-713
-
-
Burre, J.1
-
6
-
-
84939599004
-
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
-
Nalls MA, Pankratz N, Lill CM, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 2014;46(9):989–993. doi: 10.1038/ng.3043
-
(2014)
Nat Genet
, vol.46
, Issue.9
, pp. 989-993
-
-
Nalls, M.A.1
Pankratz, N.2
Lill, C.M.3
-
7
-
-
85030174340
-
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
-
Chang D, Nalls MA, Hallgrimsdottir IB, et al. A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. Nat Genet 2017;49(10):1511-1516.
-
(2017)
Nat Genet
, vol.49
, Issue.10
, pp. 1511-1516
-
-
Chang, D.1
Nalls, M.A.2
Hallgrimsdottir, I.B.3
-
8
-
-
84937516707
-
Targeting alpha-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
-
Dehay B, Bourdenx M, Gorry P, et al. Targeting alpha-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations. Lancet Neurol 2015;14(8):855-866.
-
(2015)
Lancet Neurol
, vol.14
, Issue.8
, pp. 855-866
-
-
Dehay, B.1
Bourdenx, M.2
Gorry, P.3
-
9
-
-
85027890379
-
Animal models of alpha-synucleinopathy for Parkinson disease drug development
-
Koprich JB, Kalia LV, Brotchie JM. Animal models of alpha-synucleinopathy for Parkinson disease drug development. Nat Rev Neurosci 2017;18(9):515-529.
-
(2017)
Nat Rev Neurosci
, vol.18
, Issue.9
, pp. 515-529
-
-
Koprich, J.B.1
Kalia, L.V.2
Brotchie, J.M.3
-
10
-
-
85027934032
-
How can rAAV-alpha-synuclein and the fibril alpha-synuclein models advance our understanding of Parkinson's disease?
-
Volpicelli-Daley LA, Kirik D, Stoyka LE, Standaert DG, Harms AS. How can rAAV-alpha-synuclein and the fibril alpha-synuclein models advance our understanding of Parkinson's disease? J Neurochem 2016;139(suppl 1):131-155.
-
(2016)
J Neurochem
, vol.139
, pp. 131-155
-
-
Volpicelli-Daley, L.A.1
Kirik, D.2
Stoyka, L.E.3
Standaert, D.G.4
Harms, A.S.5
-
11
-
-
84869109864
-
Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
Luk KC, Kehm V, Carroll J, et al. Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012;338(6109):949-953.
-
(2012)
Science
, vol.338
, Issue.6109
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
-
12
-
-
84862609075
-
Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice
-
Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice. J Exp Med 2012;209(5):975-986.
-
(2012)
J Exp Med
, vol.209
, Issue.5
, pp. 975-986
-
-
Luk, K.C.1
Kehm, V.M.2
Zhang, B.3
O'Brien, P.4
Trojanowski, J.Q.5
Lee, V.M.6
-
13
-
-
84984787903
-
Widespread transneuronal propagation of alpha-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease
-
Rey NL, Steiner JA, Maroof N, et al. Widespread transneuronal propagation of alpha-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. J Exp Med 2016;213(9):1759-1778.
-
(2016)
J Exp Med
, vol.213
, Issue.9
, pp. 1759-1778
-
-
Rey, N.L.1
Steiner, J.A.2
Maroof, N.3
-
14
-
-
85009353170
-
The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
-
Rey NL, Wesson DW, Brundin P. The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases. Neurobiol Dis 2018;109(Pt B):226-248.
-
(2018)
Neurobiol Dis
, vol.109
, pp. 226-248
-
-
Rey, N.L.1
Wesson, D.W.2
Brundin, P.3
-
15
-
-
84894244854
-
Alpha-synuclein imaging: a critical need for Parkinson's disease research
-
Eberling JL, Dave KD, Frasier MA. Alpha-synuclein imaging: a critical need for Parkinson's disease research. J Parkinsons Dis 2013;3(4):565-567.
-
(2013)
J Parkinsons Dis
, vol.3
, Issue.4
, pp. 565-567
-
-
Eberling, J.L.1
Dave, K.D.2
Frasier, M.A.3
-
16
-
-
85023597040
-
Small-molecule PET Tracers for Imaging Proteinopathies
-
Mathis CA, Lopresti BJ, Ikonomovic MD, Klunk WE. Small-molecule PET Tracers for Imaging Proteinopathies. Semin Nucl Med 2017;47(5):553-575.
-
(2017)
Semin Nucl Med
, vol.47
, Issue.5
, pp. 553-575
-
-
Mathis, C.A.1
Lopresti, B.J.2
Ikonomovic, M.D.3
Klunk, W.E.4
-
17
-
-
85010641760
-
Current status of the development of PET radiotracers for imaging alpha synuclein aggregates in Lewy bodies and Lewy neurites
-
Kotzbauer P, Tu Z, Mach R. Current status of the development of PET radiotracers for imaging alpha synuclein aggregates in Lewy bodies and Lewy neurites. J Clin Trans Imaging 2017;5(1):3-14.
