메뉴 건너뛰기




Volumn 65, Issue 6, 2017, Pages 967-975

Serum LL-37 levels associated with severity of bronchiolitis and viral etiology

Author keywords

Bronchiolitis; Ll 37; Microbiota; Respiratory syncytial virus; Severity of illness

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN;

EID: 85031943419     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cix483     Document Type: Article
Times cited : (27)

References (39)
  • 3
    • 84865610947 scopus 로고    scopus 로고
    • MARC-30 investigators. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis
    • Mansbach JM, Piedra PA, Teach SJ, et al; MARC-30 Investigators. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med 2012; 166:700-6.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , pp. 700-706
    • Mansbach, J.M.1    Piedra, P.A.2    Teach, S.J.3
  • 4
    • 39749112781 scopus 로고    scopus 로고
    • Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department
    • Mansbach JM, McAdam AJ, Clark S, et al. Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med 2008; 15:111-8.
    • (2008) Acad Emerg Med , vol.15 , pp. 111-118
    • Mansbach, J.M.1    McAdam, A.J.2    Clark, S.3
  • 5
    • 33748935159 scopus 로고    scopus 로고
    • LL-37, the only human member of the cathelicidin family of antimicrobial peptides
    • Durr UH, Sudheendra US, Ramamoorthy A. LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta 2006; 1758:1408-25.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1408-1425
    • Durr, U.H.1    Sudheendra, U.S.2    Ramamoorthy, A.3
  • 6
    • 84887915050 scopus 로고    scopus 로고
    • Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
    • Hilchie AL, Wuerth K, Hancock RE. Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol 2013; 9:761-8.
    • (2013) Nat Chem Biol , vol.9 , pp. 761-768
    • Hilchie, A.L.1    Wuerth, K.2    Hancock, R.E.3
  • 7
    • 58749088922 scopus 로고    scopus 로고
    • Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis
    • Gombart AF, Bhan I, Borregaard N, et al. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. Clin Infect Dis 2009; 48:418-24.
    • (2009) Clin Infect Dis , vol.48 , pp. 418-424
    • Gombart, A.F.1    Bhan, I.2    Borregaard, N.3
  • 8
    • 84883431889 scopus 로고    scopus 로고
    • The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus
    • Currie SM, Findlay EG, McHugh BJ, et al. The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. PLoS One 2013; 8:e73659.
    • (2013) PLoS One , vol.8 , pp. e73659
    • Currie, S.M.1    Findlay, E.G.2    McHugh, B.J.3
  • 9
    • 84962575116 scopus 로고    scopus 로고
    • Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans
    • Currie SM, Gwyer Findlay E, McFarlane AJ, et al. Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans. J Immunol 2016; 196:2699-710.
    • (2016) J Immunol , vol.196 , pp. 2699-2710
    • Currie, S.M.1    Gwyer, F.E.2    McFarlane, A.J.3
  • 10
    • 84953410451 scopus 로고    scopus 로고
    • Human cathelicidin, LL-37, inhibits respiratory syncytial virus infection in polarized airway epithelial cells
    • Harcourt JL, McDonald M, Svoboda P, Pohl J, Tatti K, Haynes LM. Human cathelicidin, LL-37, inhibits respiratory syncytial virus infection in polarized airway epithelial cells. BMC Res Notes 2016; 9:11.
    • (2016) BMC Res Notes , vol.9 , pp. 11
    • Harcourt, J.L.1    McDonald, M.2    Svoboda, P.3    Pohl, J.4    Tatti, K.5    Haynes, L.M.6
  • 11
    • 84958074420 scopus 로고    scopus 로고
    • Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37
    • Schogler A, Muster RJ, Kieninger E, et al. Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37. Eur Respir J 2016; 47:520-30.
