Vitamin D deficiency in human and murine sepsis

Critical Care Medicine

Volumn 45, Issue 2, 2017, Pages 282-289

  Parekh, Dhruv ^a,b   Patel, Jaimin M ^a,c   Scott, Aaron ^a   Lax, Sian ^a   Dancer, Rachel C A ^a   D'souza, Vijay ^a   Greenwood, Hannah ^a   Fraser, William D ^d   Gao, Fang ^a,c   Sapey, Elizabeth ^a   Perkins, Gavin D ^b,c   Thickett, David R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

cecal ligation and puncture; sepsis; Vitamin D deficiency

Indexed keywords

CALCIFEDIOL; CATHELICIDIN; COLECALCIFEROL; POLYPEPTIDE ANTIBIOTIC AGENT;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTEREMIA; BACTERIUM CULTURE; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CELL DAMAGE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HOSPITAL ADMISSION; HUMAN; HYPOXIA; INFLAMMATION; LUNG ALVEOLUS; LUNG INJURY; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; MOUSE; NEUTROPHILIA; NONHUMAN; PERITONEUM; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANIMAL; BLOOD; C57BL MOUSE; CASE CONTROL STUDY; COMPLICATION; DISEASE MODEL; HOSPITAL MORTALITY; MORTALITY; RISK FACTOR;

AGED; ANIMALS; CALCIFEDIOL; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MICE; MICE, INBRED C57BL; RISK FACTORS; SEPSIS; VITAMIN D DEFICIENCY;

EID: 84987909246     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000002095     Document Type: Article

References (33)

1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20: 864-874
2. Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign Management Guidelines Committee: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32: 858-873
3. Nathani N, Perkins GD, Tunnicliffe W, et al. Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome. Crit Care 2008; 12: R12
4. Greenwood H, Patel J, Mahida R, et al. Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): Study protocol for a randomised placebo-controlled trial. Trials 2014; 15: 332
5. van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab 2011; 25: 671-680
6. Shoben AB, Kestenbaum B, Levin G, et al. Seasonal variation in 25-hydroxyvitamin D concentrations in the cardiovascular health study. Am J Epidemiol 2011; 174: 1363-1372
7. Sherman SS, Hollis BW, Tobin JD. Vitamin D status and related parameters in a healthy population: The effects of age, sex, and season. J Clin Endocrinol Metab 1990; 71: 405-413
8. Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y. Nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr 2007; 85: 860-868
9. Danai PA, Sinha S, Moss M, et al. Seasonal variation in the epidemiology of sepsis. Crit Care Med 2007; 35: 410-415
10. Parekh D, Thickett DR, Turner AM. Vitamin D deficiency and acute lung injury. Inflamm Allergy Drug Targets 2013; 12: 253-261
11. Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. FASEB J 2005; 19: 1067-1077
12. Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008; 13: 6-20
13. Remmelts HH, van de Garde EM, Meijvis SC, et al. Addition of vitamin D status to prognostic scores improves the prediction of outcome in community-Acquired pneumonia. Clin Infect Dis 2012; 55: 1488-1494
14. Braun AB, Litonjua AA, Moromizato T, et al. Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill. Crit Care Med 2012; 40: 3170-3179
15. Braun AB, Gibbons FK, Litonjua AA, et al. Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med 2012; 40: 63-72
16. Moromizato T, Litonjua AA, Braun AB, et al. Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill. Crit Care Med 2014; 42: 97-107
17. de Haan K, Groeneveld AB, de Geus HR, et al. Vitamin D deficiency as a risk factor for infection, sepsis and mortality in the critically ill: Systematic review and meta-Analysis. Crit Care 2014; 18: 660
18. Upala S, Sanguankeo A, Permpalung N. Significant association between vitamin D deficiency and sepsis: A systematic review and meta-Analysis. BMC Anesthesiol 2015; 15: 84
19. Dancer RC, Parekh D, Lax S, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax 2015; 70: 617-624
20. Patel JM, Snaith C, Thickett DR, et al. Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care 2012; 16: R231
21. Owens DJ, Webber D, Impey SG, et al. Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males. Eur J Appl Physiol 2014; 114: 1309-1320
22. Marcinowska-Suchowierska E, Walicka M, Talalaj M, et al. Vitamin D supplementation in adults - guidelines. Endokrynol Pol 2010; 61: 723-729
23. Lax S, Wilson MR, Takata M, et al. Using a non-invasive assessment of lung injury in a murine model of acute lung injury. BMJ Open Respir Res 2014; 1: e000014
24. Kovach MA, Ballinger MN, Newstead MW, et al. Cathelicidin-related antimicrobial peptide is required for effective lung mucosal immunity in Gram-negative bacterial pneumonia. J Immunol 2012; 189: 304-311
25. Quraishi SA, Litonjua AA, Moromizato T, et al. Association between prehospital vitamin D status and hospital-Acquired bloodstream infections. Am J Clin Nutr 2013; 98: 952-959
26. Thickett DR, Moromizato T, Litonjua AA, et al. Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: A retrospective cohort study. BMJ Open Respir Res 2015; 2: e000074
27. Parekh D, Dancer RC, Lax S, et al. Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO): Study protocol for a randomised placebo controlled trial. Trials 2013; 14: 100
28. Møller S, Laigaard F, Olgaard K, et al. Effect of 1, 25-dihydroxy-vitamin D3 in experimental sepsis. Int J Med Sci 2007; 4: 190-195
29. Jeng L, Yamshchikov AV, Judd SE, et al. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 2009; 7: 28
30. Leaf DE, Croy HE, Abrahams SJ, et al. Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients. Crit Care 2015; 19: 80
31. Leaf DE, Raed A, Donnino MW, et al. Randomized controlled trial of calcitriol in severe sepsis. Am J Respir Crit Care Med 2014; 190: 533-541
32. Amrein K, Schnedl C, Holl A, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: The VITdAL-ICU randomized clinical trial. JAMA 2014; 312: 1520-1530
33. Nair P, Venkatesh B, Lee P, et al A randomized study of a single dose of intramuscular cholecalciferol in critically ill adults. Crit Care Med 2015; 43: 2313-2320