Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Advanced Healthcare Materials

Volumn 6, Issue 13, 2017, Pages

  Udhayakumar, Vimal K ^a   De Beuckelaer, Ans ^a   McCaffrey, Joanne ^b   McCrudden, Cian M ^b   Kirschman, Jonathan L ^c   Vanover, Daryll ^c   Van Hoecke, Lien ^a   Roose, Kenny ^a   Deswarte, Kim ^a,d   De Geest, Bruno G ^a   Lienenklaus, Stefan ^e   Santangelo, Philip J ^c   Grooten, Johan ^a   McCarthy, Helen O ^b   De Koker, Stefaan ^a  

^a GHENT UNIVERSITY   (Belgium)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c Emory University   (United States)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

CD8+ T cell responses; cpp; endosomal escape; mRNA vaccines; RALA mRNA nanocomplexes

Indexed keywords

ANTIGENS; ARGININE; CYTOLOGY; PEPTIDES; RNA; VACCINES;

CELL-PENETRATING PEPTIDE; CELLULAR UPTAKE; DENDRITIC CELLS; ENDOSOMAL ESCAPES; NANOCOMPLEXES; STRUCTURAL ORGANIZATION; T-CELL RESPONSE; UNIQUE SEQUENCE;

T-CELLS;

ARGININE RICH PEPTIDE; CELL PENETRATING PEPTIDE; MESSENGER RNA; PSEUDOURIDINE; RAL PROTEIN; UNCLASSIFIED DRUG; ANTIGEN; NANOMATERIAL;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGENICITY; ARTICLE; CELLULAR IMMUNITY; CLINICAL EFFECTIVENESS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOSOME; FEMALE; GENE TARGETING; IMMUNE SYSTEM; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN STRUCTURE; T LYMPHOCYTE; VACCINATION; ANIMAL; CD8+ T LYMPHOCYTE; CHEMISTRY; CYTOPLASM; DRUG DELIVERY SYSTEM; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL-PENETRATING PEPTIDES; CYTOPLASM; DRUG DELIVERY SYSTEMS; ENDOSOMES; FEMALE; MICE; MICE, KNOCKOUT; NANOSTRUCTURES; RNA, MESSENGER;

EID: 85018746720     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201601412     Document Type: Article

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