A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15821-15829

  Perry, Andrew J ^a   Wijeyewickrema, Lakshmi C ^a   Wilmann, Pascal G ^a   Gunzburg, Menachem J ^a   D'Andrea, Laura ^a   Irving, James A ^a,b   Pang, Siew Siew ^a   Duncan, Renee C ^a,c   Wilce, Jacqueline A ^a   Whisstock, James C ^a   Pike, Robert N ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c BURNET INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT SYSTEMS; CONTROL OF THE INTERACTION; IMMUNE RESPONSE; MICROBIAL PATHOGENS; MOLECULAR SWITCHES; SEQUENTIAL ACTIVATION; SERINE PROTEASE; STRUCTURAL EXPLANATION;

AMINO ACIDS; ENZYME ACTIVITY;

DIGITAL STORAGE;

COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C4;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE;

ACTIVATION; C1S; C4; COMPLEMENT; CRYSTAL STRUCTURE; ENZYME STRUCTURE; PROTEASE; SERINE PROTEASE; ZYMOGEN;

COMPLEMENT C1S; COMPLEMENT C4; ENZYME PRECURSORS; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878407764     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.464545     Document Type: Article

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