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Volumn 8, Issue 1, 2017, Pages

The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN FIBRIN RECEPTOR C TYPE LECTIN LIKE 2; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; GLYCOPROTEIN VI; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PODOPLANIN; PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CHEMOKINE; CLEC-2 PROTEIN, MOUSE; CYTOKINE; FIBRINOGEN RECEPTOR; GP38 PROTEIN, MOUSE; LECTIN; MEMBRANE PROTEIN; PLATELET MEMBRANE GLYCOPROTEIN VI;

EID: 85042355250     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-02402-6     Document Type: Article
Times cited : (104)

References (56)
  • 1
    • 84883076264 scopus 로고    scopus 로고
    • Severe sepsis and septic shock
    • Angus, D. C. & van der Poll, T. Severe sepsis and septic shock. N. Engl. J. Med. 369, 840-851 (2013).
    • (2013) N. Engl. J. Med. , vol.369 , pp. 840-851
    • Angus, D.C.1    Van Der Poll, T.2
  • 2
    • 77958108729 scopus 로고    scopus 로고
    • Critical care and the global burden of critical illness in adults
    • Adhikari, N. K., Fowler, R. A., Bhagwanjee, S. & Rubenfeld, G. D. Critical care and the global burden of critical illness in adults. Lancet 376, 1339-1346 (2010).
    • (2010) Lancet , vol.376 , pp. 1339-1346
    • Adhikari, N.K.1    Fowler, R.A.2    Bhagwanjee, S.3    Rubenfeld, G.D.4
  • 3
    • 0038578608 scopus 로고    scopus 로고
    • Novel strategies for the treatment of sepsis
    • Riedemann, N. C., Guo, R. F. & Ward, P. A. Novel strategies for the treatment of sepsis. Nat. Med. 9, 517-524 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 517-524
    • Riedemann, N.C.1    Guo, R.F.2    Ward, P.A.3
  • 5
    • 0037508533 scopus 로고    scopus 로고
    • Inflammation and coagulation: Implications for the septic patient
    • Dellinger, R. P. Inflammation and coagulation: implications for the septic patient. Clin. Infect. Dis. 36, 1259-1265 (2003).
    • (2003) Clin. Infect. Dis. , vol.36 , pp. 1259-1265
    • Dellinger, R.P.1
  • 6
    • 84866386143 scopus 로고    scopus 로고
    • Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis
    • McDonald, B. et al. Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis. Cell Host Microbe 12, 324-333 (2012).
    • (2012) Cell Host Microbe , vol.12 , pp. 324-333
    • McDonald, B.1
  • 7
    • 84864121891 scopus 로고    scopus 로고
    • Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice
    • Meng, W. et al. Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice. Crit. Care 16, R137 (2012).
    • (2012) Crit. Care , vol.16 , pp. R137
    • Meng, W.1
  • 8
    • 65549084772 scopus 로고    scopus 로고
    • PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
    • Huang, X., Venet, F. & Wang, Y. L. et al. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc. Natl Acad. Sci. USA 106, 6303-6308 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6303-6308
    • Huang, X.1    Venet, F.2    Wang, Y.L.3
  • 9
    • 84925357077 scopus 로고    scopus 로고
    • PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
    • Martinod, K., Fuchs, T. A. & Zitomersky, N. L. et al. PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock. Blood 125, 1948-1956 (2015).
    • (2015) Blood , vol.125 , pp. 1948-1956
    • Martinod, K.1    Fuchs, T.A.2    Zitomersky, N.L.3
  • 10
    • 79952205667 scopus 로고    scopus 로고
    • Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis
    • Ocuin, L. M. et al. Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis. J. Leukoc. Biol. 89, 423-432 (2011).
    • (2011) J. Leukoc. Biol. , vol.89 , pp. 423-432
    • Ocuin, L.M.1
  • 13
    • 84889570738 scopus 로고    scopus 로고
    • Platelets protect from septic shock by inhibiting macrophagedependent inflammation via the cyclooxygenase 1 signalling pathway
    • Xiang, B. et al. Platelets protect from septic shock by inhibiting macrophagedependent inflammation via the cyclooxygenase 1 signalling pathway. Nat. Commun. 4, 2657 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2657
    • Xiang, B.1
  • 14
    • 84973619512 scopus 로고    scopus 로고
    • Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients
    • Claushuis, T. A. et al. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients. Blood 127, 3062-3072 (2016).