-
(2017)
J Clin Trans Imaging
, vol.5
, Issue.1
, pp. 3-14
-
-
Kotzbauer, P.1
Tu, Z.2
Mach, R.3
-
18
-
-
85028058287
-
A user's guide for alpha-synuclein biomarker studies in biological fluids: perianalytical considerations
-
Mollenhauer B, Batrla R, El-Agnaf O, et al. A user's guide for alpha-synuclein biomarker studies in biological fluids: perianalytical considerations. Mov Disord 2017;32(8):1117-1130.
-
(2017)
Mov Disord
, vol.32
, Issue.8
, pp. 1117-1130
-
-
Mollenhauer, B.1
Batrla, R.2
El-Agnaf, O.3
-
19
-
-
84985896386
-
The antibody aducanumab reduces Abeta plaques in Alzheimer's disease
-
Sevigny J, Chiao P, Bussiere T, et al. The antibody aducanumab reduces Abeta plaques in Alzheimer's disease. Nature 2016;537(7618):50-56.
-
(2016)
Nature
, vol.537
, Issue.7618
, pp. 50-56
-
-
Sevigny, J.1
Chiao, P.2
Bussiere, T.3
-
20
-
-
85015220604
-
Neuropathological staging of brain pathology in sporadic Parkinson's disease: separating the wheat from the chaff
-
Braak H, Del Tredici K. Neuropathological staging of brain pathology in sporadic Parkinson's disease: separating the wheat from the chaff. J Parkinsons Dis 2017;7(s1):S73-S87.
-
(2017)
J Parkinsons Dis
, vol.7
, Issue.s1
, pp. S73-S87
-
-
Braak, H.1
Del Tredici, K.2
-
22
-
-
85029162851
-
Therapies targeting DNA and RNA in Huntington's disease
-
Wild EJ, Tabrizi SJ. Therapies targeting DNA and RNA in Huntington's disease. Lancet Neurol 2017;16(10):837-847.
-
(2017)
Lancet Neurol
, vol.16
, Issue.10
, pp. 837-847
-
-
Wild, E.J.1
Tabrizi, S.J.2
-
24
-
-
84936818605
-
shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model
-
Zharikov AD, Cannon JR, Tapias V, et al. shRNA targeting alpha-synuclein prevents neurodegeneration in a Parkinson's disease model. J Clin Invest 2015;125(7):2721-2735.
-
(2015)
J Clin Invest
, vol.125
, Issue.7
, pp. 2721-2735
-
-
Zharikov, A.D.1
Cannon, J.R.2
Tapias, V.3
-
25
-
-
85058829974
-
Snca targeted antisense oligonucleotides mediate progression of pathological deposition in alpha synuclein rodent transmission models of Parkinson's disease
-
Cole T, Paumier K, Zhao H, Weihofen A, Kordasiewicz HB, Swayze EE. Snca targeted antisense oligonucleotides mediate progression of pathological deposition in alpha synuclein rodent transmission models of Parkinson's disease. Neurology 2016;86(16 suppl):P6.239.
-
(2016)
Neurology
, vol.86
, Issue.16
, pp. P6.239
-
-
Cole, T.1
Paumier, K.2
Zhao, H.3
Weihofen, A.4
Kordasiewicz, H.B.5
Swayze, E.E.6
-
26
-
-
77955176216
-
In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration
-
Gorbatyuk OS, Li S, Nash K, et al. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Mol Ther 2010;18(8):1450-1457.
-
(2010)
Mol Ther
, vol.18
, Issue.8
, pp. 1450-1457
-
-
Gorbatyuk, O.S.1
Li, S.2
Nash, K.3
-
27
-
-
85029541597
-
beta2-Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson's disease
-
Mittal S, Bjornevik K, Im DS, et al. beta2-Adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of Parkinson's disease. Science 2017;357(6354):891-898.
-
(2017)
Science
, vol.357
, Issue.6354
, pp. 891-898
-
-
Mittal, S.1
Bjornevik, K.2
Im, D.S.3
-
28
-
-
77953248483
-
Diagnosis and management of essential tremor and dystonic tremor
-
Gironell A, Kulisevsky J. Diagnosis and management of essential tremor and dystonic tremor. Ther Adv Neurol Disord 2009;2(4):215-222.
-
(2009)
Ther Adv Neurol Disord
, vol.2
, Issue.4
, pp. 215-222
-
-
Gironell, A.1
Kulisevsky, J.2
-
29
-
-
84898743262
-
Can intrabodies serve as neuroprotective therapies for Parkinson's disease? Beginning thoughts
-
Bhatt MA, Messer A, Kordower JH. Can intrabodies serve as neuroprotective therapies for Parkinson's disease? Beginning thoughts. J Parkinsons Dis 2013;3(4):581-591.
-
(2013)
J Parkinsons Dis
, vol.3
, Issue.4
, pp. 581-591
-
-
Bhatt, M.A.1
Messer, A.2
Kordower, J.H.3
-
30
-
-
84879606955
-
alpha-Synuclein and protein degradation systems: a reciprocal relationship
-
Xilouri M, Brekk OR, Stefanis L. alpha-Synuclein and protein degradation systems: a reciprocal relationship. Mol Neurobiol 2013;47(2):537-551.
