Analogous interactions in initiating complexes of the classical and lectin pathways of complement

Journal of Immunology

Volumn 182, Issue 12, 2009, Pages 7708-7717

  Phillips, Anna E ^a   Toth, Julia ^a   Dodds, Alister W ^b   Girija, Umakhanth Venkatraman ^a,b   Furze, Christopher M ^a   Pala, Eleni ^a   Sim, Robert B ^b   Reid, Kenneth B M ^b   Schwaeble, Wilhelm J ^a   Schmid, Ralf ^a   Keeble, Anthony H ^a   Wallis, Russell ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; EPIDERMAL GROWTH FACTOR; LECTIN; COMPLEMENT; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STOICHIOMETRY; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COMPLEMENT SYSTEM PROTEINS; HUMANS; KINETICS; LECTINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 67649232598     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900666     Document Type: Article

References (51)

1. Porter, R. R., and K. B. M. Reid. 1978. The biochemistry of complement. Nature 275: 699-704.
2. Carroll, M. C. 2004. The complement system in regulation of adaptive immunity. Nat. Immunol. 5: 981-986.
3. Gaboriaud, C., F. Teillet, L. A. Gregory, N. M. Thielens, and G. J. Arlaud. 2007. Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights. Immunobiology 212: 279-288.
4. Girija, U. V., A. W. Dodds, S. Roscher, K. B. Reid, and R. Wallis. 2007. Localization and characterization of the mannose-binding lectin (MBL)-associatedserine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins. J. Immunol. 179: 455-462.
5. Reid, K. B., R. B. Sim, and A. P. Faiers. 1977. Inhibition of the reconstitution of the haemolytic activity of the first component of human complement by a pepsin-derived fragment of subcomponent C1q. Biochem. J. 161: 239-245.
6. Teillet, F., M. Lacroix, S. Thiel, D. Weilguny, T. Agger, G. J. Arlaud, and N. M. Thielens. 2007. Identification of the site of human mannan-binding lectin involved in the interaction with its partner serine proteases: the essential role of Lys55. J. Immunol. 178: 5710-5716.
7. Wallis, R., J. M. Shaw, J. Uitdehaag, C. B. Chen, D. Torgersen, and K. Drickamer. 2004. Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activation. J. Biol. Chem. 279: 14065-14073.
8. Sim, R. B., and S. A. Tsiftsoglou. 2004. Proteases of the complement system. Biochem. Soc. Trans. 32: 21-27.
9. Harmat, V., P. Gal, J. Kardos, K. Szilagyi, G. Ambrus, B. Vegh, G. Naray-Szabo, and P. Zavodszky. 2004. The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions. J. Mol. Biol. 342: 1533-1546.
10. Teillet, F., C. Gaboriaud, M. Lacroix, L. Martin, G. J. Arlaud, and N. M. Thielens. 2008. Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J. Biol. Chem. 283: 25715-25724.
11. Teillet, F., B. Dublet, J. P. Andrieu, C. Gaboriaud, G. J. Arlaud, and N. M. Thielens. 2005. The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases. J. Immunol. 174: 2870-2877.
12. Wallis, R., and K. Drickamer. 1999. Molecular determinants of oligomer formation and complement fixation in mannose-binding proteins. J. Biol. Chem. 274: 3580-3589.
13. Feinberg, H., J. C. Uitdehaag, J. M. Davies, R. Wallis, K. Drickamer, and W. I. Weis. 2003. Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J. 22: 2348-2359.
14. Chen, C. B., and R. Wallis. 2001. Stoichiometry of complexes between mannosebinding protein and its associated serine proteases: defining functional units for complement activation. J. Biol. Chem. 276: 25894-25902.
15. Reid, K. B., and R. R. Porter. 1976. Subunit composition and structure of subcomponent C1q of the first component of human complement. Biochem. J. 155: 19-23.
16. Budayova-Spano, M., M. Lacroix, N. M. Thielens, G. J. Arlaud, J. C. Fontecilla-Camps, and C. Gaboriaud. 2002. The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. EMBO J. 21: 231-239.
17. Busby, T. F., and K. C. Ingham. 1990. NH2-terminal calcium-binding domain of human complement C1s-mediates the interaction of C1r- with C1q. Biochemistry 29: 4613-4618.
18. 2+-dependent interaction with C1s. J. Biol. Chem. 274: 9149-9159.
19. 2+-binding interaction domain of C1s: insights into the assembly of the C1 complex of complement. J. Biol. Chem. 278: 32157-32164.
20. Poon, P. H., and V. N. Schumaker. 1991. Measurement of macromolecular interactions between complement subcomponents C1q, C1r, C1s, and immunoglobulin IgM by sedimentation analysis using the analytical ultracentrifuge. J. Biol. Chem. 266: 5723-5727.
21. Sim, R. B. 1981. The first component of human complement-C1. Methods Enzymol. 80: 6-16.
22. Gaboriaud, C., N. M. Thielens, L. A. Gregory, V. Rossi, J. C. Fontecilla-Camps, and G. J. Arlaud. 2004. Structure and activation of the C1 complex of complement: unraveling the puzzle. Trends Immunol. 25: 368-373.
23. 2 complex of the classical pathway of complement, without involvement of C1q. J. Immunol. 144: 2287-2294.