    • (2016) Blood , vol.127 , pp. 3062-3072
    • Claushuis, T.A.1
  • 15
    • 84871809432 scopus 로고    scopus 로고
    • Thrombocytopenia as a predictor of severe acute kidney injury in patients with Hantaan virus infections
    • Wang, M. et al. Thrombocytopenia as a predictor of severe acute kidney injury in patients with Hantaan virus infections. PLoS ONE 8, e53236 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e53236
    • Wang, M.1
  • 16
    • 84991031123 scopus 로고    scopus 로고
    • Thrombocytopenia in adult patients with sepsis: Incidence, risk factors, and its association with clinical outcome
    • Venkata, C., Kashyap, R., Farmer, J. C. & Afessa, B. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. J. Intensive care 1, 9 (2013).
    • (2013) J. Intensive Care , vol.1 , pp. 9
    • Venkata, C.1    Kashyap, R.2    Farmer, J.C.3    Afessa, B.4
  • 17
    • 46749098410 scopus 로고    scopus 로고
    • Inflammation induces hemorrhage in thrombocytopenia
    • Goerge, T. et al. Inflammation induces hemorrhage in thrombocytopenia. Blood 111, 4958-4964 (2008).
    • (2008) Blood , vol.111 , pp. 4958-4964
    • Goerge, T.1
  • 19
    • 84873377815 scopus 로고    scopus 로고
    • Platelet ITAM signaling is critical for vascular integrity in inflammation
    • Boulaftali, Y. et al. Platelet ITAM signaling is critical for vascular integrity in inflammation. J. Clin. Invest. 123, 908-916 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 908-916
    • Boulaftali, Y.1
  • 20
    • 84940063259 scopus 로고    scopus 로고
    • Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice
    • Gros, A. et al. Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice. Blood 126, 1017-1026 (2015).
    • (2015) Blood , vol.126 , pp. 1017-1026
    • Gros, A.1
  • 21
    • 0030796363 scopus 로고    scopus 로고
    • Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis
    • Breiteneder-Geleff, S. et al. Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am. J. Pathol. 151, 1141-1152 (1997).
    • (1997) Am. J. Pathol. , vol.151 , pp. 1141-1152
    • Breiteneder-Geleff, S.1
  • 22
    • 0028984957 scopus 로고
    • Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives
    • Rishi, A. K. et al. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev. Biol. 167, 294-306 (1995).
    • (1995) Dev. Biol. , vol.167 , pp. 294-306
    • Rishi, A.K.1
  • 23
    • 0026722290 scopus 로고
    • Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues
    • Farr, A. G. et al. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J. Exp. Med. 176, 1477-1482 (1992).
    • (1992) J. Exp. Med. , vol.176 , pp. 1477-1482
    • Farr, A.G.1
  • 24
    • 0029881460 scopus 로고    scopus 로고
    • Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes
    • Wetterwald, A. et al. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone 18, 125-132 (1996).
    • (1996) Bone , vol.18 , pp. 125-132
    • Wetterwald, A.1
  • 25
    • 77956912413 scopus 로고    scopus 로고
    • A distinct subset of podoplanin (gp38) expressing F4/80 + macrophages mediate phagocytosis and are induced following zymosan peritonitis
    • Hou, T. Z. et al. A distinct subset of podoplanin (gp38) expressing F4/80 + macrophages mediate phagocytosis and are induced following zymosan peritonitis. FEBS Lett. 584, 3955-3961 (2010).
    • (2010) FEBS Lett , vol.584 , pp. 3955-3961
    • Hou, T.Z.1
  • 26
    • 84863412801 scopus 로고    scopus 로고
    • Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2
    • Kerrigan, A. M. et al. Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2. J. Thromb. Haemost. 10, 484-486 (2012).
    • (2012) J. Thromb. Haemost. , vol.10 , pp. 484-486
    • Kerrigan, A.M.1
  • 27
    • 84355166761 scopus 로고    scopus 로고
    • Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation
    • Peters, A. et al. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 35, 986-996 (2011).
    • (2011) Immunity , vol.35 , pp. 986-996
    • Peters, A.1
  • 28
    • 84873339567 scopus 로고    scopus 로고
    • Podoplanin: Emerging functions in development, the immune system, and cancer
    • Astarita, J. L., Acton, S. E. & Turley, S. J. Podoplanin: emerging functions in development, the immune system, and cancer. Front. Immunol. 3, 283 (2012).
    • (2012) Front. Immunol. , vol.3 , pp. 283
    • Astarita, J.L.1    Acton, S.E.2    Turley, S.J.3
  • 29
    • 77956510719 scopus 로고    scopus 로고
    • Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway
    • Devi, S. et al. Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Am. J. Pathol. 177, 1131-1142 (2010).