-
(2013)
Mol Neurobiol
, vol.47
, Issue.2
, pp. 537-551
-
-
Xilouri, M.1
Brekk, O.R.2
Stefanis, L.3
-
31
-
-
84922364789
-
Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment
-
Poehler AM, Xiang W, Spitzer P, et al. Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment. Autophagy 2014;10(12):2171-2192.
-
(2014)
Autophagy
, vol.10
, Issue.12
, pp. 2171-2192
-
-
Poehler, A.M.1
Xiang, W.2
Spitzer, P.3
-
32
-
-
85012094057
-
The interplay between alpha-synuclein clearance and spreading
-
Lopes da Fonseca T, Villar-Pique A, Outeiro TF. The interplay between alpha-synuclein clearance and spreading. Biomolecules 2015;5(2):435-471.
-
(2015)
Biomolecules
, vol.5
, Issue.2
, pp. 435-471
-
-
Lopes da Fonseca, T.1
Villar-Pique, A.2
Outeiro, T.F.3
-
33
-
-
84871721552
-
mTOR: on target for novel therapeutic strategies in the nervous system
-
Maiese K, Chong ZZ, Shang YC, Wang S. mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med 2013;19(1):51-60.
-
(2013)
Trends Mol Med
, vol.19
, Issue.1
, pp. 51-60
-
-
Maiese, K.1
Chong, Z.Z.2
Shang, Y.C.3
Wang, S.4
-
34
-
-
84877351078
-
TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity
-
Decressac M, Mattsson B, Weikop P, Lundblad M, Jakobsson J, Bjorklund A. TFEB-mediated autophagy rescues midbrain dopamine neurons from alpha-synuclein toxicity. Proc Natl Acad Sci U S A 2013;110(19):E1817-E1826.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.19
, pp. E1817-E1826
-
-
Decressac, M.1
Mattsson, B.2
Weikop, P.3
Lundblad, M.4
Jakobsson, J.5
Bjorklund, A.6
-
35
-
-
85003601650
-
Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease
-
Ghosh A, Tyson T, George S, et al. Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease. Sci Trans Med 2016;8(368):368ra174.
-
(2016)
Sci Trans Med
, vol.8
, Issue.368
, pp. 368ra174
-
-
Ghosh, A.1
Tyson, T.2
George, S.3
-
36
-
-
85032815362
-
c-Abl and Parkinson's disease: mechanisms and therapeutic potential
-
Brahmachari S, Karuppagounder SS, Ge P, et al. c-Abl and Parkinson's disease: mechanisms and therapeutic potential. J Parkinsons Dis 2017;7(4):589-601.
-
(2017)
J Parkinsons Dis
, vol.7
, Issue.4
, pp. 589-601
-
-
Brahmachari, S.1
Karuppagounder, S.S.2
Ge, P.3
-
37
-
-
84899892500
-
The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
-
Karuppagounder SS, Brahmachari S, Lee Y, Dawson VL, Dawson TM, Ko HS. The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Sci Rep 2014;4:4874.
-
(2014)
Sci Rep
, vol.4
, pp. 4874
-
-
Karuppagounder, S.S.1
Brahmachari, S.2
Lee, Y.3
Dawson, V.L.4
Dawson, T.M.5
Ko, H.S.6
-
38
-
-
84983738240
-
Nilotinib effects in Parkinson's disease and Dementia with Lewy bodies
-
Pagan F, Hebron M, Valadez EH, et al. Nilotinib effects in Parkinson's disease and Dementia with Lewy bodies. J Parkinsons Dis 2016;6(3):503-517.
-
(2016)
J Parkinsons Dis
, vol.6
, Issue.3
, pp. 503-517
-
-
Pagan, F.1
Hebron, M.2
Valadez, E.H.3
-
39
-
-
84983747466
-
Nilotinib—differentiating the Hope from the Hype
-
Wyse RK, Brundin P, Sherer TB. Nilotinib—differentiating the Hope from the Hype. J Parkinsons Dis 2016;6(3):519-522.
-
(2016)
J Parkinsons Dis
, vol.6
, Issue.3
, pp. 519-522
-
-
Wyse, R.K.1
Brundin, P.2
Sherer, T.B.3
-
40
-
-
85030710090
-
Therapeutic approaches to target alpha-synuclein pathology
-
Brundin P, Dave KD, Kordower JH. Therapeutic approaches to target alpha-synuclein pathology. Exp Neurol 2017;298(Pt B):225-235.
-
(2017)
Exp Neurol
, vol.298
, pp. 225-235
-
-
Brundin, P.1
Dave, K.D.2
Kordower, J.H.3
-
41
-
-
85013652187
-
Solving the conundrum of insoluble protein aggregates
-
George S, Brundin P. Solving the conundrum of insoluble protein aggregates. Lancet Neurol 2017;16(4):258-259.
-
(2017)
Lancet Neurol
, vol.16
, Issue.4
, pp. 258-259
-
-
George, S.1
Brundin, P.2
-
42
-
-
84874510614
-
Axonopathy in an alpha-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated alpha-synuclein
-
Games D, Seubert P, Rockenstein E, et al. Axonopathy in an alpha-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated alpha-synuclein. Am J Pathol 2013;182(3):940-953.
