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Volumn 3, Issue 1, 2017, Pages

LRRK2 levels in immune cells are increased in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; MEMBRANE PROTEIN; TUMOR NECROSIS FACTOR;

EID: 85084783827     PISSN: None     EISSN: 23738057     Source Type: Journal    
DOI: 10.1038/s41531-017-0010-8     Document Type: Article
Times cited : (178)

References (53)
  • 1
    • 8844266996 scopus 로고    scopus 로고
    • Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    • Paisan-Ruiz, C. et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600 (2004).
    • (2004) Neuron , vol.44 , pp. 595-600
    • Paisan-Ruiz, C.1
  • 2
    • 8844233579 scopus 로고    scopus 로고
    • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
    • Zimprich, A. et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607 (2004).
    • (2004) Neuron , vol.44 , pp. 601-607
    • Zimprich, A.1
  • 3
    • 70449474155 scopus 로고    scopus 로고
    • The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews
    • Thaler, A., Ash, E., Gan-Or, Z., Orr-Urtreger, A. & Giladi, N. The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews. J. Neural. Transm. 116, 1473-1482 (2009).
    • (2009) J. Neural. Transm. , vol.116 , pp. 1473-1482
    • Thaler, A.1    Ash, E.2    Gan-Or, Z.3    Orr-Urtreger, A.4    Giladi, N.5
  • 4
    • 18244394793 scopus 로고    scopus 로고
    • Clinical features of LRRK2-associated Parkinson's disease in central Norway
    • Aasly, J. O. et al. Clinical features of LRRK2-associated Parkinson's disease in central Norway. Ann. Neurol. 57, 762-765 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 762-765
    • Aasly, J.O.1
  • 5
    • 42049094200 scopus 로고    scopus 로고
    • Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease
    • Haugarvoll, K. et al. Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. Neurology 70, 1456-1460 (2008).
    • (2008) Neurology , vol.70 , pp. 1456-1460
    • Haugarvoll, K.1
  • 7
    • 0036196860 scopus 로고    scopus 로고
    • A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11. 2-q13. 1
    • Funayama, M. et al. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11. 2-q13. 1. Ann. Neurol. 51, 296-301 (2002).
    • (2002) Ann. Neurol , vol.51 , pp. 296-301
    • Funayama, M.1
  • 8
    • 34548604567 scopus 로고    scopus 로고
    • The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
    • Guo, L. et al. The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp. Cell Res. 313, 3658-3670 (2007).
    • (2007) Exp. Cell Res. , vol.313 , pp. 3658-3670
    • Guo, L.1
  • 9
    • 84862996255 scopus 로고    scopus 로고
    • Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
    • Gilsbach, B. K. et al. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc. Natl Acad. Sci. USA 109, 10322-10327 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.109 , pp. 10322-10327
    • Gilsbach, B.K.1
  • 10
    • 84991112144 scopus 로고    scopus 로고
    • MTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1
    • Manzoni, C. et al. mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Sci. Rep. 6, 35106 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 35106
    • Manzoni, C.1
  • 11
    • 84993945191 scopus 로고    scopus 로고
    • LRRK2 deficiency impacts ceramide metabolism in brain
    • Ferrazza, R. et al. LRRK2 deficiency impacts ceramide metabolism in brain. Biochem. Biophys. Res. Commun. 478, 1141-1146 (2016).
    • (2016) Biochem. Biophys. Res. Commun. , vol.478 , pp. 1141-1146
    • Ferrazza, R.1
  • 12
    • 39549117093 scopus 로고    scopus 로고
    • Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
    • Plowey, E. D., Cherra, S. J., Liu, Y. J. & Chu, C. T. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J. Neurochem. 105, 1048-1056 (2008).
    • (2008) J. Neurochem. , vol.105 , pp. 1048-1056
    • Plowey, E.D.1    Cherra, S.J.2    Liu, Y.J.3    Chu, C.T.4
  • 13
    • 84902163498 scopus 로고    scopus 로고
    • Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
    • Schapansky, J., Nardozzi, J. D., Felizia, F. & LaVoie, M. J. Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. Hum. Genet. 23, 4201-4214 (2014).
