메뉴 건너뛰기




Volumn 14, Issue 4, 2018, Pages 671-684

Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2)

Author keywords

autophagy; glycolysis; hexokinase 2; liver cancer; SQSTM1 p62; TRAF6; ubiquitination

Indexed keywords

GLUCOSE 6 PHOSPHATE; HEXOKINASE; HEXOKINASE 2; SEQUESTOSOME 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; GLUCOSE; HEXOKINASE 2, HUMAN; UBIQUITIN PROTEIN LIGASE;

EID: 85042870498     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2017.1381804     Document Type: Article
Times cited : (194)

References (47)
  • 1
    • 62949091373 scopus 로고    scopus 로고
    • Autophagy: a lysosomal degradation pathway with a central role in health and disease
    • Eskelinen EL, Saftig P. Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta. 2009;1793(4):664–673. doi:10.1016/j.bbamcr.2008.07.014.
    • (2009) Biochim Biophys Acta , vol.1793 , Issue.4 , pp. 664-673
    • Eskelinen, E.L.1    Saftig, P.2
  • 2
    • 77954597127 scopus 로고    scopus 로고
    • An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis
    • 20522742, PMID
    • Hidvegi T, Ewing M, Hale P, et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science. 2010;329(5988):229–232. doi:10.1126/science.1190354. PMID:20522742.
    • (2010) Science , vol.329 , Issue.5988 , pp. 229-232
    • Hidvegi, T.1    Ewing, M.2    Hale, P.3
  • 3
    • 84876287362 scopus 로고    scopus 로고
    • Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice
    • 23339953, PMID
    • Lin CW, Zhang H, Li M, et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol. 2013;58(5):993–999. doi:10.1016/j.jhep.2013.01.011. PMID:23339953.
    • (2013) J Hepatol , vol.58 , Issue.5 , pp. 993-999
    • Lin, C.W.1    Zhang, H.2    Li, M.3
  • 4
    • 84883017889 scopus 로고    scopus 로고
    • Functions of autophagy in normal and diseased liver
    • 23774882, PMID
    • Czaja MJ, Ding WX, Donohue TM, Jr., et al. Functions of autophagy in normal and diseased liver. Autophagy. 2013;9(8):1131–1158. doi:10.4161/auto.25063. PMID:23774882.
    • (2013) Autophagy , vol.9 , Issue.8 , pp. 1131-1158
    • Czaja, M.J.1    Ding, W.X.2    Donohue, T.M.3
  • 5
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • 14638851, PMID
    • Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112(12):1809–1820. doi:10.1172/JCI20039. PMID:14638851.
    • (2003) J Clin Invest , vol.112 , Issue.12 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 6
    • 79955377420 scopus 로고    scopus 로고
    • Autophagy-deficient mice develop multiple liver tumors
    • 21498569, PMID
    • Takamura A, Komatsu M, Hara T, et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011;25(8):795–800. doi:10.1101/gad.2016211. PMID:21498569.
    • (2011) Genes Dev , vol.25 , Issue.8 , pp. 795-800
    • Takamura, A.1    Komatsu, M.2    Hara, T.3
  • 7
    • 79955492012 scopus 로고    scopus 로고
    • Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
    • 21482715, PMID
    • Inami Y, Waguri S, Sakamoto A, et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol. 2011;193(2):275–284. doi:10.1083/jcb.201102031. PMID:21482715.
    • (2011) J Cell Biol , vol.193 , Issue.2 , pp. 275-284
    • Inami, Y.1    Waguri, S.2    Sakamoto, A.3
  • 8
    • 80052350645 scopus 로고    scopus 로고
    • Potential role of p62 in tumor development
    • Komatsu M. Potential role of p62 in tumor development. Autophagy. 2014;7(9):1088–1090. doi:10.4161/auto.7.9.16474.
