Hepatoprotective effects of ginseng in rats fed cholesterol rich diet

Acta Scientiae Veterinariae

Volumn 44, Issue 1, 2018, Pages

  Uluısık, Deniz ^a   Keskin, Ercan ^a  

^a SELCUK UNIVERSITY   (Turkey)

Author keywords

Cholesterol; Ginseng; Liver enzyme; Rat

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; GINSENG EXTRACT; LIVER ENZYME;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CHOLESTEROL DIET; CONTROLLED STUDY; DATA ANALYSIS; GINSENG; LIVER PROTECTION; MALE; NONHUMAN; RAT;

EID: 85042496579     PISSN: 16780345     EISSN: 16799216     Source Type: Journal    
DOI: 10.22456/1679-9216.80887     Document Type: Article

References (50)

1. Alpers D.H., Sabesin S.M. & White H.M. 1993. Fatty liver: biochemical and clinical aspect. In: Schiff L. & Schitt E.R. (Eds). Diseases of liver. 7th edn. Philadelphia: J.B. Lippincott Co., pp.825-871.
2. Attele A.S., Wu J.A. & Yuan C.S. 1999. Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology. 58(11): 1685-1693.
3. Burt A.D., Mutton A. & Day C.P. 1998. Diagnosis and interpretation of steatosis and steatohepatitis. Seminars in Diagnostic Pathology. 15(4): 246-258.
4. Buyssens N., Kockx M.M., Herman A.G., Lazou J.M., Van den Berg K., Wisse E. & Geerts A. 1996. Centrolobular liver fibrosis in the hypercholesterolemic rabbit. Hepatology. 24(4): 939-946.
5. Castelli W.P., Garrison R.J., Wilson P.W., Abbott R.D., Kalousdian S. & Kannel W.B. 1986. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. The Journal of the American Medical Association. 256(20): 2835-2838.
6. Cho H.C. 2010. The association between serum GGT concentration and diabetic peripheral polyneuropathy in type 2 diabetic patients. Korean Diabetes Journal. 34(2): 111-118.
7. Del Moral M.L., Esteban F.J., Torres M.I., Camacho M.V., Hernandez R., Jimenez A., Aranega A., Pedrosa J.A. & Peinado M.A. 1997. High-fat sunflower and olive oil diets affect serum lipid levels in steatotic rat liver differently. Journal of Nutritional Science and Vitaminology. 43(1): 155-160.
8. Dixit V.R., Jain P., Bhandari K. & Purohit A.K. 1991. Effects of ginseng (G-115) serum lipids of hyperlipidaemic rhesus monkeys (Macaca mulatta). Indian Journal of Pharmaceutical Sciences. 53(3): 88-91.
9. Drozdz R., Parmentier C., Hachad H., Leroy P., Siest G. & Wellman M. 1998. Gamma-glutamyltransferase dependent generation of reactive oxygen species from a glutsthione/transferrin system. Free Radical Biology and Medicine. 25(7): 786-792.
10. Farrell G.C. & Larter C.Z. 2006. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 43(2 suppl 1): 99-112.
11. Ferre N., Martinez-Clemente M., Lopez-Parra M., Gonzalez-Periz A., Horrillo R., Planaguma A., Camps J., Joven J., Tres A., Guardiola F., Bataller R., Arroyo V. & Claria J. 2009. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. American Journal of Physiology Gastrointestinal Liver Physiology. 296(3): 553-562.
12. Hwang S.Y., Son D.J., Kim I.W., Kim D.M., Sohn S.H., Lee J.J. & Kim S.K. 2008. Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits. Phytotherapy Research. 22(6): 778-783.
13. Jeong T.C., Kim H.J., Park J.I., Ha C.S., Park J.D., Kim S.I. & Roh J.K. 1997. Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatoxicity in Spargue Dawley rats. Planta Medica. 63(2): 136-140.
