Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats

Carbohydrate Polymers

Volumn 99, Issue , 2014, Pages 297-305

  Bshara, Hamza ^a   Osman, Rihab ^a   Mansour, Samar ^a   El Shamy, Abd El Hameed A ^a  

^a Ain Shams University   (Egypt)

Author keywords

Brain targeting; Buspirone hydrochloride; Chitosan; Intranasal delivery; Microemulsion; Mucoadhesive

Indexed keywords

BRAIN TARGETING; BUSPIRONE HYDROCHLORIDE; HISTOPATHOLOGICAL EXAMINATIONS; INTRANASAL; INTRAVENOUS ADMINISTRATION; MUCOADHESIVE; PHARMACOKINETIC STUDIES; PLASMA CONCENTRATION;

BIOCHEMISTRY; CHITOSAN; CYCLODEXTRINS; DRUG PRODUCTS; PHARMACOKINETICS; RATS;

MICROEMULSIONS;

RATTUS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; ANXIOLYTIC AGENT; BETA CYCLODEXTRIN DERIVATIVE; BUSPIRONE; CHITOSAN; DRUG DERIVATIVE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BRAIN; BRAIN TARGETING; CHEMISTRY; DRUG EFFECT; EMULSION; INTRANASAL DELIVERY; INTRANASAL DRUG ADMINISTRATION; MALE; METABOLISM; MICROEMULSION; MUCOADHESIVE; NOSE MUCOSA; RAT; TISSUE DISTRIBUTION; VASCULARIZATION; WISTAR RAT;

BRAIN TARGETING; BUSPIRONE HYDROCHLORIDE; CHITOSAN; INTRANASAL DELIVERY; MICROEMULSION; MUCOADHESIVE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTI-ANXIETY AGENTS; AREA UNDER CURVE; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; BRAIN; BUSPIRONE; CHITOSAN; EMULSIONS; MALE; NASAL MUCOSA; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 84883635050     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2013.08.027     Document Type: Article

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