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Volumn 13, Issue 5, 2017, Pages 561-571

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

(16)  Weiner, Michael W a,b,c   Veitch, Dallas P a   Aisen, Paul S d   Beckett, Laurel A e   Cairns, Nigel J f   Green, Robert C g   Harvey, Danielle e   Jack, Clifford R h   Jagust, William i   Morris, John C d   Petersen, Ronald C h   Salazar, Jennifer d   Saykin, Andrew J j   Shaw, Leslie M k   Toga, Arthur W d   Trojanowski, John Q l  


Author keywords

Alzheimer's disease; Amyloid phenotyping; Brain Health Registry; Centiloid method; Clinical trial biomarkers; Functional connectivity; Tau imaging

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; BIOLOGICAL MARKER; FLORBETABEN; FLORBETAPIR F 18; PITTSBURGH COMPOUND B; TAR DNA BINDING PROTEIN; TAU PROTEIN;

EID: 85008701998     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2016.10.006     Document Type: Review
Times cited : (290)

References (84)
  • 1
    • 84963972074 scopus 로고    scopus 로고
    • 2016 Alzheimer's disease facts and figures
    • [1] Alzheimer's Association. 2016 Alzheimer's disease facts and figures. Alzheimers Dement 12 (2016), 459–509.
    • (2016) Alzheimers Dement , vol.12 , pp. 459-509
  • 3
    • 84931096931 scopus 로고    scopus 로고
    • 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    • [3] Weiner, M.W., Veitch, D.P., Aisen, P.S., Beckett, L.A., Cairns, N.J., Cedarbaum, J., et al. 2014 Update of the Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement 11 (2015), e1–e120.
    • (2015) Alzheimers Dement , vol.11 , pp. e1-e120
    • Weiner, M.W.1    Veitch, D.P.2    Aisen, P.S.3    Beckett, L.A.4    Cairns, N.J.5    Cedarbaum, J.6
  • 5
    • 77955474351 scopus 로고    scopus 로고
    • The Alzheimer's disease neuroimaging initiative: progress report and future plans
    • [5] Weiner, M.W., Aisen, P.S., Jack, C.R. Jr., Jagust, W.J., Trojanowski, J.Q., Shaw, L., et al. The Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimers Dement 6 (2010), 202–211.e7.
    • (2010) Alzheimers Dement , vol.6 , pp. 202-211.e7
    • Weiner, M.W.1    Aisen, P.S.2    Jack, C.R.3    Jagust, W.J.4    Trojanowski, J.Q.5    Shaw, L.6
  • 7
    • 77954028958 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative special issue
    • [7] Frisoni, G.B., Weiner, M.W., Alzheimer's Disease Neuroimaging Initiative special issue. Neurobiol Aging 31 (2010), 1259–1262.
    • (2010) Neurobiol Aging , vol.31 , pp. 1259-1262
    • Frisoni, G.B.1    Weiner, M.W.2
  • 8
    • 84937573700 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative: a decade of progress in Alzheimer's disease
    • [8] Thies, W.H., Alzheimer's Disease Neuroimaging Initiative: a decade of progress in Alzheimer's disease. Alzheimers Dement 11 (2015), 727–729.
    • (2015) Alzheimers Dement , vol.11 , pp. 727-729
    • Thies, W.H.1
  • 9
    • 77954034844 scopus 로고    scopus 로고
    • Perspective on the Alzheimer's disease neuroimaging initiative: progress report and future plans
    • [9] Khachaturian, Z.S., Perspective on the Alzheimer's disease neuroimaging initiative: progress report and future plans. Alzheimers Dement 6 (2010), 199–201.
    • (2010) Alzheimers Dement , vol.6 , pp. 199-201
    • Khachaturian, Z.S.1
  • 10
    • 84856414697 scopus 로고    scopus 로고
    • The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    • [10] Weiner, M.W., Veitch, D.P., Aisen, P.S., Beckett, L.A., Cairns, N.J., Green, R.C., et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement 8 (2012), S1–S68.
    • (2012) Alzheimers Dement , vol.8 , pp. S1-S68
    • Weiner, M.W.1    Veitch, D.P.2    Aisen, P.S.3    Beckett, L.A.4    Cairns, N.J.5    Green, R.C.6
  • 11
    • 84883552519 scopus 로고    scopus 로고
    • The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception
    • [11] Weiner, M.W., Veitch, D.P., Aisen, P.S., Beckett, L.A., Cairns, N.J., Green, R.C., et al. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement 9 (2013), e111–e194.
