Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Kim, So Yeon ^a   Jeong, Jong Min ^a   Kim, Soo Jin ^a   Seo, Wonhyo ^a   Kim, Myung Ho ^a   Choi, Won Mook ^a   Yoo, Wonbeak ^a   Lee, Jun Hee ^a   Shim, Young Ri ^a   Yi, Hyon Seung ^b   Lee, Young Sun ^c   Eun, Hyuk Soo ^b   Lee, Byung Seok ^b   Chun, Kwangsik ^b   Kang, Suk Jo ^a   Kim, Sun Chang ^a,d   Gao, Bin ^e   Kunos, George ^e   Kim, Ho Min ^a   Jeong, Won Il ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chungnam National University   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d Intelligent Synthetic Biology Center   (South Korea)

^e NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD68 ANTIGEN; DYNAMIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PALMITIC ACID; PROTEIN MD 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; CD11B ANTIGEN; CYBB PROTEIN, MOUSE; LY96 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL INFILTRATION; CONTROLLED STUDY; ENDOCYTOSIS; FATTY LIVER; GENE EXPRESSION; HIGH-FAT DIET-INDUCED STEATOHEPATITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; KUPFFER CELL; MACROPHAGE; MALE; MOLECULAR PATHOLOGY; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; INFLAMMATION; LIPID DIET; LIVER; METABOLISM; RAW 264.7 CELL LINE;

MUS;

ANIMALS; CD11B ANTIGEN; DIET, HIGH-FAT; ENDOCYTOSIS; ENZYME ACTIVATION; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION; LIVER; LYMPHOCYTE ANTIGEN 96; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE 2; NON-ALCOHOLIC FATTY LIVER DISEASE; PALMITIC ACID; RAW 264.7 CELLS; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 4;

EID: 85042357204     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02325-2     Document Type: Article

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