Evaluating web-based cognitive-affective remediation in recent trauma survivors: study rationale and protocol;Evaluación de la reparación cognitivo-afectiva basada en la web en sobrevivientes recientes de trauma: Fundamentos del estudio y protocolo

European Journal of Psychotraumatology

Volumn 9, Issue 1, 2018, Pages

  Fine, Naomi B ^a   Achituv, Michal ^a   Etkin, Amit ^b   Merin, Ofer ^c   Shalev, Arieh Y ^d  

^a SHAARE ZEDEK MEDICAL CENTER   (Israel)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cognitive affective remediation; emotion bias; emotional regulation; executive function; neuroplasticity; Post traumatic stress disorder

Indexed keywords

EID: 85045092047     PISSN: 20008198     EISSN: 20008066     Source Type: Journal    
DOI: 10.1080/20008198.2018.1442602     Document Type: Article

References (73)

1. Akiki, T. J., Averill, C. L., & Abdallah, C. G., (2017). A network-based neurobiological model of PTSD: Evidence from structural and functional neuroimaging studies. Current Psychiatry Reports, 19(11), 81. doi:10.1007/s11920-017-0840-4
2. Aupperle, R. L., Melrose, A. J., Stein, M. B., & Paulus, M. P., (2011). Executive function and PTSD: Disengaging from trauma. Neuropharmacology, 62(2), 686–11. doi:10.1016/j.neuropharm.2011.02.008
3. Beck, A. T., Epstein, N., Brown, G., & Steer, R. A., (1988). An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology, 56(6), 893–897.
4. Beck, A. T., Steer, R. A., & Brown, G. K., (1996). Beck depression inventory-II. San Antonio, 78(2), 490–498.
5. Beevers, C. G., Lee, H. J., Wells, T. T., Ellis, A. J., & Telch, M. J., (2011). Association of predeployment gaze bias for emotion stimuli with later symptoms of PTSD and depression in soldiers deployed in Iraq. American Journal of Psychiatry, 168(7), 735–741. doi:10.1176/appi.ajp.2011.10091309
6. Berg, A. O., Breslau, N., Lezak, M. D., Matchar, D. B., Mellman, T. A., Spiegel, D., & Vega, W. A., (2008). Treatment of posttraumatic stress disorder: An assessment of the evidence. Institute of Medicine of The National Academies. Washington, DC: The National Academies Press.
7. Binder, E. B., Bradley, R. G., Liu, W., Epstein, M. P., Deveau, T. C., Mercer, K. B., … Schwartz, A. C., (2008). Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. Jama, 299(11), 1291–1305. doi:10.1001/jama.299.11.1291
8. Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M., (1995). The development of a clinician‐administered PTSD scale. Journal of Traumatic Stress, 8(1), 75–90.
9. Blevins, C. A., Weathers, F. W., Davis, M. T., Witte, T. K., & Domino, J. L., (2015). The posttraumatic stress disorder checklist for DSM 5 (PCL 5): Development and initial psychometric evaluation. Journal of Traumatic Stress, 28(6), 489–498. doi:10.1002/jts.22059
10. Brewin, C. R., Andrews, B., & Valentine, J. D., (2000). Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. Journal of Consulting and Clinical Psychology, 68(5), 748–766.