    • (2014) Autophagy , vol.7 , Issue.9 , pp. 1088-1090
    • Komatsu, M.1
  • 9
    • 84939943461 scopus 로고    scopus 로고
    • Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis
    • 25526090, PMID
    • Tian Y, Kuo CF, Sir D, et al. Autophagy inhibits oxidative stress and tumor suppressors to exert its dual effect on hepatocarcinogenesis. Cell Death Differ. 2015;22(6):1025–1034. doi:10.1038/cdd.2014.201. PMID:25526090.
    • (2015) Cell Death Differ , vol.22 , Issue.6 , pp. 1025-1034
    • Tian, Y.1    Kuo, C.F.2    Sir, D.3
  • 10
    • 84964502107 scopus 로고    scopus 로고
    • Autophagy positively regulates DNA damage recognition by nucleotide excision repair
    • 26565512, PMID
    • Qiang L, Zhao B, Shah P, et al. Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Autophagy. 2016;12(2):357–368. doi:10.1080/15548627.2015.1110667. PMID:26565512.
    • (2016) Autophagy , vol.12 , Issue.2 , pp. 357-368
    • Qiang, L.1    Zhao, B.2    Shah, P.3
  • 11
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • 19460998, PMID
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033. doi:10.1126/science.1160809. PMID:19460998.
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 12
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • 22549953, PMID
    • Dang CV. Links between metabolism and cancer. Genes Dev. 2012;26(9):877–890. doi:10.1101/gad.189365.112. PMID:22549953.
    • (2012) Genes Dev , vol.26 , Issue.9 , pp. 877-890
    • Dang, C.V.1
  • 13
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • 15516961, PMID
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004;4(11):891–899. doi:10.1038/nrc1478. PMID:15516961.
    • (2004) Nat Rev Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 14
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27441–27464. doi:10.1146/annurev-cellbio-092910-154237.
    • (2011) Annu Rev Cell Dev Biol , pp. 27441-27464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 15
    • 84983523249 scopus 로고    scopus 로고
    • LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism
    • 27546620, PMID
    • Zeng Q, Chen J, Li Y, et al. LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism. Oncogene. 2017;36(9):1245–1255. doi:10.1038/onc.2016.290. PMID:27546620.
    • (2017) Oncogene , vol.36 , Issue.9 , pp. 1245-1255
    • Zeng, Q.1    Chen, J.2    Li, Y.3
  • 16
    • 84942551319 scopus 로고    scopus 로고
    • MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer
    • 26054020, PMID
    • Guo W, Qiu Z, Wang Z, et al. MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer. Hepatology. 2015;62(4):1132–1144. doi:10.1002/hep.27929. PMID:26054020.
    • (2015) Hepatology , vol.62 , Issue.4 , pp. 1132-1144
    • Guo, W.1    Qiu, Z.2    Wang, Z.3
  • 17
    • 84885583038 scopus 로고    scopus 로고
    • Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth
    • 24124231, PMID
    • Ros S, Schulze A. Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth. Cancer Discov. 2013;3(10):1105–1107. doi:10.1158/2159-8290.CD-13-0565. PMID:24124231.
    • (2013) Cancer Discov , vol.3 , Issue.10 , pp. 1105-1107
    • Ros, S.1    Schulze, A.2
  • 18
    • 84867171577 scopus 로고    scopus 로고
    • Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival
    • 23071593, PMID
    • Kwee SA, Hernandez B, Chan O, et al. Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival. PLoS One. 2012;7(10):e46591. doi:10.1371/journal.pone.0046591. PMID:23071593.
    • (2012) PLoS One , vol.7 , Issue.10
    • Kwee, S.A.1    Hernandez, B.2    Chan, O.3
  • 19
    • 84894105147 scopus 로고    scopus 로고
    • Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition
    • 24462113, PMID
    • Roberts DJ, Tan-Sah VP, Ding EY, et al. Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition. Mol Cell. 2014;53(4):521–533. doi:10.1016/j.molcel.2013.12.019. PMID:24462113.