-
(2013)
Am J Pathol
, vol.182
, Issue.3
, pp. 940-953
-
-
Games, D.1
Seubert, P.2
Rockenstein, E.3
-
43
-
-
85005931200
-
First-in-human assessment of PRX002, an anti-alpha-synuclein monoclonal antibody, in healthy volunteers
-
Schenk DB, Koller M, Ness DK, et al. First-in-human assessment of PRX002, an anti-alpha-synuclein monoclonal antibody, in healthy volunteers. Mov Disord 2017;32(2):211-218.
-
(2017)
Mov Disord
, vol.32
, Issue.2
, pp. 211-218
-
-
Schenk, D.B.1
Koller, M.2
Ness, D.K.3
-
44
-
-
85058854795
-
Results from a phase 1b multiple ascending-dose study of PRX002, an anti–alpha-synuclein monoclonal antibody, in patients with Parkinson's disease [abstract]
-
Jankovic J, Goodman I, Safirstein B, et al. Results from a phase 1b multiple ascending-dose study of PRX002, an anti–alpha-synuclein monoclonal antibody, in patients with Parkinson's disease [abstract]. Mov Disord 2017;32(suppl 2):1418.
-
(2017)
Mov Disord
, vol.32
, pp. 1418
-
-
Jankovic, J.1
Goodman, I.2
Safirstein, B.3
-
45
-
-
85039063426
-
Binding and functional characterization of human-derived anti-alpha-synuclein antibody BIIB054
-
Weihofen A, Patel H, Huy C, et al. Binding and functional characterization of human-derived anti-alpha-synuclein antibody BIIB054. Neurodegener Dis 2017;17(suppl 1):59.
-
(2017)
Neurodegener Dis
, vol.17
, pp. 59
-
-
Weihofen, A.1
Patel, H.2
Huy, C.3
-
46
-
-
85047822163
-
Randomized, double-blind, placebo-controled, single ascending dose study of anti-alpha synuclein antibody BIIB054 in healthy volunteers
-
Brys M, Hung S, Fanning L, et al. Randomized, double-blind, placebo-controled, single ascending dose study of anti-alpha synuclein antibody BIIB054 in healthy volunteers. Neurodegener Dis 2017;17(suppl 1).
-
(2017)
Neurodegener Dis
, vol.17
-
-
Brys, M.1
Hung, S.2
Fanning, L.3
-
47
-
-
85047820194
-
-
Randomized, double-blind, placebo-controlled, single ascending dose study of antialpha-synuclein antibody BIIB054 in patients with Parkinson's disease. Paper presented at The American Academy of Neurology Annual Meeting Apr 21 - 27, 2018. Los Angeles CA, USA
-
Brys M, Ellenbogen A, Fanning L, et al. Randomized, double-blind, placebo-controlled, single ascending dose study of antialpha-synuclein antibody BIIB054 in patients with Parkinson's disease. Paper presented at: The American Academy of Neurology Annual Meeting Apr 21 - 27, 2018. Los Angeles CA, USA.
-
-
-
Brys, M.1
Ellenbogen, A.2
Fanning, L.3
-
50
-
-
84882306577
-
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
-
Holmes BB, DeVos SL, Kfoury N, et al. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A 2013;110(33):E3138-E3147.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.33
, pp. E3138-E3147
-
-
Holmes, B.B.1
DeVos, S.L.2
Kfoury, N.3
-
51
-
-
85047591129
-
Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3
-
Mao X, Ou MT, Karuppagounder SS, et al. Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science 2016;353(6307):3374-1–3374-12. doi: 10.1126/science.aah3374
-
(2016)
Science
, vol.353
, Issue.6307
, pp. 3374-1-3374-12
-
-
Mao, X.1
Ou, M.T.2
Karuppagounder, S.S.3
-
52
-
-
0029773625
-
Occurrence of Parkinson's syndrome in type I Gaucher disease
-
Neudorfer O, Giladi N, Elstein D, et al. Occurrence of Parkinson's syndrome in type I Gaucher disease. QJM 1996;89(9):691-694.
-
(1996)
QJM
, vol.89
, Issue.9
, pp. 691-694
-
-
Neudorfer, O.1
Giladi, N.2
Elstein, D.3
-
53
-
-
10844278246
-
Parkinsonism among Gaucher disease carriers
-
Goker-Alpan O, Schiffmann R, LaMarca ME, Nussbaum RL, McInerney-Leo A, Sidransky E. Parkinsonism among Gaucher disease carriers. J Med Genet 2004;41(12):937-940.
-
(2004)
J Med Genet
, vol.41
, Issue.12
, pp. 937-940
-
-
Goker-Alpan, O.1
Schiffmann, R.2
LaMarca, M.E.3
Nussbaum, R.L.4
McInerney-Leo, A.5
Sidransky, E.6
-
54
-
-
70350319531
-
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
-
Sidransky E, Nalls MA, Aasly JO, et al. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med 2009;361(17):1651-1661.