    • (2013) Alzheimers Dement , vol.9 , pp. e111-e194
    • Weiner, M.W.1    Veitch, D.P.2    Aisen, P.S.3    Beckett, L.A.4    Cairns, N.J.5    Green, R.C.6
  • 12
    • 84872023531 scopus 로고    scopus 로고
    • Amyloid-beta imaging with Pittsburgh compound B and florbetapir: comparing radiotracers and quantification methods
    • [12] Landau, S.M., Breault, C., Joshi, A.D., Pontecorvo, M., Mathis, C.A., Jagust, W.J., et al. Amyloid-beta imaging with Pittsburgh compound B and florbetapir: comparing radiotracers and quantification methods. J Nucl Med 54 (2013), 70–77.
    • (2013) J Nucl Med , vol.54 , pp. 70-77
    • Landau, S.M.1    Breault, C.2    Joshi, A.D.3    Pontecorvo, M.4    Mathis, C.A.5    Jagust, W.J.6
  • 13
    • 84928257011 scopus 로고    scopus 로고
    • Measurement of longitudinal beta-amyloid change with 18F-florbetapir PET and standardized uptake value ratios
    • [13] Landau, S.M., Fero, A., Baker, S.L., Koeppe, R., Mintun, M., Chen, K., et al. Measurement of longitudinal beta-amyloid change with 18F-florbetapir PET and standardized uptake value ratios. J Nucl Med 56 (2015), 567–574.
    • (2015) J Nucl Med , vol.56 , pp. 567-574
    • Landau, S.M.1    Fero, A.2    Baker, S.L.3    Koeppe, R.4    Mintun, M.5    Chen, K.6
  • 15
    • 65249159879 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    • [15] Shaw, L.M., Vanderstichele, H., Knapik-Czajka, M., Clark, C.M., Aisen, P.S., Petersen, R.C., et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol 65 (2009), 403–413.
    • (2009) Ann Neurol , vol.65 , pp. 403-413
    • Shaw, L.M.1    Vanderstichele, H.2    Knapik-Czajka, M.3    Clark, C.M.4    Aisen, P.S.5    Petersen, R.C.6
  • 16
    • 79958102380 scopus 로고    scopus 로고
    • Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI
    • [16] Shaw, L.M., Vanderstichele, H., Knapik-Czajka, M., Figurski, M., Coart, E., Blennow, K., et al. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathol 121 (2011), 597–609.
    • (2011) Acta Neuropathol , vol.121 , pp. 597-609
    • Shaw, L.M.1    Vanderstichele, H.2    Knapik-Czajka, M.3    Figurski, M.4    Coart, E.5    Blennow, K.6
  • 17
    • 84878439275 scopus 로고    scopus 로고
    • Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-beta(1-42) and tau proteins as Alzheimer disease biomarkers
    • [17] Kang, J.H., Korecka, M., Toledo, J.B., Trojanowski, J.Q., Shaw, L.M., Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-beta(1-42) and tau proteins as Alzheimer disease biomarkers. Clin Chem 59 (2013), 903–916.
    • (2013) Clin Chem , vol.59 , pp. 903-916
    • Kang, J.H.1    Korecka, M.2    Toledo, J.B.3    Trojanowski, J.Q.4    Shaw, L.M.5
  • 18
    • 84994500045 scopus 로고    scopus 로고
    • Incidence and clinical progression of placebo-treated amyloid-negative subjects with mild-moderate Alzheimer's disease: results from the phase 3 PET sub-studies of bapineuzumab and solanezumab
    • [18] Salloway, S., Sperling, R., Gregg, K., Yu, P., Joshi, A.D., Lu, M., et al. Incidence and clinical progression of placebo-treated amyloid-negative subjects with mild-moderate Alzheimer's disease: results from the phase 3 PET sub-studies of bapineuzumab and solanezumab. Alzheimers Dement 9:4 Suppl (2013), P888–P889.
    • (2013) Alzheimers Dement , vol.9 , Issue.4 , pp. P888-P889
    • Salloway, S.1    Sperling, R.2    Gregg, K.3    Yu, P.4    Joshi, A.D.5    Lu, M.6
  • 19
    • 84882308754 scopus 로고    scopus 로고
    • Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force
    • [19] Vellas, B., Carrillo, M.C., Sampaio, C., Brashear, H.R., Siemers, E., Hampel, H., et al. Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force. Alzheimers Dement 9 (2013), 438–444.
    • (2013) Alzheimers Dement , vol.9 , pp. 438-444
    • Vellas, B.1    Carrillo, M.C.2    Sampaio, C.3    Brashear, H.R.4    Siemers, E.5    Hampel, H.6
  • 21
    • 79960894260 scopus 로고    scopus 로고
    • The relative efficiency of time-to-threshold and rate of change in longitudinal data
    • [21] Donohue, M.C., Gamst, A.C., Thomas, R.G., Xu, R., Beckett, L., Petersen, R.C., et al. The relative efficiency of time-to-threshold and rate of change in longitudinal data. Contemp Clin Trials 32 (2011), 685–693.