    • (2014) Hum. Genet. , vol.23 , pp. 4201-4214
    • Schapansky, J.1    Nardozzi, J.D.2    Felizia, F.3    LaVoie, M.J.4
  • 14
    • 79953758383 scopus 로고    scopus 로고
    • Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2
    • Ramonet, D. et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS ONE 6, e18568 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e18568
    • Ramonet, D.1
  • 15
    • 84868156773 scopus 로고    scopus 로고
    • LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6
    • Berwick, D. C. & Harvey, K. LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Genet. 21, 4966-4979 (2012).
    • (2012) Hum. Genet. , vol.21 , pp. 4966-4979
    • Berwick, D.C.1    Harvey, K.2
  • 16
    • 80054933395 scopus 로고    scopus 로고
    • The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
    • Liu, Z. et al. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 12, 1063-1070 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 1063-1070
    • Liu, Z.1
  • 17
    • 84939885719 scopus 로고    scopus 로고
    • The role of LRRK2 in the regulation of monocyte adhesion to endothelial cells
    • Hongge, L., Kexin, G., Xiaojie, M., Nian, X. & Jinsha, H. The role of LRRK2 in the regulation of monocyte adhesion to endothelial cells. J. Mol. Neurosci. 55, 233-239 (2015).
    • (2015) J. Mol. Neurosci. , vol.55 , pp. 233-239
    • Hongge, L.1    Kexin, G.2    Xiaojie, M.3    Nian, X.4    Jinsha, H.5
  • 18
    • 28544441389 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease: LRRK2 on the rise
    • Brice, A. Genetics of Parkinson's disease: LRRK2 on the rise. Brain 128(Pt 12), 2760-2762 (2005).
    • (2005) Brain , vol.128 , pp. 2760-2762
    • Brice, A.1
  • 19
    • 84944865481 scopus 로고    scopus 로고
    • Heterogeneity of leucine-rich repeat kinase 2 mutations: Genetics, mechanisms and therapeutic implications
    • Rudenko, I. N. & Cookson, M. R. Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications. Neurotherapeutics 11, 738-750 (2014).
    • (2014) Neurotherapeutics , vol.11 , pp. 738-750
    • Rudenko, I.N.1    Cookson, M.R.2
  • 20
    • 84896708886 scopus 로고    scopus 로고
    • The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease
    • Rideout, H. J. & Stefanis, L. The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease. Neurochem. Res. 39, 576-592 (2014).
    • (2014) Neurochem. Res. , vol.39 , pp. 576-592
    • Rideout, H.J.1    Stefanis, L.2
  • 21
    • 77953395313 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 mutations and Parkinson's disease: Three questions
    • Greggio, E. & Cookson, M. R. Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions. ASN Neuro. 1, AN20090007 (2009).
    • (2009) ASN Neuro. , vol.1 , pp. AN20090007
    • Greggio, E.1    Cookson, M.R.2
  • 22
    • 79956199220 scopus 로고    scopus 로고
    • Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
    • Hakimi, M. et al. Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J. Neural. Transm. 118, 795-808 (2011).
    • (2011) J. Neural. Transm. , vol.118 , pp. 795-808
    • Hakimi, M.1
  • 23
    • 78149473340 scopus 로고    scopus 로고
    • LRRK2 is involved in the IFN-gamma response and host response to pathogens
    • Gardet, A. et al. LRRK2 is involved in the IFN-gamma response and host response to pathogens. J. Immunol. 185, 5577-5585 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 5577-5585
    • Gardet, A.1
  • 24
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett, J. C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 955-962
    • Barrett, J.C.1
  • 25
    • 74049127960 scopus 로고    scopus 로고
    • Genomewide association study of leprosy
    • Zhang, F. R. et al. Genomewide association study of leprosy. N. Eng. J. Med. 361, 2609-2618 (2009).
    • (2009) N. Eng. J. Med. , vol.361 , pp. 2609-2618
    • Zhang, F.R.1
  • 26
    • 14744299357 scopus 로고    scopus 로고
    • The RIP kinases: Crucial integrators of cellular stress
    • Meylan, E. & Tschopp, J. The RIP kinases: crucial integrators of cellular stress. TIBS 30, 151-159 (2005).
