-
1
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4:891-9.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
2
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander, H.M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
3
-
-
0038714272
-
Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function
-
Wilson JE. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol 2003; 206:2049-57.
-
(2003)
J Exp Biol
, vol.206
, pp. 2049-2057
-
-
Wilson, J.E.1
-
4
-
-
0028279307
-
Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines
-
Shinohara Y, Yamamoto K, Kogure K, Ichihara J, Terada H. Steady state transcript levels of the type II hexokinase and type 1 glucose transporter in human tumor cell lines. Cancer Lett 1994; 82:27-32.
-
(1994)
Cancer Lett
, vol.82
, pp. 27-32
-
-
Shinohara, Y.1
Yamamoto, K.2
Kogure, K.3
Ichihara, J.4
Terada, H.5
-
5
-
-
33746924468
-
Hexokinase II: Cancer's doubleedged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
-
Mathupala SP, Ko YH, Pedersen PL. Hexokinase II: cancer's doubleedged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 2006; 25:4777-86.
-
(2006)
Oncogene
, vol.25
, pp. 4777-4786
-
-
Mathupala, S.P.1
Ko, Y.H.2
Pedersen, P.L.3
-
6
-
-
84881557242
-
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
-
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, et al. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell 2013; 24:213-28.
-
(2013)
Cancer Cell
, vol.24
, pp. 213-228
-
-
Patra, K.C.1
Wang, Q.2
Bhaskar, P.T.3
Miller, L.4
Wang, Z.5
Wheaton, W.6
-
7
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, Cairns R, et al. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 2011; 208:313-26.
-
(2011)
J Exp Med
, vol.208
, pp. 313-326
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
Cairns, R.6
-
8
-
-
70349484491
-
Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis
-
Palmieri D, Fitzgerald D, Shreeve SM, Hua E, Bronder JL, Weil RJ, et al. Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. Mol Cancer Res 2009; 7:1438-45.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1438-1445
-
-
Palmieri, D.1
Fitzgerald, D.2
Shreeve, S.M.3
Hua, E.4
Bronder, J.L.5
Weil, R.J.6
-
9
-
-
84863316020
-
M icroRNA-143 (miR- 143) regulates cancer glycolysis via targeting hexokinase 2 gene
-
Fang R, Xiao T, Fang Z, Sun Y, Li F, Gao Y, et al. M icroRNA-143 (miR- 143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem 2012; 287:23227-35.
-
(2012)
J Biol Chem
, vol.287
, pp. 23227-23235
-
-
Fang, R.1
Xiao, T.2
Fang, Z.3
Sun, Y.4
Li, F.5
Gao, Y.6
-
10
-
-
0036510541
-
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
-
Pastorino JG, Shulga N, Hoek JB. Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 2002; 277:7610-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 7610-7618
-
-
Pastorino, J.G.1
Shulga, N.2
Hoek, J.B.3
-
11
-
-
46649106720
-
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels
-
Chiara F, Castellaro D, Marin O, Petronilli V, Brusilow WS, Juhaszova M, et al. Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PloS One 2008; 3:e1852.
-
(2008)
PloS One
, vol.3
-
-
Chiara, F.1
Castellaro, D.2
Marin, O.3
Petronilli, V.4
Brusilow, W.S.5
Juhaszova, M.6
-
12
-
-
4544355934
-
Mitochondrial bound hexokinase activity as a preventive antioxidant defense: Steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria
-
da-Silva WS, Gomez-Puyou A, de Gomez-Puyou MT, Moreno- Sanchez R, De Felice FG, de Meis L, et al. Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen species generation in mitochondria. J Biol Chem 2004; 279:39846-55.
-
(2004)
J Biol Chem
, vol.279
, pp. 39846-39855
-
-
Da-Silva, W.S.1
Gomez-Puyou, A.2
de Gomez-Puyou, M.T.3
Moreno-Sanchez, R.4
de Felice, F.G.5
de Meis, L.6
-
13
-
-
84870918602
-
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
-
Cheung EC, Ludwig RL, Vousden KH. Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A 2012; 109:20491-6.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 20491-20496
-
-
Cheung, E.C.1
Ludwig, R.L.2
Vousden, K.H.3
-
14
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey RB, Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 2006; 25:4683-96.
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
15
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 2004; 16:819-30
-
(2004)
Mol Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
|