    • (2016) Eur Respir J , vol.47 , pp. 520-530
    • Schogler, A.1    Muster, R.J.2    Kieninger, E.3
  • 12
    • 84869098336 scopus 로고    scopus 로고
    • Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis
    • e1
    • Mansbach JM, Piedra PA, Borregaard N, et al. Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis. J Allergy Clin Immunol 2012; 130:1007-8.e1.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1007-1008
    • Mansbach, J.M.1    Piedra, P.A.2    Borregaard, N.3
  • 13
    • 85008225342 scopus 로고    scopus 로고
    • Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis
    • Hasegawa K, Mansbach JM, Ajami NJ, et al. Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis. J Allergy Clin Immunol 2017; 139:1383-6.
    • (2017) J Allergy Clin Immunol , vol.139 , pp. 1383-1386
    • Hasegawa, K.1    Mansbach, J.M.2    Ajami, N.J.3
  • 14
    • 84969749461 scopus 로고    scopus 로고
    • High dose Vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial
    • Han JE, Jones JL, Tangpricha V, et al. High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial. J Clin Transl Endocrinol 2016; 4:59-65.
    • (2016) J Clin Transl Endocrinol , vol.4 , pp. 59-65
    • Han, J.E.1    Jones, J.L.2    Tangpricha, V.3
  • 15
    • 84929658044 scopus 로고    scopus 로고
    • Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: Multicenter cohort studies in the United States and Finland
    • Hasegawa K, Jartti T, Mansbach JM, et al. Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis 2015; 211:1550-9.
    • (2015) J Infect Dis , vol.211 , pp. 1550-1559
    • Hasegawa, K.1    Jartti, T.2    Mansbach, J.M.3
  • 16
    • 84882770091 scopus 로고    scopus 로고
    • Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes
    • Leaf DE, Waikar SS, Wolf M, Cremers S, Bhan I, Stern L. Dysregulated mineral metabolism in patients with acute kidney injury and risk of adverse outcomes. Clin Endocrinol (Oxf) 2013; 79:491-8.
    • (2013) Clin Endocrinol (Oxf) , vol.79 , pp. 491-498
    • Leaf, D.E.1    Waikar, S.S.2    Wolf, M.3    Cremers, S.4    Bhan, I.5    Stern, L.6
  • 17
    • 79959490945 scopus 로고    scopus 로고
    • Vitamin D-binding protein modifies the Vitamin D-bone mineral density relationship
    • Powe CE, Ricciardi C, Berg AH, et al. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res 2011; 26:1609-16.
    • (2011) J Bone Miner Res , vol.26 , pp. 1609-1616
    • Powe, C.E.1    Ricciardi, C.2    Berg, A.H.3
  • 18
    • 17344366818 scopus 로고    scopus 로고
    • Respiratory viral infections in patients with chronic, obstructive pulmonary disease
    • Beckham JD, Cadena A, Lin J, et al. Respiratory viral infections in patients with chronic, obstructive pulmonary disease. J Infect 2005; 50:322-30.
    • (2005) J Infect , vol.50 , pp. 322-330
    • Beckham, J.D.1    Cadena, A.2    Lin, J.3
  • 19
    • 33645762067 scopus 로고    scopus 로고
    • Evaluation of real-Time PCR for diagnosis of Bordetella pertussis infection
    • Knorr L, Fox JD, Tilley PA, Ahmed-Bentley J. Evaluation of real-Time PCR for diagnosis of Bordetella pertussis infection. BMC Infect Dis 2006; 6:62.
    • (2006) BMC Infect Dis , vol.6 , pp. 62
    • Knorr, L.1    Fox, J.D.2    Tilley, P.A.3    Ahmed-Bentley, J.4
  • 20
    • 53649096226 scopus 로고    scopus 로고
    • Evaluation of three real-Time PCR assays for detection of Mycoplasma pneumoniae in an outbreak investigation
    • Winchell JM, Thurman KA, Mitchell SL, Thacker WL, Fields BS. Evaluation of three real-Time PCR assays for detection of Mycoplasma pneumoniae in an outbreak investigation. J Clin Microbiol 2008; 46:3116-8.
    • (2008) J Clin Microbiol , vol.46 , pp. 3116-3118