-
(2009)
N Engl J Med
, vol.361
, Issue.17
, pp. 1651-1661
-
-
Sidransky, E.1
Nalls, M.A.2
Aasly, J.O.3
-
55
-
-
84887574376
-
Glucocerebrosidase mutations and the pathogenesis of Parkinson disease
-
Beavan MS, Schapira AH. Glucocerebrosidase mutations and the pathogenesis of Parkinson disease. Ann Med 2013;45(8):511-521.
-
(2013)
Ann Med
, vol.45
, Issue.8
, pp. 511-521
-
-
Beavan, M.S.1
Schapira, A.H.2
-
56
-
-
84990249645
-
Survival and dementia in GBA-associated Parkinson disease: the mutation matters
-
Cilia R, Tunesi S, Marotta G, et al. Survival and dementia in GBA-associated Parkinson disease: the mutation matters. Ann Neurol 2016. doi: 10.1002/ana.24777.
-
(2016)
Ann Neurol
-
-
Cilia, R.1
Tunesi, S.2
Marotta, G.3
-
57
-
-
84995745476
-
Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
-
Liu G, Boot B, Locascio JJ, et al. Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's. Ann Neurol 2016;80(5):674-685.
-
(2016)
Ann Neurol
, vol.80
, Issue.5
, pp. 674-685
-
-
Liu, G.1
Boot, B.2
Locascio, J.J.3
-
58
-
-
84998694373
-
Association of GBA mutations and the E326K polymorphism with motor and cognitive progression in Parkinson disease
-
Davis MY, Johnson CO, Leverenz JB, et al. Association of GBA mutations and the E326K polymorphism with motor and cognitive progression in Parkinson disease. JAMA Neurol 2016;73(10):1217-1224.
-
(2016)
JAMA Neurol
, vol.73
, Issue.10
, pp. 1217-1224
-
-
Davis, M.Y.1
Johnson, C.O.2
Leverenz, J.B.3
-
59
-
-
84878798127
-
A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies
-
Nalls MA, Duran R, Lopez G, et al. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol 2013;70(6):727-735.
-
(2013)
JAMA Neurol
, vol.70
, Issue.6
, pp. 727-735
-
-
Nalls, M.A.1
Duran, R.2
Lopez, G.3
-
60
-
-
84902140288
-
Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes
-
Alcalay RN, Dinur T, Quinn T, et al. Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes. JAMA Neurol 2014;71(6):752-757.
-
(2014)
JAMA Neurol
, vol.71
, Issue.6
, pp. 752-757
-
-
Alcalay, R.N.1
Dinur, T.2
Quinn, T.3
-
61
-
-
79960009804
-
Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies
-
Mazzulli JR, Xu YH, Sun Y, et al. Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies. Cell 2011;146(1):37-52.
-
(2011)
Cell
, vol.146
, Issue.1
, pp. 37-52
-
-
Mazzulli, J.R.1
Xu, Y.H.2
Sun, Y.3
-
62
-
-
84922216790
-
Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle
-
Sardi SP, Cheng SH, Shihabuddin LS. Gaucher-related synucleinopathies: The examination of sporadic neurodegeneration from a rare (disease) angle. Prog Neurobiol 2015;125C:47-62.
-
(2015)
Prog Neurobiol
, vol.125C
, pp. 47-62
-
-
Sardi, S.P.1
Cheng, S.H.2
Shihabuddin, L.S.3
-
63
-
-
85013658130
-
The complicated relationship between Gaucher disease and parkinsonism: insights from a rare disease
-
Aflaki E, Westbroek W, Sidransky E. The complicated relationship between Gaucher disease and parkinsonism: insights from a rare disease. Neuron 2017;93(4):737-746.
-
(2017)
Neuron
, vol.93
, Issue.4
, pp. 737-746
-
-
Aflaki, E.1
Westbroek, W.2
Sidransky, E.3
-
64
-
-
84902201548
-
iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis
-
Schondorf DC, Aureli M, McAllister FE, et al. iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis. Nat Commun 2014;5:4028.
-
(2014)
Nat Commun
, vol.5
, pp. 4028
-
-
Schondorf, D.C.1
Aureli, M.2
McAllister, F.E.3
-
65
-
-
85030678068
-
Glucosylsphingosine promotes alpha-synuclein pathology in mutant GBA-associated Parkinson's disease
-
Taguchi YV, Liu J, Ruan J, et al. Glucosylsphingosine promotes alpha-synuclein pathology in mutant GBA-associated Parkinson's disease. J Neurosci 2017;37(40):9617-9631.
-
(2017)
J Neurosci
, vol.37
, Issue.40
, pp. 9617-9631
-
-
Taguchi, Y.V.1
Liu, J.2
Ruan, J.3
-
66
-
-
85014699365
-
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
-
Sardi SP, Viel C, Clarke J, et al. Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models. Proc Natl Acad Sci U S A 2017;114(10):2699-2704.
-
(2017)
Proc Natl Acad Sci U S A
, vol.114
, Issue.10
, pp. 2699-2704
-
-
Sardi, S.P.1
Viel, C.2
Clarke, J.3
-
67
-
-
85027401319
-
The role of lipids interacting with alpha-synuclein in the pathogenesis of Parkinson's disease
-
Galvagnion C. The role of lipids interacting with alpha-synuclein in the pathogenesis of Parkinson's disease. J Parkinsons Dis 2017;7(3):433-450.
