Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

Science

Volumn 359, Issue 6377, 2018, Pages 794-797

  Ugurlar, Deniz ^a   Howes, Stuart C ^b   De Kreuk, Bart Jan ^c   Koning, Roman I ^b,d   De Jong, Rob N ^c   Beurskens, Frank J ^c   Schuurman, Janine ^c   Koster, Abraham J ^b,d   Sharp, Thomas H ^b   Parren, W H I ^b,c   Gros, Piet ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c GENMAB   (Netherlands)

^d LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; LIPOSOME; PHOSPHATIDYLSERINE; ALARMIN; COMPLEMENT COMPONENT C1; MONOCLONAL ANTIBODY;

ANTIBODY; CELL COMPONENT; ENZYME; ENZYME ACTIVITY; GENE; IMMUNE RESPONSE; PATTERN RECOGNITION; PROTEIN;

ANTIGEN BINDING; ARTICLE; BINDING SITE; COMPLEMENT DEPENDENT CYTOTOXICITY; CONFORMATIONAL TRANSITION; CRYOELECTRON MICROSCOPY; GENE MUTATION; HOST CELL; HUMAN; IMMUNOGLOBULIN STRUCTURE; INNATE IMMUNITY; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECOGNITION; CHEMISTRY; COMPLEMENT ACTIVATION; GENETICS; ULTRASTRUCTURE;

ALARMINS; ANTIBODIES, MONOCLONAL; BINDING SITES; COMPLEMENT ACTIVATION; COMPLEMENT C1; CRYOELECTRON MICROSCOPY; HUMANS; IMMUNOGLOBULIN G;

EID: 85042187400     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aao4988     Document Type: Article

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