Emotional learning during dissociative states in borderline personality disorder

Journal of Psychiatry and Neuroscience

Volumn 34, Issue 3, 2009, Pages 214-222

  Ebner Priemer, Ulrich W ^a   Mauchnik, Jana ^a   Kleindienst, Nikolaus ^a   Schmahl, Christian ^a   Peper, Martin ^b   Rosenthal, M Zachary ^c   Flor, Herta ^a   Bohus, Martin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; AROUSAL; ARTICLE; AUDITORY THRESHOLD; BORDERLINE STATE; CLINICAL ARTICLE; COGNITION; CONDITIONING; CONTROLLED STUDY; DECLARATIVE MEMORY; DISSOCIATIVE DISORDER; EMOTION; FEMALE; HUMAN; LEARNING; PSYCHOTHERAPY; REINFORCEMENT; SKIN CONDUCTANCE;

EID: 67749124388     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Sierra M, Senior C, Dalton J, et al. Autonomic response in depersonalization disorder. Arch Gen Psychiatry 2002;59:833-8.
2. Sierra M, Senior C, Phillips ML, et al. Autonomic response in the perception of disgust and happiness in depersonalization disorder. Psychiatry Res 2006;145:225-31.
3. Phillips ML, Medford N, Senior C, et al. Depersonalization disorder: thinking without feeling. Psychiatry Res 2001;108:145-60.
4. Medford N, Brierley B, Brammer M, et al. Emotional memory in depersonalization disorder: a functional MRI study. Psychiatry Res 2006;148:93-102.
5. Lanius RA, Williamson PC, Boksman K, et al. Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation. Biol Psychiatry 2002;52:305-11.
6. Lanius RA, Williamson PC, Menon RS. Neuroimaging of hyperaroused and dissociative states in posttraumatic stress disorder. CPA Bulletin 2002;34:22-5. Available: http://ww1.cpa-apc.org:8080 /publications/ archives/Bulletin/2002/august/laniusEn.asp (accessed 2009 Mar. 2).
7. Lanius RA, Williamson PC, Bluhm RL, et al. Functional connectivity of disassociative responses in posttraumatic stress disorder: a functional magnetic resonance imaging investigation. Biol Psychiatry 2005;57:873-84.
8. Simeon D, Knutelska M, Yehuda R, et al. Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biol Psychiatry 2007;61:966-73.
9. Ebner-Priemer UW, Badeck S, Beckmann CF, et al. Affective dysregulation and dissociative experience in female patients with borderline personality disorder: a startle response study. J Psychiatr Res 2005;39:85-92.
10. Michelson L, Vives A, Testa S, et al. The role of trauma and dissociation in cognitive-behavioral psychotherapy outcome and maintenance for panic disorder with agoraphobia. Behav Res Ther 1998;36:1011-50.
11. Rufer M, Held D, Cremer J, et al. Dissociation as a predictor of cognitive behavior therapy outcome in patients with obsessive-compulsive Disorder. Psychother Psychosom 2006;75:40-6.
12. Sierra M, Berrios GE. Depersonalization: neurobiological perspectives. Biol Psychiatry 1998;44:898-908.
13. Rosen JB, Hitchcock JM, Sananes CB, et al. A direct projection from the central nucleus of the amygdala to the acoustic startle pathway: anterograde and retrograde tracing studies. Behav Neurosci 1991;105:817-25.
14. Jaycox LH, Foa EB, Morral AR. Influence of emotional engagement and habituation on exposure therapy for PTSD. J Consult Clin Psychol 1998;66:185-92.
15. Giesbrecht T, Lynn SJ, Lilienfeld SO, et al. Cognitive processes in dissociation: an analysis of core theoretical assumptions. Psychol Bull 2008;134:617-47.
16. Bechara A, Tranel D, Damasio H, et al. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995;269:1115-8.
17. Williams LM, Phillips ML, Brammer MJ, et al. Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage 2001; 14:1070-9.
18. Campeau S, Davis M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 1995;15:2301-11.
19. LaBar KS, Gatenby JC, Gore JC, et al. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron 1998;20:937-45.