24. Thielens, N. E., S. Cseh, S. Thiel, T. Vorup-Jensen, V. Rossi, J. C. Jensenius, and G. J. Arlaud. 2001. Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL. J. Immunol. 166: 5068-5077.
25. Wallis, R., A. W. Dodds, D. A. Mitchell, R. B. Sim, K. B. Reid, and W. J. Schwaeble. 2007. Molecular Interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. J. Biol. Chem. 282: 7844-7851.
26. Arlaud, G. J., R. B. Sim, A. M. Duplaa, and M. G. Colomb. 1979. Differential elution of Clq, Clr and Cls from human Cl bound to immune aggregates: use in the rapid purification of Cl subcomponents. Mol. Immunol. 16: 445-450.
27. Reid, K. B. 1981. Preparation of human C1 q, a subcomponent of the first component of the classical pathway of complement. Methods Enzymol. 80: 16-25.
28. Sim, R. B. 1981. The human complement system serine proteases C1r and C1s and their proenzymes. Methods Enzymol. 80: 26-42.
29. Wallis, R., and R. B. Dodd. 2000. Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations. J. Biol. Chem. 275: 30962-30969.
30. Chen, C. B., and R. Wallis. 2004. Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. J. Biol. Chem. 279: 26058-26065.
31. Kaufman, R. J., M. V. Davies, L. C. Wasley, and D. Michnick. 1991. Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus. Nucleic Acids Res. 19: 4485-4490.
32. Roumenina, L. T., M. M. Ruseva, A. Zlatarova, R. Ghai, M. Kolev, N. Olova, M. Gadjeva, A. Agrawal, B. Bottazzi, A. Mantovani, et al. 2006. Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains. Biochemistry 45: 4093-4104.
33. Biro, A., Z. Rovo, D. Papp, L. Cervenak, L. Varga, G. Fust, N. M. Thielens, G. J. Arlaud, and Z. Prohaszka. 2007. Studies on the interactions between C-reactive protein and complement proteins. Immunology 121: 40-50.
34. Paidassi, H., P. Tacnet-Delorme, V. Garlatti, C. Darnault, B. Ghebrehiwet, C. Gaboriaud, G. J. Arlaud, and P. Frachet. 2008. C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J. Immunol. 180: 2329-2338.
35. Fiser, A., and A. Sali. 2003. Modeller: generation and refinement of homology-based protein structure models. Methods Enzymol. 374: 461-491.
36. DeLano, W. L. 2002. The Pymol Molecular Graphics System. DeLano Scientific, San Carlos, CA.
37. Gaboriaud, C., J. Juanhuix, A. Gruez, M. Lacroix, C. Darnault, D. Pignol, D. Verger, J. C. Fontecilla-Camps, and G. J. Arlaud. 2003. The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. J. Biol. Chem. 278: 46974-46982.
38. Perkins, S. J. 1985. Molecular modelling of human complement subcomponent C1q and its complex with C1r2C1s2 derived from neutron-scattering curves and hydrodynamic properties. Biochem. J. 228: 13-26.
39. Siegel, R. C., and V. N. Schumaker. 1983. Measurement of the association constants of the complexes formed between intact C1q or pepsin-treated C1q stalks and the unactivated or activated C1r2C1s2 tetramers. Mol. Immunol. 20: 53-66.
40. Tseng, Y., P. Zavodszky, and V. N. Schumaker. 1997. The human complement C1 complex has a picomolar dissociation constant at room temperature. J. Immunol. 158: 937-944. (Pubitemid 127492674)
41. +-dependent interactions of the isolated NH2-terminal α fragments of human complement proteases C1-r and C1-s. J. Biol. Chem. 265: 14469-14475.
42. Ecker, E. E. 1948. Complement. Annu. Rev. Microbiol. 2: 255-268.
43. Batista, F. D., and M. S. Neuberger. 1998. Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate. Immunity 8: 751-759.
44. Ladbury, J. E., and S. Arold. 2000. Searching for specificity in SH domains. Chem. Biol. 7: R3-8.
45. Li, W., A. H. Keeble, C. Giffard, R. James, G. R. Moore, and C. Kleanthous. 2004. Highly discriminating protein-protein interaction specificities in the context of a conserved binding energy hotspot. J. Mol. Biol. 337: 743-759.
46. Matsushita, M., A. Matsushita, Y. Endo, M. Nakata, N. Kojima, T. Mizuochi, and T. Fujita. 2004. Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin. Proc. Natl. Acad. Sci. USA 101: 10127-10131.
47. Poon, P. H., V. N. Schumaker, M. L. Phillips, and C. J. Strang. 1983. Conformation and restricted segmental flexibility of C1, the first component of human complement. J. Mol. Biol. 168: 563-577.
48. Strang, C. J., R. C. Siegel, M. L. Phillips, P. H. Poon, and V. N. Schumaker. 1982. Ultrastructure of the first component of human complement: electron microscopy of the crosslinked complex. Proc. Natl. Acad. Sci. USA 79: 586-590.
49. Kardos, J., V. Harmat, A. Pallo, O. Barabas, K. Szilagyi, L. Graf, G. Naray-Szabo, Y. Goto, P. Zavodszky, and P. Gal. 2008. Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r. Mol. Immunol. 45: 1752-1760.
50. Reid, K. B. 1979. Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement. Biochem. J. 179: 367-371.
51. Thiel, S., S. V. Petersen, T. Vorup-Jensen, M. Matsushita, T. Fujita, C. M. Stover, W. J. Schwaeble, and J. C. Jensenius. 2000. Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19. J. Immunol. 165: 878-887. (Pubitemid 30484755)