    • (2014) Mol Cell , vol.53 , Issue.4 , pp. 521-533
    • Roberts, D.J.1    Tan-Sah, V.P.2    Ding, E.Y.3
  • 20
    • 84941696058 scopus 로고    scopus 로고
    • p63 supports aerobic respiration through hexokinase II
    • 26324887, PMID
    • Viticchie G, Agostini M, Lena AM, et al. p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A. 2015;112(37):11577–11582. doi:10.1073/pnas.1508871112. PMID:26324887.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.37 , pp. 11577-11582
    • Viticchie, G.1    Agostini, M.2    Lena, A.M.3
  • 21
    • 79952355107 scopus 로고    scopus 로고
    • Selective autophagy mediated by autophagic adapter proteins
    • 21189453, PMID
    • Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy. 2011;7(3):279–296. doi:10.4161/auto.7.3.14487. PMID:21189453.
    • (2011) Autophagy , vol.7 , Issue.3 , pp. 279-296
    • Johansen, T.1    Lamark, T.2
  • 22
    • 84875083992 scopus 로고    scopus 로고
    • SnapShot: Selective autophagy
    • 23332767, PMID
    • Jin M, Liu X, Klionsky DJ. SnapShot: Selective autophagy. Cell. 2013;152(1-2):368–e2. doi:10.1016/j.cell.2013.01.004. PMID:23332767.
    • (2013) Cell , vol.152 , Issue.1-2 , pp. 368-372
    • Jin, M.1    Liu, X.2    Klionsky, D.J.3
  • 23
    • 84870601009 scopus 로고    scopus 로고
    • Selective autophagy degrades DICER and AGO2 and regulates miRNA activity
    • 23143396, PMID
    • Gibbings D, Mostowy S, Jay F, et al. Selective autophagy degrades DICER and AGO2 and regulates miRNA activity. Nat Cell Biol. 2012;14(12):1314–1321. doi:10.1038/ncb2611. PMID:23143396.
    • (2012) Nat Cell Biol , vol.14 , Issue.12 , pp. 1314-1321
    • Gibbings, D.1    Mostowy, S.2    Jay, F.3
  • 24
    • 79952318885 scopus 로고    scopus 로고
    • Selective removal of dishevelled by autophagy: a role of p62
    • 21079413, PMID
    • Gao C, Chen YG. Selective removal of dishevelled by autophagy: a role of p62. Autophagy. 2011;7(3):334–335. doi:10.4161/auto.7.3.14072. PMID:21079413.
    • (2011) Autophagy , vol.7 , Issue.3 , pp. 334-335
    • Gao, C.1    Chen, Y.G.2
  • 25
    • 58149083873 scopus 로고    scopus 로고
    • Selective turnover of p62/A170/SQSTM1 by autophagy
    • 18776737, PMID
    • Ichimura Y, Kominami E, Tanaka K, et al. Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy. 2008;4(8):1063–1066. doi:10.4161/auto.6826. PMID:18776737.
    • (2008) Autophagy , vol.4 , Issue.8 , pp. 1063-1066
    • Ichimura, Y.1    Kominami, E.2    Tanaka, K.3
  • 26
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • 19450525, PMID
    • Kirkin V, McEwan DG, Novak I, et al. A role for ubiquitin in selective autophagy. Mol Cell. 2009;34(3):259–269. doi:10.1016/j.molcel.2009.04.026. PMID:19450525.
    • (2009) Mol Cell , vol.34 , Issue.3 , pp. 259-269
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3
  • 27
    • 34548259958 scopus 로고    scopus 로고
    • p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • 17580304, PMID
    • Pankiv S, Clausen TH, Lamark T, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 2007;282(33):24131–24145. doi:10.1074/jbc.M702824200. PMID:17580304.
    • (2007) J Biol Chem , vol.282 , Issue.33 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3
  • 28
    • 78249282307 scopus 로고    scopus 로고
    • Regulation and cytoprotective role of hexokinase III
    • 21072205, PMID
    • Wyatt E, Wu R, Rabeh W, et al. Regulation and cytoprotective role of hexokinase III. PLoS One. 2010;5(11):e13823. doi:10.1371/journal.pone.0013823. PMID:21072205.