-
(2017)
J Parkinsons Dis
, vol.7
, Issue.3
, pp. 433-450
-
-
Galvagnion, C.1
-
68
-
-
85040558820
-
Reversible conformational conversion of alpha-synuclein into toxic assemblies by glucosylceramide
-
Zunke F, Moise AC, Belur NR, et al. Reversible conformational conversion of alpha-synuclein into toxic assemblies by glucosylceramide. Neuron 2017;S0896-6273(17)31135–2. doi: 10.1016/j.neuron.2017.12.012
-
(2017)
Neuron
, vol.896
, Issue.17
, pp. 31135-31132
-
-
Zunke, F.1
Moise, A.C.2
Belur, N.R.3
-
69
-
-
85040865717
-
GBA1 deficiency negatively affects physiological alpha-synuclein tetramers and related multimers
-
Kim S, Yun SP, Lee S, et al. GBA1 deficiency negatively affects physiological alpha-synuclein tetramers and related multimers. Proc Natl Acad Sci U S A 2018;115(4):798–803. doi: 10.1073/pnas.1700465115
-
(2018)
Proc Natl Acad Sci U S A
, vol.115
, Issue.4
, pp. 798-803
-
-
Kim, S.1
Yun, S.P.2
Lee, S.3
-
70
-
-
84867036900
-
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
-
Gegg ME, Burke D, Heales SJ, et al. Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains. Ann Neurol 2012;72(3):455-463.
-
(2012)
Ann Neurol
, vol.72
, Issue.3
, pp. 455-463
-
-
Gegg, M.E.1
Burke, D.2
Heales, S.J.3
-
71
-
-
84904427435
-
Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease
-
Parnetti L, Chiasserini D, Persichetti E, et al. Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease. Mov Disord 2014;29(8):1019-1027.
-
(2014)
Mov Disord
, vol.29
, Issue.8
, pp. 1019-1027
-
-
Parnetti, L.1
Chiasserini, D.2
Persichetti, E.3
-
72
-
-
84940770418
-
Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations
-
Alcalay RN, Levy OA, Waters CC, et al. Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations. Brain 2015;138(Pt 9):2648-2658.
-
(2015)
Brain
, vol.138
, pp. 2648-2658
-
-
Alcalay, R.N.1
Levy, O.A.2
Waters, C.C.3
-
73
-
-
79961083395
-
CNS expression of glucocerebrosidase corrects {alpha}-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
-
Sardi SP, Clarke J, Kinnecom C, et al. CNS expression of glucocerebrosidase corrects {alpha}-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy Proc Natl Acad Sci U S A 2011;108(29):12101-12106.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.29
, pp. 12101-12106
-
-
Sardi, S.P.1
Clarke, J.2
Kinnecom, C.3
-
74
-
-
84874487118
-
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
-
Sardi SP, Clarke J, Viel C, et al. Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies. Proc Natl Acad Sci U S A 2013;110(9):3537-3542.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.9
, pp. 3537-3542
-
-
Sardi, S.P.1
Clarke, J.2
Viel, C.3
-
75
-
-
85016028593
-
Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease
-
Rockenstein E, Clarke J, Viel C, et al. Glucocerebrosidase modulates cognitive and motor activities in murine models of Parkinson's disease. Hum Mol Genet 2016;25(13):2645–2660. doi: 10.1093/hmg/ddw124.
-
(2016)
Hum Mol Genet
, vol.25
, Issue.13
, pp. 2645-2660
-
-
Rockenstein, E.1
Clarke, J.2
Viel, C.3
-
76
-
-
84895442417
-
Parkinson's disease gene therapy: success by design meets failure by efficacy
-
Bartus RT, Weinberg MS, Samulski RJ. Parkinson's disease gene therapy: success by design meets failure by efficacy. Mol Ther 2014;22(3):487-497.
-
(2014)
Mol Ther
, vol.22
, Issue.3
, pp. 487-497
-
-
Bartus, R.T.1
Weinberg, M.S.2
Samulski, R.J.3
-
77
-
-
84995802014
-
Ambroxol effects in glucocerebrosidase and alpha-synuclein transgenic mice
-
Migdalska-Richards A, Daly L, Bezard E, Schapira AH. Ambroxol effects in glucocerebrosidase and alpha-synuclein transgenic mice. Ann Neurol 2016;80(5):766-775.
-
(2016)
Ann Neurol
, vol.80
, Issue.5
, pp. 766-775
-
-
Migdalska-Richards, A.1
Daly, L.2
Bezard, E.3
Schapira, A.H.4
-
78
-
-
85016460436
-
Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate
-
Migdalska-Richards A, Ko WKD, Li Q, Bezard E, Schapira AHV. Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate. Synapse 2017;71(7). doi: 10.1002/syn.21967
-
(2017)
Synapse
, vol.71
, Issue.7
-
-
Migdalska-Richards, A.1
Ko, W.K.D.2
Li, Q.3
Bezard, E.4
Schapira, A.H.V.5
-
79
-
-
84876225140
-
Pharmacological chaperones as therapeutics for lysosomal storage diseases
-
Boyd RE, Lee G, Rybczynski P, et al. Pharmacological chaperones as therapeutics for lysosomal storage diseases. J Med Chem 2013;56(7):2705-2725.