    • (2011) Contemp Clin Trials , vol.32 , pp. 685-693
    • Donohue, M.C.1    Gamst, A.C.2    Thomas, R.G.3    Xu, R.4    Beckett, L.5    Petersen, R.C.6
  • 22
    • 79952730827 scopus 로고    scopus 로고
    • Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer's disease or mild cognitive impairment does not lead to more efficient clinical trials
    • author reply 7–9
    • [22] Donohue, M.C., Gamst, A.C., Aisen, P.S., Requiring an amyloid-beta1-42 biomarker for prodromal Alzheimer's disease or mild cognitive impairment does not lead to more efficient clinical trials. Alzheimers Dement 7 (2011), 245–246 author reply 7–9.
    • (2011) Alzheimers Dement , vol.7 , pp. 245-246
    • Donohue, M.C.1    Gamst, A.C.2    Aisen, P.S.3
  • 23
    • 84863469055 scopus 로고    scopus 로고
    • Mixed model of repeated measures versus slope models in Alzheimer's disease clinical trials
    • [23] Donohue, M.C., Aisen, P.S., Mixed model of repeated measures versus slope models in Alzheimer's disease clinical trials. J Nutr Health Aging 16 (2012), 360–364.
    • (2012) J Nutr Health Aging , vol.16 , pp. 360-364
    • Donohue, M.C.1    Aisen, P.S.2
  • 25
    • 78751613397 scopus 로고    scopus 로고
    • Report of the task force on designing clinical trials in early (predementia) AD
    • [25] Aisen, P.S., Andrieu, S., Sampaio, C., Carrillo, M., Khachaturian, Z.S., Dubois, B., et al. Report of the task force on designing clinical trials in early (predementia) AD. Neurology 76 (2011), 280–286.
    • (2011) Neurology , vol.76 , pp. 280-286
    • Aisen, P.S.1    Andrieu, S.2    Sampaio, C.3    Carrillo, M.4    Khachaturian, Z.S.5    Dubois, B.6
  • 26
    • 84863211664 scopus 로고    scopus 로고
    • Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology
    • [26] Vellas, B., Hampel, H., Rouge-Bugat, M.E., Grundman, M., Andrieu, S., Abu-Shakra, S., et al. Alzheimer's disease therapeutic trials: EU/US Task Force report on recruitment, retention, and methodology. J Nutr Health Aging 16 (2012), 339–345.
    • (2012) J Nutr Health Aging , vol.16 , pp. 339-345
    • Vellas, B.1    Hampel, H.2    Rouge-Bugat, M.E.3    Grundman, M.4    Andrieu, S.5    Abu-Shakra, S.6
  • 27
    • 84863808449 scopus 로고    scopus 로고
    • Age and rate of cognitive decline in Alzheimer disease: implications for clinical trials
    • [27] Bernick, C., Cummings, J., Raman, R., Sun, X., Aisen, P., Age and rate of cognitive decline in Alzheimer disease: implications for clinical trials. Arch Neurol 69 (2012), 901–905.
    • (2012) Arch Neurol , vol.69 , pp. 901-905
    • Bernick, C.1    Cummings, J.2    Raman, R.3    Sun, X.4    Aisen, P.5
  • 28
    • 84873670904 scopus 로고    scopus 로고
    • Effect of study partner on the conduct of Alzheimer disease clinical trials
    • [28] Grill, J.D., Raman, R., Ernstrom, K., Aisen, P., Karlawish, J., Effect of study partner on the conduct of Alzheimer disease clinical trials. Neurology 80 (2013), 282–288.
    • (2013) Neurology , vol.80 , pp. 282-288
    • Grill, J.D.1    Raman, R.2    Ernstrom, K.3    Aisen, P.4    Karlawish, J.5
  • 30
    • 84933514600 scopus 로고    scopus 로고
    • Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials
    • [30] Grill, J.D., Raman, R., Ernstrom, K., Aisen, P., Dowsett, S.A., Chen, Y.F., et al. Comparing recruitment, retention, and safety reporting among geographic regions in multinational Alzheimer's disease clinical trials. Alzheimers Res Ther, 7, 2015, 39.
    • (2015) Alzheimers Res Ther , vol.7 , pp. 39
    • Grill, J.D.1    Raman, R.2    Ernstrom, K.3    Aisen, P.4    Dowsett, S.A.5    Chen, Y.F.6
  • 31
    • 82655173747 scopus 로고    scopus 로고
    • Testing the right target and right drug at the right stage
    • [31] Sperling, R.A., Jack, C.R. Jr., Aisen, P.S., Testing the right target and right drug at the right stage. Sci Transl Med, 3, 2011, 111cm33.