    • (2010) PLoS One , vol.5 , Issue.11
    • Wyatt, E.1    Wu, R.2    Rabeh, W.3
  • 29
    • 84869495080 scopus 로고    scopus 로고
    • p62/SQSTM1/A170: physiology and pathology
    • 22841931, PMID
    • Komatsu M, Kageyama S, Ichimura Y. p62/SQSTM1/A170: physiology and pathology. Pharmacol Res. 2012;66(6):457–462. doi:10.1016/j.phrs.2012.07.004. PMID:22841931.
    • (2012) Pharmacol Res , vol.66 , Issue.6 , pp. 457-462
    • Komatsu, M.1    Kageyama, S.2    Ichimura, Y.3
  • 30
    • 84896707770 scopus 로고    scopus 로고
    • Impaired autophagy response in human hepatocellular carcinoma
    • 24369267, PMID
    • Bao L, Chandra PK, Moroz K, et al. Impaired autophagy response in human hepatocellular carcinoma. Exp Mol Pathol. 2014;96(2):149–154. doi:10.1016/j.yexmp.2013.12.002. PMID:24369267.
    • (2014) Exp Mol Pathol , vol.96 , Issue.2 , pp. 149-154
    • Bao, L.1    Chandra, P.K.2    Moroz, K.3
  • 31
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • 15866887, PMID
    • Komatsu M, Waguri S, Ueno T, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169(3):425–434. doi:10.1083/jcb.200412022. PMID:15866887.
    • (2005) J Cell Biol , vol.169 , Issue.3 , pp. 425-434
    • Komatsu, M.1    Waguri, S.2    Ueno, T.3
  • 32
    • 84959470663 scopus 로고    scopus 로고
    • Regulation of Liver Metabolism by Autophagy
    • 26453774, PMID
    • Madrigal-Matute J, Cuervo AM. Regulation of Liver Metabolism by Autophagy. Gastroenterology. 2016;150(2):328–339. doi:10.1053/j.gastro.2015.09.042. PMID:26453774.
    • (2016) Gastroenterology , vol.150 , Issue.2 , pp. 328-339
    • Madrigal-Matute, J.1    Cuervo, A.M.2
  • 33
    • 79959371914 scopus 로고    scopus 로고
    • Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
    • 21700219, PMID
    • Lv L, Li D, Zhao D, et al. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell. 2011;42(6):719–730. doi:10.1016/j.molcel.2011.04.025. PMID:21700219.
    • (2011) Mol Cell , vol.42 , Issue.6 , pp. 719-730
    • Lv, L.1    Li, D.2    Zhao, D.3
  • 34
    • 84876417170 scopus 로고    scopus 로고
    • Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer
    • 23523103, PMID
    • Zhao D, Zou SW, Liu Y, et al. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 2013;23(4):464–476. doi:10.1016/j.ccr.2013.02.005. PMID:23523103.
    • (2013) Cancer Cell , vol.23 , Issue.4 , pp. 464-476
    • Zhao, D.1    Zou, S.W.2    Liu, Y.3
  • 35
    • 84962177627 scopus 로고    scopus 로고
    • Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
    • 26323688, PMID
    • Xia HG, Najafov A, Geng J, et al. Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death. J Cell Biol. 2015;210(5):705–716. doi:10.1083/jcb.201503044. PMID:26323688.
    • (2015) J Cell Biol , vol.210 , Issue.5 , pp. 705-716
    • Xia, H.G.1    Najafov, A.2    Geng, J.3
  • 36
    • 84919918303 scopus 로고    scopus 로고
    • Dual proteolytic pathways govern glycolysis and immune competence
    • 25525876, PMID
    • Lu W, Zhang Y, McDonald DO, et al. Dual proteolytic pathways govern glycolysis and immune competence. Cell. 2014;159(7):1578–1590. doi:10.1016/j.cell.2014.12.001. PMID:25525876.
    • (2014) Cell , vol.159 , Issue.7 , pp. 1578-1590
    • Lu, W.1    Zhang, Y.2    McDonald, D.O.3
  • 37
    • 66449114033 scopus 로고    scopus 로고
    • p62 at the crossroads of autophagy, apoptosis, and cancer
    • 19524504, PMID
    • Moscat J, Diaz-Meco MT. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell. 2009;137(6):1001–1004. doi:10.1016/j.cell.2009.05.023. PMID:19524504.