    • (2005) TIBS , vol.30 , pp. 151-159
    • Meylan, E.1    Tschopp, J.2
  • 27
    • 77957274045 scopus 로고    scopus 로고
    • Receptor-interacting protein (RIP) kinase family
    • Zhang, D., Lin, J. & Han, J. Receptor-interacting protein (RIP) kinase family. Cell. Mol. Immunol. 7, 243-249 (2010).
    • (2010) Cell. Mol. Immunol. , vol.7 , pp. 243-249
    • Zhang, D.1    Lin, J.2    Han, J.3
  • 29
    • 84902360686 scopus 로고    scopus 로고
    • Interferon-gamma induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages
    • Kuss, M., Adamopoulou, E. & Kahle, P. J. Interferon-gamma induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages. J. Neurochem. 129, 980-987 (2014).
    • (2014) J. Neurochem. , vol.129 , pp. 980-987
    • Kuss, M.1    Adamopoulou, E.2    Kahle, P.J.3
  • 30
    • 84856632181 scopus 로고    scopus 로고
    • LRRK2 inhibition attenuates microglial inflammatory responses
    • Moehle, M. S. et al. LRRK2 inhibition attenuates microglial inflammatory responses. J. Neurosci. 32, 1602-1611 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 1602-1611
    • Moehle, M.S.1
  • 31
    • 84981239949 scopus 로고    scopus 로고
    • Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker
    • Perera, G., Ranola, M., Rowe, D. B., Halliday, G. M. & Dzamko, N. Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker. Sci. Rep. 6, 31391 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 31391
    • Perera, G.1    Ranola, M.2    Rowe, D.B.3    Halliday, G.M.4    Dzamko, N.5
  • 32
    • 84899138668 scopus 로고    scopus 로고
    • LRRK2 and neuroinflammation: Partners in crime in Parkinson's disease
    • Russo, I., Bubacco, L. & Greggio, E. LRRK2 and neuroinflammation: partners in crime in Parkinson's disease J. Neuroinflammation 11, 52 (2014).
    • (2014) J. Neuroinflammation , vol.11 , pp. 52
    • Russo, I.1    Bubacco, L.2    Greggio, E.3
  • 33
    • 84872770499 scopus 로고    scopus 로고
    • Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease
    • Pradhan, S. & Andreasson, K. Commentary: progressive inflammation as a contributing factor to early development of Parkinson's disease. Exp. Neurol. 241, 148-155 (2013).
    • (2013) Exp. Neurol. , vol.241 , pp. 148-155
    • Pradhan, S.1    Andreasson, K.2
  • 34
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: An essential link between degeneration and regeneration
    • Neumann, H., Kotter, M. R. & Franklin, R. J. M. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132, 288-295 (2009).
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.M.3
  • 35
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer, P. L., Itagaki, S., Boyes, B. E. & McGeer, E. G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurol. 38, 1285-1291 (1988).
    • (1988) Neurol. , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 36
    • 34247366072 scopus 로고    scopus 로고
    • Inflammation as a causative factor in the aetiology of Parkinson's disease
    • Whitton, P. S. Inflammation as a causative factor in the aetiology of Parkinson's disease. British. J. Pharmacol. 150, 963-976 (2007).
    • (2007) British. J. Pharmacol. , vol.150 , pp. 963-976
    • Whitton, P.S.1
  • 37
    • 84875860420 scopus 로고    scopus 로고
    • CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease
    • Saunders, J. A. et al. CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease. J. Neuroimmune Pharmacol 7, 927-938 (2012).
    • (2012) J. Neuroimmune Pharmacol , vol.7 , pp. 927-938
    • Saunders, J.A.1
  • 38
    • 84858620880 scopus 로고    scopus 로고
    • Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
    • Gillardon, F., Schmid, R. & Draheim, H. Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity. Neurosci. 208, 41-48 (2012).
    • (2012) Neurosci. , vol.208 , pp. 41-48
    • Gillardon, F.1    Schmid, R.2    Draheim, H.3
  • 39
    • 0034511922 scopus 로고    scopus 로고
    • Lessons from the bare lymphocyte syndrome: Molecular mechanisms regulating MHC class II expression
    • Waldburger, J. M. et al. Lessons from the bare lymphocyte syndrome: molecular mechanisms regulating MHC class II expression. Immunol. Rev. 178, 148-165 (2000).