    • (2011) Sci Transl Med , vol.3 , pp. 111cm33
    • Sperling, R.A.1    Jack, C.R.2    Aisen, P.S.3
  • 33
    • 84875697254 scopus 로고    scopus 로고
    • Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease
    • [33] Aisen, P.S., Vellas, B., Hampel, H., Moving towards early clinical trials for amyloid-targeted therapy in Alzheimer's disease. Nat Rev Drug Discov, 12, 2013, 324.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 324
    • Aisen, P.S.1    Vellas, B.2    Hampel, H.3
  • 34
    • 84939567406 scopus 로고    scopus 로고
    • Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions
    • [34] Andrieu, S., Coley, N., Lovestone, S., Aisen, P.S., Vellas, B., Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions. Lancet Neurol 14 (2015), 926–944.
    • (2015) Lancet Neurol , vol.14 , pp. 926-944
    • Andrieu, S.1    Coley, N.2    Lovestone, S.3    Aisen, P.S.4    Vellas, B.5
  • 35
    • 84887650863 scopus 로고    scopus 로고
    • Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly
    • [35] Salmon, D.P., Ferris, S.H., Thomas, R.G., Sano, M., Cummings, J.L., Sperling, R.A., et al. Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly. Neuropsychology 27 (2013), 391–401.
    • (2013) Neuropsychology , vol.27 , pp. 391-401
    • Salmon, D.P.1    Ferris, S.H.2    Thomas, R.G.3    Sano, M.4    Cummings, J.L.5    Sperling, R.A.6
  • 36
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • [36] Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7 (2011), 280–292.
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3    Bennett, D.A.4    Craft, S.5    Fagan, A.M.6
  • 38
    • 79958271479 scopus 로고    scopus 로고
    • Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease
    • [38] Sano, M., Raman, R., Emond, J., Thomas, R.G., Petersen, R., Schneider, L.S., et al. Adding delayed recall to the Alzheimer Disease Assessment Scale is useful in studies of mild cognitive impairment but not Alzheimer disease. Alzheimer Dis Assoc Disord 25 (2011), 122–127.
    • (2011) Alzheimer Dis Assoc Disord , vol.25 , pp. 122-127
    • Sano, M.1    Raman, R.2    Emond, J.3    Thomas, R.G.4    Petersen, R.5    Schneider, L.S.6
  • 39
    • 84905969638 scopus 로고    scopus 로고
    • The preclinical Alzheimer cognitive composite: measuring amyloid-related decline
    • [39] Donohue, M.C., Sperling, R.A., Salmon, D.P., Rentz, D.M., Raman, R., Thomas, R.G., et al. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. JAMA Neurol 71 (2014), 961–970.
    • (2014) JAMA Neurol , vol.71 , pp. 961-970
    • Donohue, M.C.1    Sperling, R.A.2    Salmon, D.P.3    Rentz, D.M.4    Raman, R.5    Thomas, R.G.6
  • 40
    • 84914674657 scopus 로고    scopus 로고
    • Cognitive and functional decline and their relationship in patients with mild Alzheimer's dementia
    • [40] Liu-Seifert, H., Siemers, E., Sundell, K., Price, K., Han, B., Selzler, K., et al. Cognitive and functional decline and their relationship in patients with mild Alzheimer's dementia. J Alzheimers Dis 43 (2015), 949–955.
    • (2015) J Alzheimers Dis , vol.43 , pp. 949-955
    • Liu-Seifert, H.1    Siemers, E.2    Sundell, K.3    Price, K.4    Han, B.5    Selzler, K.6
  • 41
    • 84928159328 scopus 로고    scopus 로고
    • Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument
    • [41] Amariglio, R.E., Donohue, M.C., Marshall, G.A., Rentz, D.M., Salmon, D.P., Ferris, S.H., et al. Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument. JAMA Neurol 72 (2015), 446–454.
    • (2015) JAMA Neurol , vol.72 , pp. 446-454
    • Amariglio, R.E.1    Donohue, M.C.2    Marshall, G.A.3    Rentz, D.M.4    Salmon, D.P.5    Ferris, S.H.6
  • 42
    • 84876385490 scopus 로고    scopus 로고
    • Meta-analysis of amyloid-cognition relations in cognitively normal older adults
    • [42] Hedden, T., Oh, H., Younger, A.P., Patel, T.A., Meta-analysis of amyloid-cognition relations in cognitively normal older adults. Neurology 80 (2013), 1341–1348.
    • (2013) Neurology , vol.80 , pp. 1341-1348
    • Hedden, T.1    Oh, H.2    Younger, A.P.3    Patel, T.A.4
  • 43
    • 84860215480 scopus 로고    scopus 로고
    • Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
    • [43] Nelson, P.T., Alafuzoff, I., Bigio, E.H., Bouras, C., Braak, H., Cairns, N.J., et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71 (2012), 362–381.