    • (2009) Cell , vol.137 , Issue.6 , pp. 1001-1004
    • Moscat, J.1    Diaz-Meco, M.T.2
  • 38
    • 80052350645 scopus 로고    scopus 로고
    • Potential role of p62 in tumor development
    • 21617386, PMID
    • Komatsu M. Potential role of p62 in tumor development. Autophagy. 2011;7(9):1088–1090. doi:10.4161/auto.7.9.16474. PMID:21617386.
    • (2011) Autophagy , vol.7 , Issue.9 , pp. 1088-1090
    • Komatsu, M.1
  • 39
    • 84883830467 scopus 로고    scopus 로고
    • Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
    • 24011591, PMID
    • Ichimura Y, Waguri S, Sou YS, et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell. 2013;51(5):618–631. doi:10.1016/j.molcel.2013.08.003. PMID:24011591.
    • (2013) Mol Cell , vol.51 , Issue.5 , pp. 618-631
    • Ichimura, Y.1    Waguri, S.2    Sou, Y.S.3
  • 40
    • 79952139698 scopus 로고    scopus 로고
    • Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
    • 21220332, PMID
    • Fujita K, Maeda D, Xiao Q, et al. Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc Natl Acad Sci U S A. 2011;108(4):1427–1432. doi:10.1073/pnas.1014156108. PMID:21220332.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.4 , pp. 1427-1432
    • Fujita, K.1    Maeda, D.2    Xiao, Q.3
  • 41
    • 84975468197 scopus 로고    scopus 로고
    • p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
    • 27211490, PMID
    • Umemura A, He F, Taniguchi K, et al. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016;29(6):935–948. doi:10.1016/j.ccell.2016.04.006. PMID:27211490.
    • (2016) Cancer Cell , vol.29 , Issue.6 , pp. 935-948
    • Umemura, A.1    He, F.2    Taniguchi, K.3
  • 42
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • 10604474, PMID
    • Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999;402(6762):672–676. doi:10.1038/45257. PMID:10604474.
    • (1999) Nature , vol.402 , Issue.6762 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 43
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • 14657337, PMID
    • Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A. 2003;100(25):15077–15082. doi:10.1073/pnas.2436255100. PMID:14657337.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.25 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3
  • 44
    • 84890432985 scopus 로고    scopus 로고
    • p53 status determines the role of autophagy in pancreatic tumour development
    • 24305049, PMID
    • Rosenfeldt MT, O'Prey J, Morton JP, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013;504(7479):296–300. doi:10.1038/nature12865. PMID:24305049.
    • (2013) Nature , vol.504 , Issue.7479 , pp. 296-300
    • Rosenfeldt, M.T.1    O'Prey, J.2    Morton, J.P.3
  • 45
    • 84940037396 scopus 로고    scopus 로고
    • Autophagy: Surviving stress in pancreatic cancer
    • 26299587, PMID
    • Alderton GK. Autophagy: Surviving stress in pancreatic cancer. Nat Rev Cancer. 2015;15(9):513. doi:10.1038/nrc4005. PMID:26299587.
    • (2015) Nat Rev Cancer , vol.15 , Issue.9 , pp. 513
    • Alderton, G.K.1
  • 46
    • 84905497318 scopus 로고    scopus 로고
    • Autophagy is required for glucose homeostasis and lung tumor maintenance
    • 24875857, PMID
    • Karsli-Uzunbas G, Guo JY, Price S, et al. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014;4(8):914–927. doi:10.1158/2159-8290.CD-14-0363. PMID:24875857.
    • (2014) Cancer Discov , vol.4 , Issue.8 , pp. 914-927
    • Karsli-Uzunbas, G.1    Guo, J.Y.2    Price, S.3
  • 47
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • 15680329, PMID
    • Lum JJ, Bauer DE, Kong M, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005;120(2):237–248. doi:10.1016/j.cell.2004.11.046. PMID:15680329.
    • (2005) Cell , vol.120 , Issue.2 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.