11. Brunet, A., Weiss, D. S., Metzler, T. J., Best, S. R., Neylan, T. C., Rogers, C., … Marmar, C. R., (2001). The peritraumatic distress inventory: A proposed measure of PTSD criterion A2. American Journal of Psychiatry, 158(9), 1480–1485. doi:10.1176/appi.ajp.158.9.1480
12. Burri, A., Maercker, A., Krammer, S., & Simmen-Janevska, K., (2013). Childhood trauma and PTSD symptoms increase the risk of cognitive impairment in a sample of former indentured child laborers in old age. PloS One, 8(2), e57826. doi:10.1371/journal.pone.0057826
13. Cannon, R., Lubar, J., Congedo, M., Thornton, K., Towler, K., & Hutchens, T., (2007). The effects of neurofeedback training in the cognitive division of the anterior cingulate gyrus. International Journal of Neuroscience, 117(3), 337–357. doi:10.1080/00207450500514003
14. Cohen, H., Kaplan, Z., Koresh, O., Matar, M. A., Geva, A. B., & Zohar, J., (2011). Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD. European Neuropsychopharmacology, 21(3), 230–240. doi:10.1016/j.euroneuro.2010.11.011
15. Dandeneau, S. D., Baldwin, M. W., Baccus, J. R., Sakellaropoulo, M., & Pruessner, J. C., (2007). Cutting stress off at the pass: Reducing vigilance and responsiveness to social threat by manipulating attention. Journal of Personality and Social Psychology, 93(4), 651–666. doi:10.1037/0022-3514.93.4.651
16. De Bellis, M. D., Woolley, D. P., & Hooper, S. R., (2013). Neuropsychological findings in pediatric maltreatment: Relationship of PTSD, dissociative symptoms, and abuse/neglect indices to neurocognitive outcomes. Child Maltreatment, 18(3), 171–183. doi:10.1177/1077559513497420
17. Dunkin, J. J., Leuchter, A. F., Cook, I. A., Kasl-Godley, J. E., Abrams, M., & Rosenberg-Thompson, S., (2000). Executive dysfunction predicts nonresponse to fluoxetine in major depression. Journal of Affective Disorders, 60(1), 13–23.
18. Ebner-Priemer, U. W., Mauchnik, J., Kleindienst, N., Schmahl, C., Peper, M., Rosenthal, M. Z., & Bohus, M., (2009). Emotional learning during dissociative states in borderline personality disorder. Journal of Psychiatry & Neuroscience: JPN, 34(3), 214–222.
19. Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J., (2006). Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron, 51(6), 871–882. doi:10.1016/j.neuron.2006.07.029
20. Etkin, A., & Wager, T. D., (2007). Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164(10), 1476–1488.
21. Falconer, E., Allen, A., Felmingham, K. L., Williams, L. M., & Bryant, R. A., (2013). Inhibitory neural activity predicts response to cognitive-behavioral therapy for posttraumatic stress disorder. The Journal of Clinical Psychiatry, 74(9), 895–901. doi:10.4088/JCP.12m08020
22. Fani, N., Kitayama, N., Ashraf, A., Reed, L., Afzal, N., Jawed, F., & Bremner, J. D., (2009). Neuropsychological functioning in patients with posttraumatic stress disorder following short-term paroxetine treatment. Psychopharmacology Bulletin, 42(1), 53–68.
23. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W., (1995). Biometrics research. New York State Psychiatric Institute; New York: 2002. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. Clinical Trials Version (SCID-CT), 9(2), 92–104.
24. Friesen, W. V., & Ekman, P., (1976). Pictures of facial affect. Palo Alto, CA: Consulting psychologists press.
25. Geuze, E., Vermetten, E., de Kloet, C. S., Hijman, R., & Westenberg, H. G., (2009). Neuropsychological performance is related to current social and occupational functioning in veterans with posttraumatic stress disorder. Depression and Anxiety, 26(1), 7–15. doi:10.1002/da.20476
26. Gilbertson, M. W., Paulus, L. A., Williston, S. K., Gurvits, T. V., Lasko, N. B., Pitman, R. K., & Orr, S. P., (2006). Neurocognitive function in monozygotic twins discordant for combat exposure: Relationship to posttraumatic stress disorder. Journal of Abnormal Psychology, 115(3), 484–495. doi:10.1037/0021-843X.115.3.484
27. Gruzelier, J. H., (2014). EEG-neurofeedback for optimising performance. I: A review of cognitive and affective outcome in healthy participants. Neuroscience & Biobehavioral Reviews, 44, 124–141. doi:10.1016/j.neubiorev.2013.09.015
28. Gyurak, A., Gross, J., Chan, L., & Etkin, A., (2013). Cognitive-affective remediation training intervention in anxiety and depression. Neuropsychopharmacology, 38, 231.
