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Volumn 217, Issue 7, 2018, Pages 1160-1169

Respiratory Syncytial Virus and Rhinovirus Bronchiolitis Are Associated with Distinct Metabolic Pathways

Author keywords

Bronchiolitis; metabolomics; microbiome; respiratory syncytial virus; rhinovirus

Indexed keywords

4 HYDROXYPHENYLPYRUVATE; 4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; ADENINE; AFALANINE; AMINO ACID; AZELAIC ACID; BETA HYDROXYISOVALERATE; CAPRATE; CYSTINE; FOLIC ACID; GLUCONIC ACID; GLUCURONIC ACID; GLYCEROL; GLYCEROPHOSPHATE; LAURIC ACID; LIPID; MEVALONOLACTONE; N ACETYLARGININE; N ACETYLGLUTAMIC ACID; N ACETYLISOLEUCINE; N ACETYLLEUCINE; N ACETYLTAURINE; N ACETYLTHREONINE; N ACETYLTYROSINE; N ACETYLVALINE; N FORMYLPHENYLALANINE; N6 ACETYLLYSINE; PALMITIC AMIDE; SULFATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 85044210978     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix680     Document Type: Article
Times cited : (50)

References (43)
  • 2
    • 84865610947 scopus 로고    scopus 로고
    • Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis
    • MARC-30 Investigators
    • Mansbach JM, Piedra PA, Teach SJ, et al.; MARC-30 Investigators. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med 2012; 166:700-6.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , pp. 700-706
    • Mansbach, J.M.1    Piedra, P.A.2    Teach, S.J.3
  • 3
    • 84908881839 scopus 로고    scopus 로고
    • Clinical practice guideline: The diagnosis, management, and prevention of bronchiolitis
    • American Academy of Pediatrics
    • Ralston SL, Lieberthal AS, Meissner HC, et al.; American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics 2014; 134:e1474-502.
    • (2014) Pediatrics , vol.134 , pp. e1474-e1502
    • Ralston, S.L.1    Lieberthal, A.S.2    Meissner, H.C.3
  • 4
    • 34547230736 scopus 로고    scopus 로고
    • A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis
    • Bronchiolitis Study Group of the Pediatric Emergency Care Applied Research Network (PECARN)
    • Corneli HM, Zorc JJ, Mahajan P, et al.; Bronchiolitis Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med 2007; 357:331-9.
    • (2007) N Engl J Med , vol.357 , pp. 331-339
    • Corneli, H.M.1    Zorc, J.J.2    Mahajan, P.3
  • 5
    • 65649099285 scopus 로고    scopus 로고
    • Pediatric Emergency Research Canada (PERC). Epinephrine and dexamethasone in children with bronchiolitis
    • Plint AC, Johnson DW, Patel H, et al.; Pediatric Emergency Research Canada (PERC). Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med 2009; 360:2079-89.
    • (2009) N Engl J Med , vol.360 , pp. 2079-2089
    • Plint, A.C.1    Johnson, D.W.2    Patel, H.3
  • 6
    • 84977533970 scopus 로고    scopus 로고
    • A clustering approach to identify severe bronchiolitis profiles in children
    • Dumas O, Mansbach JM, Jartti T, et al. A clustering approach to identify severe bronchiolitis profiles in children. Thorax 2016; 71:712-8.
    • (2016) Thorax , vol.71 , pp. 712-718
    • Dumas, O.1    Mansbach, J.M.2    Jartti, T.3
  • 7
    • 52749097374 scopus 로고    scopus 로고
    • Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children
    • Jackson DJ, Gangnon RE, Evans MD, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178:667-72.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 667-672
    • Jackson, D.J.1    Gangnon, R.E.2    Evans, M.D.3
  • 8
    • 84992210037 scopus 로고    scopus 로고
    • Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence
    • Rubner FJ, Jackson DJ, Evans MD, et al. Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence. J Allergy Clin Immunol 2017; 139:501-7.
    • (2017) J Allergy Clin Immunol , vol.139 , pp. 501-507
    • Rubner, F.J.1    Jackson, D.J.2    Evans, M.D.3
  • 9
    • 84962467486 scopus 로고    scopus 로고
    • Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota
    • e4
