Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease

Journal of Experimental Medicine

Volumn 213, Issue 9, 2016, Pages 1759-1778

  Rey, Nolwen L ^a   Steiner, Jennifer A ^a   Maroof, Nazia ^a,b   Luk, Kelvin C ^c   Madaj, Zachary ^a   Trojanowski, John Q ^c   Lee, Virginia M Y ^c   Brundin, Patrik ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CINGULATE; ARTICLE; BASAL AMYGDALA; BRAIN REGION; CELL DENSITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORTICAL AMYGDALA; DORSAL RAPHE NUCLEUS; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMAN; IMMUNOREACTIVITY; LOCUS CERULEUS; MEDIAN RAPHE NUCLEUS; MITRAL CELL; MOTONEURON NUCLEUS; MOUSE; NEUROPATHOLOGY; NONHUMAN; ODOR RECOGNITION TEST; OLFACTORY BULB; OLFACTORY DISCRIMINATION; OLFACTORY NUCLEUS; OLFACTORY TRACT; OLFACTORY TUBERCLE; OPEN FIELD TEST; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PYRIFORM CORTEX; SUBSTANTIA NIGRA; SYNAPSE; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE COURSE; DISEASE MODEL; LEWY BODY; METABOLISM; NERVE TRACT; PATHOLOGY; PROTEIN AGGREGATION, PATHOLOGICAL;

ALPHA-SYNUCLEIN; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; LEWY BODIES; MICE; MICE, INBRED C57BL; NEURAL PATHWAYS; OLFACTORY BULB; OLFACTORY TUBERCLE; PARKINSON DISEASE; PROTEIN AGGREGATION, PATHOLOGICAL;

EID: 84984787903     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20160368     Document Type: Article

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