    • (2010) Am. J. Pathol. , vol.177 , pp. 1131-1142
    • Devi, S.1
  • 30
    • 84942279085 scopus 로고    scopus 로고
    • Fibrin activates GPVI in human and mouse platelets
    • Alshehri, O. M. et al. Fibrin activates GPVI in human and mouse platelets. Blood 126, 1601-1608 (2015).
    • (2015) Blood , vol.126 , pp. 1601-1608
    • Alshehri, O.M.1
  • 31
    • 84940023454 scopus 로고    scopus 로고
    • Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation
    • Mammadova-Bach, E. et al. Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation. Blood 126, 683-691 (2015).
    • (2015) Blood , vol.126 , pp. 683-691
    • Mammadova-Bach, E.1
  • 32
    • 84948843996 scopus 로고    scopus 로고
    • Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets
    • Hitchcock, J. R. et al. Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J. Clin. Invest. 125, 4429-4446 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 4429-4446
    • Hitchcock, J.R.1
  • 33
    • 85027337371 scopus 로고    scopus 로고
    • Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis
    • Payne, H., Ponomaryov, T., Watson, S. P. & Brill, A. Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood 129, 2013-2020 (2017).
    • (2017) Blood , vol.129 , pp. 2013-2020
    • Payne, H.1    Ponomaryov, T.2    Watson, S.P.3    Brill, A.4
  • 34
    • 12544254834 scopus 로고    scopus 로고
    • Acute inflammatory response to endotoxin in mice and humans
    • Copeland, S. et al. Acute inflammatory response to endotoxin in mice and humans. Clin. Diagn. Lab. Immunol. 12, 60-67 (2005).
    • (2005) Clin. Diagn. Lab. Immunol. , vol.12 , pp. 60-67
    • Copeland, S.1
  • 35
    • 0033969341 scopus 로고    scopus 로고
    • Pro-versus antiinflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options
    • Gogos, C. A., Drosou, E., Bassaris, H. P. & Skoutelis, A. Pro-versus antiinflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J. Infect. Dis. 181, 176-180 (2000).
    • (2000) J. Infect. Dis. , vol.181 , pp. 176-180
    • Gogos, C.A.1    Drosou, E.2    Bassaris, H.P.3    Skoutelis, A.4
  • 37
    • 0031836105 scopus 로고    scopus 로고
    • Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
    • Belaaouaj, A. et al. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 4, 615-618 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 615-618
    • Belaaouaj, A.1
  • 38
    • 84891645973 scopus 로고    scopus 로고
    • The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer?
    • Boomer, J. S., Green, J. M. & Hotchkiss, R. S. The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer? Virulence 5, 45-56 (2014).
    • (2014) Virulence , vol.5 , pp. 45-56
    • Boomer, J.S.1    Green, J.M.2    Hotchkiss, R.S.3
  • 39
    • 0029348036 scopus 로고
    • Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture
    • Remick, D. et al. Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock 4, 89-95 (1995).
    • (1995) Shock , vol.4 , pp. 89-95
    • Remick, D.1
  • 40
    • 84892735965 scopus 로고    scopus 로고
    • Role of cytokines as a double-edged sword in sepsis
    • Chaudhry, H., Zhou, J. & Zhong, Y. et al. Role of cytokines as a double-edged sword in sepsis. In. Vivo. 27, 669-684 (2013).
    • (2013) Vivo. , vol.27 , pp. 669-684
    • Chaudhry, H.1    Zhou, J.2    Zhong, Y.3
  • 41
    • 0036604216 scopus 로고    scopus 로고
    • Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney
    • Cunningham, P. N. et al. Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney. J. Immunol. 168, 5817-5823 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5817-5823
    • Cunningham, P.N.1
  • 42
    • 85013962639 scopus 로고    scopus 로고
    • GPVI and thromboxane receptor on platelets promote proinflammatory macrophage phenotypes during cutaneous inflammation
    • Pierre, S. et al. GPVI and thromboxane receptor on platelets promote proinflammatory macrophage phenotypes during cutaneous inflammation. J. Invest. Dermatol. 137, 686-695 (2017).
    • (2017) J. Invest. Dermatol. , vol.137 , pp. 686-695
    • Pierre, S.1
  • 43
    • 33646559569 scopus 로고    scopus 로고
    • Roles of protease-activated receptors in a mouse model of endotoxemia
    • Camerer, E. et al. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood 107, 3912-3921 (2006).
