Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

Nature Structural and Molecular Biology

Volumn 25, Issue 1, 2018, Pages 53-60

  Hughes, Taylor E T ^a   Lodowski, David T ^a   Huynh, Kevin W ^a,b   Yazici, Aysenur ^c   Del Rosario, John ^c   Kapoor, Abhijeet ^d   Basak, Sandip ^a   Samanta, Amrita ^a   Han, Xu ^a   Chakrapani, Sudha ^a   Zhou, Z Hong ^b   Filizola, Marta ^d   Rohacs, Tibor ^c   Han, Seungil ^e   Moiseenkova Bell, Vera Y ^a,f  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECONAZOLE; PHOSPHATIDYLINOSITIDE; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 5;

ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CONFORMATIONAL TRANSITION; CRYOELECTRON MICROSCOPY; DRUG STRUCTURE; ION TRANSPORT; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIMULATION;

EID: 85042762807     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/s41594-017-0009-1     Document Type: Article

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