Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 6, 2016, Pages 1909-1913.e4

  Mansbach, Jonathan M ^a   Hasegawa, Kohei ^b   Henke, David M ^c   Ajami, Nadim J ^c   Petrosino, Joseph F ^c   Shaw, Chad A ^c   Piedra, Pedro A ^c   Sullivan, Ashley F ^b   Espinola, Janice A ^b   Camargo, Carlos A ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA 16S;

CHILD HOSPITALIZATION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FIRMICUTES; HAEMOPHILUS; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INCIDENCE; LETTER; MICROFLORA; MOLECULAR INTERACTION; MORAXELLA; MULTICENTER STUDY (TOPIC); NASOPHARYNGEAL ASPIRATION; NASOPHARYNX; PRIORITY JOURNAL; RHINOVIRUS; STREPTOCOCCUS; VIRAL BRONCHIOLITIS; CLINICAL TRIAL; FEMALE; INFANT; MALE; MICROBIOLOGY; MULTICENTER STUDY; NEWBORN; NOSE CAVITY; PHARYNX; PICORNAVIRUS INFECTION; RESPIRATORY SYNCYTIAL VIRUS INFECTION;

BRONCHIOLITIS, VIRAL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICROBIOTA; NASAL CAVITY; PHARYNX; PICORNAVIRIDAE INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RHINOVIRUS;

EID: 84962467486     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.01.036     Document Type: Article

References (25)

1. K. Hasegawa, J.M. Mansbach, and C.A. Camargo Jr. Infectious pathogens and bronchiolitis outcomes Expert Rev Anti Infect Ther 12 2014 817 828
2. Y.J. Huang, and H.A. Boushey The microbiome in asthma J Allergy Clin Immunol 135 2015 25 30
3. M. Vissers, R. de Groot, and G. Ferwerda Severe viral respiratory infections: are bugs bugging? Mucosal Immunol 7 2014 227 238
4. J.M. Mansbach, P.A. Piedra, S.J. Teach, A.F. Sullivan, T. Forgey, S. Clark, and et al. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Arch Pediatr Adolesc Med 166 2012 700 706
5. A.A. Bosch, G. Biesbroek, K. Trzcinski, E.A. Sanders, and D. Bogaert Viral and bacterial interactions in the upper respiratory tract PLoS Pathog 9 2013 e1003057
6. K.M. Kloepfer, W.M. Lee, T.E. Pappas, T.J. Kang, R.F. Vrtis, M.D. Evans, and et al. Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations J Allergy Clin Immunol 133 2014 1301 1307
7. F. Gulraiz, C. Bellinghausen, C.A. Bruggeman, and F.R. Stassen Haemophilus influenzae increases the susceptibility and inflammatory response of airway epithelial cells to viral infections FASEB J 29 2015 849 858
8. S.M. Teo, D. Mok, K. Pham, M. Kusel, M. Serralha, N. Troy, and et al. The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development Cell Host Microbe 17 2015 704 715
9. G. Gerna, A. Piralla, F. Rovida, V. Rognoni, A. Marchi, F. Locatelli, and et al. Correlation of rhinovirus load in the respiratory tract and clinical symptoms in hospitalized immunocompetent and immunocompromised patients J Med Virol 81 2009 1498 1507
10. A.S. Lieberthal, H. Bauchner, C.B. Hall, D.W. Johnson, U. Kotagal, M.J. Light, and et al. Diagnosis and management of bronchiolitis Pediatrics 118 2006 1774 1793
11. J.M. Mansbach, P.A. Piedra, S.J. Teach, A.F. Sullivan, T. Forgey, S. Clark, and et al. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis Arch Pediatr Adolesc Med 166 2012 700 706
12. J.D. Beckham, A. Cadena, J. Lin, P.A. Piedra, W.P. Glezen, S.B. Greenberg, and et al. Respiratory viral infections in patients with chronic, obstructive pulmonary disease J Infect 50 2005 322 330
13. L. Knorr, J.D. Fox, P.A. Tilley, and J. Ahmed-Bentley Evaluation of real-time PCR for diagnosis of Bordetella pertussis infection BMC Infect Dis 6 2006 62
14. J.M. Winchell, K.A. Thurman, S.L. Mitchell, W.L. Thacker, and B.S. Fields Evaluation of three real-time PCR assays for detection of Mycoplasma pneumoniae in an outbreak investigation J Clin Microbiol 46 2008 3116 3118
15. Human Microbiome Project Consortium A framework for human microbiome research Nature 486 2012 215 221
16. Human Microbiome Project Consortium Structure, function and diversity of the healthy human microbiome Nature 486 2012 207 214
17. J.G. Caporaso, J. Kuczynski, J. Stombaugh, K. Bittinger, F.D. Bushman, E.K. Costello, and et al. QIIME allows analysis of high-throughput community sequencing data Nat Methods 7 2010 335 336
18. J.G. Caporaso, C.L. Lauber, W.A. Walters, D. Berg-Lyons, J. Huntley, N. Fierer, and et al. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms ISME J 6 2012 1621 1624
19. R.C. Edgar Search and clustering orders of magnitude faster than BLAST Bioinformatics 26 2010 2460 2461
20. R.C. Edgar UPARSE: highly accurate OTU sequences from microbial amplicon reads Nat Methods 10 2013 996 998
21. C. Quast, E. Pruesse, P. Yilmaz, J. Gerken, T. Schweer, P. Yarza, and et al. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools Nucleic Acids Res 41 2013 D590 D596
22. C. Lozupone, M.E. Lladser, D. Knights, J. Stombaugh, and R. Knight UniFrac: an effective distance metric for microbial community comparison ISME J 5 2011 169 172
23. C. Lozupone, and R. Knight UniFrac: a new phylogenetic method for comparing microbial communities Appl Environ Microbiol 71 2005 8228 8235
24. Team R Core. R: a language and environment for statistical computing 2014 R Foundation for Statistical Computing Vienna, Austria
25. P.J. McMurdie, and S. Holmes phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data PLoS One 8 2013 e61217