    • (2006) Blood , vol.107 , pp. 3912-3921
    • Camerer, E.1
  • 44
    • 17144432366 scopus 로고    scopus 로고
    • Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models
    • Corral, J. et al. Role of Lipopolysaccharide and Cecal Ligation and Puncture on Blood Coagulation and Inflammation in Sensitive and Resistant Mice Models. Am. J. Pathol. 166, 1089-1098 (2005).
    • (2005) Am. J. Pathol. , vol.166 , pp. 1089-1098
    • Corral, J.1
  • 45
    • 85012840960 scopus 로고    scopus 로고
    • Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice
    • McDonald, B. et al. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood 129, 1357-1367 (2017).
    • (2017) Blood , vol.129 , pp. 1357-1367
    • McDonald, B.1
  • 47
    • 84940959573 scopus 로고    scopus 로고
    • The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state
    • Lowe, K. L. et al. The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. Eur. J. Immunol. 45, 2484-2493 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 2484-2493
    • Lowe, K.L.1
  • 48
    • 84930002747 scopus 로고    scopus 로고
    • HCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells
    • Siegemund, S., Shepherd, J., Xiao, C. & Sauer, K. hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells. PLoS ONE 10, e0124661 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0124661
    • Siegemund, S.1    Shepherd, J.2    Xiao, C.3    Sauer, K.4
  • 49
    • 84857565263 scopus 로고    scopus 로고
    • CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development
    • Finney, B. A. et al. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood 119, 1747-1756 (2012).
    • (2012) Blood , vol.119 , pp. 1747-1756
    • Finney, B.A.1
  • 50
    • 79959841785 scopus 로고    scopus 로고
    • Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl (3)-induced thrombosis
    • Bender, M., Hagedorn, I. & Nieswandt, B. Genetic and antibody-induced glycoprotein VI deficiency equally protects mice from mechanically and FeCl (3)-induced thrombosis. J. Thromb. Haemost. 9, 1423-1426 (2011).
    • (2011) J. Thromb. Haemost. , vol.9 , pp. 1423-1426
    • Bender, M.1    Hagedorn, I.2    Nieswandt, B.3
  • 51
    • 84876289215 scopus 로고    scopus 로고
    • Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice
    • Bender, M. et al. Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler. Thromb. Vasc. Biol. 33, 926-934 (2013).
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 926-934
    • Bender, M.1
  • 52
    • 0037247603 scopus 로고    scopus 로고
    • Podocyte-specific expression of cre recombinase in transgenic mice
    • Moeller, M. J., Sanden, S. K., Soofi, A., Wiggins, R. C. & Holzman, L. B. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 35, 39-42 (2003).
    • (2003) Genesis , vol.35 , pp. 39-42
    • Moeller, M.J.1    Sanden, S.K.2    Soofi, A.3    Wiggins, R.C.4    Holzman, L.B.5
  • 53
    • 84987909246 scopus 로고    scopus 로고
    • Vitamin D deficiency in human and murine sepsis
    • Parekh, D. et al. Vitamin D deficiency in human and murine sepsis. Crit. Care Med. 45, 282-289 (2017).
    • (2017) Crit. Care Med. , vol.45 , pp. 282-289
    • Parekh, D.1
  • 54
    • 84899474295 scopus 로고    scopus 로고
    • A robust scoring system to evaluate sepsis severity in an animal model
    • Shrum, B. et al. A robust scoring system to evaluate sepsis severity in an animal model. BMC Res. Notes 7, 233 (2014).
    • (2014) BMC Res. Notes , vol.7 , pp. 233
    • Shrum, B.1
  • 55
    • 84919911314 scopus 로고    scopus 로고
    • The Nterminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets
    • Hughes, C. E., Finney, B. A., Koentgen, F., Lowe, K. L. & Watson, S. P. The Nterminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. Blood 125, 144-154 (2015).
    • (2015) Blood , vol.125 , pp. 144-154
    • Hughes, C.E.1    Finney, B.A.2    Koentgen, F.3    Lowe, K.L.4    Watson, S.P.5
  • 56
    • 84880884552 scopus 로고    scopus 로고
    • Cell density during differentiation can alter the phenotype of bone marrow-derived macrophages
    • Lee, C. M. & Hu, J. Cell density during differentiation can alter the phenotype of bone marrow-derived macrophages. Cell Biosci. 3, 30 (2013).
    • (2013) Cell Biosci. , vol.3 , pp. 30
    • Lee, C.M.1    Hu, J.2


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