Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 37, 2014, Pages 13445-13450

  Degn, Søren E ^a   Kjaer, Troels R ^a   Kidmose, Rune T ^b   Jensen, Lisbeth ^a   Hansen, Annette G ^a   Tekin, Mustafa ^c   Jensenius, Jens C ^a   Andersen, Gregers R ^b   Thiel, Steffen ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Collectin; Homeostasis; Inflammation; Innate immunity

Indexed keywords

FICOLIN; LECTIN; LIGAND; MANNAN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; MULTIPROTEIN COMPLEX; PATTERN RECOGNITION RECEPTOR; PROTEIN BINDING;

CHEMICAL STRUCTURE; COMPLEMENT ACTIVATION; HUMAN; METABOLISM; PROTEIN MULTIMERIZATION;

COMPLEMENT ACTIVATION; HUMANS; LECTINS; LIGANDS; MANNANS; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTORS, PATTERN RECOGNITION;

EID: 84907215709     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406849111     Document Type: Article

References (20)

1. Ricklin D, Hajishengallis G, Yang K, Lambris JD (2010) Complement: A key system for immune surveillance and homeostasis. Nat Immunol 11(9):785-797.
2. Venkatraman Girija U, et al. (2013) Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc Natl Acad Sci USA 110(34):13916-13920.
3. Gaboriaud C, et al. (2004) Structure and activation of the C1 complex of complement: Unraveling the puzzle. Trends Immunol 25(7):368-373.
4. Gingras AR, et al. (2011) Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: Implications for complement activation. Structure 19(11):1635-1643.
5. Wallis R, Mitchell DA, Schmid R, Schwaeble WJ, Keeble AH (2010) Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology 215(1):1-11.
6. Henriksen ML, et al. (2013) Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. J Immunol 191(12):6117-6127.
7. Dahl MR, et al. (2001) MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15(1):127-135.
8. Teillet F, et al. (2005) The two major oligomeric forms of human mannan-binding lectin: Chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases. J Immunol 174(5):2870-2877.
9. Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T (2000) Proteolytic activities of two types ofmannose-binding lectin-associated serine protease. J Immunol 165(5):2637-2642.
10. Rossi V, et al. (2001) Substrate specificities of recombinant mannan-binding lectinassociated serine proteases-1 and -2. J Biol Chem 276(44):40880-40887.
11. Chen CB, Wallis R (2004) Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. J Biol Chem 279(25):26058-26065.
12. Gál P, et al. (2005) A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations. J Biol Chem 280(39):33435-33444.
13. Takahashi M, et al. (2008) Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol 180(9):6132-6138.
14. Takahashi M, Mori S, Shigeta S, Fujita T (2007) Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway. Adv Exp Med Biol 598:93-104.
15. Degn SE, et al. (2012) Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function. J Immunol 189(8):3957-3969.
16. Héja D, et al. (2012) Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2. Proc Natl Acad Sci USA 109(26):10498-10503.
17. Shi L, et al. (2004) Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med 199(10):1379-1390.
18. Degn SE, Jensen L, Olszowski T, Jensenius JC, Thiel S (2013) Co-complexes of MASP-1 and MASP-2 associated with the soluble pattern-recognition molecules drive lectin pathway activation in a manner inhibitable by MAp44. J Immunol 191(3):1334-1345.
19. Kirschner KN, Lins RD, Maass A, Soares TA (2012) A glycam-based force field for simulations of lipopolysaccharide membranes: Parametrization and validation. J Chem Theory Comput 8(11):4719-4731.
20. Kjaer TR, Thiel S, Andersen GR (2013) Toward a structure-based comprehension of the lectin pathway of complement. Mol Immunol 56(4):413-422.