20. Knight DC, Nguyen HT, Bandettini PA. The role of the human] amygdala in the production of conditioned fear responses. Neuroimage 2005;26:1193-200.
21. Büchel C, Morris J, Dolan RJ, et al. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron 1998; 20:947-57.
22. First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). Washington (DC): American Psychiatric Press; 1996.
23. Loranger AW. Assessment and diagnosis of personality disorders: International Personality Disorder Examination (IPDE). New York (NY): Cambridge; 1997.
24. Stiglmayr CE, Shapiro DA, Stieglitz RD, et al. Experience of aversive tension and dissociation in female patients with borderline personality disorder - a controlled study. J Psychiatr Res 2001;35:111-8.
25. Bernstein EM, Putnam FW. Development, reliability, and validity of a dissociation scale. J Nerv Ment Dis 1986;174:727-35.
26. Nijenhuis ERS, Spinhoven P, van Dyck R, et al. The development and psychometric characteristics of the Somatoform Dissociation Questionnaire (SDQ-20). J Nerv Ment Dis 1996;184:688-94.
27. Stiglmayr CE, Braakmann D, Haaf B, et al. Construction and psychometric properties of the Dissoziations-Spannungs-Skala (DSSakut), a self-rating scale assessing dissociative symptoms and aversive inner tensions. Psychother Psychosom Med Psychol 2003;53:287-94.
28. Freyberger HJ, Spitzer C, Stieglitz RD, et al. Adaptation and psychometric properties of the German version of the Dissociative Experience Scale. J Trauma Stress 1998;11:799-809.
29. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97-113.
30. Bohus M, Limberger MF, Frank U, et al. Psychometric properties of the Borderline Symptom List (BSL). Psychopathology 2007;40:126-32.
31. Schmahl C, Bohus M, Esposito F, et al. Neural correlates of antinociception in borderline personality disorder. Arch Gen Psychiatry 2006; 63:659-67.
32. Peper M, Karcher S, Wohlfarth R, et al. Aversive learning in patients with unilateral lesions of the amygdala and hippocampus. Biol Psychol 2001;58:1-23.
33. Michael T, Blechert J, Vriends N, et al. Fear conditioning in panic disorder: enhanced resistance to extinction. J Abnorm Psychol 2007; 116:612-7.
34. Baeyens F, Eelen P, Van den Bergh O. Contingency awareness in evaluative conditioning: a case for unaware affective-evaluative learning. Cogn Emot 1990;4:3-18.
35. Boucsein W. Electrodermal activity. New York (NY): Plenum; 1992. p. 136.
36. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale (NJ): Lawrence Erlbaum Associates; 1988.
37. Wilensky AE, Schafe GE, Kristensen MP, et al. Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J Neurosci 2006;26:12387-96.
38. Pare D, Quirk GJ, LeDoux JE. New vistas on amygdala networks in conditioned fear. J Neurophysiol 2004;92:1-9.
39. Fischer AH. Gender and emotion. New York (NY): Cambridge University Press; 2000.
40. Sar V, Akyuz G, Kugu N, et al. Axis I dissociative disorder comorbidity in borderline personality disorder and reports of childhood trauma. J Clin Psychiatry 2006;67:1583-90.
41. Sar V, Kundakci T, Kiziltan E, et al. The Axis-I dissociative disorder comorbidity of borderline personality disorder among psychiatric outpatients. J Trauma Dissociation 2003;4:119-36.
42. Holmes EA, Brown RJ, Mansell W, et al. Are there two qualitatively distinct forms of dissociation? A review and some clinical implications. Clin Psychol Rev 2005;25:1-23.
43. Stiglmayr CE, Ebner-Priemer UW, Bretz J, et al. Dissociative symptoms are positively related to stress in borderline personality disorder. Acta Psychiatr Scand 2008;117:139-47.
44. Barad M, Gean PW, Lutz B. The role of the amygdala in the extinction of conditioned fear. Biol Psychiatry 2006;60:322-8.
45. Grosjean B, Tsai GE. NMDA neurotransmission as a critical mediator of borderline personality disorder. J Psychiatry Neurosci 2007;32: 103-15.