    • Winchell, J.M.1    Thurman, K.A.2    Mitchell, S.L.3    Thacker, W.L.4    Fields, B.S.5
  • 21
    • 84994259528 scopus 로고    scopus 로고
    • Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalized for bronchiolitis
    • Hasegawa K, Mansbach JM, Ajami NJ, et al. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalized for bronchiolitis. Eur Respir J 2016; 48:1329-39.
    • (2016) Eur Respir J , vol.48 , pp. 1329-1339
    • Hasegawa, K.1    Mansbach, J.M.2    Ajami, N.J.3
  • 22
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-Term dietary patterns with gut microbial enterotypes
    • Wu GD, Chen J, Hoffmann C, et al. Linking long-Term dietary patterns with gut microbial enterotypes. Science 2011; 334:105-8.
    • (2011) Science , vol.334 , pp. 105-108
    • Wu, G.D.1    Chen, J.2    Hoffmann, C.3
  • 23
    • 0023453329 scopus 로고
    • Silhouettes: A graphical aid to the interpretation and validation of cluster analysis
    • Rousseeuw PJ. Silhouettes: A graphical aid to the interpretation and validation of cluster analysis. J Comput Appl Math 1987; 20:53-65.
    • (1987) J Comput Appl Math , vol.20 , pp. 53-65
    • Rousseeuw, P.J.1
  • 24
    • 84938743946 scopus 로고    scopus 로고
    • Rhinovirusinduced bronchiolitis: Lack of association between virus genomic load and shortterm outcomes
    • e11
    • Jartti T, Hasegawa K, Mansbach JM, Piedra PA, Camargo CA Jr. Rhinovirusinduced bronchiolitis: lack of association between virus genomic load and shortterm outcomes. J Allergy Clin Immunol 2015; 136:509-12.e11.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 509-512
    • Jartti, T.1    Hasegawa, K.2    Mansbach, J.M.3    Piedra, P.A.4    Camargo, C.A.5
  • 25
    • 84865718292 scopus 로고    scopus 로고
    • MARC-30 investigators. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation
    • Mansbach JM, Piedra PA, Stevenson MD, et al; MARC-30 Investigators. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics 2012; 130:e492-e500.
    • (2012) Pediatrics , vol.130 , pp. e492-e500
    • Mansbach, J.M.1    Piedra, P.A.2    Stevenson, M.D.3
  • 27
    • 84942117832 scopus 로고    scopus 로고
    • Effect of cholecalciferol supplementation on Vitamin D status and cathelicidin levels in sepsis: A randomized, placebo-controlled trial
    • Quraishi SA, DePascale G, Needleman JS, et al. Effect of cholecalciferol supplementation on vitamin D status and cathelicidin levels in sepsis: A randomized, placebo-controlled trial. Crit Care Med 2015; 43:1928-37.
    • (2015) Crit Care Med , vol.43 , pp. 1928-1937
    • Quraishi, S.A.1    De Pascale, G.2    Needleman, J.S.3
  • 28
    • 21744438757 scopus 로고    scopus 로고
    • Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the Vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyVitamin D3
    • Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. FASEB J 2005; 19:1067-77.
    • (2005) FASEB J , vol.19 , pp. 1067-1077
    • Gombart, A.F.1    Borregaard, N.2    Koeffler, H.P.3
  • 29
    • 84876427223 scopus 로고    scopus 로고
    • Phyloseq: An R package for reproducible interactive analysis and graphics of microbiome census data
    • McMurdie PJ, Holmes S. phyloseq: An R package for reproducible interactive analysis and graphics of microbiome census data. PLoS One 2013; 8:e61217.
    • (2013) PLoS One , vol.8 , pp. e61217
    • McMurdie, P.J.1    Holmes, S.2
  • 30
    • 84966441152 scopus 로고    scopus 로고
    • Mechanisms and consequences of bacterial resistance to antimicrobial peptides
    • Andersson DI, Hughes D, Kubicek-Sutherland JZ. Mechanisms and consequences of bacterial resistance to antimicrobial peptides. Drug Resist Updat 2016; 26:43-57.