14. Jeong W.I., Jeong D.H., Do S.H., Kim Y.K., Park H.Y., Kwon O.D., Kim T.H. & Jeong K.S. 2005. Mild hepatic fibrosis in cholesterol and sodium cholate diet-fed rats. Journal of Veterinary Medical Science. 67(3): 235-242.
15. Jeong W.I., Lee C.S., Park S.J., Chung J.Y. & Jeong K.S. 2002. Kinetics of macrophages, myofibroblasts and mast cells in carbon tetrachloride-induced rat liver cirrhosis. Anticancer Research. 22(2A): 869-877.
16. Johnson S.J., Hines J.E. & Burt A.D. 1992. Macrophage and perisinusoidal cell kinetics in acute liver injury. The Journal of Pathology. 166(4): 351-358.
17. Jou J., Choi S.S. & Diehl A.M. 2008. Mechanisms of disease progression in nonalcoholic fatty liver disease. Seminars in Liver Disease. 28(4): 370-379.
18. Kalkan Y., Kapakin K.A.T., Kara A., Atabay T., Karadeniz A., Simsek N., Karakus E., Can I., Yildirim S., Ozkanlar S. & Sengul E. 2012. Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate. Journal of Molecular Histology. 43(5): 603-613.
19. Karadeniz A., Cemek M. & Simsek N. 2009. The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats. Ecotoxicology and Environmental Safety. 72(1): 231-235.
20. Karadeniz A., Yıldırım A., Karakoc A., Kalkan Y. & Celebi F. 2009. Protective effect of Panax ginseng on carbon tetrachloride induced liver, heart and kidney injury in rats. Revue de Médecine Vétérinaire. 160(5): 237-243.
21. Kim D.J., Seong K.S., Kim D.W., Ko S.R. & Chang C.C. 2004. Antioxidative effects of red ginseng saponins on paraquat-induced oxidative stress. Journal of Ginseng Research. 28(1): 5-10.
22. Kim H.J., Lee S.G., Chae I.G., Kim M.J., Im N.K., Yu M.H., Lee E.J. & Lee I.S. 2011. Antioxidant effects of fermented red ginseng extracts in streptozotocin-induced diabetic rats. Journal of Ginseng Research. 35(2): 129-137.
23. Kim K. & Kim H.Y. 2008. Korean red ginseng stimulates insulin release from isolated ratpancreatic islets. Journal of Ethnopharmacology. 120(2): 190-195.
24. Kim Y.S., Kim Y.H., Noh J.R., Cho E.S., Park J.H. & Son H.Y. 2011. Protective effect of Korean red ginseng against aflatoxin B1-induced hepatotoxicity in rat. Journal of Gin-seng Research. 35(2): 243-249.
25. Kitts D.D. & Hu C. 2000. Efficacy and safety of ginseng. Public Health Nutrition. 3(4A): 473-485.
26. Kwak Y.S., Kyung J.S., Kim J.S., Cho J.Y. & Rhee M.H. 2010. Antihyperlipidemic effects of red ginseng acidic polysaccharides from Korean red ginseng. Biological and Pharmaceutical Bulletin. 33(3): 468-472.
27. Lee C.K., Choi J.W., Kim H. & Han Y.N. 1999. Biological activities of acidic polysaccharide of Korean red ginseng. II. Effects on hyperlipidemia induced by alcohol. Journal of Ginseng Research. 23(1): 8-12.
28. Lee H.U., Bae E.A., Han M.J. & Kim D.H. 2005. Hepatoprotective effect of 20(S) ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury. Biological and Pharmaceutical Bulletin. 28(10): 1992-1994.
29. Lee H.U., Bae E.A., Han M.J., Kim N.J. & Kim D.H. 2005. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver International. 25(5): 1069-1073.
30. Lee S.J., Sung J.H., Lee S.J., Moo C.K. & Lee B.H. 1999. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Letters. 144(1): 39-43.
31. Liu R., Zhang J., Liu W., Kimura Y. & Zheng Y. 2010. Anti-obesity effects of protopanaxdiol types of ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet. Fitoterapia. 81(8): 1079-1087.