29. Hallion, L. S., & Ruscio, A. M., (2011). A meta-analysis of the effect of cognitive bias modification on anxiety and depression. Psychological Bulletin, 137(6), 940–958. doi:10.1037/a0024355
30. Hayes, J. P., Hayes, S. M., & Mikedis, A. M., (2012). Quantitative meta-analysis of neural activity in posttraumatic stress disorder. Biology of Mood & Anxiety Disorders, 2(1), 9. doi:10.1186/2045-5380-2-9
31. Heinrichs, M., Wagner, D., Schoch, W., Soravia, L. M., Hellhammer, D. H., & Ehlert, U., (2005). Predicting posttraumatic stress symptoms from pretraumatic risk factors: A 2-year prospective follow-up study in firefighters. American Journal of Psychiatry, 162(12), 2276–2286. doi:10.1176/appi.ajp.162.12.2276
32. Hirschfeld, R. M., Williams, J. B., Spitzer, R. L., Calabrese, J. R., Flynn, L., Keck, P. E., Jr, … Russell, J. M., (2000). Development and validation of a screening instrument for bipolar spectrum disorder: The Mood Disorder Questionnaire. American Journal of Psychiatry, 157(11), 1873–1875. doi:10.1176/appi.ajp.157.11.1873
33. Hoge, C. W., Castro, C. A., Messer, S. C., McGurk, D., Cotting, D. I., & Koffman, R. L., (2004). Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. New England Journal of Medicine, 2004(351), 13–22. doi:10.1056/NEJMoa040603
34. Hoge, E. A., Worthington, J. J., Nagurney, J. T., Chang, Y., Kay, E. B., Feterowski, C. M., … Zusman, R. M., (2012). Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script‐driven imagery. CNS Neuroscience & Therapeutics, 18(1), 21–27. doi:10.1111/j.1755-5949.2010.00227.x
35. Ipser, J., Seedat, S., & Stein, D. J., (2006). Pharmacotherapy for post-traumatic stress disorder-a systematic review and meta-analysis. South African Medical Journal, 96(10), 1088–1096.
36. Jaeger, J., & Vieta, E., (2007). Functional outcome and disability in bipolar disorders: Ongoing research and future directions. Bipolar Disorders, 9(1‐2), 1–2. doi:10.1111/j.1399-5618.2007.00441.x
37. Johnsen, G. E., & Asbjørnsen, A. E., (2008). Consistent impaired verbal memory in PTSD: A meta-analysis. Journal of Affective Disorders, 111(1), 74–82. doi:10.1016/j.jad.2008.02.007
38. Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., … Nemeroff, C. B., (2013). Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neuroscience, 16(1), 33–41. doi:10.1038/nn.3275
39. Koren, D., Arnon, I., & Klein, E., (2001). Long term course of chronic posttraumatic stress disorder in traffic accident victims: A three-year prospective follow-up study. Behavior Research and Therapy, 39(12), 1449–1458. doi:10.1016/S0005-7967(01)00025-0
40. Kremen, W. S., Koenen, K. C., Boake, C., Purcell, S., Eisen, S. A., Franz, C. E., … Lyons, M. J., (2007). Pretrauma cognitive ability and risk for posttraumatic stress disorder: A twin study. Archives of General Psychiatry, 64(3), 361–368. doi:10.1001/archpsyc.64.3.361
41. Lanius, R. A., Frewen, P. A., Tursich, M., Jetly, R., & McKinnon, M. C., (2015). Restoring large-scale brain networks in PTSD and related disorders: A proposal for neuroscientifically-informed treatment interventions. European Journal of Psychotraumatology, 6(1), 27313. doi:10.3402/ejpt.v6.27313
42. Lanius, R. A., Vermetten, E., Loewenstein, R. J., Brand, B., Schmahl, C., Bremner, J. D., & Spiegel, D., (2010). Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype. American Journal of Psychiatry, 167(6), 640–647. doi:10.1176/appi.ajp.2009.09081168
43. Mayr, U., Awh, E., & Laurey, P., (2003). Conflict adaptation effects in the absence of executive control. Nature Neuroscience, 6(5), 450–452. doi:10.1038/nn1051