    • (2012) J Neuropathol Exp Neurol , vol.71 , pp. 362-381
    • Nelson, P.T.1    Alafuzoff, I.2    Bigio, E.H.3    Bouras, C.4    Braak, H.5    Cairns, N.J.6
  • 44
    • 18144415471 scopus 로고    scopus 로고
    • Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    • [44] Fox, N.C., Black, R.S., Gilman, S., Rossor, M.N., Griffith, S.G., Jenkins, L., et al. Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology 64 (2005), 1563–1572.
    • (2005) Neurology , vol.64 , pp. 1563-1572
    • Fox, N.C.1    Black, R.S.2    Gilman, S.3    Rossor, M.N.4    Griffith, S.G.5    Jenkins, L.6
  • 45
    • 82255179817 scopus 로고    scopus 로고
    • A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
    • [45] Salloway, S., Sperling, R., Keren, R., Porsteinsson, A.P., van Dyck, C.H., Tariot, P.N., et al. A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology 77 (2011), 1253–1262.
    • (2011) Neurology , vol.77 , pp. 1253-1262
    • Salloway, S.1    Sperling, R.2    Keren, R.3    Porsteinsson, A.P.4    van Dyck, C.H.5    Tariot, P.N.6
  • 46
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • [46] Salloway, S., Sperling, R., Gilman, S., Fox, N.C., Blennow, K., Raskind, M., et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 73 (2009), 2061–2070.
    • (2009) Neurology , vol.73 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3    Fox, N.C.4    Blennow, K.5    Raskind, M.6
  • 47
    • 84892695519 scopus 로고    scopus 로고
    • Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
    • [47] Salloway, S., Sperling, R., Fox, N.C., Blennow, K., Klunk, W., Raskind, M., et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med 370 (2014), 322–333.
    • (2014) N Engl J Med , vol.370 , pp. 322-333
    • Salloway, S.1    Sperling, R.2    Fox, N.C.3    Blennow, K.4    Klunk, W.5    Raskind, M.6
  • 48
    • 84979269425 scopus 로고    scopus 로고
    • The rate of clinical progression and brain atrophy is greater with increasing severity of Alzheimer's disease: results from the volumetric MRI substudies of two phase III trials with bapineuzumab
    • [48] Novak, G., Einstein, S., Tudor, I.C., Gregg, K., Collins, P., Wyman, B., et al. The rate of clinical progression and brain atrophy is greater with increasing severity of Alzheimer's disease: results from the volumetric MRI substudies of two phase III trials with bapineuzumab. Alzheimers Dement, 9, 2013, 287.
    • (2013) Alzheimers Dement , vol.9 , pp. 287
    • Novak, G.1    Einstein, S.2    Tudor, I.C.3    Gregg, K.4    Collins, P.5    Wyman, B.6
  • 49
    • 65249138789 scopus 로고    scopus 로고
    • Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer's disease: the ALZHEMED (Tramiprosate) experience
    • [49] Saumier, D., Aisen, P.S., Gauthier, S., Vellas, B., Ferris, S.H., Duong, A., et al. Lessons learned in the use of volumetric MRI in therapeutic trials in Alzheimer's disease: the ALZHEMED (Tramiprosate) experience. J Nutr Health Aging 13 (2009), 370–372.
    • (2009) J Nutr Health Aging , vol.13 , pp. 370-372
    • Saumier, D.1    Aisen, P.S.2    Gauthier, S.3    Vellas, B.4    Ferris, S.H.5    Duong, A.6
  • 50
    • 0029013727 scopus 로고
    • Staging of Alzheimer's disease-related neurofibrillary changes
    • discussion 8–84
    • [50] Braak, H., Braak, E., Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging 16 (1995), 271–278 discussion 8–84.
    • (1995) Neurobiol Aging , vol.16 , pp. 271-278
    • Braak, H.1    Braak, E.2
  • 53
    • 84945253818 scopus 로고    scopus 로고
    • Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease
    • [53] Portelius, E., Zetterberg, H., Skillback, T., Tornqvist, U., Andreasson, U., Trojanowski, J.Q., et al. Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease. Brain 138:Pt 11 (2015), 3373–3385.
    • (2015) Brain , vol.138 , pp. 3373-3385
    • Portelius, E.1    Zetterberg, H.2    Skillback, T.3    Tornqvist, U.4    Andreasson, U.5    Trojanowski, J.Q.6
  • 54
    • 79960817113 scopus 로고    scopus 로고
    • Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup
    • [54] Sperling, R.A., Jack, C.R. Jr., Black, S.E., Frosch, M.P., Greenberg, S.M., Hyman, B.T., et al. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement 7 (2011), 367–385.
    • (2011) Alzheimers Dement , vol.7 , pp. 367-385
    • Sperling, R.A.1    Jack, C.R.2    Black, S.E.3    Frosch, M.P.4    Greenberg, S.M.5    Hyman, B.T.6
  • 55
    • 84937548717 scopus 로고    scopus 로고
    • The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: a review of progress and plans
    • [55] Kang, J.H., Korecka, M., Figurski, M.J., Toledo, J.B., Blennow, K., Zetterberg, H., et al. The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: a review of progress and plans. Alzheimers Dement 11 (2015), 772–791.