    • Mansbach JM, Hasegawa K, Henke DM, et al. Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota. J Allergy Clin Immunol 2016; 137:1909-1913. e4.
    • (2016) J Allergy Clin Immunol , vol.137 , pp. 1909-1913
    • Mansbach, J.M.1    Hasegawa, K.2    Henke, D.M.3
  • 10
    • 85026304198 scopus 로고    scopus 로고
    • Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. A multiomic analysis
    • Stewart CJ, Mansbach JM, Wong MC, et al. Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. A multiomic analysis. Am J Respir Crit Care Med 2017; 196:882-91.
    • (2017) Am J Respir Crit Care Med , vol.196 , pp. 882-891
    • Stewart, C.J.1    Mansbach, J.M.2    Wong, M.C.3
  • 11
    • 84929658044 scopus 로고    scopus 로고
    • Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: Multicenter cohort studies in the United States and Finland
    • Hasegawa K, Jartti T, Mansbach JM, et al. Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis 2015; 211:1550-9.
    • (2015) J Infect Dis , vol.211 , pp. 1550-1559
    • Hasegawa, K.1    Jartti, T.2    Mansbach, J.M.3
  • 12
    • 68849083050 scopus 로고    scopus 로고
    • Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
    • Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 2009; 81:6656-67.
    • (2009) Anal Chem , vol.81 , pp. 6656-6667
    • Evans, A.M.1    DeHaven, C.D.2    Barrett, T.3    Mitchell, M.4    Milgram, E.5
  • 13
    • 84994259528 scopus 로고    scopus 로고
    • Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis
    • the MARC-35 Investigators
    • Hasegawa K, Mansbach JM, Ajami NJ, et al.; the MARC-35 Investigators. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis. Eur Respir J 2016; 48:1329-39.
    • (2016) Eur Respir J , vol.48 , pp. 1329-1339
    • Hasegawa, K.1    Mansbach, J.M.2    Ajami, N.J.3
  • 14
    • 84864718456 scopus 로고    scopus 로고
    • A framework for human microbiome research
    • Human T, Project M, Huttenhower C, et al. A framework for human microbiome research. Nature 2012; 486:207-214.
    • (2012) Nature , vol.486 , pp. 207-214
    • Human, T.1    Project, M.2    Huttenhower, C.3
  • 15
    • 84863981120 scopus 로고    scopus 로고
    • Ultra-highthroughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
    • Caporaso JG, Lauber CL, Walters WA, et al. Ultra-highthroughput microbial community analysis on the Illumina HiSeq and MiSeq platforms. ISME J 2012; 6:1621-4.
    • (2012) ISME J , vol.6 , pp. 1621-1624
    • Caporaso, J.G.1    Lauber, C.L.2    Walters, W.A.3
  • 17
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 1995; 57:289-300.
    • (1995) J R Stat Soc ser B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 18
    • 70350694448 scopus 로고    scopus 로고
    • IntegrOmics: An R package to unravel relationships between two omics datasets
    • Le Cao KA, Gonzalez I, Dejean S. integrOmics: an R package to unravel relationships between two omics datasets. Bioinformatics 2009; 25:2855-6.
    • (2009) Bioinformatics , vol.25 , pp. 2855-2856
    • Le Cao, K.A.1    Gonzalez, I.2    Dejean, S.3
  • 19
    • 84863304598 scopus 로고    scopus 로고
    • Team RC. Vienna, Austria: R Foundation for Statistical Computing. Accessed 16 January 2018
    • Team RC. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2014. http://www. r-project. org/. Accessed 16 January 2018.
    • (2014) R: A Language and Environment for Statistical Computing
  • 20
    • 85009754961 scopus 로고    scopus 로고
    • Systematic characterization and analysis of the taxonomic drivers of functional shifts in the human microbiome
    • Manor O, Borenstein E. Systematic characterization and analysis of the taxonomic drivers of functional shifts in the human microbiome. Cell Host Microbe 2017; 21:254-67.
    • (2017) Cell Host Microbe , vol.21 , pp. 254-267
    • Manor, O.1    Borenstein, E.2
  • 21
    • 85041927917 scopus 로고    scopus 로고
    • Metabolic model-based integration of microbiome taxonomic and metabolomic profiles elucidates mechanistic links between ecological and metabolic variation