44. McKinnon, M. C., Boyd, J. E., Frewen, P. A., Lanius, U. F., Jetly, R., Richardson, J. D., & Lanius, R. A., (2016). A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions. Neuropsychologia, 90, 210–234. doi:10.1016/j.neuropsychologia.2016.07.017
45. Nishi, D., Matsuoka, Y., Yonemoto, N., Noguchi, H., Kim, Y., & Kanba, S., (2010). Peritraumatic Distress Inventory as a predictor of post-traumatic stress disorder after a severe motor vehicle accident. Psychiatry and Clinical Neurosciences, 64(2), 149–156. doi:10.1111/j.1440-1819.2010.02065.x
46. Ogle, C. M., Rubin, D. C., & Siegler, I. C., (2013). The impact of the developmental timing of trauma exposure on PTSD symptoms and psychosocial functioning among older adults. Developmental Psychology, 49(11), 2191–2200. doi:10.1037/a0031985
47. Parlar, M., Frewen, P. A., Oremus, C., Lanius, R. A., & McKinnon, M. C., (2016). Dissociative symptoms are associated with reduced neuropsychological performance in patients with recurrent depression and a history of trauma exposure. European Journal of Psychotraumatology, 7(1), 29061. doi:10.3402/ejpt.v7.29061
48. Pechtel, P., & Pizzagalli, D. A., (2011). Effects of early life stress on cognitive and affective function: An integrated review of human literature. Psychopharmacology, 214(1), 55–70. doi:10.1007/s00213-010-2009-2
49. Perkonigg, A., Pfister, H., Stein, M. B., Höfler, M., Lieb, R., Maercker, A., & Wittchen, H. U., (2005). Longitudinal course of posttraumatic stress disorder and posttraumatic stress disorder symptoms in a community sample of adolescents and young adults. American Journal of Psychiatry, 162(7), 1320–1327. doi:10.1176/appi.ajp.162.7.1320
50. Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., … Liberzon, I., (2012). Biological studies of post-traumatic stress disorder. Nature Reviews Neuroscience, 13(11), 769–787. doi:10.1038/nrn3339
51. Pitman, R. K., Sanders, K. M., Zusman, R. M., Healy, A. R., Cheema, F., Lasko, N. B., … Orr, S. P., (2002). Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry, 51(2), 189–192.
52. Polak, A. R., Witteveen, A. B., Reitsma, J. B., & Olff, M., (2012). The role of executive function in posttraumatic stress disorder: A systematic review. Journal of Affective Disorders, 141(1), 11–21. doi:10.1016/j.jad.2012.01.001
53. Rivera-Vélez, G. M., González-Viruet, M., Martínez-Taboas, A., & Pérez-Mojica, D., (2014). Post-traumatic stress disorder, dissociation, and neuropsychological performance in Latina victims of childhood sexual abuse. Journal of Child Sexual Abuse, 23(1), 55–73. doi:10.1080/10538712.2014.864746
54. Roberts, D., Kitchiner, N. J., Kenardy, J., & Bisson, J. I., (2009). Systematic review and meta-analysis of multiple-session early interventions following traumatic events. American Journal of Psychiatry, 166(3), 293–301. doi:10.1176/appi.ajp.2008.08040590
55. Roberts, N. P., Kitchiner, N. J., Kenardy, J., & Bisson, J. I., (2010). Early psychological interventions to treat acute traumatic stress symptoms. The Cochrane Library: Cochrane Database of Systematic Reviews, 3, CD007944. doi: 10.1002/14651858.CD007944.pub2.
56. Roca, V., Hart, J., Kimbrell, T., & Freeman, T., (2006). Cognitive function and dissociative disorder status among veteran subjects with chronic posttraumatic stress disorder: A preliminary study. The Journal of Neuropsychiatry and Clinical Neurosciences, 18(2), 226–230. doi:10.1176/jnp.2006.18.2.226
57. Rohde, P., Lewinsohn, P. M., & Seeley, J. R., (1997). Comparability of telephone and face-to-face interviews in assessing axis I and II disorders. American Journal of Psychiatry, 154(11), 1593–1598. doi:10.1176/ajp.154.11.1593
58. Samuelson, K. W., (2011). Post-traumatic stress disorder and declarative memory functioning: A review. Dialogues in Clinical Neuroscience, 13(3), 346.
