Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing

Particle and Fibre Toxicology

Volumn 14, Issue 1, 2017, Pages

  Riedle, Sebastian ^a,b,c   Pele, Laetitia C ^d   Otter, Don E ^a,e   Hewitt, Rachel E ^d,f   Singh, Harjinder ^b   Roy, Nicole C ^a,b   Powell, Jonathan J ^d,f  

^a AGRESEARCH GRASSLANDS   (New Zealand)

^b MASSEY UNIVERSITY   (New Zealand)

^c Conreso GmbH ^*  (Germany)

^d MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

E171; IL 1 ; Muramyl dipeptide; Nano; NOD2; Particle; Peptidoglycan; TiO2; TNF

Indexed keywords

INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MURAMYL DIPEPTIDE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; PEPTIDOGLYCAN; PIGMENT; TITANIUM DIOXIDE NANOPARTICLE; TUMOR NECROSIS FACTOR; AUTACOID; CARD15 PROTEIN, MOUSE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; FOOD ADDITIVE; IL1B PROTEIN, MOUSE; IMMUNOLOGICAL ADJUVANT; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; FEMALE; GENE MUTATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE CELL; MOUSE; NOD2 GENE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PHENOTYPE;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD ADDITIVES; GENOTYPE; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; PHENOTYPE; TITANIUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85045904438     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-017-0232-2     Document Type: Article

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