Validation of an HPLC-UV method for analysis of Kaempferol-loaded nanoemulsion and its application to in vitro and in vivo tests

Journal of Pharmaceutical and Biomedical Analysis

Volumn 145, Issue , 2017, Pages 831-837

  Colombo, Mariana ^a   Melchiades, Gabriela de Lima ^a   Figueiró, Fabrício ^a   Battastini, Ana Maria Oliveira ^a   Teixeira, Helder Ferreira ^a   Koester, Letícia Scherer ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Brain delivery; High performance liquid chromatography; Kaempferol; Nanoemulsion; Permeation retention assays; Validation

Indexed keywords

KAEMPFEROL DERIVATIVE;

ANIMAL; DRUG DELIVERY SYSTEM; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; RAT; REPRODUCIBILITY; VALIDATION STUDY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; EMULSIONS; KAEMPFEROLS; MICE; RATS; REPRODUCIBILITY OF RESULTS;

EID: 85027511654     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2017.07.046     Document Type: Article

References (30)

1. Aherne, S.A., O'Brien, N.M., Dietary flavonols: chemistry, food content, and metabolism. Nutrition 18:1 (2002), 75–81.
2. Spencer, J.P., Flavonoids: modulators of brain function?. Br. J. Nutr., 99(1), 2008.
3. Calderon-Montano, J.M., Burgos-Moron, E., Perez-Guerrero, C., Lopez-Lazaro, M., A review on the dietary flavonoid kaempferol. Mini-Rev. Med. Chem. 11:4 (2011), 298–344.
4. Devi, K.P., Malar, D.S., Nabavi, S.F., Sureda, A., Xiao, J., Nabavi, S.M., Daglia, M., Kaempferol and inflammation. From chemistry to medicine. Pharmacol. Res. 99 (2015), 1–10.
5. Chen, A.Y., Chen, Y.C., A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 138:4 (2013), 2099–2107.
6. Sharma, V., Joseph, C., Ghosh, S., Agarwal, A., Mishra, M.K., Sen, E., Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol. Cancer Ther. 6:9 (2007), 2544–2553.
7. Filomeni, G., Graziani, I., De Zio, D., Dini, L., Centonze, D., Rotilio, G., Ciriolo, M.R., Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol. Aging 33:4 (2012), 767–785.
8. Barve, A., Chen, C., Hebbar, V., Desiderio, J., Saw, C.L., Kong, A.N., Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm. Drug Dispos. 30:7 (2009), 356–365.
9. Kozlovskaya, L., Abou-Kaoud, M., Stepensky, D., Quantitative analysis of drug delivery to the brain via nasal route. J. Control. Release 189 (2014), 133–140.
10. Ong, W.Y., Shalini, S.M., Costantino, L., Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders. Curr. Med. Chem. 21:37 (2014), 4247–4256.
11. Illum, L., Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11:1 (2000), 1–18.
12. Comfort, C., Garrastazu, G., Pozzoli, M., Sonvico, F., Opportunities and challenges for the nasal administration of nanoemulsions. Curr. Top. Med. Chem. 15:4 (2015), 356–368.
13. Carvalho, F.C., Campos, M.L., Peccinini, R.G., Gremiao, M.P., Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy. Eur. J. Pharm. Biopharm. 84:1 (2013), 219–227.
14. ICH, International Conference on Harmonization, Technical Requirements for the Registration of Pharmaceutical for Human Use, Validation of Analytical Procedures: Text and Methodology Q2(R1). 2005, 1–13.
15. Food, F.D.A., Administration, Drug, Center for drug evaluation and research. Guidance Industry: Bioanal. Method Vali., 2013, 1–34.
16. EMA, European Medicines Agency, EMEA/CHMP/EWP/192217/2009 Guideline on Bioanalytical Method Validation. 2011, 1–22.
17. Food, F.D.A., Administration, Drug, Center for Drug Evaluation and Research Reviewer Guidance: Validation of Chromatographic Methods. 1994, 1–30.
18. Nemitz, M.C., Yatsu, F.K., Bidone, J., Koester, L.S., Bassani, V.L., Garcia, C.V., Mendez, A.S., von Poser, G.L., Teixeira, H.F., A versatile, stability-indicating and high-throughput ultra-fast liquid chromatography method for the determination of isoflavone aglycones in soybeans, topical formulations, and permeation assays. Talanta 134 (2015), 183–193.
19. Bianchi, S.E., Teixeira, H.F., Kaiser, S., Ortega, G.G., Schneider, P.H., Bassani, V.L., A bioanalytical HPLC method for coumestrol quantification in skin permeation tests followed by UPLC-QTOF/HDMS stability-indicating method for identification of degradation products. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1 (2016), 43–52.
20. Carini, J.P., Kaiser, S., Ortega, G.G., Bassani, V.L., Development, optimisation and validation of a stability-indicating HPLC method of achyrobichalcone quantification using experimental designs. Phytochem. Anal. 24:3 (2013), 193–200.
21. Dube, A., Ng, K., Nicolazzo, J.A., Larson, I., Effective use of reducing agents and nanoparticle encapsulation in stabilizing catechins in alkaline solution. Food Chem. 122:3 (2010), 662–667.
22. Chiu, M.L., Lawi, W., Snyder, S.T., Wong, P.K., Liao, J.C., Gau, V., Matrix effects—a challenge toward automation of molecular analysis. J. Assoc. Labor. Automa. 15:3 (2010), 233–242.
23. Mistry, A., Stolnik, S., Illum, L., Nose-to-Brain delivery investigation of the transport of nanoparticles with different surface characteristics and sizes in excised porcine olfactory epithelium. Mol. Pharm. 12:8 (2015), 2755–2766.
24. Ng, S.F., Rouse, J.J., Sanderson, F.D., Meidan, V., Eccleston, G.M., Validation of a static Franz diffusion cell system for in vitro permeation studies. AAPS PharmSciTech 11:3 (2010), 1432–1441.
25. Zhang, Q., Zhang, Y., Zhang, Z., Lu, Z., Sensitive determination of kaempferol in rat plasma by high-performance liquid chromatography with chemiluminescence detection and application to a pharmacokinetic study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877:29 (2009), 3595–3600.
26. Moradi-Afrapoli, F., Oufir, M., Walter, F.R., Deli, M.A., Smiesko, M., Zabela, V., Butterweck, V., Hamburger, M., Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies. J. Pharm. Biomed. Anal. 128 (2016), 264–274.
27. Zhang, K., Gu, L., Chen, J., Zhang, Y., Jiang, Y., Zhao, L., Bi, K., Chen, X., Preparation and evaluation of kaempferol-phospholipid complex for pharmacokinetics and bioavailability in SD rats. J. Pharm. Biomed. Anal. 114 (2015), 168–175.
28. Chao, Y., Huang, C.T., Fu, L.T., Huang, Y.B., Tsai, Y.H., Wu, P.C., The effect of submicron emulsion systems on transdermal delivery of kaempferol. Chem. Pharm. Bull. 60:9 (2012), 1171–1175.
29. Ilk, S., Saglam, N., Ozgen, M., Kaempferol loaded lecithin/chitosan nanoparticles: preparation, characterization, and their potential applications as a sustainable antifungal agent. Artif Cells Nanomed. Biotechnol. 45:5 (2017), 907–916.
30. Yang, Y., Bai, L., Li, X., Xiong, J., Xu, P., Guo, C., Xue, M., Transport of active flavonoids, based on cytotoxicity and lipophilicity: an evaluation using the blood-brain barrier cell and Caco-2 cell models. Toxicol. In Vitro 28:3 (2014), 388–396.