Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Cell Metabolism

Volumn 27, Issue 4, 2018, Pages 935-943.e4

  Best, Sarah A ^a,b   De Souza, David P ^c   Kersbergen, Ariena ^a   Policheni, Antonia N ^a,b   Dayalan, Saravanan ^c   Tull, Dedreia ^c   Rathi, Vivek ^b   Gray, Daniel H ^a,b   Ritchie, Matthew E ^a,b,d   McConville, Malcolm J ^c   Sutherland, Kate D ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Keap1; non small cell lung cancer; Nrf2; PD L1; Pten; Taldo1

Indexed keywords

EPITHELIAL CELL ADHESION MOLECULE; FOXJ1 PROTEIN; GAMMA INTERFERON; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LACTIC ACID; ME1 PROTEIN; MESSENGER RNA; MUCIN 5AC; PDPN PROTEIN; PGD PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; SCGB1A1 PROTEIN; SFTPC PROTEIN; TALDO1 PROTEIN; TKT PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; KEAP1 PROTEIN, MOUSE; NFE2L2 PROTEIN, MOUSE; PTEN PROTEIN, HUMAN; PTEN PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHIOLE CELL; CARCINOGENESIS; CD8+ T LYMPHOCYTE; CELL HYPERPLASIA; CELL INFILTRATION; COMPARATIVE STUDY; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; INTRACELLULAR SPACE; LACTATE BLOOD LEVEL; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LUNG ADENOCARCINOMA; LUNG WEIGHT; MALE; MASS FRAGMENTOGRAPHY; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; TUMOR REGRESSION; TUMOR VOLUME; UPREGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; LOSS OF FUNCTION MUTATION; LUNG TUMOR; METABOLISM; MUTANT MOUSE STRAIN; PHYSIOLOGY;

ADENOCARCINOMA OF LUNG; ANIMALS; CARCINOGENESIS; CARCINOMA, NON-SMALL-CELL LUNG; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LOSS OF FUNCTION MUTATION; LUNG NEOPLASMS; MICE, MUTANT STRAINS; NF-E2-RELATED FACTOR 2; PENTOSE PHOSPHATE PATHWAY; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE;

EID: 85042664270     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2018.02.006     Document Type: Article

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