Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

Journal of Cell Biology

Volumn 210, Issue 5, 2015, Pages 705-716

  Xia, Hong guang ^a   Najafov, Ayaz ^a   Geng, Jiefei ^a   Galan Acosta, Lorena ^b   Han, Xuemei ^c   Guo, Yuan ^d   Shan, Bing ^d   Zhang, Yaoyang ^d   Norberg, Erik ^b   Zhang, Tao ^d   Pan, Lifeng ^d   Liu, Junli ^d   Coloff, Jonathan L ^a   Ofengeim, Dimitry ^a   Zhu, Hong ^a   Wu, Kejia ^d   Cai, Yu ^d   Yates, John R ^c   Zhu, Zhengjiang ^d   Yuan, Junying ^a,d   Vakifahmetoglu Norberg, Helin ^a,b   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CD135 ANTIGEN; HEAT SHOCK COGNATE PROTEIN 70; HEXOKINASE; HEXOKINASE 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; QUIZARTINIB; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; CARBANILAMIDE DERIVATIVE; CHAPERONE; FLT3 PROTEIN, HUMAN; GLUCOSE;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; AUTOPHAGY; AUTOPHOSPHORYLATION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHAPERONE-MEDIATED AUTOPHAGY; CONTROLLED STUDY; ENZYME ACTIVATION; FATTY ACID OXIDATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; IC50; LEUKEMIA CELL; MACROAUTOPHAGY; METABOLIC REGULATION; METABOLIC STRESS; MITOCHONDRIAL RESPIRATION; NUCLEAR REPROGRAMMING; NUTRITIONAL STATUS; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; HUMAN; LYSOSOME; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

AUTOPHAGY; BENZOTHIAZOLES; CELL LINE, TUMOR; FMS-LIKE TYROSINE KINASE 3; GLUCOSE; GLYCOLYSIS; HEXOKINASE; HUMANS; LEUKEMIA, MYELOID; LYSOSOMES; MOLECULAR CHAPERONES; PHENYLUREA COMPOUNDS; PROTEOLYSIS;

EID: 84962177627     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201503044     Document Type: Article

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