Monomeric structures of the zymogen and active catalytic domain of complement protease C1r: Further insights into the C1 activation mechanism

Structure

Volumn 10, Issue 11, 2002, Pages 1509-1519

  Budayova Spano, Monika ^a   Grabarse, Wolfgang ^b   Thielens, Nicole M ^a   Hillen, Heinz ^c   Lacroix, Monique ^a   Schmidt, Martin ^c   Fontecilla Camps, Juan Carlos ^a   Arlaud, Gérard J ^a   Gaboriaud, Christine ^a  

^a CEA GRENOBLE   (France)

^b BASF SE   (Germany)

^c ABBOTT GMBH AND CO KG   (Germany)

Author keywords

Activation; Complement; Innate immunity; Serine protease; Substrate specificity

Indexed keywords

ENZYME PRECURSOR; PROTEINASE; PROTEINASE C1R; UNCLASSIFIED DRUG; COMPLEMENT COMPONENT C1R;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENT ACTIVATION; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; CATALYTIC DOMAIN; COMPLEMENT ACTIVATION; COMPLEMENT C1R; ENZYME PRECURSORS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 0036850943     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(02)00881-X     Document Type: Article

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