Structural basis of dual Ca 2+ /pH regulation of the endolysosomal TRPML1 channel

Nature Structural and Molecular Biology

Volumn 24, Issue 3, 2017, Pages 205-213

  Li, Minghui ^a   Zhang, Wei K ^b,c,d   Benvin, Nicole M ^a   Zhou, Xiaoyuan ^e   Su, Deyuan ^b,c,f   Li, Huan ^b,c,f   Wang, Shu ^b,c,f   Michailidis, Ioannis E ^a   Tong, Liang ^a   Li, Xueming ^e   Yang, Jian ^a,b,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c KUNMING INSTITUTE OF ZOOLOGY   (China)

^d SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES   (China)

^e TSINGHUA UNIVERSITY   (China)

^f UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYSTEINE; PROTEIN TRPML1; PROTON; TETRAMER; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG; AMINO ACID; CALCIUM; PROTEIN BINDING; PROTEIN SUBUNIT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM1 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; ENDOSOME; FEMALE; HUMAN; HUMAN CELL; LYSOSOME; MISSENSE MUTATION; MUCOLIPIDOSIS TYPE 4; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PH; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STRUCTURE ACTIVITY RELATION; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR MODEL; MUCOLIPIDOSIS; PROTEIN MULTIMERIZATION; PROTEIN SUBUNIT; REPRODUCIBILITY; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS; CALCIUM; CRYSTALLOGRAPHY, X-RAY; ENDOSOMES; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MODELS, MOLECULAR; MUCOLIPIDOSES; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; REPRODUCIBILITY OF RESULTS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 85010872102     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3362     Document Type: Article

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