    • Noecker C, Eng A, Srinivasan S, et al. Metabolic model-based integration of microbiome taxonomic and metabolomic profiles elucidates mechanistic links between ecological and metabolic variation. mSystems 2016; 1:e00013-15.
    • (2016) MSystems , vol.1 , pp. e00013-15
    • Noecker, C.1    Eng, A.2    Srinivasan, S.3
  • 22
    • 0002154022 scopus 로고    scopus 로고
    • A new method for non-parametric multivariate analysis of variance
    • Anderson MJ. A new method for non-parametric multivariate analysis of variance. Austral Ecol 2001; 26:32-46.
    • (2001) Austral Ecol , vol.26 , pp. 32-46
    • Anderson, M.J.1
  • 23
    • 84954057636 scopus 로고    scopus 로고
    • Viral bronchiolitis in children
    • Meissner HC. Viral bronchiolitis in children. N Engl J Med 2016; 374:62-72.
    • (2016) N Engl J Med , vol.374 , pp. 62-72
    • Meissner, H.C.1
  • 24
    • 84947930955 scopus 로고    scopus 로고
    • Detection of respiratory syncytial virus and rhinovirus in healthy infants
    • Hasegawa K, Linnemann RW, Avadhanula V, et al. Detection of respiratory syncytial virus and rhinovirus in healthy infants. BMC Res Notes 2015; 8:718.
    • (2015) BMC Res Notes , vol.8 , pp. 718
    • Hasegawa, K.1    Linnemann, R.W.2    Avadhanula, V.3
  • 25
    • 84971457547 scopus 로고    scopus 로고
    • Children hospitalized with rhinovirus bronchiolitis have asthma-like characteristics
    • e1
    • Mansbach JM, Clark S, Teach SJ, et al. Children hospitalized with rhinovirus bronchiolitis have asthma-like characteristics. J Pediatr 2016; 172:202-204. e1.
    • (2016) J Pediatr , vol.172 , pp. 202-204
    • Mansbach, J.M.1    Clark, S.2    Teach, S.J.3
  • 26
    • 78349243640 scopus 로고    scopus 로고
    • Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    • DeVincenzo JP, Wilkinson T, Vaishnaw A, et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am J Respir Crit Care Med 2010; 182:1305-14.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1305-1314
    • DeVincenzo, J.P.1    Wilkinson, T.2    Vaishnaw, A.3
  • 27
    • 84938743946 scopus 로고    scopus 로고
    • Rhinovirus-induced bronchiolitis: Lack of association between virus genomic load and short-term outcomes
    • e11
    • Jartti T, Hasegawa K, Mansbach JM, Piedra PA, Camargo CA. Rhinovirus-induced bronchiolitis: lack of association between virus genomic load and short-term outcomes. J Allergy Clin Immunol 2015; 136:509-12. e11.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 509-512
    • Jartti, T.1    Hasegawa, K.2    Mansbach, J.M.3    Piedra, P.A.4    Camargo, C.A.5
  • 29
    • 77954013335 scopus 로고    scopus 로고
    • Bacterial protein acetylation: The dawning of a new age
    • Linda IH, Bruno PL, Alan JW. Bacterial protein acetylation: the dawning of a new age. Mol Microbiol 2010; 77:15-21.
    • (2010) Mol Microbiol , vol.77 , pp. 15-21
    • Linda, I.H.1    Bruno, P.L.2    Alan, J.W.3
  • 30
    • 14744285888 scopus 로고    scopus 로고
    • Histone acetylation and deacetylation: Importance in inflammatory lung diseases
    • Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 2005; 25:552-63.
    • (2005) Eur Respir J , vol.25 , pp. 552-563
    • Barnes, P.J.1    Adcock, I.M.2    Ito, K.3
  • 31
    • 70350494508 scopus 로고    scopus 로고
    • Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma
    • Mansbach JM, Camargo CA Jr. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med 2009; 29:741-55.
    • (2009) Clin Lab Med , vol.29 , pp. 741-755
    • Mansbach, J.M.1    Camargo, C.A.2
  • 33
    • 84954320531 scopus 로고    scopus 로고
    • Understanding the association of human rhinovirus with asthma
    • Stone CA Jr, Miller EK. Understanding the association of human rhinovirus with asthma. Clin Vaccine Immunol 2015; 23:6-10.
    • (2015) Clin Vaccine Immunol , vol.23 , pp. 6-10
    • Stone, C.A.1    Miller, E.K.2
  • 34
    • 84949604733 scopus 로고    scopus 로고
    • Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome
