Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway

Nature Communications

Volumn 4, Issue , 2013, Pages

  Xiang, Binggang ^a   Zhang, Guoying ^a   Guo, Ling ^a   Li, Xiang An ^a   Morris, Andrew J ^a   Daugherty, Alan ^a   Whiteheart, Sidney W ^a   Smyth, Susan S ^a,b   Li, Zhenyu ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b LEXINGTON VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; CYCLOOXYGENASE 1; INTERLEUKIN 6; LACTATE DEHYDROGENASE; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY; BACTERIUM; BLOOD; DISEASE TREATMENT; ENZYME ACTIVITY; INHIBITION; MORTALITY; PATHOLOGY; PUBLIC HEALTH; RODENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BACTEREMIA; BLEEDING; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; DISEASE SEVERITY; ENDOTOXEMIA; INFLAMMATION; MACROPHAGE; MACROPHAGE FUNCTION; MALE; MORTALITY; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PROTEIN EXPRESSION; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SURVIVAL RATE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

BACTERIA (MICROORGANISMS); MUS;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; BLOOD PLATELETS; CYCLOOXYGENASE 1; DINOPROSTONE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PLATELET TRANSFUSION; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; THROMBOCYTOPENIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84889570738     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3657     Document Type: Article

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