    • (2015) Alzheimers Dement , vol.11 , pp. 772-791
    • Kang, J.H.1    Korecka, M.2    Figurski, M.J.3    Toledo, J.B.4    Blennow, K.5    Zetterberg, H.6
  • 57
    • 85005916228 scopus 로고    scopus 로고
    • Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
    • [57] Motsinger-Reif, A.A., Zhu, H., Kling, M.A., Matson, W., Sharma, S., Fiehn, O., et al. Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging. Acta Neuropathol Commun, 1, 2013, 28.
    • (2013) Acta Neuropathol Commun , vol.1 , pp. 28
    • Motsinger-Reif, A.A.1    Zhu, H.2    Kling, M.A.3    Matson, W.4    Sharma, S.5    Fiehn, O.6
  • 58
    • 84902528704 scopus 로고    scopus 로고
    • Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative
    • [58] Weiner, M.W., Veitch, D.P., Hayes, J., Neylan, T., Grafman, J., Aisen, P.S., et al. Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement 10 (2014), S226–S235.
    • (2014) Alzheimers Dement , vol.10 , pp. S226-S235
    • Weiner, M.W.1    Veitch, D.P.2    Hayes, J.3    Neylan, T.4    Grafman, J.5    Aisen, P.S.6
  • 59
    • 84875159286 scopus 로고    scopus 로고
    • The multilingual naming test in Alzheimer's disease: clues to the origin of naming impairments
    • [59] Ivanova, I., Salmon, D.P., Gollan, T.H., The multilingual naming test in Alzheimer's disease: clues to the origin of naming impairments. J Int Neuropsychol Soc 19 (2013), 272–283.
    • (2013) J Int Neuropsychol Soc , vol.19 , pp. 272-283
    • Ivanova, I.1    Salmon, D.P.2    Gollan, T.H.3
  • 60
    • 84936970996 scopus 로고    scopus 로고
    • Age and education corrected older adult normative data for a short form version of the Financial Capacity Instrument
    • [60] Gerstenecker, A., Eakin, A., Triebel, K., Martin, R., Swenson-Dravis, D., Petersen, R.C., et al. Age and education corrected older adult normative data for a short form version of the Financial Capacity Instrument. Psychol Assess 28 (2016), 737–749.
    • (2016) Psychol Assess , vol.28 , pp. 737-749
    • Gerstenecker, A.1    Eakin, A.2    Triebel, K.3    Martin, R.4    Swenson-Dravis, D.5    Petersen, R.C.6
  • 61
    • 84938571923 scopus 로고    scopus 로고
    • Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer's disease
    • [61] Maruff, P., Lim, Y.Y., Darby, D., Ellis, K.A., Pietrzak, R.H., Snyder, P.J., et al. Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer's disease. BMC Psychol, 1, 2013, 30.
    • (2013) BMC Psychol , vol.1 , pp. 30
    • Maruff, P.1    Lim, Y.Y.2    Darby, D.3    Ellis, K.A.4    Pietrzak, R.H.5    Snyder, P.J.6
  • 63
    • 84939264152 scopus 로고    scopus 로고
    • Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer disease: phase 3 study
    • [63] Sabri, O., Sabbagh, M.N., Seibyl, J., Barthel, H., Akatsu, H., Ouchi, Y., et al. Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer disease: phase 3 study. Alzheimers Dement 11 (2015), 964–974.
    • (2015) Alzheimers Dement , vol.11 , pp. 964-974
    • Sabri, O.1    Sabbagh, M.N.2    Seibyl, J.3    Barthel, H.4    Akatsu, H.5    Ouchi, Y.6
  • 65
    • 84919839320 scopus 로고    scopus 로고
    • Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia
    • [65] Alsop, D.C., Detre, J.A., Golay, X., Gunther, M., Hendrikse, J., Hernandez-Garcia, L., et al. Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73 (2015), 102–116.
    • (2015) Magn Reson Med , vol.73 , pp. 102-116
    • Alsop, D.C.1    Detre, J.A.2    Golay, X.3    Gunther, M.4    Hendrikse, J.5    Hernandez-Garcia, L.6
  • 66
    • 84922254527 scopus 로고    scopus 로고
    • Effects of age and Alzheimer's disease on hippocampal subfields: comparison between manual and FreeSurfer volumetry
    • [66] de Flores, R., La Joie, R., Landeau, B., Perrotin, A., Mezenge, F., de La Sayette, V., et al. Effects of age and Alzheimer's disease on hippocampal subfields: comparison between manual and FreeSurfer volumetry. Hum Brain Mapp 36 (2015), 463–474.