    • Quinn RA, Phelan VV, Whiteson KL, et al. Microbial, host and xenobiotic diversity in the cystic fibrosis sputum metabolome. ISME J 2016; 10:1483-98.
    • (2016) ISME J , vol.10 , pp. 1483-1498
    • Quinn, R.A.1    Phelan, V.V.2    Whiteson, K.L.3
  • 35
    • 84856694085 scopus 로고    scopus 로고
    • Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling
    • Hartel T, Eylert E, Schulz C, et al. Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. J Biol Chem 2012; 287:4260-74.
    • (2012) J Biol Chem , vol.287 , pp. 4260-4274
    • Hartel, T.1    Eylert, E.2    Schulz, C.3
  • 36
    • 84966710186 scopus 로고    scopus 로고
    • Composition and predicted metabolic capacity of upper and lower airway microbiota of healthy dogs in relation to the fecal microbiota
    • Ericsson AC, Personett AR, Grobman ME, Rindt H, Reinero CR. Composition and predicted metabolic capacity of upper and lower airway microbiota of healthy dogs in relation to the fecal microbiota. PLoS One 2016; 11:e0154646.
    • (2016) PLoS One , vol.11 , pp. e0154646
    • Ericsson, A.C.1    Personett, A.R.2    Grobman, M.E.3    Rindt, H.4    Reinero, C.R.5
  • 37
    • 84865610947 scopus 로고    scopus 로고
    • Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis
    • MARC-30 Investigators
    • Mansbach JM, Piedra PA, Teach SJ, et al.; MARC-30 Investigators. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med 2012; 166:700-6.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , pp. 700-706
    • Mansbach, J.M.1    Piedra, P.A.2    Teach, S.J.3
  • 38
    • 84902501262 scopus 로고    scopus 로고
    • Hospital length-ofstay is associated with rhinovirus etiology of bronchiolitis
    • Jartti T, Aakula M, Mansbach JM, et al. Hospital length-ofstay is associated with rhinovirus etiology of bronchiolitis. Pediatr Infect Dis J 2014; 33:829-34.
    • (2014) Pediatr Infect Dis J , vol.33 , pp. 829-834
    • Jartti, T.1    Aakula, M.2    Mansbach, J.M.3
  • 39
    • 85026304198 scopus 로고    scopus 로고
    • Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. A multiomic analysis
    • Stewart CJ, Mansbach JM, Wong MC, et al. Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. A multiomic analysis. Am J Respir Crit Care Med 2017; 196:882-91.
    • (2017) Am J Respir Crit Care Med , vol.196 , pp. 882-891
    • Stewart, C.J.1    Mansbach, J.M.2    Wong, M.C.3
  • 40
    • 85031943419 scopus 로고    scopus 로고
    • Serum LL-37 levels associated with severity of bronchiolitis and viral etiology
    • Mansbach JM, Hasegawa K, Ajami NJ, et al. Serum LL-37 levels associated with severity of bronchiolitis and viral etiology. Clin Infect Dis 2017; 65:967-75.
    • (2017) Clin Infect Dis , vol.65 , pp. 967-975
    • Mansbach, J.M.1    Hasegawa, K.2    Ajami, N.J.3
  • 41
    • 85017420969 scopus 로고    scopus 로고
    • The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis
    • Hasegawa K, Mansbach JM, Ajami NJ, et al. The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis. Allergy 2017; 72:1796-800.
    • (2017) Allergy , vol.72 , pp. 1796-1800
    • Hasegawa, K.1    Mansbach, J.M.2    Ajami, N.J.3
  • 42
    • 80053122563 scopus 로고    scopus 로고
    • Topographical continuity of bacterial populations in the healthy human respiratory tract
    • Charlson ES, Bittinger K, Haas AR, et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. Am J Respir Crit Care Med 2011; 184:957-63.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 957-963
    • Charlson, E.S.1    Bittinger, K.2    Haas, A.R.3
  • 43
    • 84896701857 scopus 로고    scopus 로고
    • Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease
    • e12
    • Poole A, Urbanek C, Eng C, et al. Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. J Allergy Clin Immunol 2014; 133:670-8. e12.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 670-678
    • Poole, A.1    Urbanek, C.2    Eng, C.3


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