    • (2000) Immunol. Rev. , vol.178 , pp. 148-165
    • Waldburger, J.M.1
  • 41
    • 0033574449 scopus 로고    scopus 로고
    • Brefeldin A: The advantage of being uncompetitive
    • Chardin, P. & McCormick, F. Brefeldin A: the advantage of being uncompetitive. Cell 97, 153-155 (1999).
    • (1999) Cell , vol.97 , pp. 153-155
    • Chardin, P.1    McCormick, F.2
  • 42
    • 33847789122 scopus 로고    scopus 로고
    • The CD14+ CD16+ blood monocytes: Their role in infection and inflammation
    • Ziegler-Heitbrock, L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J. Leukoc. Biol. 81, 584-592 (2007).
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 584-592
    • Ziegler-Heitbrock, L.1
  • 43
    • 84921938850 scopus 로고    scopus 로고
    • Inflammatory dysregulation of blood monocytes in Parkinson's disease patients
    • Grozdanov, V. et al. Inflammatory dysregulation of blood monocytes in Parkinson's disease patients. Acta Neuropathol. 128, 651-663 (2014).
    • (2014) Acta Neuropathol. , vol.128 , pp. 651-663
    • Grozdanov, V.1
  • 44
    • 79952918505 scopus 로고    scopus 로고
    • Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
    • Deng, X. et al. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat. Chem. Biol. 7, 203-205 (2011).
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 203-205
    • Deng, X.1
  • 45
    • 84955722920 scopus 로고    scopus 로고
    • Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson's disease: An observational and case-control study
    • Kannarkat, G. T. et al. Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson's disease: an observational and case-control study. NPJ Parkinsons Dis. 1, 15002 (2015).
    • (2015) NPJ Parkinsons Dis. , vol.1 , pp. 15002
    • Kannarkat, G.T.1
  • 46
    • 35748969588 scopus 로고    scopus 로고
    • Induction of the CTLA-4 Gene in human lymphocytes is dependent on NFAT binding the proximal promoter
    • Gibson, H. M. et al. Induction of the CTLA-4 Gene in human lymphocytes is dependent on NFAT binding the proximal promoter. J. Immunol. 179, 3831-3840 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 3831-3840
    • Gibson, H.M.1
  • 47
    • 33947515418 scopus 로고    scopus 로고
    • Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons
    • Mount, M. P. et al. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J. Neurosci. 27, 3328-3337 (2007).
    • (2007) J. Neurosci. , vol.27 , pp. 3328-3337
    • Mount, M.P.1
  • 48
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi, M. et al. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180, 147-150 (1994).
    • (1994) Neurosci. Lett. , vol.180 , pp. 147-150
    • Mogi, M.1
  • 49
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen, D. et al. Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202, 17-20 (1995).
    • (1995) Neurosci. Lett. , vol.202 , pp. 17-20
    • Blum-Degen, D.1
  • 50
    • 77950505354 scopus 로고    scopus 로고
    • Smoking duration, intensity, and risk of Parkinson disease
    • Chen, H. et al. Smoking duration, intensity, and risk of Parkinson disease. Neurology 74, 878-884 (2010).
    • (2010) Neurology , vol.74 , pp. 878-884
    • Chen, H.1
  • 51
    • 77949899236 scopus 로고    scopus 로고
    • Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis
    • Gagne, J. J. & Power, M. C. Anti-inflammatory drugs and risk of Parkinson disease: a meta-analysis. Neurology 74, 995-1002 (2010).
    • (2010) Neurology , vol.74 , pp. 995-1002
    • Gagne, J.J.1    Power, M.C.2
  • 52
    • 0036714747 scopus 로고    scopus 로고
    • A metaanalysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
    • Hernán, M. A., Takkouche, B., Caamaño-Isorna, F. & Gestal-Otero, J. J. A metaanalysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann. Neurol. 52, 276-284 (2002).
    • (2002) Ann. Neurol. , vol.52 , pp. 276-284
    • Hernán, M.A.1    Takkouche, B.2    Caamaño-Isorna, F.3    Gestal-Otero, J.J.4
  • 53
    • 0041653249 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
    • Chen, H. et al. Nonsteroidal anti-inflammatory drugs and the risk of parkinson disease. Arch. Neurol. 60, 1059-1064 (2003).
    • (2003) Arch. Neurol. , vol.60 , pp. 1059-1064
    • Chen, H.1


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