Unifying in vitro and in vivo IVT mRNA expression discrepancies in skeletal muscle via mechanotransduction

Biomaterials

Volumn 159, Issue , 2018, Pages 189-203

  Bhosle, Sushma M ^a   Loomis, Kristin H ^a   Kirschman, Jonathan L ^a   Blanchard, Emmeline L ^a   Vanover, Daryll A ^a   Zurla, Chiara ^a   Habrant, Damien ^b   Edwards, Darin ^c   Baumhof, Patrick ^d   Pitard, Bruno ^b   Santangelo, Philip J ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b In Cell Art   (France)

^c SANOFI PASTEUR   (France)

^d CureVac GmbH   (Germany)

Author keywords

ECM protein; Hydrogels; Mechanotransduction; mRNA delivery; Nanoparticles; Skeletalmuscle cells

Indexed keywords

CELLS; MUSCLE; NANOPARTICLES; PROTEINS; STIFFNESS MATRIX; VACCINES; VEHICLES;

ECM PROTEINS; EXTRACELLULAR MATRICES; MECHANOTRANSDUCTION; MRNA DELIVERY; PROTEIN EXPRESSION LEVELS; PROTEIN EXPRESSIONS; SKELETAL MUSCLE CELLS; TRANSLATIONAL EFFICIENCIES;

HYDROGELS;

AMINOGLYCOSIDE; MESSENGER RNA; NANOPARTICLE; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RELEASE; DRUG TRANSPORT; ENDOSOME; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX STIFFNESS; FEMALE; FLUORESCENCE ANALYSIS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MECHANOTRANSDUCTION; MOUSE; MUSCLE CELL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; FLOW CYTOMETRY; HELA CELL LINE; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL LINE; ENDOSOMES; EXTRACELLULAR MATRIX; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; HYDROGELS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED BALB C; MUSCLE, SKELETAL; NANOPARTICLES; RNA, MESSENGER;

EID: 85042634240     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2018.01.010     Document Type: Article

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