    • (2016) Drug Resist Updat , vol.26 , pp. 43-57
    • Andersson, D.I.1    Hughes, D.2    Kubicek-Sutherland, J.Z.3
  • 31
    • 84862899930 scopus 로고    scopus 로고
    • Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in gram-negative bacterial pneumonia
    • Kovach MA, Ballinger MN, Newstead MW, et al. Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in gram-negative bacterial pneumonia. J Immunol 2012; 189:304-11.
    • (2012) J Immunol , vol.189 , pp. 304-311
    • Kovach, M.A.1    Ballinger, M.N.2    Newstead, M.W.3
  • 32
    • 84899671206 scopus 로고    scopus 로고
    • A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort
    • Lambert AA, Kirk GD, Astemborski J, et al. A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort. PLoS One 2014; 9:e95099.
    • (2014) PLoS One , vol.9 , pp. e95099
    • Lambert, A.A.1    Kirk, G.D.2    Astemborski, J.3
  • 33
    • 79955442543 scopus 로고    scopus 로고
    • Vitamin D, innate immunity and outcomes in community acquired pneumonia
    • Leow L, Simpson T, Cursons R, Karalus N, Hancox RJ. Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology 2011; 16:611-6.
    • (2011) Respirology , vol.16 , pp. 611-616
    • Leow, L.1    Simpson, T.2    Cursons, R.3    Karalus, N.4    Hancox, R.J.5
  • 34
    • 84902501262 scopus 로고    scopus 로고
    • Hospital length-of-stay is associated with rhinovirus etiology of bronchiolitis
    • Jartti T, Aakula M, Mansbach JM, et al. Hospital length-of-stay is associated with rhinovirus etiology of bronchiolitis. Pediatr Infect Dis J 2014; 33:829-34.
    • (2014) Pediatr Infect Dis J , vol.33 , pp. 829-834
    • Jartti, T.1    Aakula, M.2    Mansbach, J.M.3
  • 35
    • 84962467486 scopus 로고    scopus 로고
    • Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota
    • e4
    • Mansbach JM, Hasegawa K, Henke DM, et al. Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota. J Allergy Clin Immunol 2016; 137:1909-1913.e4.
    • (2016) J Allergy Clin Immunol , vol.137 , pp. 1909-1913
    • Mansbach, J.M.1    Hasegawa, K.2    Henke, D.M.3
  • 36
    • 84865718292 scopus 로고    scopus 로고
    • MARC-30 investigators. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation
    • Mansbach JM, Piedra PA, Stevenson MD, et al; MARC-30 Investigators. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics 2012; 130:e492-e500.
    • (2012) Pediatrics , vol.130 , pp. e492-e500
    • Mansbach, J.M.1    Piedra, P.A.2    Stevenson, M.D.3
  • 37
    • 33645224419 scopus 로고    scopus 로고
    • Toll-like receptor triggering of a Vitamin D-mediated human antimicrobial response
    • Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311:1770-3.
    • (2006) Science , vol.311 , pp. 1770-1773
    • Liu, P.T.1    Stenger, S.2    Li, H.3
  • 38
    • 84908881839 scopus 로고    scopus 로고
    • American academy of pediatrics. Clinical practice guideline: The diagnosis, management, and prevention of bronchiolitis
    • Ralston SL, Lieberthal AS, Meissner HC, et al; American Academy of Pediatrics. Clinical practice guideline: The diagnosis, management, and prevention of bronchiolitis. Pediatrics 2014; 134:e1474-502.
    • (2014) Pediatrics , vol.134 , pp. e1474-e1502
    • Ralston, S.L.1    Lieberthal, A.S.2    Meissner, H.C.3
  • 39
    • 84989298293 scopus 로고    scopus 로고
    • The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy
    • Hsieh IN, Hartshorn KL. The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy. Pharmaceuticals (Basel) 2016; 9:53.
    • (2016) Pharmaceuticals (Basel) , vol.9 , pp. 53
    • Hsieh, I.N.1    Hartshorn, K.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.