    • (2015) Hum Brain Mapp , vol.36 , pp. 463-474
    • de Flores, R.1    La Joie, R.2    Landeau, B.3    Perrotin, A.4    Mezenge, F.5    de La Sayette, V.6
  • 67
    • 84916607308 scopus 로고    scopus 로고
    • Collaboration for a systematic comparison of different techniques to measure subfield volumes: announcement and first results
    • [67] Mueller, S., Yushkevich, P., Wang, L., Van Leemput, K., Mezher, A., Iglesias, J.E., et al. Collaboration for a systematic comparison of different techniques to measure subfield volumes: announcement and first results. Alzheimers Dement, 9, 2013, P51.
    • (2013) Alzheimers Dement , vol.9 , pp. P51
    • Mueller, S.1    Yushkevich, P.2    Wang, L.3    Van Leemput, K.4    Mezher, A.5    Iglesias, J.E.6
  • 68
    • 84863952177 scopus 로고    scopus 로고
    • In vivo analysis of hippocampal subfield atrophy in mild cognitive impairment via semi-automatic segmentation of T2-weighted MRI
    • [68] Pluta, J., Yushkevich, P., Das, S., Wolk, D., In vivo analysis of hippocampal subfield atrophy in mild cognitive impairment via semi-automatic segmentation of T2-weighted MRI. J Alzheimers Dis 31 (2012), 85–99.
    • (2012) J Alzheimers Dis , vol.31 , pp. 85-99
    • Pluta, J.1    Yushkevich, P.2    Das, S.3    Wolk, D.4
  • 69
    • 84916925772 scopus 로고    scopus 로고
    • Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment
    • [69] Yushkevich, P.A., Pluta, J.B., Wang, H., Xie, L., Ding, S.L., Gertje, E.C., et al. Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Hum Brain Mapp 36 (2015), 258–287.
    • (2015) Hum Brain Mapp , vol.36 , pp. 258-287
    • Yushkevich, P.A.1    Pluta, J.B.2    Wang, H.3    Xie, L.4    Ding, S.L.5    Gertje, E.C.6
  • 70
    • 84927566319 scopus 로고    scopus 로고
    • Qualification of a surrogate matrix-based absolute quantification method for amyloid-beta(4)(2) in human cerebrospinal fluid using 2D UPLC-tandem mass spectrometry
    • [70] Korecka, M., Waligorska, T., Figurski, M., Toledo, J.B., Arnold, S.E., Grossman, M., et al. Qualification of a surrogate matrix-based absolute quantification method for amyloid-beta(4)(2) in human cerebrospinal fluid using 2D UPLC-tandem mass spectrometry. J Alzheimers Dis 41 (2014), 441–451.
    • (2014) J Alzheimers Dis , vol.41 , pp. 441-451
    • Korecka, M.1    Waligorska, T.2    Figurski, M.3    Toledo, J.B.4    Arnold, S.E.5    Grossman, M.6
  • 71
    • 84903703012 scopus 로고    scopus 로고
    • Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-beta in cerebrospinal fluid
    • [71] Leinenbach, A., Pannee, J., Dulffer, T., Huber, A., Bittner, T., Andreasson, U., et al. Mass spectrometry-based candidate reference measurement procedure for quantification of amyloid-beta in cerebrospinal fluid. Clin Chem 60 (2014), 987–994.
    • (2014) Clin Chem , vol.60 , pp. 987-994
    • Leinenbach, A.1    Pannee, J.2    Dulffer, T.3    Huber, A.4    Bittner, T.5    Andreasson, U.6
  • 72
    • 84954025387 scopus 로고    scopus 로고
    • Round robin test on quantification of amyloid-beta 1-42 in cerebrospinal fluid by mass spectrometry
    • [72] Pannee, J., Gobom, J., Shaw, L.M., Korecka, M., Chambers, E.E., Lame, M., et al. Round robin test on quantification of amyloid-beta 1-42 in cerebrospinal fluid by mass spectrometry. Alzheimers Dement 12 (2016), 55–59.
    • (2016) Alzheimers Dement , vol.12 , pp. 55-59
    • Pannee, J.1    Gobom, J.2    Shaw, L.M.3    Korecka, M.4    Chambers, E.E.5    Lame, M.6
  • 73
    • 84952053119 scopus 로고    scopus 로고
    • Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid(1-42) in human cerebrospinal fluid
    • [73] Bittner, T., Zetterberg, H., Teunissen, C., Ostlund, R.E., Militello, M., Andreasson, U., et al. Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid(1-42) in human cerebrospinal fluid. Alzheimers Dement 12 (2015), 517–526.
    • (2015) Alzheimers Dement , vol.12 , pp. 517-526
    • Bittner, T.1    Zetterberg, H.2    Teunissen, C.3    Ostlund, R.E.4    Militello, M.5    Andreasson, U.6
  • 74
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    • [74] Lambert, J.C., Ibrahim-Verbaas, C.A., Harold, D., Naj, A.C., Sims, R., Bellenguez, C., et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 45 (2013), 1452–1458.