32. Liu W., Zheng Y., Han L., Wang H., Saito M., Ling M., Kimura Y. & Feng Y. 2008. Saponins (Ginsenosides) from stems and leaves of Panax quinquefolium prevented high-fat diet-induced obesity in mice. Phytomedicine. 15(12): 1140-1145.
33. Lones T.J. 1991. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes ? Diabetes Medicine. 8(5): 411-419.
34. Ng T.B. & Yeung H.W. 1985. Hypoglycemic constituents of Panax ginseng. General Pharmacology. 16(6): 549-552.
35. Park E., Hwang I., Song J.Y. & Jee Y. 2011. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta Histochemica. 113(1): 19-23.
36. Park E.K., Choo M.K., Han M.J. & Kim D.H. 2004. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. International Archives of Allergy and Immunology. 133(2): 113-120.
37. Park W.H., Lee S.K. & Kim C.H. 2005. A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats. Life Sciences. 76(15): 1675-1690.
38. Ramesh T., Kim S.W., Hwang S.Y., Sohn S.H., Yoo S.K. & Kim S.K. 2012. Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats. Nutrition Research. 32(9): 718-726.
39. RameshT.,KimS.W.,SungJ.H.,HwangS.Y.,SohnS.H.,YooS.K.&KimS.K.2012.EffectoffermentedPanaxginsengextract (GINST)onoxidativestressandantioxidantactivitiesinmajororgansofagedrats.ExperimentalGerontology.47(1):77-84.
40. Ronnemaa T., Pelliniemi T.T. & Kulonen E. 1976. Factors stimulating collagen synthesis from the livers of hypercholesterolemic rats. Atherosclerosis. 24(1-2): 311-321.
41. TaiE.S.,LimS.C.,TanB.Y.,ChewS.K.,HengD.&TanC.E.2000.Screeningfordiabetesmellitus:atwo-stepapproachinindividualswithimpairedfastingglucoseimprovesindetectionofthoseatriskofcomplications.DiabetesMedicine.17(11):771-775.
42. Takaku T., Kameda K., Matsuura Y., Sekiya K. & Okuda H. 1990. Studies on insulin like stances in Korean red ginseng. Planta Medica. 56(1): 27-30.
43. Tanaka N., Tanaka O. & Shibata S. 1972. Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng; Stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc. Chemical and Pharmaceutical Bulletin. 20(6): 1212-1216.
44. Wakabayashi C., Hasegewa H., Murata J. & Saiki I. 1997. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncology Research. 9(8): 411-417.
45. Wanless I.R., Belgiorno J. & Huet P.M. 1996. Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole. Hepatology. 24(4): 855-864.
46. Wu J.Y., Gardner B.H., Murphy C.I., Seals J.R., Kensil C.R., Recchia J., Beltz G.A., Newman G.W. & Newman M.J. 1992. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine. The Journal of Immunology. 148(5): 1519-1525.
47. Yokozawa T., Kim H.Y., Kim H.J., Tanaka T., Sugino H., Okubo T., Chu D.C. & Juneja L.R. 2007. Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress. Journal of Agricultural and Food Chemistry. 55(19): 7744-7752.
48. Yoshikawa M., Morikawa T., Kashima Y., Ninomuya K. & Matsuda H. 2003. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and Hepatoprotective effects of principal ginseng saponins. Journal of Natural Products. 66(7): 922-927.
49. Yun S.H. & Joo C.N. 1993. Study on the preventive effect of ginsenosides against hypercholesterolemia and its mechanism. Korean Journal of Ginseng Science. 17(1): 1-12.
50. Yun T.K., Lee Y.S., Lee Y.H., Kim S.I. & Yun H.Y. 2001. Anticarcinogenic effect of Panax ginseng and identification of active compounds. Journal of Korean Medical Science. 16(S): 6-18.