-
(2013)
J Med Chem
, vol.56
, Issue.7
, pp. 2705-2725
-
-
Boyd, R.E.1
Lee, G.2
Rybczynski, P.3
-
80
-
-
84978826732
-
A new glucocerebrosidase chaperone reduces alpha-synuclein and glycolipid levels in iPSC-derived dopaminergic neurons from patients with Gaucher disease and parkinsonism
-
Aflaki E, Borger DK, Moaven N, et al. A new glucocerebrosidase chaperone reduces alpha-synuclein and glycolipid levels in iPSC-derived dopaminergic neurons from patients with Gaucher disease and parkinsonism. J Neurosci 2016;36(28):7441-7452.
-
(2016)
J Neurosci
, vol.36
, Issue.28
, pp. 7441-7452
-
-
Aflaki, E.1
Borger, D.K.2
Moaven, N.3
-
81
-
-
84978758175
-
Activation of beta-glucocerebrosidase reduces pathological alpha-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons
-
Mazzulli JR, Zunke F, Tsunemi T, et al. Activation of beta-glucocerebrosidase reduces pathological alpha-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons. J Neurosci 2016;36(29):7693-7706.
-
(2016)
J Neurosci
, vol.36
, Issue.29
, pp. 7693-7706
-
-
Mazzulli, J.R.1
Zunke, F.2
Tsunemi, T.3
-
82
-
-
85047831351
-
Gaucher disease
-
In, Pagon RA, Adam MP, Ardinger HH, eds., Seattle, WA, University of Washington, Seattle
-
Pastores GM, Hughes DA. Gaucher disease. In: Pagon RA, Adam MP, Ardinger HH, et al., eds. GeneReviews. Seattle, WA; University of Washington, Seattle 2015.
-
(2015)
GeneReviews
-
-
Pastores, G.M.1
Hughes, D.A.2
-
83
-
-
85047815093
-
-
MJFF. First trial begins testing drug in people with GBA mutation, Accessed on Feb 1, 2018
-
MJFF. First trial begins testing drug in people with GBA mutation. https://www.michaeljfox.org/foundation/news-detail.php?first-trial-begins-testing-drug-in-people-with-gba-mutation. Accessed on Feb 1, 2018.
-
-
-
-
85
-
-
84930207660
-
LRRK2 pathways leading to neurodegeneration
-
Cookson MR. LRRK2 pathways leading to neurodegeneration. Curr Neurol Neurosci Rep 2015;15(7):42.
-
(2015)
Curr Neurol Neurosci Rep
, vol.15
, Issue.7
, pp. 42
-
-
Cookson, M.R.1
-
86
-
-
85084783827
-
LRRK2 levels in immune cells are increased in Parkinson's disease
-
Cook DA, Kannarkat GT, Cintron AF, et al. LRRK2 levels in immune cells are increased in Parkinson's disease. NPJ Parkinsons Dis 2017;3:11.
-
(2017)
NPJ Parkinsons Dis
, vol.3
, pp. 11
-
-
Cook, D.A.1
Kannarkat, G.T.2
Cintron, A.F.3
-
87
-
-
85027177383
-
Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
-
West AB. Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease. Exp Neurol 2017;298(Pt B):236-245.
-
(2017)
Exp Neurol
, vol.298
, pp. 236-245
-
-
West, A.B.1
-
88
-
-
84922674609
-
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
-
Fuji RN, Flagella M, Baca M, et al. Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Sci Trans Med 2015;7(273):273ra215.
-
(2015)
Sci Trans Med
, vol.7
, Issue.273
, pp. 273ra215
-
-
Fuji, R.N.1
Flagella, M.2
Baca, M.3
-
90
-
-
85029310621
-
LRRK2 antisense oligonucleotides ameliorate alpha-synuclein inclusion formation in a Parkinson's disease mouse model
-
Zhao HT, John N, Delic V, et al. LRRK2 antisense oligonucleotides ameliorate alpha-synuclein inclusion formation in a Parkinson's disease mouse model. Mol Ther Nucleic Acid 2017;8:508-519.
-
(2017)
Mol Ther Nucleic Acid
, vol.8
, pp. 508-519
-
-
Zhao, H.T.1
John, N.2
Delic, V.3
-
91
-
-
85046120944
-
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils
-
Fan Y, Howden AJM, Sarhan AR, et al. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. Biochem J 2018;475(1):23-44.
-
(2018)
Biochem J
, vol.475
, Issue.1
, pp. 23-44
-
-
Fan, Y.1
Howden, A.J.M.2
Sarhan, A.R.3
-
92
-
-
85047803069
-
-
Denali website. Denali therapeutics announces advancement and expansion of its LRRK2 inhibitor clinical program for Parkinson's disease, Accessed on Feb 1, 2018
-
Denali website. Denali therapeutics announces advancement and expansion of its LRRK2 inhibitor clinical program for Parkinson's disease. http://investors.denalitherapeutics.com/news-releases/news-release-details/denali-therapeutics-announces-advancement-and-expansion-its. Accessed on Feb 1, 2018.