    • (2013) Nat Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3    Naj, A.C.4    Sims, R.5    Bellenguez, C.6
  • 75
    • 84937580795 scopus 로고    scopus 로고
    • Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities, and plans
    • [75] Saykin, A.J., Shen, L., Yao, X., Kim, S., Nho, K., Risacher, S.L., et al. Genetic studies of quantitative MCI and AD phenotypes in ADNI: progress, opportunities, and plans. Alzheimers Dement 11 (2015), 792–814.
    • (2015) Alzheimers Dement , vol.11 , pp. 792-814
    • Saykin, A.J.1    Shen, L.2    Yao, X.3    Kim, S.4    Nho, K.5    Risacher, S.L.6
  • 76
    • 84899809381 scopus 로고    scopus 로고
    • Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
    • [76] Shen, L., Thompson, P.M., Potkin, S.G., Bertram, L., Farrer, L.A., Foroud, T.M., et al. Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav 8 (2014), 183–207.
    • (2014) Brain Imaging Behav , vol.8 , pp. 183-207
    • Shen, L.1    Thompson, P.M.2    Potkin, S.G.3    Bertram, L.4    Farrer, L.A.5    Foroud, T.M.6
  • 77
    • 84894027752 scopus 로고    scopus 로고
    • Gene-based GWAS and biological pathway analysis of the resilience of executive functioning
    • [77] Mukherjee, S., Kim, S., Ramanan, V.K., Gibbons, L.E., Nho, K., Glymour, M.M., et al. Gene-based GWAS and biological pathway analysis of the resilience of executive functioning. Brain Imaging Behav 8 (2014), 110–118.
    • (2014) Brain Imaging Behav , vol.8 , pp. 110-118
    • Mukherjee, S.1    Kim, S.2    Ramanan, V.K.3    Gibbons, L.E.4    Nho, K.5    Glymour, M.M.6
  • 78
    • 84952902285 scopus 로고    scopus 로고
    • GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP
    • [78] Ramanan, V.K., Risacher, S.L., Nho, K., Kim, S., Shen, L., McDonald, B.C., et al. GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP. Brain 138 (2015), 3076–3088.
    • (2015) Brain , vol.138 , pp. 3076-3088
    • Ramanan, V.K.1    Risacher, S.L.2    Nho, K.3    Kim, S.4    Shen, L.5    McDonald, B.C.6
  • 79
    • 84875269684 scopus 로고    scopus 로고
    • Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
    • [79] Jahanshad, N., Rajagopalan, P., Hua, X., Hibar, D.P., Nir, T.M., Toga, A.W., et al. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Proc Natl Acad Sci U S A 110 (2013), 4768–4773.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 4768-4773
    • Jahanshad, N.1    Rajagopalan, P.2    Hua, X.3    Hibar, D.P.4    Nir, T.M.5    Toga, A.W.6
  • 81
    • 84862767786 scopus 로고    scopus 로고
    • An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease
    • [81] Jack, C.R. Jr., Knopman, D.S., Weigand, S.D., Wiste, H.J., Vemuri, P., Lowe, V., et al. An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease. Ann Neurol 71 (2012), 765–775.
    • (2012) Ann Neurol , vol.71 , pp. 765-775
    • Jack, C.R.1    Knopman, D.S.2    Weigand, S.D.3    Wiste, H.J.4    Vemuri, P.5    Lowe, V.6
  • 82
    • 0026578425 scopus 로고
    • Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)
    • [82] Bramblett, G.T., Trojanowski, J.Q., Lee, V.M., Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins). Lab Invest 66 (1992), 212–222.
    • (1992) Lab Invest , vol.66 , pp. 212-222
    • Bramblett, G.T.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 83
    • 84946398793 scopus 로고    scopus 로고
    • Precision medicine: clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases
    • [83] Montine, T.J., Montine, K.S., Precision medicine: clarity for the clinical and biological complexity of Alzheimer's and Parkinson's diseases. J Exp Med 212 (2015), 601–605.
    • (2015) J Exp Med , vol.212 , pp. 601-605
    • Montine, T.J.1    Montine, K.S.2
  • 84
    • 84923331513 scopus 로고    scopus 로고
    • Building a roadmap for developing combination therapies for Alzheimer's disease
    • [84] Perry, D., Sperling, R., Katz, R., Berry, D., Dilts, D., Hanna, D., et al. Building a roadmap for developing combination therapies for Alzheimer's disease. Expert Rev Neurother 15 (2015), 327–333.
    • (2015) Expert Rev Neurother , vol.15 , pp. 327-333
    • Perry, D.1    Sperling, R.2    Katz, R.3    Berry, D.4    Dilts, D.5    Hanna, D.6


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