59. Saunders, N., Downham, R., Turman, B., Kropotov, J., Clark, R., Yumash, R., & Szatmary, A., (2015). Working memory training with tDCS improves behavioral and neurophysiological symptoms in pilot group with post-traumatic stress disorder (PTSD) and with poor working memory. Neurocase, 21(3), 271–278. doi:10.1080/13554794.2014.890727
60. Scott, J. C., Matt, G. E., Wrocklage, K. M., Crnich, C., Jordan, J., Southwick, S. M., & Schweinsburg, B. C., (2015). A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder. Psychological Bulletin, 141(1), 105–140. doi:10.1037/a0038039
61. Shalev, A. Y., Ankri, Y., Israeli-Shalev, Y., Peleg, T., Adessky, R., & Freedman, S., (2012). Prevention of posttraumatic stress disorder by early treatment: Results from the Jerusalem Trauma Outreach And Prevention study. Archives of General Psychiatry, 69(2), 166–176. doi:10.1001/archgenpsychiatry.2011.127
62. Shalev, A. Y., Ankri, Y. L., Peleg, T., Israeli-Shalev, Y., & Freedman, S., (2011). Barriers to receiving early care for PTSD: Results from the Jerusalem trauma outreach and prevention study. Psychiatric Services, 62(7), 765–773. doi:10.1176/ps.62.7.pss6207_0765
63. Silverstein, S. M., Berten, S., Olson, P., Paul, R., Williams, L. M., Cooper, N., & Gordon, E., (2007). Development and validation of a World-Wide-Web-based neurocognitive assessment battery: WebNeuro. Behavior Research Methods, 39(4), 940–949.
64. Sripada, R. K., King, A. P., Welsh, R. C., Garfinkel, S. N., Wang, X., Sripada, C. S., & Liberzon, I., (2012). Neural dysregulation in posttraumatic stress disorder: Evidence for disrupted equilibrium between salience and default mode brain networks. Psychosomatic Medicine, 74(9), 904. doi:10.1097/PSY.0b013e318273bf33
65. Stein, M. B., Kerridge, C., Dimsdale, J. E., & Hoyt, D. B., (2007). Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof‐of‐concept trial in physically injured patients. Journal of Traumatic Stress, 20(6), 923–932. doi:10.1002/jts.20270
66. Stroop, J. R., (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18(6), 643. doi:10.1037/h0054651
67. Vasterling, J. J., & Brailey, K., (2005). Neuropsychological findings in adults with PTSD. In J. J. Vasterling & C. R. Brewin (Eds.), Neuropsychology of PTSD: Biological, cognitive, and clinical perspectives (pp. 178–207). New York: Guilford Press.
68. Vernon, D., Egner, T., Cooper, N., Compton, T., Neilands, C., Sheri, A., & Gruzelier, J., (2003). The effect of training distinct neurofeedback protocols on aspects of cognitive performance. International Journal of Psychophysiology, 47(1), 75–85.
69. Wald, I., Shechner, T., Bitton, S., Holoshitz, Y., Charney, D. S., Muller, D., … Bar-Haim, Y., (2011). Attention bias away from threat during life threatening danger predicts PTSD symptoms at one‐year follow-up. Depression and Anxiety, 28(5), 406–411. doi:10.1002/da.20808
70. Weathers, F. W., Blake, D. D., Schnurr, P. P., Kaloupek, D. G., Marx, B. P., & Keane, T. M., (2016). The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). 2013. Interview available from the National Center for PTSD at www.ptsd.va.gov.
71. Weathers, F. W., Bovin, M. J., Lee, D. J., Sloan, D. M., Schnurr, P. P., Kaloupek, D. G., … Marx, B. P., (2017). The clinician-administered PTSD scale for DSM–5 (CAPS-5): Development and initial psychometric evaluation in military veterans. White River Junction, VT: National Center for PTSD.
72. Wild, J., & Gur, R. C., (2008). Verbal memory and treatment response in post-traumatic stress disorder. The British Journal of Psychiatry, 193(3), 254–255. doi:10.1192/bjp.bp.107.045922
73. Wrocklage, K. M., Schweinsburg, B. C., Krystal, J. H., Trejo, M., Roy, A., Weisser, V., & Scott, J. C., (2016). Neuropsychological functioning in veterans with posttraumatic stress disorder: Associations with performance validity, comorbidities, and functional outcomes. Journal of the International Neuropsychological Society, 22(4), 399–411. doi:10.1017/S1355617716000059