-
-
-
-
93
-
-
84939946760
-
Commonalities and challenges in the development of clinical trial measures in neurology
-
Cedarbaum JM, Stephenson D, Rudick R, et al. Commonalities and challenges in the development of clinical trial measures in neurology. Neurotherapeutics 2015;12(1):151-169.
-
(2015)
Neurotherapeutics
, vol.12
, Issue.1
, pp. 151-169
-
-
Cedarbaum, J.M.1
Stephenson, D.2
Rudick, R.3
-
94
-
-
85008701998
-
The Alzheimer's Disease Neuroimaging Initiative 3: continued innovation for clinical trial improvement
-
Weiner MW, Veitch DP, Aisen PS, et al. The Alzheimer's Disease Neuroimaging Initiative 3: continued innovation for clinical trial improvement. Alzheimers Dement 2017;13(5):561-571.
-
(2017)
Alzheimers Dement
, vol.13
, Issue.5
, pp. 561-571
-
-
Weiner, M.W.1
Veitch, D.P.2
Aisen, P.S.3
-
95
-
-
85017390734
-
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: reviewing progress toward improved AD clinical trials
-
Weiner MW, Veitch DP, Aisen PS, et al. Recent publications from the Alzheimer's Disease Neuroimaging Initiative: reviewing progress toward improved AD clinical trials. Alzheimers Dement 2017;13(4):e1-e85.
-
(2017)
Alzheimers Dement
, vol.13
, Issue.4
, pp. e1-e85
-
-
Weiner, M.W.1
Veitch, D.P.2
Aisen, P.S.3
-
96
-
-
85047783096
-
-
Parkinson Progression Markers Initiative. The Parkinson Progression Marker Initiative (PPMI), Accessed on Feb 1, 2018
-
Parkinson Progression Markers Initiative. The Parkinson Progression Marker Initiative (PPMI). http://www.ppmi-info.org/. Accessed on Feb 1, 2018.
-
-
-
-
97
-
-
85047792674
-
-
Critical Path for Parkinson's., Accessed on Feb 1, 2018
-
Critical Path for Parkinson's. https://c-path.org/programs/cpp/. Accessed on Feb 1, 2018.
-
-
-
-
98
-
-
85026304892
-
Dopamine transporter neuroimaging as an enrichment biomarker in early parkinson's disease clinical trials: a disease progression modeling analysis
-
Conrado DJ, Nicholas T, Tsai K, et al. Dopamine transporter neuroimaging as an enrichment biomarker in early parkinson's disease clinical trials: a disease progression modeling analysis. Clin Trans Sci 2018;11(1):63-70.
-
(2018)
Clin Trans Sci
, vol.11
, Issue.1
, pp. 63-70
-
-
Conrado, D.J.1
Nicholas, T.2
Tsai, K.3
-
99
-
-
85047832285
-
-
EMA., Letter of support for molecular imaging of the dopamine transporter biomarker as an enrichment biomarker for clinical trials for early Parkinson's disease, Accessed on Feb 1, 2018
-
EMA. Letter of support for molecular imaging of the dopamine transporter biomarker as an enrichment biomarker for clinical trials for early Parkinson's disease. http://www.ema.europa.eu/docs/en_GB/document_library/Other/2016/10/WC500213914.pdf. Accessed on Feb 1, 2018.
-
-
-
-
100
-
-
84918571393
-
Prediagnostic presentations of Parkinson's disease in primary care: a case-control study
-
Schrag A, Horsfall L, Walters K, Noyce A, Petersen I. Prediagnostic presentations of Parkinson's disease in primary care: a case-control study. Lancet Neurol 2015;14(1):57-64.
-
(2015)
Lancet Neurol
, vol.14
, Issue.1
, pp. 57-64
-
-
Schrag, A.1
Horsfall, L.2
Walters, K.3
Noyce, A.4
Petersen, I.5
-
101
-
-
84985911015
-
Technology in Parkinson's disease: challenges and opportunities
-
Espay AJ, Bonato P, Nahab FB, et al. Technology in Parkinson's disease: challenges and opportunities. Mov Disord 2016;31(9):1272-1282.
-
(2016)
Mov Disord
, vol.31
, Issue.9
, pp. 1272-1282
-
-
Espay, A.J.1
Bonato, P.2
Nahab, F.B.3
-
102
-
-
85032508559
-
Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem
-
Arneric SP, Cedarbaum JM, Khozin S, et al. Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem. Nat Rev Drug Discovery 2017;16(10):736.
-
(2017)
Nat Rev Drug Discovery
, vol.16
, Issue.10
, pp. 736
-
-
Arneric, S.P.1
Cedarbaum, J.M.2
Khozin, S.3
-
103
-
-
85046350638
-
Elephants, Parkinson's disease and “proof of concept” clinical trials
-
in press
-
Cedarbaum JM. Elephants, Parkinson's disease and “proof of concept” clinical trials. Mov Disord 2018; in press.
-
(2018)
Mov Disord
-
-
Cedarbaum, J.M.1
|